Molecular Therapy — Methods & Clinical Development: now indexed in PubMed and PubMed Central
An online-only, open access journal publishing top-quality, novel methods and technology development, as well as significant improvements to established research techniques in basic, translational, and clinical cell and gene therapy.
Explore the benefits of submitting your next manuscript. | | | | | | Editorial | Top | | New Momentum for the Field of Oligonucleotide TherapeuticsAnnemieke Aartsma-Rus Mol Ther 2016 24: 193-194; 10.1038/mt.2016.14 Full Text | | In This Issue | Top | | In This IssueMol Ther 2016 24: 196; 10.1038/mt.2016.15 Full Text | | Research Highlights | Top | | Research HighlightsMol Ther 2016 24: 197; 10.1038/mt.2016.16 Full Text | | Commentaries | Top | | Genotoxicity in Mice Following AAV Gene Delivery: A Safety Concern for Human Gene Therapy?Randy J Chandler, Matthew C LaFave, Gaurav K Varshney, Shawn M Burgess and Charles P Venditti Mol Ther 2016 24: 198-201; 10.1038/mt.2016.17 Full Text | | | | The BCG Strain Pool: Diversity MattersDaria Bottai and Roland Brosch Mol Ther 2016 24: 201-203; 10.1038/mt.2016.18 Full Text | | | | Under Pressure: Elevated Blood Pressure Enhances Targeting of Tumors by Oncolytic VirusesLeonard W Seymour and Kerry D Fisher Mol Ther 2016 24: 204-205; 10.1038/mt.2016.19 Full Text | | Original Articles | Top | | Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VIIMTOPENBrittney L Gurda, Adrien De Guilhem De Lataillade, Peter Bell, Yanqing Zhu, Hongwei Yu, Ping Wang, Jessica Bagel, Charles H Vite, Tracey Sikora, Christian Hinderer, Roberto Calcedo, Alexander D Yox, Richard A Steet, Therese Ruane, Patricia O'Donnell, Guangping Gao, James M Wilson, Margret Casal, Katherine P Ponder and Mark E Haskins Mol Ther 2016 24: 206-216; advance online publication, October 8, 2015; 10.1038/mt.2015.189 Abstract | Full Text | | | | Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During OsteoporosisHuan Jing, Li Liao, Yulin An, Xiaoxia Su, Shiyu Liu, Yi Shuai, Xinjing Zhang and Yan Jin Mol Ther 2016 24: 217-229; advance online publication, August 26, 2015; 10.1038/mt.2015.152 Abstract | Full Text | | | | Virus-mediated EpoR76E Therapy Slows Optic Nerve Axonopathy in Experimental GlaucomaWesley S Bond, Jessica Hines-Beard, YPaul L GoldenMerry, Mara Davis, Alma Farooque, Rebecca M Sappington, David J Calkins and Tonia S Rex Mol Ther 2016 24: 230-239; advance online publication, October 27, 2015; 10.1038/mt.2015.198 Abstract | Full Text | | | | AAV6-mediated Cardiac-specific Overexpression of Ribonucleotide Reductase Enhances Myocardial ContractilityStephen C Kolwicz, Jr, Guy L Odom, Sarah G Nowakowski, Farid Moussavi-Harami, Xiaolan Chen, Hans Reinecke, Stephen D Hauschka, Charles E Murry, Gregory G Mahairas and Michael Regnier Mol Ther 2016 24: 240-250; advance online publication, September 21, 2015; 10.1038/mt.2015.176 Abstract | Full Text | | | | PAX4 Gene Transfer Induces α-to-β Cell Phenotypic Conversion and Confers Therapeutic Benefits for Diabetes TreatmentYanqing Zhang, Genevieve E Fava, Hongjun Wang, Franck Mauvais-Jarvis, Vivian A Fonseca and Hongju Wu Mol Ther 2016 24: 251-260; advance online publication, October 5, 2015; 10.1038/mt.2015.181 Abstract | Full Text | | | | SET1A Cooperates With CUDR to Promote Liver Cancer Growth and Hepatocyte-like Stem Cell Malignant Transformation EpigeneticallyTianming Li, Qidi Zheng, Jiahui An, Mengying Wu, Haiyan Li, Xin Gui, Hu Pu and Dongdong Lu Mol Ther 2016 24: 261-275; advance online publication, November 19, 2015; 10.1038/mt.2015.208 Abstract | Full Text | | | | A Comprehensive Map of CNS Transduction by Eight Recombinant Adeno-associated Virus Serotypes Upon Cerebrospinal Fluid Administration in PigsNicolina Cristina Sorrentino, Veronica Maffia, Sandra Strollo, Vincenzo Cacace, Noemi Romagnoli, Anna Manfredi, Domenico Ventrella, Francesco Dondi, Francesca Barone, Massimo Giunti, Anne-Renee Graham, Yan Huang, Susan L Kalled, Alberto Auricchio, Maria Laura Bacci, Enrico Maria Surace and Alessandro Fraldi Mol Ther 2016 24: 276-286; advance online publication, December 7, 2015; 10.1038/mt.2015.212 Abstract | Full Text | | | | Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical VectorJoshua C Grieger, Stephen M Soltys and Richard Jude Samulski Mol Ther 2016 24: 287-297; advance online publication, October 6, 2015; 10.1038/mt.2015.187 Abstract | Full Text | | | | A Recombinant Bispecific CD20×CD95 Antibody With Superior Activity Against Normal and Malignant B-cellsKristina Nalivaiko, Martin Hofmann, Karina Kober, Nadine Teichweyde, Peter H Krammer, Hans-Georg Rammensee, Ludger Grosse-Hovest and Gundram Jung Mol Ther 2016 24: 298-305; advance online publication, November 19, 2015; 10.1038/mt.2015.209 Abstract | Full Text | | | | Perfusion Pressure Is a Critical Determinant of the Intratumoral Extravasation of Oncolytic VirusesAmber Miller, Rebecca Nace, Camilo Ayala-Breton C, Michael Steele, Kent Bailey, Kah Whye Peng and Stephen J Russell Mol Ther 2016 24: 306-317; advance online publication, December 9, 2015; 10.1038/mt.2015.219 Abstract | Full Text | | | | PTH Induces Systemically Administered Mesenchymal Stem Cells to Migrate to and Regenerate Spine InjuriesDmitriy Sheyn, Galina Shapiro, Wafa Tawackoli, Douk Soo Jun, Youngdo Koh, Kyu Bok Kang, Susan Su, Xiaoyu Da, Shiran Ben-David, Maxim Bez, Eran Yalon, Ben Antebi, Pablo Avalos, Tomer Stern, Elazar Zelzer, Edward M Schwarz, Zulma Gazit, Gadi Pelled, Hyun M Bae and Dan Gazit Mol Ther 2016 24: 318-330; advance online publication, November 20, 2015; 10.1038/mt.2015.211 Abstract | Full Text | | | | Glucocorticoid Cell Priming Enhances Transfection Outcomes in Adult Human Mesenchymal Stem CellsAbby M Kelly, Sarah A Plautz, Janos Zempleni and Angela K Pannier Mol Ther 2016 24: 331-341; advance online publication, October 19, 2015; 10.1038/mt.2015.195 Abstract | Full Text | | | | Absence of WASp Enhances Hematopoietic and Megakaryocytic Differentiation in a Human Embryonic Stem Cell ModelMTOPENMiguel G Toscano, Pilar Muñoz, Almudena Sánchez-Gilabert, Marién Cobo, Karim Benabdellah, Per Anderson, Verónica Ramos-Mejía, Pedro J Real, Olaf Neth, Agueda Molinos-Quintana, Philip D Gregory, Michael C Holmes and Francisco Martin Mol Ther 2016 24: 342-353; advance online publication, October 27, 2015; 10.1038/mt.2015.196 Abstract | Full Text | | | | Characterization and Functional Analysis of scFv-based Chimeric Antigen Receptors to Redirect T Cells to IL13Rα2-positive GliomaGiedre Krenciute, Simone Krebs, David Torres, Meng-Fen Wu, Hao Liu, Gianpietro Dotti, Xiao-Nan Li, Maciej S Lesniak, Irina V Balyasnikova and Stephen Gottschalk Mol Ther 2016 24: 354-363; advance online publication, October 30, 2015; 10.1038/mt.2015.199 Abstract | Full Text | | | | Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma ModelYao Lu, Lei Miao, Yuhua Wang, Zhenghong Xu, Yi Zhao, Youqing Shen, Guangya Xiang and Leaf Huang Mol Ther 2016 24: 364-374; advance online publication, September 3, 2015; 10.1038/mt.2015.165 Abstract | Full Text | | | | Increased Valency of Conserved-mosaic Vaccines Enhances the Breadth and Depth of Epitope RecognitionSultan Abdul-Jawad, Beatrice Ondondo, Andy van Hateren, Andrew Gardner, Tim Elliott, Bette Korber and Tomáš Hanke Mol Ther 2016 24: 375-384; advance online publication, November 19, 2015; 10.1038/mt.2015.210 Abstract | Full Text | | | | Genetic Immunization With In Vivo Dendritic Cell-targeting Liposomal DNA Vaccine Carrier Induces Long-lasting Antitumor Immune ResponseArup Garu, Gopikrishna Moku, Suresh Kumar Gulla and Arabinda Chaudhuri Mol Ther 2016 24: 385-397; advance online publication, December 15, 2015; 10.1038/mt.2015.215 Abstract | Full Text | | | | Variable Virulence and Efficacy of BCG Vaccine Strains in Mice and Correlation With Genome PolymorphismsMTOPENLu Zhang, Huan-wei Ru, Fu-zeng Chen, Chun-yan Jin, Rui-feng Sun, Xiao-yong Fan, Ming Guo, Jun-tao Mai, Wen-xi Xu, Qing-xia Lin and Jun Liu Mol Ther 2016 24: 398-405; advance online publication, December 8, 2015; 10.1038/mt.2015.216 Abstract | Full Text | | | | Please note that you need to be a subscriber or site-license holder to enjoy full-text access to Molecular Therapy. 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