Leukemia - Table of Contents alert Volume 30 Issue 2

If you are unable to see the message below, click here to view.

TABLE OF CONTENTS Volume 30, Issue 2 (February 2016) In this issue Original Articles Letters To The Editor Also new AOP Sign up for e-alerts Recommend to your library Web feed Follow on Twitter Subscribe Original Articles Top ACUTE MYELOID LEUKEMIA Clofarabine salvage therapy before allogeneic hematopoietic stem cell transplantation in patients with relapsed or refractory AML: results of the BRIDGE trial J M Middeke, R Herbst, S Parmentier, G Bug, M Hänel, G Stuhler, K Schäfer-Eckart, W Rösler, S Klein, W Bethge, U Bitz, B Büttner, H Knoth, N Alakel, M Schaich, A Morgner, M Kramer, K Sockel, M von Bonin, F Stölzel, U Platzbecker, C Röllig, C Thiede, G Ehninger, M Bornhäuser and J Schetelig for the Study Alliance Leukemia (SAL) Leukemia 2016 30: 261-267; advance online publication, August 18, 2015; 10.1038/leu.2015.226 Abstract | Full Text A phase II study of decitabine and gemtuzumab ozogamicin in newly diagnosed and relapsed acute myeloid leukemia and high-risk myelodysplastic syndrome N Daver, H Kantarjian, F Ravandi, E Estey, X Wang, G Garcia-Manero, E Jabbour, M Konopleva, S O'Brien, S Verstovsek, T Kadia, C Dinardo, S Pierce, X Huang, N Pemmaraju, M Diaz-Pines-Mateo, J Cortes and G Borthakur Leukemia 2016 30: 268-273; advance online publication, September 14, 2015; 10.1038/leu.2015.244 Abstract | Full Text Prognostic significance of NPM1 mutation-modulated microRNA−mRNA regulation in acute myeloid leukemia Y-C Chiu, M-H Tsai, W-C Chou, Y-C Liu, Y-Y Kuo, H-A Hou, T-P Lu, L-C Lai, Y Chen, H-F Tien and E Y Chuang Leukemia 2016 30: 274-284; advance online publication, September 16, 2015; 10.1038/leu.2015.253 Abstract | Full Text Defining AML and MDS second cancer risk dynamics after diagnoses of first cancers treated or not with radiation T Radivoyevitch, R K Sachs, R P Gale, R J Molenaar, D J Brenner, B T Hill, M E Kalaycio, H E Carraway, S Mukherjee, M A Sekeres and J P Maciejewski Leukemia 2016 30: 285-294; advance online publication, September 22, 2015; 10.1038/leu.2015.258 Abstract | Full Text Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression T Kim, K Yoshida, Y K Kim, M S Tyndel, H J Park, S H Choi, J-S Ahn, S-H Jung, D-H Yang, J-J Lee, H J Kim, G Kong, S Ogawa, Z Zhang, H J Kim and D D Kim Leukemia 2016 30: 295-302; advance online publication, October 1, 2015; 10.1038/leu.2015.264 Abstract | Full Text Expression of a passenger miR-9* predicts favorable outcome in adults with acute myeloid leukemia less than 60 years of age K Nowek, S M Sun, M K Dijkstra, L Bullinger, H Döhner, S J Erkeland, B Löwenberg and M Jongen-Lavrencic Leukemia 2016 30: 303-309; advance online publication, October 14, 2015; 10.1038/leu.2015.282 Abstract | Full Text ACUTE LYMPHOBLASTIC LEUKEMIA Improved survival in adult patients with acute lymphoblastic leukemia in the Netherlands: a population-based study on treatment, trial participation and survival A G Dinmohamed, A Szabó, M van der Mark, O Visser, P Sonneveld, J J Cornelissen, M Jongen-Lavrencic and A W Rijneveld Leukemia 2016 30: 310-317; advance online publication, August 19, 2015; 10.1038/leu.2015.230 Abstract | Full Text Array-based comparative genomic hybridization detects copy number variations with prognostic relevance in 80% of ALL with normal karyotype or failed chromosome analysis V Mühlbacher, T Haferlach, W Kern, M Zenger, S Schnittger and C Haferlach Leukemia 2016 30: 318-324; advance online publication, October 9, 2015; 10.1038/leu.2015.276 Abstract | Full Text CHRONIC LYMPHOCYTIC LEUKEMIA Outcomes for patients with chronic lymphocytic leukemia and acute leukemia or myelodysplastic syndrome F P Tambaro, G Garcia-Manero, S M O'Brien, S H Faderl, A Ferrajoli, J A Burger, S Pierce, X Wang, K-A Do, H M Kantarjian, M J Keating and W G Wierda Leukemia 2016 30: 325-330; advance online publication, August 20, 2015; 10.1038/leu.2015.227 Abstract | Full Text Risk of non-hematologic cancer in individuals with high-count monoclonal B-cell lymphocytosis B M Solomon, K G Chaffee, J Moreira, S M Schwager, J R Cerhan, T G Call, N E Kay, S L Slager and T D Shanafelt Leukemia 2016 30: 331-336; advance online publication, August 27, 2015; 10.1038/leu.2015.235 Abstract | Full Text The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells R Thijssen, J ter Burg, G G W van Bochove, M F M de Rooij, A Kuil, M H Jansen, T W Kuijpers, J W Baars, A Virone-Oddos, M Spaargaren, C Egile, M H J van Oers, E Eldering, M J Kersten and A P Kater Leukemia 2016 30: 337-345; advance online publication, September 4, 2015; 10.1038/leu.2015.241 Abstract | Full Text Incidence and description of autoimmune cytopenias during treatment with ibrutinib for chronic lymphocytic leukemia K A Rogers, A S Ruppert, A Bingman, L A Andritsos, F T Awan, K A Blum, J M Flynn, S M Jaglowski, G Lozanski, K J Maddocks, J C Byrd, J A Woyach and J A Jones Leukemia 2016 30: 346-350; advance online publication, October 7, 2015; 10.1038/leu.2015.273 Abstract | Full Text The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1 M Larrayoz, S J Blakemore, R C Dobson, M D Blunt, M J J Rose-Zerilli, R Walewska, A Duncombe, D Oscier, K Koide, F Forconi, G Packham, M Yoshida, M S Cragg, J C Strefford and A J Steele Leukemia 2016 30: 351-360; advance online publication, October 21, 2015; 10.1038/leu.2015.286 Abstract | Full Text LYMPHOMA Primary testicular diffuse large B-cell lymphoma displays distinct clinical and biological features for treatment failure in rituximab era: a report from the International PTL Consortium L Deng, Z Y Xu-Monette, S Loghavi, G C Manyam, Y Xia, C Visco, J Huh, L Zhang, Q Zhai, Y Wang, L Qiu, K Dybkær, A Chiu, A M Perry, S Zhang, A Tzankov, H Rao, J Abramson, A R Sohani, M Xu, E D Hsi, J Zhu, M Ponzoni, S Wang, Ling Li, M Zhang, A J M Ferreri, B M Parsons, Y Li, M A Piris, L J Medeiros and K H Young Leukemia 2016 30: 361-372; advance online publication, August 26, 2013; 10.1038/leu.2015.237 Abstract | Full Text Familial risk of non-Hodgkin lymphoma by sex, relationship, age at diagnosis and histology: a joint study from five Nordic countries M Fallah, E Kharazmi, E Pukkala, S Tretli, J H Olsen, L Tryggvadottir, K Sundquist and K Hemminki Leukemia 2016 30: 373-378; advance online publication, October 6, 2015; 10.1038/leu.2015.272 Abstract | Full Text MULTIPLE MYELOMA, GAMMOPATHIES Targeting IL-17A in multiple myeloma: a potential novel therapeutic approach in myeloma R H Prabhala, M Fulciniti, D Pelluru, N Rashid, A Nigroiu, P Nanjappa, C Pai, S Lee, N S Prabhala, R L Bandi, R Smith, S B Lazo-Kallanian, S Valet, N Raje, J S Gold, P G Richardson, J F Daley, K C Anderson, S A Ettenberg, F Di Padova and N C Munshi Leukemia 2016 30: 379-389; advance online publication, August 21, 2015; 10.1038/leu.2015.228 Abstract | Full Text Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo J Teramachi, R Silbermann, P Yang, W Zhao, K S Mohammad, J Guo, J L Anderson, D Zhou, R Feng, K-Z Myint, N Maertz, J H Beumer, J L Eiseman, J J Windle, X-Q Xie, G D Roodman and N Kurihara Leukemia 2016 30: 390-398; advance online publication, August 19, 2015; 10.1038/leu.2015.229 Abstract | Full Text SAR650984 directly induces multiple myeloma cell death via lysosomal-associated and apoptotic pathways, which is further enhanced by pomalidomide H Jiang, C Acharya, G An, M Zhong, X Feng, L Wang, N Dasilva, Z Song, G Yang, F Adrian, L Qiu, P Richardson, N C Munshi, Y-T Tai and K C Anderson Leukemia 2016 30: 399-408; advance online publication, September 4, 2015; 10.1038/leu.2015.240 Abstract | Full Text Osteolytic lesions, cytogenetic features and bone marrow levels of cytokines and chemokines in multiple myeloma patients: Role of chemokine (C-C motif) ligand 20 B Dalla Palma, D Guasco, M Pedrazzoni, M Bolzoni, F Accardi, F Costa, G Sammarelli, L Craviotto, M De Filippo, L Ruffini, P Omedè, R Ria, F Aversa and N Giuliani Leukemia 2016 30: 409-416; advance online publication, September 30, 2015; 10.1038/leu.2015.259 Abstract | Full Text 18F-FDG PET/CT focal, but not osteolytic, lesions predict the progression of smoldering myeloma to active disease E Zamagni, C Nanni, F Gay, A Pezzi, F Patriarca, M Bellò, I Rambaldi, P Tacchetti, J Hillengass, B Gamberi, L Pantani, V Magarotto, A Versari, M Offidani, B Zannetti, F Carobolante, M Balma, P Musto, M Rensi, K Mancuso, A Dimitrakopoulou-Strauss, S Chauviè, S Rocchi, N Fard, G Marzocchi, G Storto, P Ghedini, A Palumbo, S Fanti and M Cavo Leukemia 2016 30: 417-422; advance online publication, October 22, 2015; 10.1038/leu.2015.291 Abstract | Full Text Clinical value of molecular subtyping multiple myeloma using gene expression profiling N Weinhold, C J Heuck, A Rosenthal, S Thanendrarajan, C K Stein, F Van Rhee, M Zangari, A Hoering, E Tian, F E Davies, B Barlogie and G J Morgan Leukemia 2016 30: 423-430; advance online publication, November 3, 2015; 10.1038/leu.2015.309 Abstract | Full Text CHRONIC MYLEPROLIFERATIVE NEOPLASMS Differential clinical effects of different mutation subtypes in CALR-mutant myeloproliferative neoplasms OPEN D Pietra, E Rumi, V V Ferretti, C A Di Buduo, C Milanesi, C Cavalloni, E Sant'Antonio, V Abbonante, F Moccia, I C Casetti, M Bellini, M C Renna, E Roncoroni, E Fugazza, C Astori, E Boveri, V Rosti, G Barosi, A Balduini and M Cazzola Leukemia 2016 30: 431-438; advance online publication, October 9, 2015; 10.1038/leu.2015.277 Abstract | Full Text STEM CELL BIOLOGY A simple one-tube assay for immunophenotypical quantification of leukemic stem cells in acute myeloid leukemia W Zeijlemaker, A Kelder, Y J M Oussoren-Brockhoff, W J Scholten, A N Snel, D Veldhuizen, J Cloos, G J Ossenkoppele and G J Schuurhuis Leukemia 2016 30: 439-446; advance online publication, September 16, 2015; 10.1038/leu.2015.252 Abstract | Full Text STEM CELL TRANSPLANTATION Is there a stronger graft-versus-leukemia effect using HLA-haploidentical donors compared with HLA-identical siblings? O Ringdén, M Labopin, F Ciceri, A Velardi, A Bacigalupo, W Arcese, A Ghavamzadeh, R M Hamladji, C Schmid, A Nagler and M Mohty for the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation Leukemia 2016 30: 447-455; advance online publication, August 21, 2015; 10.1038/leu.2015.232 Abstract | Full Text CD56dimCD57+NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT F Cichocki, S Cooley, Z Davis, T E DeFor, H Schlums, B Zhang, C G Brunstein, B R Blazar, J Wagner, D J Diamond, M R Verneris, Y T Bryceson, D J Weisdorf and J S Miller Leukemia 2016 30: 456-463; advance online publication, September 29, 2015; 10.1038/leu.2015.260 Abstract | Full Text MOLECULAR TARGETS FOR THERAPY Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth B Peter, G E Winter, K Blatt, K L Bennett, G Stefanzl, U Rix, G Eisenwort, E Hadzijusufovic, M Gridling, C Dutreix, G Hoermann, J Schwaab, D Radia, J Roesel, P W Manley, A Reiter, G Superti-Furga and P Valent Leukemia 2016 30: 464-472; advance online publication, September 9, 2015; 10.1038/leu.2015.242 Abstract | Full Text MECHANISMS OF RESISTANCE NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells A K Jayavelu, J P Müller, R Bauer, S-A Böhmer, J Lässig, S Cerny-Reiterer, W R Sperr, P Valent, B Maurer, R Moriggl, K Schröder, A M Shah, M Fischer, S Scholl, J Barth, T Oellerich, T Berg, H Serve, S Frey, T Fischer, F H Heidel and F-D Böhmer Leukemia 2016 30: 473-483; advance online publication, August 26, 2015; 10.1038/leu.2015.234 Abstract | Full Text IMMUNOTHERAPY Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism C Krupka, P Kufer, R Kischel, G Zugmaier, F S Lichtenegger, T Köhnke, B Vick, I Jeremias, K H Metzeler, T Altmann, S Schneider, M Fiegl, K Spiekermann, P A Bauerle, W Hiddemann, G Riethmüller and M Subklewe Leukemia 2016 30: 484-491; advance online publication, August 4, 2015; 10.1038/leu.2015.214 Abstract | Full Text Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo D Sommermeyer, M Hudecek, P L Kosasih, T Gogishvili, D G Maloney, C J Turtle and S R Riddell Leukemia 2016 30: 492-500; advance online publication, September 15, 2015; 10.1038/leu.2015.247 Abstract | Full Text Letters To The Editor Top Somatic mutational landscape of AML with inv(16) or t(8;21) identifies patterns of clonal evolution in relapse leukemia R Sood, N F Hansen, F X Donovan, B Carrington, D Bucci, B Maskeri, A Young, N S Trivedi, J Kohlschmidt, R M Stone, M A Caligiuri, S C Chandrasekharappa, G Marcucci, J C Mullikin, C D Bloomfield and P Liu Leukemia 2016 30: 501-504; advance online publication, June 15, 2015; 10.1038/leu.2015.141 Full Text HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist S G T Devaraj, W Fiskus, B Shah, J Qi, B Sun, S P Iyer, S Sharma, J E Bradner and K N Bhalla Leukemia 2016 30: 504-508; advance online publication, June 15, 2015; 10.1038/leu.2015.142 Full Text Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner S He, B Malik, D Borkin, H Miao, S Shukla, K Kempinska, T Purohit, J Wang, L Chen, B Parkin, S N Malek, G Danet-Desnoyers, A G Muntean, T Cierpicki and J Grembecka Leukemia 2016 30: 508-513; advance online publication, June 18, 2015; 10.1038/leu.2015.144 Full Text Persistent CD49d engagement in circulating CLL cells: a role for blood-borne ligands? D Benedetti, E Tissino, C Caldana, M Dal Bo, R Bomben, D Marconi, S Ganghammer, F Zaja, G Pozzato, F Di Raimondo, T N Hartmann, G Del Poeta, A VanMeter, A Zucchetto, V Espina, L Liotta and V Gattei Leukemia 2016 30: 513-517; advance online publication, June 19, 2015; 10.1038/leu.2015.149 Full Text Clonal architecture of del(5q) myelodysplastic syndromes: aberrant CD5 or CD7 expression within the myeloid progenitor compartment defines a subset with high clonal burden OPEN U Oelschlaegel, M Alexander Röhnert, B Mohr, K Sockel, S Herold, G Ehninger, M Bornhäuser, C Thiede and U Platzbecker Leukemia 2016 30: 517-520; advance online publication, June 24, 2015; 10.1038/leu.2015.158 Full Text Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Leukemia. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group |One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.