Nature Structural & Molecular Biology Contents: 2016 Volume #23 pp 93-186

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Advertisement Molecular Biology of Assemblies and Machines  by Steven, Baumeister, Johnson, Perham Click For Discount Information TABLE OF CONTENTS February 2016 Volume 23, Issue 2 News and Views Perspective Review Articles Advertisement Nature Insight Frontiers in Biology This year's Frontiers in Biology Insight features Reviews on the processes that underlie metastasis, the positive influence of inflammation on tissue repair, the role of endothelial cells in organ development, growth and regeneration, the endoplasmic reticulum stress response and its contribution to disease, and antibiotic resistance. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement New! Nature Microbiology - First issue now published. The first issue of Nature Microbiology is now published and free to access online! This new journal covers all aspects of microorganisms, be it their evolution, physiology and cell biology; their interactions with each other, with a host or with an environment; or their societal significance. Ensure you stay up to date with future content by registering to receive the monthly e-alert.   News and Views Top Molecular basis of HSF regulation   pp93 - 95 Akira Nakai doi:10.1038/nsmb.3165 Two structural studies provide new insights into the mechanisms regulating the DNA binding and activation of human HSF family members. See also: Article by Neudegger et al. | Article by Jaeger et al. Exploiting the exploiter: a viral inhibitor stabilizes TAP for cryo-EM   pp95 - 97 Rutger D Luteijn and Emmanuel J H J Wiertz doi:10.1038/nsmb.3168 Unraveling the molecular arms race between virus and host has been taken to a new level. A cryo-EM study reveals in unprecedented detail how the herpesvirus immune-evasion protein ICP47 inhibits the peptide transporter TAP. Structure of a DNA enzyme   p97 Katrina Woolcock doi:10.1038/nsmb0216-97 Perspective N6-methyladenosine-encoded epitranscriptomics   pp98 - 102 Nian Liu and Tao Pan doi:10.1038/nsmb.3162 This Perspective highlights recent progress on the location, functions and mechanisms of N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA. In particular, the authors discuss how m6A modification affects the mammalian RNA life cycle at multiple stages. Structural & Molecular Biology JOBS of the week Post-Doctoral Research Fellow - Peptide Drug Discovery Fred Hutchinson Cancer Research Center PhD Students in Molecular Medicine & Bioinformatics Institute for Molecular Medicine Finland (FIMM) PhD Students in Molecular Medicine – Translational Neuroscience Danish Research Institute for Translational Neuroscience (DANDRITE) / Nordic EMBL Partnership PhD scholarships in the life sciences Max Planck Institute for Developmental Biology, IMPRS "From Molecules to Organisms" Research Assistant / Associate in Structural Biology - Biochemistry (Fixed Term) University of Cambridge More Science jobs from Review Top Replication stress: getting back on track   pp103 - 109 Matteo Berti and Alessandro Vindigni doi:10.1038/nsmb.3163 In this Review, the authors discuss emerging mechanisms of how the replication machinery of mammalian cells overcomes replication-fork obstacles, thus ensuring faithful genome duplication. Articles Top N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics   pp110 - 115 Junhong Choi, Ka-Weng Ieong, Hasan Demirci, Jin Chen, Alexey Petrov, Arjun Prabhakar, Seân E O'Leary, Dan Dominissini, Gideon Rechavi, S Michael Soltis, Måns Ehrenberg & Joseph D Puglisi doi:10.1038/nsmb.3148 Methylation of adenosine within mRNA coding regions delays tRNA accommodation during translation and thus changes translation dynamics, which might influence protein folding. Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation   pp116 - 124 Lars Schomacher, Dandan Han, Michael U Musheev, Khelifa Arab, Sabine Kienhöfer, Annika von Seggern & Christof Niehrs doi:10.1038/nsmb.3151 During oxidative DNA demethylation, Neil DNA glycosylases stimulate processing of abasic sites generated by Tdg, which excises 5-methylcytosine oxidation products generated by Tet dioxygenases, promoting restoration of unmodified cytosines via base excision repair. EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome   pp125 - 131 Dejiu Zhang, Kaige Yan, Guangqiao Liu, Guangtao Song, Jiejian Luo, Yi Shi, Erchao Cheng, Shan Wu, Taijiao Jiang, Jizhong Lou, Ning Gao & Yan Qin doi:10.1038/nsmb.3160 Cryo-EM structures of EF4 with the 70S ribosome, in conjunction with functional assays, reveal insights into the mechanism of EF4-mediated tRNA back-translocation. Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation   pp132 - 139 Eric Metzger, Dominica Willmann, Joel McMillan, Ignasi Forne, Philipp Metzger, Stefan Gerhardt, Kerstin Petroll, Anne von Maessenhausen, Sylvia Urban, Anne-Kathrin Schott, Alexsandra Espejo, Adrien Eberlin, Daniel Wohlwend, Katrin M Schüle, Michael Schleicher, Sven Perner, Mark T Bedford, Manfred Jung, Jörn Dengjel, Ralf Flaig, Axel Imhof, Oliver Einsle & Roland Schüle doi:10.1038/nsmb.3153 Methylation of the lysine demethylase KDM1A and the recognition of this modification by the chromodomain helicase CHD1 control androgen-dependent gene transcription and TMPRSS2-ERG gene fusion, a common translocation event in prostate cancer. Structure of human heat-shock transcription factor 1 in complex with DNA   pp140 - 146 Tobias Neudegger, Jacob Verghese, Manajit Hayer-Hartl, F Ulrich Hartl and Andreas Bracher doi:10.1038/nsmb.3149 Crystal structures of human HSF1 DNA-binding domain in complex with DNA and of the coiled-coil domain from a fungal ortholog provide insight into the mode of interaction of this transcription factor with DNA. See also: News and Views by Nakai Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors   pp147 - 154 Alex M Jaeger, Charles W Pemble IV, Lea Sistonen and Dennis J Thiele doi:10.1038/nsmb.3150 Crystal structures of human HSF2 DNA-binding domain bound to DNA, along with biochemical and cellular analyses, offer insight into potential regulatory interactions of this transcription factor. See also: News and Views by Nakai Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation   pp155 - 163 Manuel Carminati, Sara Gallini, Laura Pirovano, Andrea Alfieri, Sara Bisi et al. doi:10.1038/nsmb.3152 The adhesion molecule Afadin acts as a scaffold coordinating the cortical assembly of the cellular machinery that orients the mitotic spindle and drives planar cell division. Structural basis and function of XRN2 binding by XTB domains   pp164 - 171 Hannes Richter, Iskra Katic, Heinz Gut and Helge Groβzhans doi:10.1038/nsmb.3155 Interaction of the RNase XRN2 with PAXT-1 and related XTB domain-containing proteins is important for XRN2 function in vivo and probably serves to increase XRN2 stability in the absence of substrate. Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2   pp172 - 179 Nicola De Franceschi, Antti Arjonen, Nadia Elkhatib, Konstantin Denessiouk, Antoni G Wrobel, Thomas A Wilson, Jeroen Pouwels, Guillaume Montagnac, David J Owen & Johanna Ivaska doi:10.1038/nsmb.3161 An evolutionarily conserved YxxΦ motif present in a subset of integrin α-chains directs selective endocytosis of integrin heterodimers via interaction with the clathrin adaptor AP2, which is important for cell motility. Cryo-electron microscopy structure of the TRPV2 ion channel   pp180 - 186 Lejla Zubcevic, Mark A Herzik Jr, Ben C Chung, Zhirui Liu, Gabriel C Lander & Seok-Yong Lee doi:10.1038/nsmb.3159 A cryo-EM structure of rabbit TRPV2 in a putative desensitized state suggests secondary-structure reorganization in S6 during channel gating. Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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