The EMBO Journal Table of Contents for January 2016; Vol. 35, No. 1

January 2016 | Volume 35, Number 1 Submit Table of Contents News & Views Review Articles Resource Volume 35, Number 1 News & Views Putting chromatin in its place: the pioneer factor NeuroD1 modulates chromatin state to drive cell fate decisions New work illustrates how transcription factor NeuroD1 reshapes the chromatin landscape to elicit a specific neurogenic program and drive cells down a distinct differentiation pathway. Alexander Glahs and Robert P Zinzen Published online 13.11.2015 PEPRs spice up plant immunity A new study links pathogen‐induced perturbation of pattern recognition receptor co‐receptor BAK1 to increased signaling via danger peptide receptors PEPRs. Dingzhong Tang and Jian‐Min Zhou Published online 01.12.2015 Review Spatiotemporal regulation of posttranslational modifications in the DNA damage response Cellular responses to all kinds of DNA damage involve a complex interplay of phosphorylation, ubiquitination, poly(ADP‐ribosyl)ation and other modifications, the intricacies of which are conceptualized in this review. Nico P Dantuma and Haico van Attikum Published online 01.12.2015 Articles NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program Using a genome‐wide approach this study delineates the binding requirements and target sites for NeuroD1, illustrating how this factor drives the formation of a transcriptional and epigenetic program to ensure neuronal differentiation. Abhijeet Pataskar, Johannes Jung, Pawel Smialowski, Florian Noack, Federico Calegari, Tobias Straub, and Vijay K Tiwari Published online 29.10.2015 Danger peptide receptor signaling in plants ensures basal immunity upon pathogen‐induced depletion of BAK1 LRR signaling co‐receptor BAK1 is a central mediator of plant immunity, but when absent—as seen upon certain fungal invasions—its function is compensated by signaling through danger peptide receptors PEPRs. Kohji Yamada, Misuzu Yamashita‐Yamada, Taishi Hirase, Tadashi Fujiwara, Kenichi Tsuda, Kei Hiruma, and Yusuke Saijo Published online 16.11.2015 PTPRN2 and PLCβ1 promote metastatic breast cancer cell migration through PI(4,5)P2‐dependent actin remodeling The phosphatidylinositol phosphatase activity harboring protein tyrosine phosphatase PTPRN2 and the phospholipase PLCβ1 are overexpressed in breast cancer. Both enzymes reduce plasma membrane PI(4,5)P2 levels, thereby enhancing cofilin‐mediated actin remodeling and breast cancer metastasis. Caitlin A Sengelaub, Kristina Navrazhina, Jason B Ross, Nils Halberg, and Sohail F Tavazoie Published online 30.11.2015 Fundamental physical cellular constraints drive self‐organization of tissues Cell shapes in naturally packed tissues have different polygon distributions. Voronoi tessellations‐based analysis suggests that polygon frequencies are restricted by the distribution of cell areas, and that this restriction emanates from the balance of forces within the tissue. Daniel Sánchez‐Gutiérrez, Melda Tozluoglu, Joseph D Barry, Alberto Pascual, Yanlan Mao, and Luis M Escudero Published online 23.11.2015 Gatekeeper role of brain antigen‐presenting CD11c+ cells in neuroinflammation Specific dendritic cells are fundamental for attracting autoinflammatory Th17 cells to the central nervous system in chronic autoimmune diseases. Magdalena Paterka, Volker Siffrin, Jan O Voss, Johannes Werr, Nicola Hoppmann, René Gollan, Patrick Belikan, Julia Bruttger, Jérôme Birkenstock, Steffen Jung, Enric Esplugues, Nir Yogev, Richard A Flavell, Tobias Bopp, and Frauke Zipp Published online 26.11.2015 Resource A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level RFP‐ and GFP‐based reporters require oxygen to mature. The Japanese eel green fluorescent protein UnaG matures independently of oxygen, which makes it an ideal reporter to reveal hypoxia. Raghu Erapaneedi, Vsevolod V Belousov, Michael Schäfers, and Friedemann Kiefer Published online 23.11.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.