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TABLE OF CONTENTS
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February 2016 Volume 11, Issue 2 |
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| Editorial Commentaries Thesis Research Highlights News and Views Reviews Letters Articles In The Classroom | |
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Focus | Top |
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| Advanced nanopores | | | Commercial nanopore sequencers are now available. These devices are based on biological nanopores and sequence DNA using ion-current measurements. Nanopores can also be made from synthetic materials, but, at present, these nanopores are less sophisticated and capable than their biological counterparts. However, they allow read-out mechanisms other than ion-current measurements to be exploited and could, in the future, provide cheaper and more versatile devices, with applications in the analysis of DNA, proteins and beyond. In this focus we examine some of the possibilities for advanced synthetic nanopores and highlight the challenges the field faces in delivering practical devices. |
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Editorial | Top |
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Building a better nanopore p105 doi:10.1038/nnano.2016.15 Sophisticated nanopores, which utilize electron tunnelling measurements, two-dimensional materials, or concepts from molecular self-assembly, could have applications in DNA and protein sequencing; the technical problems that must be solved to realize such technologies are considerable though. |
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Commentaries | Top |
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Enhancing nanopore sensing with DNA nanotechnology pp106 - 108 Ulrich F. Keyser doi:10.1038/nnano.2016.2 Nanopores are on the brink of fundamentally changing DNA sequencing. At the same time, DNA origami provides unprecedented freedom in molecular design. Here, I suggest why a combination of solid-state nanopores and DNA nanotechnology will lead to exciting new experiments. |
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The promises and challenges of solid-state sequencing pp109 - 111 Stuart Lindsay doi:10.1038/nnano.2016.9 Sequencing methods based on electron tunnelling could lead to breakthroughs in genomics, proteomics and glycomics, but the engineering challenges involved in delivering these devices are formidable. |
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Thesis | Top |
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Towards a new scale p112 Christian Martin doi:10.1038/nnano.2016.8 Work on a new technology roadmap and an exceptional wave of consolidation hint at fundamental changes in the micro- and nanoelectronics industry, as Christian Martin explains. |
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Research Highlights | Top |
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Our choice from the recent literature p113 doi:10.1038/nnano.2016.14 |
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News and Views | Top |
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Reviews | Top |
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Decoding DNA, RNA and peptides with quantum tunnelling pp117 - 126 Massimiliano Di Ventra & Masateru Taniguchi doi:10.1038/nnano.2015.320 This article reviews the use of quantum tunnelling for sequencing DNA, RNA and peptides, highlighting the potential advantages of the approach and the significant technical challenges that must be addressed to deliver practical quantum sequencing devices. |
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Graphene nanodevices for DNA sequencing pp127 - 136 Stephanie J. Heerema & Cees Dekker doi:10.1038/nnano.2015.307 This article reviews the use of graphene nanodevices for DNA sequencing, highlighting the potential of approaches that involve DNA molecules passing through graphene nanopores, nanogaps, and nanoribbons, or the physisorption of DNA on graphene nanostructures. |
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Letters | Top |
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Revealing giant internal magnetic fields due to spin fluctuations in magnetically doped colloidal nanocrystals pp137 - 142 William D. Rice, Wenyong Liu, Thomas A. Baker, Nikolai A. Sinitsyn, Victor I. Klimov & Scott A. Crooker doi:10.1038/nnano.2015.258 Effective magnetic fields as high as 30 T can arise in magnetically doped nanocrystals due to spin fluctuations alone, and can now be observed using ultrafast optical spectroscopy. |
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Spin–orbit torque magnetization switching controlled by geometry pp143 - 146 C. K. Safeer, Emilie Jué, Alexandre Lopez, Liliana Buda-Prejbeanu, Stéphane Auffret, Stefania Pizzini, Olivier Boulle, Ioan Mihai Miron & Gilles Gaudin doi:10.1038/nnano.2015.252 Magnetic switching in spin–orbit-torque devices can be controlled by the geometry of the device, allowing different functionalities to be created from the same system. |
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Harnessing the damping properties of materials for high-speed atomic force microscopy pp147 - 151 Jonathan D. Adams, Blake W. Erickson, Jonas Grossenbacher, Juergen Brugger, Adrian Nievergelt & Georg E. Fantner doi:10.1038/nnano.2015.254 High-speed atomic force microscopy can be carried out in air by using polymer cantilevers that mimic the high damping environment of liquids. |
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A biomimetic DNA-based channel for the ligand-controlled transport of charged molecular cargo across a biological membrane pp152 - 156 Jonathan R. Burns, Astrid Seifert, Niels Fertig & Stefan Howorka doi:10.1038/nnano.2015.279 A DNA-based channel that undergoes a nanomechanical change in response to the binding of a specific ligand can be used to selectively transport small-molecule cargo across a lipid bilayer. |
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A stochastic DNA walker that traverses a microparticle surface pp157 - 163 C. Jung, P. B. Allen & A. D. Ellington doi:10.1038/nnano.2015.246 A DNA walker driven by hybridization reactions can traverse the surface of a DNA-coated microparticle, taking more than 30 continuous steps. |
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Articles | Top |
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Molecular cavity optomechanics as a theory of plasmon-enhanced Raman scattering pp164 - 169 Philippe Roelli, Christophe Galland, Nicolas Piro & Tobias J. Kippenberg doi:10.1038/nnano.2015.264 A cavity optomechanics model accounting for the intrinsic dynamics of the interaction between plasmons and molecular vibrations reveals a parametric amplification mechanism that may provide an explanation for features recently observed in nonlinear Raman spectroscopy experiments.
See also: News and Views by Schmidt & Aizpurua |
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Field-induced conductance switching by charge-state alternation in organometallic single-molecule junctions pp170 - 176 Florian Schwarz, Georg Kastlunger, Franziska Lissel, Carolina Egler-Lucas, Sergey N. Semenov, Koushik Venkatesan, Heinz Berke, Robert Stadler & Emanuel Lörtscher doi:10.1038/nnano.2015.255 Conductance switching with high-to-low ratios as high as 1,000 can be triggered by an electric field in rigid organometallic molecules containing a redox-active centre and a spin-polarized ground state. |
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Non-Boolean computing with nanomagnets for computer vision applications pp177 - 183 Sanjukta Bhanja, D. K. Karunaratne, Ravi Panchumarthy, Srinath Rajaram & Sudeep Sarkar doi:10.1038/nnano.2015.245 Arrays of circular nanomagnets are used to solve the problem of perceptual organization in computer vision by exploiting their tendency to minimize the total magnetic energy by coupling to each other. |
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High-speed DNA-based rolling motors powered by RNase H pp184 - 190 Kevin Yehl, Andrew Mugler, Skanda Vivek, Yang Liu, Yun Zhang, Mengzhen Fan, Eric R. Weeks & Khalid Salaita doi:10.1038/nnano.2015.259 A DNA-based rolling motor that is powered by RNA hydrolysis has a maximum speed and processivity that is three orders of magnitude greater than conventional DNA-based walkers. |
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Macromolecular crowding creates heterogeneous environments of gene expression in picolitre droplets pp191 - 197 Maike M. K. Hansen, Lenny H. H. Meijer, Evan Spruijt, Roel J. M. Maas, Marta Ventosa Rosquelles, Joost Groen, Hans A. Heus & Wilhelm T. S. Huck doi:10.1038/nnano.2015.243 Macromolecular crowding decreases diffusion of mRNA and proteins leading to the formation of heterogeneous environments in gene expression experiments in picolitre droplets. |
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Balancing research and funding using value of information and portfolio tools for nanomaterial risk classification pp198 - 203 Matthew E. Bates, Jeffrey M. Keisler, Niels P. Zussblatt, Kenton J. Plourde, Ben A. Wender & Igor Linkov doi:10.1038/nnano.2015.249 Data-driven analytical techniques can quantify the expected return of alternative research efforts relative to their cost, and can be used to prioritize research investments as shown here for hazard classification of some nanomaterials. |
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In The Classroom | Top |
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Learning from peer review p204 Bryden Le Bailly doi:10.1038/nnano.2016.4 Encouraging PhD students to engage with the peer-review process is of benefit to researchers, journals and the rest of the scientific community, says Bryden Le Bailly. |
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