Nature Reviews Immunology Contents February 2016 Volume 16 Number 2 pp 69-128

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TABLE OF CONTENTS
February 2016 Volume 16 Number 2
Impact Factor 34.985 *	In this issue Research Highlights Focus on: Immune memory Also this month  Featured article: Regulatory T cell memory Michael D. Rosenblum, Sing Sing Way & Abul K. Abbas
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In this issue p69 | doi:10.1038/nri.2016.11 Full Text
RESEARCH HIGHLIGHTS Top Immune memory: T-box tuning for TRM cell fate p71 | doi:10.1038/nri.2016.8 Downregulation of the T-box transcription factors eomesodermin (EOMES) and T-bet drives tissue-resident memory T cell fate. PDF Immune memory: ILC2s drive allergen recall p72 | doi:10.1038/nri.2016.10 Group 2 innate lymphoid cells drive memory T helper 2 cell responses by licensing dendritic cells. PDF Immune memory: Sequential evolution of B cell memory p72 | doi:10.1038/nri.2016.15 Memory B cells are produced early, whereas long-lived plasma cells are produced late, in the germinal centre response. PDF Immune memory: Lingering human T cells p73 | doi:10.1038/nri.2016.12 Tracking of human memory T cells infused after haematopoietic stem cell transplantation indicates that long-term persistent memory T cells originate mainly from stem cell memory T cells and are favoured by antigen rechallenge. PDF Immunometabolism: Unravelling the puzzle to longevity and immunity p74 | doi:10.1038/nri.2016.16 The longevity hormone fibroblast growth factor 21 can act as a regulator of thymic T cell production during ageing. PDF Tumour immunology: Neutrophils help tumours spread p74 | doi:10.1038/nri.2016.17 Neutrophils support the spread of breast cancer cells to the lungs through the production of leukotrienes. PDF T cell signalling: TCR takedown in TH2 cells p75 | doi:10.1038/nri.2016.14 The guanine nucleotide exchange factor DENND1B specifically regulates TCR signalling in TH2 cells and protects against allergy. PDF Immunometabolism: The antiviral effect of limiting lipids p76 | doi:10.1038/nri.2016.6 Decreased cholesterol metabolism in response to virus infection potentiates the type I interferon-mediated antiviral response. PDF Mucosal immunology: Neuroendocrine cells regulate lung inflammation p76 | doi:10.1038/nri.2016.7 A rare population of neuroendocrine cells in the lung epithelium can shape immune responses and tissue remodelling in the lungs. PDF JOURNAL CLUB The Red and white: ancient history p77 | doi:10.1038/nri.2016.1 Peter Doherty describes the 1962 paper by Jim Gowans that characterized lymphocyte-mediated immunity. PDF Immunology JOBS of the week Postdoctoral Position in Transplant Immunology Lab Cleveland Clinic Postdoctoral Position in Immunology Indiana University School of Medicine Postdoctoral Positions - Human Systems Immunology, Gut Inflammation and IBD APC Microbiome Institute, University College Cork Postdoc Immunology of IBD at UCSD University of California-San Diego Faculty Positions in Immunology ~ Dana-Farber / Harvard Medical School Dana-Farber Cancer Institute / Harvard Medical School More Science jobs from Immunology EVENT Translational Immunology in Kidney Disease - ISN Nexus Symposium 2016 14.04.16 Berlin, Germany More science events from
Focus on: Immune memory REVIEWS Top Tissue-resident memory T cells: local specialists in immune defence Scott N. Mueller & Laura K. Mackay p79 | doi:10.1038/nri.2015.3 The recent discovery that some memory T cells can become tissue resident after infection warrants further study into the mechanisms and therapeutic implications of such enhanced regional immunity. Abstract | Full Text | PDF Regulatory T cell memory Michael D. Rosenblum, Sing Sing Way & Abul K. Abbas p90 | doi:10.1038/nri.2015.1 In this Review, the authors detail the emerging evidence that supports the existence of memory populations of regulatory T (TReg) cells. They explain the immunological settings in which memory TReg cells develop, discuss the physiological relevance of these cells and address some of the key questions that remain for this rapidly evolving field. Abstract | Full Text | PDF The multifaceted role of CD4+ T cells in CD8+ T cell memory Brian J. Laidlaw, Joseph E. Craft & Susan M. Kaech p102 | doi:10.1038/nri.2015.10 The development and maintenance of protective CD8+ T cell memory require help. This is provided by CD4+ T cells in many ways. Here, the authors review the latest insights into this multifaceted role for CD4+ T cells, and the implications for vaccine design and T cell-based therapies. Abstract | Full Text | PDF Natural killer cell memory in infection, inflammation and cancer Adelheid Cerwenka & Lewis L. Lanier p112 | doi:10.1038/nri.2015.9 This Review focuses on our growing understanding of immunological memory behaviour in natural killer (NK) cells. The authors discuss the development and functions of memory NK cells and consider the potential of targeting these populations for vaccination or therapeutic purposes. Abstract | Full Text | PDF
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Focus on: Immune memory PERSPECTIVES Top VIEWPOINT Immunological memory: lessons from the past and a look to the future Donna L. Farber et al. p124 | doi:10.1038/nri.2016.13 In this Viewpoint article, Nature Reviews Immunology invites five experts to discuss the nature of immunological memory. How should we define a memory response? And can innate immune cells - as well as lymphocytes - develop into memory populations? The contributors share their thoughts on these questions and other key issues in the field. Abstract | Full Text | PDF
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