Nature Reviews Molecular Cell Biology contents March 2016 Volume 17 Number 3 pp 133-200

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TABLE OF CONTENTS
March 2016 Volume 17 Number 3		Advertisement
Impact Factor 29.852 *	In this issue Research Highlights Foreword Focus on: Pluripotent stem cells Reviews Focus on: Pluripotent stem cells Perspectives Also this month  Featured article: Molecular features of cellular reprogramming and development Zachary D. Smith, Camille Sindhu & Alexander Meissner	Live cell imaging? Kill the antibodies and Save your Cells! Intracellular epitopes typically require fixation and permeabilization. Find out how you can detect targets of interest without destroying your cells.  Learn about SmartFlare™ live cell biomarker detection technology today!
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RESEARCH HIGHLIGHTS Top Adult stem cells: Hair stem cells born without a home Published online: 28 January 2016 p133 | doi:10.1038/nrm.2016.9 A study now reveals that adult hair follicle stem cells are established through asymmetric cell divisions and asymmetric signalling, in the absence of a stem cell niche. PDF DNA replication: SUMO wrestling to get the timing right Published online: 17 February 2016 p134 | doi:10.1038/nrm.2016.15 Sumoylation of MCM inhibits DNA replication initiation by counteracting the function of the kinases that activate MCM; the loss of MCM sumoylation coincides with origin firing. PDF Ageing: Anti-ageing formula Published online: 17 February 2016 p134 | doi:10.1038/nrm.2016.16 The removal of senescent cells from middle-aged mice can extend healthspan by attenuating age-related organ dysfunction. PDF JOURNAL CLUB Pluripotent stem cells: Breaking the germ line-soma barrier Published online: 10 February 2016 p136 | doi:10.1038/nrm.2016.12 Azim Surani discusses how induced pluripotent stem cells have enabled researchers to demonstrate that it is possible to cross the germ line-soma barrier, known as the Weismann barrier. PDF Translation: Start upstream to relieve stress Published online: 10 February 2016 p136 | doi:10.1038/nrm.2016.13 A new method to validate the translation of upstream open reading frames reveals their function during the integrated stress response. PDF IN BRIEF Cell Death: Molecular insights into execution of necroptosis | Morphogenesis: Cadherin gradients sharpen somite boundaries | Organelle dynamics: How peroxisomes hitchhike on endosomes | Development: DNA methylation from oocyte to placenta | Plant cell biology: Root endodermis adapts to nutrient availability | Gene expression: CRISPR-Cas screening for enhancers PDF Molecular Cell Biology JOBS of the week Postdoctoral fellow (m / f) Klinikum der Universität München, Institut für Schlaganfall- und Demenzforschung (ISD) Post-doc Position in Translational Leukemia Research (M / F) University Hospital Würzburg Postdoctoral Fellow – Immunotherapy / Protein Engineering California Institute for Biomedical Research Research Group Leader Inserm Post-doctoral fellowship Lund University More Science jobs from
FOREWORD		Top
Nuclear reprogramming and cell replacement therapies J. B. Gurdon Published online: 23 February 2016 p137 | doi:10.1038/nrm.2016.11 J. B. Gurdon introduces this Focus issue by discussing the importance of the discovery of induced pluripotent stem cells 10 years ago and current challenges for the development of cell replacement therapies. Abstract | Full Text | PDF
Focus on: Pluripotent stem cells REVIEWS Top Molecular features of cellular reprogramming and development Zachary D. Smith, Camille Sindhu & Alexander Meissner Published online: 17 February 2016 p139 | doi:10.1038/nrm.2016.6 The ectopic expression of a defined set of transcription factors can experimentally reprogramme somatic cells into other cell types, including pluripotent cells. This method enables exploration of the molecular characteristics of pluripotency, cell specification, differentiation and cell fate stability, as well as their transcriptional and epigenetic regulation. Abstract | Full Text | PDF | Supplementary information Dynamic stem cell states: naive to primed pluripotency in rodents and humans Leehee Weinberger, Muneef Ayyash, Noa Novershtern & Jacob H. Hanna Published online: 10 February 2016 p155 | doi:10.1038/nrm.2015.28 Recent advances in our understating of the molecular underpinnings of alternative primed- and naive-like pluripotent states in rodents and humans highlight potential functional benefits of naive pluripotency and identify key unanswered questions in this rapidly evolving field. Abstract | Full Text | PDF | Supplementary information Pluripotent stem cells in disease modelling and drug discovery Yishai Avior, Ido Sagi & Nissim Benvenisty Published online: 28 January 2016 p170 | doi:10.1038/nrm.2015.27 The use of cultured human pluripotent stem cells (PSCs) to model human diseases has revolutionized the ways in which we study monogenic, multigenic and epigenetic disorders, by overcoming some of the limitations of animal models. PSC-based disease models are generated using various strategies and can be used for the discovery of new drugs and therapies. Abstract | Full Text | PDF PERSPECTIVES Top TIMELINE A decade of transcription factor-mediated reprogramming to pluripotency Kazutoshi Takahashi & Shinya Yamanaka Published online: 17 February 2016 p183 | doi:10.1038/nrm.2016.8 This year marks the tenth anniversary of the generation of induced pluripotent stem cells (iPSCs) by transcription factor-mediated somatic cell reprogramming. Takahashi and Yamanaka portray the path towards this ground-breaking discovery and discuss how, since then, research has focused on understanding the mechanisms underlying iPSC generation and on translating such advances to the clinic. Abstract | Full Text | PDF | Supplementary information SCIENCE AND SOCIETY Pluripotent stem cells progressing to the clinic Alan Trounson & Natalie D. DeWitt Published online: 23 February 2016 p194 | doi:10.1038/nrm.2016.10 Advances in the derivation of pluripotent stem cells (PSCs) and their differentiation to specific cell types could have diverse clinical applications. Trounson and DeWitt provide an overview of the progress in using embryonic stem cell and induced PSC derivatives for disease treatment and discuss the potential and limitations of such approaches. Abstract | Full Text | PDF
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