Wednesday, February 24, 2016

Molecular Therapy - Table of Contents alert Volume 24 Issue 2

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Molecular Therapy

TABLE OF CONTENTS

Volume 24, Issue 2 (February 2016)

In this issue
Editorial
In This Issue
Research Highlights
Commentaries
Original Articles

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Molecular Therapy — Methods & Clinical Development: now indexed in PubMed and PubMed Central

An online-only, open access journal publishing top-quality, novel methods and technology development, as well as significant improvements to established research techniques in basic, translational, and clinical cell and gene therapy.

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Editorial

Top

New Momentum for the Field of Oligonucleotide Therapeutics

Annemieke Aartsma-Rus

Mol Ther 2016 24: 193-194; 10.1038/mt.2016.14

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In This Issue

Top

In This Issue

Mol Ther 2016 24: 196; 10.1038/mt.2016.15

Full Text

Research Highlights

Top

Research Highlights

Mol Ther 2016 24: 197; 10.1038/mt.2016.16

Full Text

Commentaries

Top

Genotoxicity in Mice Following AAV Gene Delivery: A Safety Concern for Human Gene Therapy?

Randy J Chandler, Matthew C LaFave, Gaurav K Varshney, Shawn M Burgess and Charles P Venditti

Mol Ther 2016 24: 198-201; 10.1038/mt.2016.17

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The BCG Strain Pool: Diversity Matters

Daria Bottai and Roland Brosch

Mol Ther 2016 24: 201-203; 10.1038/mt.2016.18

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Under Pressure: Elevated Blood Pressure Enhances Targeting of Tumors by Oncolytic Viruses

Leonard W Seymour and Kerry D Fisher

Mol Ther 2016 24: 204-205; 10.1038/mt.2016.19

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Original Articles

Top

Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VIIMTOPEN

Brittney L Gurda, Adrien De Guilhem De Lataillade, Peter Bell, Yanqing Zhu, Hongwei Yu, Ping Wang, Jessica Bagel, Charles H Vite, Tracey Sikora, Christian Hinderer, Roberto Calcedo, Alexander D Yox, Richard A Steet, Therese Ruane, Patricia O'Donnell, Guangping Gao, James M Wilson, Margret Casal, Katherine P Ponder and Mark E Haskins

Mol Ther 2016 24: 206-216; advance online publication, October 8, 2015; 10.1038/mt.2015.189

Abstract | Full Text

Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During Osteoporosis

Huan Jing, Li Liao, Yulin An, Xiaoxia Su, Shiyu Liu, Yi Shuai, Xinjing Zhang and Yan Jin

Mol Ther 2016 24: 217-229; advance online publication, August 26, 2015; 10.1038/mt.2015.152

Abstract | Full Text

Virus-mediated EpoR76E Therapy Slows Optic Nerve Axonopathy in Experimental Glaucoma

Wesley S Bond, Jessica Hines-Beard, YPaul L GoldenMerry, Mara Davis, Alma Farooque, Rebecca M Sappington, David J Calkins and Tonia S Rex

Mol Ther 2016 24: 230-239; advance online publication, October 27, 2015; 10.1038/mt.2015.198

Abstract | Full Text

AAV6-mediated Cardiac-specific Overexpression of Ribonucleotide Reductase Enhances Myocardial Contractility

Stephen C Kolwicz, Jr, Guy L Odom, Sarah G Nowakowski, Farid Moussavi-Harami, Xiaolan Chen, Hans Reinecke, Stephen D Hauschka, Charles E Murry, Gregory G Mahairas and Michael Regnier

Mol Ther 2016 24: 240-250; advance online publication, September 21, 2015; 10.1038/mt.2015.176

Abstract | Full Text

PAX4 Gene Transfer Induces α-to-β Cell Phenotypic Conversion and Confers Therapeutic Benefits for Diabetes Treatment

Yanqing Zhang, Genevieve E Fava, Hongjun Wang, Franck Mauvais-Jarvis, Vivian A Fonseca and Hongju Wu

Mol Ther 2016 24: 251-260; advance online publication, October 5, 2015; 10.1038/mt.2015.181

Abstract | Full Text

SET1A Cooperates With CUDR to Promote Liver Cancer Growth and Hepatocyte-like Stem Cell Malignant Transformation Epigenetically

Tianming Li, Qidi Zheng, Jiahui An, Mengying Wu, Haiyan Li, Xin Gui, Hu Pu and Dongdong Lu

Mol Ther 2016 24: 261-275; advance online publication, November 19, 2015; 10.1038/mt.2015.208

Abstract | Full Text

A Comprehensive Map of CNS Transduction by Eight Recombinant Adeno-associated Virus Serotypes Upon Cerebrospinal Fluid Administration in Pigs

Nicolina Cristina Sorrentino, Veronica Maffia, Sandra Strollo, Vincenzo Cacace, Noemi Romagnoli, Anna Manfredi, Domenico Ventrella, Francesco Dondi, Francesca Barone, Massimo Giunti, Anne-Renee Graham, Yan Huang, Susan L Kalled, Alberto Auricchio, Maria Laura Bacci, Enrico Maria Surace and Alessandro Fraldi

Mol Ther 2016 24: 276-286; advance online publication, December 7, 2015; 10.1038/mt.2015.212

Abstract | Full Text

Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector

Joshua C Grieger, Stephen M Soltys and Richard Jude Samulski

Mol Ther 2016 24: 287-297; advance online publication, October 6, 2015; 10.1038/mt.2015.187

Abstract | Full Text

A Recombinant Bispecific CD20×CD95 Antibody With Superior Activity Against Normal and Malignant B-cells

Kristina Nalivaiko, Martin Hofmann, Karina Kober, Nadine Teichweyde, Peter H Krammer, Hans-Georg Rammensee, Ludger Grosse-Hovest and Gundram Jung

Mol Ther 2016 24: 298-305; advance online publication, November 19, 2015; 10.1038/mt.2015.209

Abstract | Full Text

Perfusion Pressure Is a Critical Determinant of the Intratumoral Extravasation of Oncolytic Viruses

Amber Miller, Rebecca Nace, Camilo Ayala-Breton C, Michael Steele, Kent Bailey, Kah Whye Peng and Stephen J Russell

Mol Ther 2016 24: 306-317; advance online publication, December 9, 2015; 10.1038/mt.2015.219

Abstract | Full Text

PTH Induces Systemically Administered Mesenchymal Stem Cells to Migrate to and Regenerate Spine Injuries

Dmitriy Sheyn, Galina Shapiro, Wafa Tawackoli, Douk Soo Jun, Youngdo Koh, Kyu Bok Kang, Susan Su, Xiaoyu Da, Shiran Ben-David, Maxim Bez, Eran Yalon, Ben Antebi, Pablo Avalos, Tomer Stern, Elazar Zelzer, Edward M Schwarz, Zulma Gazit, Gadi Pelled, Hyun M Bae and Dan Gazit

Mol Ther 2016 24: 318-330; advance online publication, November 20, 2015; 10.1038/mt.2015.211

Abstract | Full Text

Glucocorticoid Cell Priming Enhances Transfection Outcomes in Adult Human Mesenchymal Stem Cells

Abby M Kelly, Sarah A Plautz, Janos Zempleni and Angela K Pannier

Mol Ther 2016 24: 331-341; advance online publication, October 19, 2015; 10.1038/mt.2015.195

Abstract | Full Text

Absence of WASp Enhances Hematopoietic and Megakaryocytic Differentiation in a Human Embryonic Stem Cell ModelMTOPEN

Miguel G Toscano, Pilar Muñoz, Almudena Sánchez-Gilabert, Marién Cobo, Karim Benabdellah, Per Anderson, Verónica Ramos-Mejía, Pedro J Real, Olaf Neth, Agueda Molinos-Quintana, Philip D Gregory, Michael C Holmes and Francisco Martin

Mol Ther 2016 24: 342-353; advance online publication, October 27, 2015; 10.1038/mt.2015.196

Abstract | Full Text

Characterization and Functional Analysis of scFv-based Chimeric Antigen Receptors to Redirect T Cells to IL13Rα2-positive Glioma

Giedre Krenciute, Simone Krebs, David Torres, Meng-Fen Wu, Hao Liu, Gianpietro Dotti, Xiao-Nan Li, Maciej S Lesniak, Irina V Balyasnikova and Stephen Gottschalk

Mol Ther 2016 24: 354-363; advance online publication, October 30, 2015; 10.1038/mt.2015.199

Abstract | Full Text

Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model

Yao Lu, Lei Miao, Yuhua Wang, Zhenghong Xu, Yi Zhao, Youqing Shen, Guangya Xiang and Leaf Huang

Mol Ther 2016 24: 364-374; advance online publication, September 3, 2015; 10.1038/mt.2015.165

Abstract | Full Text

Increased Valency of Conserved-mosaic Vaccines Enhances the Breadth and Depth of Epitope Recognition

Sultan Abdul-Jawad, Beatrice Ondondo, Andy van Hateren, Andrew Gardner, Tim Elliott, Bette Korber and Tomáš Hanke

Mol Ther 2016 24: 375-384; advance online publication, November 19, 2015; 10.1038/mt.2015.210

Abstract | Full Text

Genetic Immunization With In Vivo Dendritic Cell-targeting Liposomal DNA Vaccine Carrier Induces Long-lasting Antitumor Immune Response

Arup Garu, Gopikrishna Moku, Suresh Kumar Gulla and Arabinda Chaudhuri

Mol Ther 2016 24: 385-397; advance online publication, December 15, 2015; 10.1038/mt.2015.215

Abstract | Full Text

Variable Virulence and Efficacy of BCG Vaccine Strains in Mice and Correlation With Genome PolymorphismsMTOPEN

Lu Zhang, Huan-wei Ru, Fu-zeng Chen, Chun-yan Jin, Rui-feng Sun, Xiao-yong Fan, Ming Guo, Jun-tao Mai, Wen-xi Xu, Qing-xia Lin and Jun Liu

Mol Ther 2016 24: 398-405; advance online publication, December 8, 2015; 10.1038/mt.2015.216

Abstract | Full Text

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