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TABLE OF CONTENTS
| February 2016 Volume 22, Issue 2 |  | | |  |  Editorial
News
News and Views
Review
Brief Communication
Articles
Letters
Corrigenda
Errata
| | | | | |
Advertisement | | | | | | | Advertisement | | | New! Nature Microbiology - First issue now published. The first issue of Nature Microbiology is now published and free to access online! This new journal covers all aspects of microorganisms, be it their evolution, physiology and cell biology; their interactions with each other, with a host or with an environment; or their societal significance.
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Now open for submissions |  | | | | | | Editorial |  Top | |  | | A windfall for US biomedical science p115
doi:10.1038/nm.4048
In December, the US government approved a $2 billion increase in the budget of the US National Institutes of Health (NIH) for the 2016 fiscal year. With that increase comes relief, optimism and the pressure to spend wisely.
| | | | News | Top | | | | | News Feature | | | | An eye to the future: Researchers debate best path for stem cell-derived therapies pp116 - 119
Shraddha Chakradhar
doi:10.1038/nm0216-116
| | | | | News in Brief | | | | Biomedical briefing pp120 - 121
doi:10.1038/nm0216-120
| | | | | News Feature | | | | Mutations as munitions: Neoantigen vaccines get a closer look as cancer treatment pp122 - 124
Alla Katsnelson
doi:10.1038/nm0216-122
| | | | | Advertisement | | An open access journal dedicated to highlighting the most important scientific advances in Parkinson's disease research, spanning the motor and non-motor disorders of Parkinson's disease.
Part of the Nature Partner Journals series, npj Parkinson's Disease is published in partnership with the Parkinson's Disease Foundation.
Open for submissions |  | | | | | | News & Views | Top | | | | Targeted stimulation of the spinal cord to restore locomotor activity pp125 - 126
Arthur Prochazka
doi:10.1038/nm.4043
A new study has located 'hot spots' in the rat spinal cord that are associated with leg flexion and extension in rats. Electrical stimulation applied in an alternating pattern between these hot spots facilitated locomotion after the hindlimbs were paralyzed as a result of spinal cord injury (SCI).
See also: Article by Wenger et al. |
| | | | Oxidation and mitochondrial origin of NET DNA in the pathogenesis of lupus pp126 - 127
Sylviane Muller and Marko Radic
doi:10.1038/nm.4044
A new study of the pathogenesis of systemic lupus erythematosus (SLE) highlights the importance of mitochondria and mitochondrial reactive oxygen species (ROS) in the generation of neutrophil extracellular traps (NETs) that have the enhanced potential to elicit interferon-induced gene expression.
See also: Article by Lood et al. |
| | Review | Top | | | | Targeting EZH2 in cancer pp128 - 134
Kimberly H Kim and Charles W M Roberts
doi:10.1038/nm.4036
Roberts and Kim discuss the mechanistic roles played by EZH2 in cancer as well as efforts to therapeutically target this epigenetic modifier.
| | Brief Communication | Top | | | | PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease pp135 - 137
Kuti Baruch, Aleksandra Deczkowska, Neta Rosenzweig, Afroditi Tsitsou-Kampeli, Alaa Mohammad Sharif et al.
doi:10.1038/nm.4022
In Alzheimer's disease, PD-1 immune checkpoint blockade reduces pathology and improves memory in mice with established disease.
| | | Articles | Top | | | | | | | | | | | Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice pp163 - 174
Suzanne M Cloonan, Kimberly Glass, Maria E Laucho-Contreras, Abhiram R Bhashyam, Morgan Cervo et al.
doi:10.1038/nm.4021
Reducing levels of mitochondrial iron by diet or pharmacological chelation ameliorates symptoms of cigarette smoke-induced chronic obstructive pulmonary disease in mice.
| | | | CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis pp175 - 182
Ting Zhang, Yan Zhang, Mingyao Cui, Li Jin, Yimei Wang et al.
doi:10.1038/nm.4017
Myocardial injury induced by ischemia-reperfusion or doxorubicin leads to cardiomyocyte necroptosis via RIP3-mediated phosphorylation of CaMKII and opening of the mitochondrial permeability transition pore.
| | | | Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice pp183 - 193
Satoko Arai, Kento Kitada, Tomoko Yamazaki, Ryosuke Takai, Xizhong Zhang et al.
doi:10.1038/nm.4012
A KIM-1-AIM interaction promotes clearance of cellular debris in renal tubules after acute kidney injury to improve disease outcome.
| | Letters | Top | | | | Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors pp194 - 201
Yi Du, Hirohito Yamaguchi, Yongkun Wei, Jennifer L Hsu, Hung-Ling Wang et al.
doi:10.1038/nm.4032
c-Met binds to and phosphorylates PARP1 in cancer cells, thereby reducing PARP1 binding to a PARP inhibitor; c-Met and PARP inhibitor combination therapy shows improved efficacy in preclinical models of breast and lung cancer.
| | | | Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis pp202 - 209
Damian J Mole, Scott P Webster, Iain Uings, Xiaozhong Zheng, Margaret Binnie et al.
doi:10.1038/nm.4020
Blocking the enzyme KMO with a small molecule reduces the levels of toxic tryptophan metabolites and reduces multiple extrapancreatic organ failure in a rat model of acute pancreatitis.
| | | | Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites pp210 - 216
Farokh Dotiwala, Sachin Mulik, Rafael B Polidoro, James A Ansara, Barbara A Burleigh et al.
doi:10.1038/nm.4023
Judy Lieberman and colleagues show that intracellular parasites are eradicated by lymphocyte delivery of cytotoxic granule contents—perforin, granulysin and granzymes—into infected cells.
| | Corrigenda | Top | | | | Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis p217
Laura S Shankman, Delphine Gomez, Olga A Cherepanova, Morgan Salmon, Gabriel F Alencar et al.
doi:10.1038/nm0216-217a
| |  | | Corrigendum: Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats p217
Frank A Duca, Clemence D Cote, Brittany A Rasmussen, Melika Zadeh-Tahmasebi, Guy A Rutter et al.
doi:10.1038/nm0216-217b
| | Errata | Top | | | | Erratum: Cardiac RKIP induces a beneficial [beta]-adrenoceptor-dependent positive inotropy p217
Evelyn Schmid, Stefan Neef, Christopher Berlin, Angela Tomasovic, Katrin Kahlert et al.
doi:10.1038/nm0216-217c
| | | | Erratum: Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. p217
M Teresa Grande, Berta Sanchez-Laorden, Cristina Lopez-Blau, Cristina A De Frutos, Agnes Boutet et al.
doi:10.1038/nm0216-217d
| | | | Erratum: Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma p217
Dany Nassar, Mathilde Latil, Bram Boeckx, Diether Lambrechts and Cedric Blanpain
doi:10.1038/nm0216-217e
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