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Molecular Therapy - Table of Contents alert Volume 24 Issue 1

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Molecular Therapy

TABLE OF CONTENTS

Volume 24, Issue 1 (February 2016)

In this issue
Editorial
In This Issue
Research Highlights
Review
Original Articles

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Molecular Therapy — Methods & Clinical Development: now indexed in PubMed and PubMed Central

An online-only, open access journal publishing top-quality, novel methods and technology development, as well as significant improvements to established research techniques in basic, translational, and clinical cell and gene therapy.

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Editorial

Top

An ASGCT Perspective on the National Academies Genome Editing Summit

Theodore Friedmann

Mol Ther 2016 24: 1-2; 10.1038/mt.2015.228

Full Text

In This Issue

Top

In This Issue

Mol Ther 2016 24: 4; 10.1038/mt.2015.229

Full Text

Research Highlights

Top

Research Highlights

Mol Ther 2016 24: 5; 10.1038/mt.2015.230

Full Text

Review

Top

Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5–based ConstructsMTOPEN

Julio Alonso-Padilla, Tibor Papp, Győző L Kaján, Mária Benkő, Menzo Havenga, Angelique Lemckert, Balázs Harrach and Andrew H Baker

Mol Ther 2016 24: 6-16; advance online publication, October 19, 2015; 10.1038/mt.2015.194

Abstract | Full Text

Original Articles

Top

Gene Therapy Restores Hair Cell Stereocilia Morphology in Inner Ears of Deaf Whirler Mice

Wade W Chien, Kevin Isgrig, Soumen Roy, Inna A Belyantseva, Meghan C Drummond, Lindsey A May, Tracy S Fitzgerald, Thomas B Friedman and Lisa L Cunningham

Mol Ther 2016 24: 17-25; advance online publication, August 26, 2015; 10.1038/mt.2015.150

Abstract | Full Text

Clinical Improvement of Alpha-mannosidosis Cat Following a Single Cisterna Magna Infusion of AAV1

Sea Young Yoon, Jessica H Bagel, Patricia A O'Donnell, Charles H Vite and John H Wolfe

Mol Ther 2016 24: 26-33; advance online publication, September 10, 2015; 10.1038/mt.2015.168

Abstract | Full Text

Targeted Proapoptotic Peptides Depleting Adipose Stromal Cells Inhibit Tumor Growth

Alexes C Daquinag, Chieh Tseng, Yan Zhang, Felipe Amaya-Manzanares, Fernando Florez, Ali Dadbin, Tao Zhang and Mikhail G Kolonin

Mol Ther 2016 24: 34-40; advance online publication, August 28, 2015; 10.1038/mt.2015.155

Abstract | Full Text

Syndecan 4 Mediates Nrf2-dependent Expansion of Bronchiolar Progenitors That Protect Against Lung InflammationMTOPEN

Arif Santoso, Toshiaki Kikuchi, Naoki Tode, Taizou Hirano, Riyo Komatsu, Triya Damayanti, Hozumi Motohashi, Masayuki Yamamoto, Tetsuhito Kojima, Toshimitsu Uede, Toshihiro Nukiwa and Masakazu Ichinose

Mol Ther 2016 24: 41-52; advance online publication, August 26, 2015; 10.1038/mt.2015.153

Abstract | Full Text

Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer

Chengwen Li, Shuqing Wu, Blake Albright, Matthew Hirsch, Wuping Li, Yu-Shan Tseng, Mavis Agbandje-McKenna, Scott McPhee, Aravind Asokan and R Jude Samulski

Mol Ther 2016 24: 53-65; advance online publication, July 29, 2015; 10.1038/mt.2015.134

Abstract | Full Text

Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression

Irene C Turnbull, Ahmed A Eltoukhy, Kenneth M Fish, Mathieu Nonnenmacher, Kiyotake Ishikawa, Jiqiu Chen, Roger J Hajjar, Daniel G Anderson and Kevin D Costa

Mol Ther 2016 24: 66-75; advance online publication, October 16, 2015; 10.1038/mt.2015.193

Abstract | Full Text

Host Anti-antibody Responses Following Adeno-associated Virus–mediated Delivery of Antibodies Against HIV and SIV in Rhesus Monkeys

José M Martinez-Navio, Sebastian P Fuchs, Sònia Pedreño-López, Eva G Rakasz, Guangping Gao and Ronald C Desrosiers

Mol Ther 2016 24: 76-86; advance online publication, October 7, 2015; 10.1038/mt.2015.191

Abstract | Full Text

Oral-tolerization Prevents Immune Responses and Improves Transgene Persistence Following Gene Transfer Mediated by Adeno-associated Viral Vector

Romain Hardet, Benjamin Chevalier, Léa Dupaty, Yassine Naïmi, Gaëtan Riou, Laurent Drouot, Laetitia Jean, Anna Salvetti, Olivier Boyer and Sahil Adriouch

Mol Ther 2016 24: 87-95; advance online publication, August 12, 2015; 10.1038/mt.2015.146

Abstract | Full Text

Grapefruit-derived Nanovectors Delivering Therapeutic miR17 Through an Intranasal Route Inhibit Brain Tumor Progression

Xiaoying Zhuang, Yun Teng, Abhilash Samykutty, Jingyao Mu, Zhongbin Deng, Lifeng Zhang, Pengxiao Cao, Yuan Rong, Jun Yan, Donald Miller and Huang-Ge Zhang

Mol Ther 2016 24: 96-105; advance online publication, October 7, 2015; 10.1038/mt.2015.188

Abstract | Full Text

Nanoparticle Delivered VEGF-A siRNA Enhances Photodynamic Therapy for Head and Neck Cancer Treatment

Rumwald Leo G Lecaros, Leaf Huang, Tsai-Chia Lee and Yih-Chih Hsu

Mol Ther 2016 24: 106-116; advance online publication, September 16, 2015; 10.1038/mt.2015.169

Abstract | Full Text

Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application

Bastian Salewsky, Gabriele Hildebrand, Susanne Rothe, Ann Christin Parplys, Janina Radszewski, Moritz Kieslich, Petra Wessendorf, Harald Krenzlin, Kerstin Borgmann, André Nussenzweig, Karl Sperling and Martin Digweed

Mol Ther 2016 24: 117-124; advance online publication, August 12, 2015; 10.1038/mt.2015.144

Abstract | Full Text

Kidney-specific Sonoporation-mediated Gene TransferMTOPEN

Ryo Ishida, Daisuke Kami, Tetsuro Kusaba, Yuhei Kirita, Tsunao Kishida, Osam Mazda, Takaomi Adachi and Satoshi Gojo

Mol Ther 2016 24: 125-134; advance online publication, September 30, 2015; 10.1038/mt.2015.171

Abstract | Full Text

An RNA Molecule Derived From Sendai Virus DI Particles Induces Antitumor Immunity and Cancer Cell-selective Apoptosis

Li-Wen Liu, Tomoyuki Nishikawa and Yasufumi Kaneda

Mol Ther 2016 24: 135-145; advance online publication, November 9, 2015; 10.1038/mt.2015.201

Abstract | Full Text

Delivery of siRNAs to Dendritic Cells Using DEC205-Targeted Lipid Nanoparticles to Inhibit Immune ResponsesMTOPEN

Joseph A Katakowski, Gayatri Mukherjee, Samantha E Wilner, Keith E Maier, Michael Travis Harrison, Teresa P DiLorenzo, Matthew Levy and Deborah Palliser

Mol Ther 2016 24: 146-155; advance online publication, September 28, 2015; 10.1038/mt.2015.175

Abstract | Full Text

Activation of Cyclic Adenosine Monophosphate Pathway Increases the Sensitivity of Cancer Cells to the Oncolytic Virus M1

Kai Li, Haipeng Zhang, Jianguang Qiu, Yuan Lin, Jiankai Liang, Xiao Xiao, Liwu Fu, Fang Wang, Jing Cai, Yaqian Tan, Wenbo Zhu, Wei Yin, Bingzheng Lu, Fan Xing, Lipeng Tang, Min Yan, Jialuo Mai, Yuan Li, Wenli Chen, Pengxin Qiu, Xingwen Su, Guangping Gao, Phillip W L Tai, Jun Hu and Guangmei Yan

Mol Ther 2016 24: 156-165; advance online publication, September 16, 2015; 10.1038/mt.2015.172

Abstract | Full Text

Combination Therapy With Reovirus and Anti-PD-1 Blockade Controls Tumor Growth Through Innate and Adaptive Immune Responses

Karishma Rajani, Christopher Parrish, Timothy Kottke, Jill Thompson, Shane Zaidi, Liz Ilett, Kevin G Shim, Rosa-Maria Diaz, Hardev Pandha, Kevin Harrington, Matt Coffey, Alan Melcher and Richard Vile

Mol Ther 2016 24: 166-174; advance online publication, August 27, 2015; 10.1038/mt.2015.156

Abstract | Full Text

Chronic Activation of Innate Immunity Correlates With Poor Prognosis in Cancer Patients Treated With Oncolytic Adenovirus

Kristian Taipale, Ilkka Liikanen, Juuso  Juhila, Riku Turkki, Siri Tähtinen, Matti Kankainen, Lotta Vassilev, Ari Ristimäki, Anniina Koski, Anna Kanerva, Iulia Diaconu, Vincenzo Cerullo, Markus Vähä-Koskela, Minna Oksanen, Nina Linder, Timo Joensuu, Johan Lundin and Akseli Hemminki

Mol Ther 2016 24: 175-183; advance online publication, August 27, 2015; 10.1038/mt.2015.143

Abstract | Full Text

The Role of Neutrophils in Measles Virus–mediated Oncolysis Differs Between B-cell Malignancies and Is Not Always Enhanced by GCSF

Aditi Dey, Yu Zhang, Anna Z Castleton, Katharine Bailey, Brendan Beaton, Bella Patel and Adele K Fielding

Mol Ther 2016 24: 184-192; advance online publication, August 17, 2015; 10.1038/mt.2015.149

Abstract | Full Text

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