Nature Reviews Microbiology contents March 2016 Volume 14 Number 3 pp 120-190

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TABLE OF CONTENTS
March 2016 Volume 14 Number 3		Advertisement
Impact Factor 23.574 *	In this issue Research Highlights News and Analysis Reviews Also this month  Featured article: Within-host evolution of bacterial pathogens Xavier Didelot, A. Sarah Walker, Tim E. Peto, Derrick W. Crook & Daniel J. Wilson	Nature Insight Frontiers in Biology This year's Frontiers in Biology Insight features Reviews on the processes that underlie metastasis, the positive influence of inflammation on tissue repair, the role of endothelial cells in organ development, growth and regeneration, the endoplasmic reticulum stress response and its contribution to disease, and antibiotic resistance.
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RESEARCH HIGHLIGHTS Top Viral infection: Playing hide and seek with HIV p120 | doi:10.1038/nrmicro.2016.14 Deep-sequencing of lymphoid tissue samples from patients infected with HIV who were undergoing suppressive antiretroviral therapy reveals ongoing replication in lymphoid tissues and replenishment of the latent reservoir. PDF Bacterial evolution: How to extend your stay p130 | doi:10.1038/nrmicro.2016.16 This study shows how Salmonella enterica subsp. enterica serovar Enteritidis evolved within an immunocompromised host from living in the gut to causing bacteraemia. PDF Parasite biology: Virulence packages p130 | doi:10.1038/nrmicro.2016.9 African trypanosomes produce extracellular membrane vesicles that transfer virulence factors to neighbouring parasites and host cells. PDF Microbiome: Transgenerational missing taxa p132 | doi:10.1038/nrmicro.2016.11 A humanized mouse model shows that consumption of a low-fibre diet results in the progressive loss of microbial diversity with each generation. PDF Microbial ecology: FISHing in the oral microbiota p132 | doi:10.1038/nrmicro.2016.21 Spectral fluorescence imaging identifies the consortium structures formed by nine key taxa of the oral microbiota. PDF Bacterial genomics: Legionella's toolbox of effectors p133 | doi:10.1038/nrmicro.2016.8 Genome analysis of 38 different Legionella species has identified a vast repertoire of effectors, many of which are species-specific and were probably acquired from amoeba hosts or co-infecting pathogens. PDF IN BRIEF Bacterial genomics: Three centuries of plague | Parasite genetics: Putting a stop to kinetoplastid transcription | Cellular microbiology: Damage limitation after friendly fire | Viral infection: AAV receptor identified | Microbiome: Add the microbiota to your birth plan | Public health: Ebola update PDF
NEWS AND ANALYSIS		Top
GENOME WATCH Genomes on ice Julian Parkhill p134 | doi:10.1038/nrmicro.2016.13 This month's Genome Watch discusses the analysis of a Helicobacter pylori genome from the preserved Copper-Age mummy known as the Iceman and how ancient genomes shed light on the history of bacterial pathogens. PDF
REVIEWS		Top
Synthetic biology to access and expand nature's chemical diversity Michael J. Smanski, Hui Zhou, Jan Claesen, Ben Shen, Michael A. Fischbach & Christopher A. Voigt p135 | doi:10.1038/nrmicro.2015.24 Advances in synthetic biology have simplified the characterization and production of biologically active molecules from various organisms. In this Review, Voigt and colleagues outline the design and construction of pathways used for the synthesis of such natural products in host microorganisms. Abstract | Full Text | PDF
Within-host evolution of bacterial pathogens Xavier Didelot, A. Sarah Walker, Tim E. Peto, Derrick W. Crook & Daniel J. Wilson p150 | doi:10.1038/nrmicro.2015.13 Advances in whole-genome sequencing have enabled within-host genome evolution to be studied with unprecedented detail. In this Review article, Didelot, Wilson and colleagues discuss how these studies have altered our view of host adaptation and antibiotic resistance during bacterial infection. Abstract | Full Text | PDF
Interactions of fungal pathogens with phagocytes Lars P. Erwig & Neil A. R. Gow p163 | doi:10.1038/nrmicro.2015.21 Phagocytes can detect and eliminate fungal pathogens, but fungi have evolved several mechanisms that enable them to subvert immune recognition, uptake and killing. In this Review, Erwig and Gow detail how fungi interact with the host innate immune system and describe the mechanisms of immune evasion used by fungal pathogens to promote infection. Abstract | Full Text | PDF
'Add, stir and reduce': Yersinia spp. as model bacteria for pathogen evolution Alan McNally, Nicholas R. Thomson, Sandra Reuter & Brendan W. Wren p177 | doi:10.1038/nrmicro.2015.29 In the genomics era, Yersinia has proven to be a model genus for studying the emergence of pathogenesis. Focusing on this model, McNally and colleagues highlight the events in genome evolution that underlie pathogenesis and argue for an 'eco-evo' perspective of pathogen evolution. Abstract | Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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