Scientific Reports Biology Table of Contents e-alert: 12 January 2016

If you are unable to see the message below, click here to view.

12 January 2016      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         Nature Genetics and Nature Reviews Cancer present: NUCLEAR REPROGRAMMING AND THE CANCER GENOME 2016 Sponsored by CapitalBio Corporation February 21-23, 2016 | La Jolla, CA, USA REGISTER NOW!           Biological Sciences               Metacommunity analysis of amoeboid protists in grassland soils ▶     Anna Maria Fiore-Donno, Jan Weinert, Tesfaye Wubet et al.     This study reveals the diversity and distribution of two major ubiquitous groups of soil amoebae, the genus Acanthamoeba and the Myxomycetes (plasmodial slime-moulds) that are …             Protein Secondary Structure Prediction Using Deep Convolutional Neural Fields ▶     Sheng Wang, Jian Peng, Jianzhu Ma et al.     Protein secondary structure (SS) prediction is important for studying protein structure and function. When only the sequence (profile) information is used as input feature, …             DNA methylation dynamics in mouse preimplantation embryos revealed by mass spectrometry ▶     Yoshinori Okamoto, Naoko Yoshida, Toru Suzuki et al.     Following fertilization in mammals, paternal genomic 5-methyl-2′-deoxycytidine (5 mC) content is thought to decrease via oxidation to 5-hydroxymethyl-2′-deoxycytidine (5 hmC). …             Network-Based Comparative Analysis of Arabidopsis Immune Responses to Golovinomyces orontii and Botrytis cinerea Infections ▶     Zhenhong Jiang, Xiaobao Dong, Ziding Zhang     A comprehensive exploration of common and specific plant responses to biotrophs and necrotrophs is necessary for a better understanding of plant immunity. Here, we compared the …             REPLACR-mutagenesis, a one-step method for site-directed mutagenesis by recombineering ▶     Ashutosh Trehan, Michał Kiełbus, Jakub Czapinski et al.     Mutagenesis is an important tool to study gene regulation, model disease-causing mutations and for functional characterisation of proteins. Most of the current methods for …             OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production ▶     Ji Eun Oh, Myeong Sup Lee, Young-Joon Kim et al.     Type I interferon (IFN) interferes with virus replication, promotes antiviral responses, and controls innate and adaptive immune responses to certain viruses. Recently, we …             Corrigendum: IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity ▶     Idan Cohen, Peleg Rider, Elena Vornov et al.                 Leucine zipper motif in RRS1 is crucial for the regulation of Arabidopsis dual resistance protein complex RPS4/RRS1 ▶     Mari Narusaka, Kazuhiro Toyoda, Tomonori Shiraishi et al.     Arabidopsis thaliana leucine-rich repeat-containing (NLR) proteins RPS4 and RRS1, known as dual resistance proteins, confer resistance to multiple pathogen isolates, such as the …             Global Transcriptomic Analysis of Interactions between Pseudomonas aeruginosa and Bacteriophage PaP3 ▶     Xia Zhao, Canhuang Chen, Wei Shen et al.     The interactions between Bacteriophage (phage) and host bacteria are widespread in nature and influences of phage replication on the host cells are complex and extensive. Here, …             TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy ▶     Barbara Costa, Eleonora Da Pozzo, Chiara Giacomelli et al.     The pharmacological activation of the cholesterol-binding Translocator Protein (TSPO) leads to an increase of endogenous steroids and neurosteroids determining benefic …             Nutritional conditions regulate transcriptional activity of SF-1 by controlling sumoylation and ubiquitination ▶     Jiwon Lee, Dong Joo Yang, Syann Lee et al.     Steroidogenic factor 1 (SF-1) is a transcription factor expressed in the ventral medial nucleus of the hypothalamus that regulates energy homeostasis. However, the molecular …             Polarization-sensitive optical projection tomography for muscle fiber imaging ▶     Mengjie Fang, Di Dong, Chaoting Zeng et al.     Optical projection tomography (OPT) is a tool used for three-dimensional imaging of millimeter-scale biological samples, with the advantage of exhibiting isotropic resolution …             Design of chimeric antigen receptors with integrated controllable transient functions ▶     Alexandre Juillerat, Alan Marechal, Jean-Marie Filhol et al.     The ability to control T cells engineered to permanently express chimeric antigen receptors (CARs) is a key feature to improve safety. Here, we describe the development of a new …             Co-utilization of glycerol and lignocellulosic hydrolysates enhances anaerobic 1,3-propanediol production by Clostridium diolis ▶     Bo Xin, Yu Wang, Fei Tao et al.     Anaerobic fermentation using lignocellulosic hydrolysates as co-substrates is an economically attractive method to enhance 1,3-propanediol (1,3-PD) production by increasing the …             Large Omnivore Movements in Response to Surface Mining and Mine Reclamation ▶     Bogdan Cristescu, Gordon B. Stenhouse, Mark S. Boyce     Increasing global demands have resulted in widespread proliferation of resource extraction. Scientists are challenged to develop environmental mitigation strategies that meet …             BRAFV600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells ▶     Toshinori Sueda, Daisuke Sakai, Koichi Kawamoto et al.     Although BRAFV600E mutation is associated with adverse clinical outcomes in patients with colorectal cancer (CRC), response and resistance mechanisms for therapeutic BRAFV600E …             Identification and preliminary characterization of chemosensory perception-associated proteins in the melon fly Bactrocera cucurbitae using RNA-seq ▶     Samia Elfekih, Chien-Yu Chen, Ju-Chun Hsu et al.     An investigation into proteins involved in chemosensory perception in the melon fly, Bactrocera cucurbitae (Diptera: Tephritidae) is described here using a newly generated …             Distribution, congruence, and hotspots of higher plants in China ▶     Lina Zhao, Jinya Li, Huiyuan Liu et al.     Identifying biodiversity hotspots has become a central issue in setting up priority protection areas, especially as financial resources for biological diversity conservation are …             A burrowing frog from the late Paleocene of Mongolia uncovers a deep history of spadefoot toads (Pelobatoidea) in East Asia ▶     Jianye Chen, Gaberiel S. Bever, Hong-Yu Yi et al.     Fossils are indispensible in understanding the evolutionary origins of the modern fauna. Crown-group spadefoot toads (Anura: Pelobatoidea) are the best-known fossorial frog clade …             A novel cell-penetrating peptide suppresses breast tumorigenesis by inhibiting β-catenin/LEF-1 signaling ▶     Tsung-Hua Hsieh, Chia-Yi Hsu, Cheng-Fang Tsai et al.     The inhibition of β-catenin/LEF-1 signaling is an emerging strategy in cancer therapy. However, clinical targeted treatment of the β-catenin/LEF-1 complex remains relatively …             A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5 ▶     Lin Xia, Yangfei Xian, Daning Wang et al.     The presence of neutralizing epitopes in human papillomavirus (HPV) L1 virus-like particles (VLPs) is the structural basis of prophylactic vaccines. An anti-HPV16 neutralizing …             Changes in pathogenicity and immunogenicity of Mycoplasma mycoides subsp. mycoides strains revealed by comparative genomics analysis ▶     Yuan Li, Yang Wang, Rui Wang et al.     Mycoplasma mycoides subsp. mycoides is the causative agent of contagious bovine pleuropneumonia. A pathogenic strain BEN-1 was isolated from bovine lung and underwent continuous …             Rsite2: an efficient computational method to predict the functional sites of noncoding RNAs ▶     Pan Zeng, Qinghua Cui     Noncoding RNAs (ncRNAs) represent a big class of important RNA molecules. Given the large number of ncRNAs, identifying their functional sites is becoming one of the most …             Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells ▶     Cynthia Morata-Tarifa, Gema Jiménez, María A. García et al.     Cancer stem cells are responsible for tumor progression, metastasis, therapy resistance and cancer recurrence, doing their identification and isolation of special relevance. Here …             Selective pressure against horizontally acquired prokaryotic genes as a driving force of plastid evolution ▶     Briardo Llorente, Flavio S. J. de Souza, Gabriela Soto et al.     The plastid organelle comprises a high proportion of nucleus-encoded proteins that were acquired from different prokaryotic donors via independent horizontal gene transfers …             Spatiotemporal dynamics of random stimuli account for trial-to-trial variability in perceptual decision making ▶     Hame Park, Jan-Matthis Lueckmann, Katharina von Kriegstein et al.     Decisions in everyday life are prone to error. Standard models typically assume that errors during perceptual decisions are due to noise. However, it is unclear how noise in the …             Identification of a small molecule that simultaneously suppresses virulence and antibiotic resistance of Pseudomonas aeruginosa ▶     Qiaoyun Guo, Yu Wei, Bin Xia et al.     The rising antibiotic resistance of bacteria imposes a severe threat on human health. Inhibition of bacterial virulence is an alternative approach to develop new antimicrobials. …             CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS ▶     Tsukasa Uchida, Yoshitaka Tamaki, Takashi Ayaki et al.     The molecular machinery responsible for cytosolic accumulation of misfolded TDP-43 in amyotrophic lateral sclerosis (ALS) remains elusive. Here we identified a cullin-2 (CUL2) …             Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins ▶     Jyoti Batra, Shashank Tripathi, Amrita Kumar et al.     A unique feature of influenza A virus (IAV) life cycle is replication of the viral genome in the host cell nucleus. The nuclear import of IAV genome is an indispensable step in …             ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging ▶     Eunsoo Lee, Jungyoon Choi, Youhwa Jo et al.     Understanding the structural organization of organs and organisms at the cellular level is a fundamental challenge in biology. This task has been approached by reconstructing …             LEGO: a novel method for gene set over-representation analysis by incorporating network-based gene weights ▶     Xinran Dong, Yun Hao, Xiao Wang et al.     Pathway or gene set over-representation analysis (ORA) has become a routine task in functional genomics studies. However, currently widely used ORA tools employ statistical …             3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained ▶     Michele Zanoni, Filippo Piccinini, Chiara Arienti et al.     The potential of a spheroid tumor model composed of cells in different proliferative and metabolic states for the development of new anticancer strategies has been amply …             A quantitative investigation of linker histone interactions with nucleosomes and chromatin ▶     Alison E. White, Aaron R. Hieb, Karolin Luger     Linker histones such as H1 are abundant basic proteins that bind tightly to nucleosomes, thereby acting as key organizers of chromatin structure. The molecular details of linker …             An interneuron progenitor maintains neurogenic potential in vivo and differentiates into GABAergic interneurons after transplantation in the postnatal rat brain ▶     Qi Wang, Peiwei Hong, Hui Gao et al.     Dysfunction of cortical GABAergic interneurons are involved in numerous neurological disorders including epilepsy, schizophrenia and autism; and replenishment of these cells by …             Evidence for contact calls in fish: conspecific vocalisations and ambient soundscape influence group cohesion in a nocturnal species ▶     L. van Oosterom, J. C. Montgomery, A. G. Jeffs et al.     Soundscapes provide a new tool for the study of fish communities. Bigeyes (Pempheris adspersa) are nocturnal planktivorous reef fish, feed in loose shoals and are soniferous. …             Spatial Abundance and Distribution of Potential Microbes and Functional Genes Associated with Anaerobic Mineralization of Pentachlorophenol in a Cylindrical Reactor ▶     Zhi-Ling Li, Jun Nan, Cong Huang et al.     Functional interplays of microbial activity, genetic diversity and contaminant transformation are poorly understood in reactors for mineralizing halogenated aromatics …             Low diversity of planktonic bacteria in the tropical ocean ▶     Mathias Milici, Jürgen Tomasch, Melissa L. Wos-Oxley et al.     The diversity of macro-organisms increases towards the equator, with almost no exceptions. It is the most conserved biogeographical pattern on earth and is thought to be related …             Risk of liver injury after α-glucosidase inhibitor therapy in advanced chronic kidney disease patients ▶     Chih-Chin Kao, Pei-Chen Wu, Che-Hsiung Wu et al.     Although α-glucosidase inhibitors (AGIs) are commonly used for controlling postprandial blood glucose, AGIs-induced liver injuries have been reported. However, the relationship …             Modified inflammation-based score as an independent malignant predictor in patients with pulmonary focal ground-glass opacity: a propensity score matching analysis ▶     Long Jiang, Shanshan Jiang, Yongbin Lin et al.     Pulmonary focal Ground-glass Opacities (fGGOs) would frequently be identified after widely implementation of low-dose computed tomography (LDCT) screening. Because of the high …             Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro ▶     Xuan Wang, Beichen Xie, Yu Qi et al.     The role of the novel transcription factor ZBED6 for the adhesion/clustering of insulin-producing mouse MIN6 and βTC6 cells was investigated. Zbed6-silencing in the insulin …             Intracoronary Transplantation of Mesenchymal Stem Cells with Overexpressed Integrin-Linked Kinase Improves Cardiac Function in Porcine Myocardial Infarction ▶     Dan Mu, Xin-Lin Zhang, Jun Xie et al.     The effect of mesenchymal stem cell (MSCs)-based therapy on treating acute myocardial infarction (MI) is limited due to poor engraftment and limited regenerative potential. Here …             Length of intact plasma membrane determines the diffusion properties of cellular water ▶     Sato Eida, Marc Van Cauteren, Yuka Hotokezaka et al.     Molecular diffusion in a boundary-free medium depends only on the molecular size, the temperature, and medium viscosity. However, the critical determinant of the molecular …             Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro ▶     S.M. Iqbal, C. Leonard, S. C. Regmi et al.     Proteoglycan 4 (PRG4/lubricin) is secreted by cells that reside in articular cartilage and line the synovial joint. Lubricin may play a role in modulating inflammatory responses …             An integrated chinmedomics strategy for discovery of effective constituents from traditional herbal medicine ▶     Xijun Wang, Aihua Zhang, Xiaohang Zhou et al.     Traditional natural product discovery affords no information about compound structure or pharmacological activities until late in the discovery process, and leads to low …             Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using 31P magnetic resonance spectroscopy ▶     Alison Sleigh, Victoria Lupson, Ajay Thankamony et al.     The growing recognition of diseases associated with dysfunction of mitochondria poses an urgent need for simple measures of mitochondrial function. Assessment of the kinetics of …             A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction ▶     Jacquelyn Y. Taylor, Karen Schwander, Sharon L. R. Kardia et al.     Cigarette smoking has been shown to be a health hazard. In addition to being considered a negative lifestyle behavior, studies have shown that cigarette smoking has been linked …             Does oral exposure to cadmium and lead mediate susceptibility to colitis? The dark-and-bright sides of heavy metals in gut ecology ▶     Jérôme Breton, Catherine Daniel, Cécile Vignal et al.     Although the heavy metals cadmium (Cd) and lead (Pb) are known environmental health concerns, their long-term impacts on gut ecology and susceptibility to gastrointestinal …             Strong reproductive isolation despite occasional hybridization between a widely distributed and a narrow endemic Rhododendron species ▶     Yong-Peng Ma, Wei-Jia Xie, Wei-Bang Sun et al.     Reproductive isolation (RI) plays an important role for speciation, but assessing reproductive barriers at all life-cycle stages remains challenging. In plants, most studies …             Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway ▶     Hong-Shuai Liu, Hai-Lian Shi, Fei Huang et al.     Inhibition of microglia activation may provide therapeutic treatment for many neurodegenerative diseases. Astragaloside IV (ASI) with anti-inflammatory properties has been tested …             Synthesis, characterization, and application of reversible PDLLA-PEG-PDLLA copolymer thermogels in vitro and in vivo ▶     Kun Shi, Ya-Li Wang, Ying Qu et al.     In this study, a series of injectable thermoreversible and thermogelling PDLLA-PEG-PDLLA copolymers were developed and a systematic evaluation of the thermogelling system both in …             In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee ▶     Deva D. Chan, Luyao Cai, Kent D. Butz et al.     The in vivo measurement of articular cartilage deformation is essential to understand how mechanical forces distribute throughout the healthy tissue and change over time in the …             Evidence for redox sensing by a human cardiac calcium channel ▶     Padmapriya Muralidharan, Henrietta Cserne Szappanos, Evan Ingley et al.     Ion channels are critical to life and respond rapidly to stimuli to evoke physiological responses. Calcium influx into heart muscle occurs through the ion conducting α1C subunit …             Adapting to Adaptations: Behavioural Strategies that are Robust to Mutations and Other Organisational-Transformations ▶     Matthew D. Egbert, Juan Pérez-Mercader     Genetic mutations, infection by parasites or symbionts, and other events can transform the way that an organism’s internal state changes in response to a given environment. We …             New insights into functional regulation in MS-based drug profiling ▶     Ana Sofia Carvalho, Henrik Molina, Rune Matthiesen     We present a novel data analysis strategy which combined with subcellular fractionation and liquid chromatography–mass spectrometry (LC-MS) based proteomics provides a simple and …             Gene targets of mouse miR-709: regulation of distinct pools ▶     Sneha Surendran, Victoria N. Jideonwo, Chris Merchun et al.     MicroRNA (miRNA) are short non-coding RNA molecules that regulate multiple cellular processes, including development, cell differentiation, proliferation and death. Nevertheless, …             The ATM- and ATR-related SCD domain is over-represented in proteins involved in nervous system development ▶     Lukas Cara, Medina Baitemirova, Jack Follis et al.     ATM and ATR are cellular kinases with a well-characterized role in the DNA-damage response. Although the complete set of ATM/ATR targets is unknown, they often contain clusters …             PKN3 is the major regulator of angiogenesis and tumor metastasis in mice ▶     Hideyuki Mukai, Aiko Muramatsu, Rana Mashud et al.     PKN, a conserved family member related to PKC, was the first protein kinase identified as a target of the small GTPase Rho. PKN is involved in various functions including …             Inhibition of ethylene production by putrescine alleviates aluminium-induced root inhibition in wheat plants ▶     Yan Yu, Chongwei Jin, Chengliang Sun et al.     Inhibition of root elongation is one of the most distinct symptoms of aluminium (Al) toxicity. Although putrescine (Put) has been identified as an important signaling molecule …             Ncl Synchronously Regulates Na+, K+, and Cl− in Soybean and Greatly Increases the Grain Yield in Saline Field Conditions ▶     Tuyen Duc Do, Huatao Chen, Vu Thi Thu Hien et al.     Salt stress inhibits soybean growth and reduces gain yield. Genetic improvement of salt tolerance is essential for sustainable soybean production in saline areas. In this study, …             Characterization of Rv0888, a Novel Extracellular Nuclease from Mycobacterium tuberculosis ▶     Guanghui Dang, Jun Cao, Yingying Cui et al.     Bacterial extracellular nucleases play important roles in virulence, biofilm formation, utilization of extracellular DNA as a nutrient, and degradation of neutrophil DNA …             Biochemical Characterization of Nonamer Binding Domain of RAG1 Reveals its Thymine Preference with Respect to Length and Position ▶     Deepthi Raveendran, Sathees C. Raghavan     RAG complex consisting of RAG1 and RAG2 is a site-specific endonuclease responsible for the generation of antigen receptor diversity. It cleaves recombination signal sequence …             RYR2, PTDSS1 and AREG genes are implicated in a Lebanese population-based study of copy number variation in autism ▶     Jihane Soueid, Silva Kourtian, Nadine J. Makhoul et al.     Autism Spectrum Disorders (ASDs) are a group of neurodevelopmental disorders characterized by ritualistic-repetitive behaviors and impaired verbal and non-verbal communication. …             Genome-wide association study identifies three key loci for high mesocarp oil content in perennial crop oil palm ▶     Chee-Keng Teh, Ai-Ling Ong, Qi-Bin Kwong et al.     GWAS in out-crossing perennial crops is typically limited by insufficient marker density to account for population diversity and effects of population structure resulting in high …             Elevated CO2 impacts bell pepper growth with consequences to Myzus persicae life history, feeding behaviour and virus transmission ability ▶     Beatriz Dáder, Alberto Fereres, Aránzazu Moreno et al.     Increasing atmospheric carbon dioxide (CO2) impacts plant growth and metabolism. Indirectly, the performance and feeding of insects is affected by plant nutritional quality and …             A new physical mapping approach refines the sex-determining gene positions on the Silene latifolia Y-chromosome ▶     Yusuke Kazama, Kotaro Ishii, Wataru Aonuma et al.     Sex chromosomes are particularly interesting regions of the genome for both molecular genetics and evolutionary studies; yet, for most species, we lack basic information, such as …             Regulatory role of FZP in the determination of panicle branching and spikelet formation in rice ▶     Xufeng Bai, Yong Huang, Donghai Mao et al.     FRIZZLE PANICLE (FZP) and RFL/ABERRANT PANICLE ORGANIZATION 2 (APO2) play important roles in regulating the ABCDE floral organ identity genes. However, the relationships among FZP…             Maternal immune activation produces neonatal excitability defects in offspring hippocampal neurons from pregnant rats treated with poly I:C ▶     Eti Patrich, Yael Piontkewitz, Asher Peretz et al.     Maternal immune activation (MIA) resulting from prenatal exposure to infectious pathogens or inflammatory stimuli is increasingly recognized to play an important etiological role …             In situ genetic correction of F8 intron 22 inversion in hemophilia A patient-specific iPSCs ▶     Yong Wu, Zhiqing Hu, Zhuo Li et al.     Nearly half of severe Hemophilia A (HA) cases are caused by F8 intron 22 inversion (Inv22). This 0.6-Mb inversion splits the 186-kb F8 into two parts with opposite transcription …             High glucose enhances progression of cholangiocarcinoma cells via STAT3 activation ▶     Charupong Saengboonmee, Wunchana Seubwai, Chawalit Pairojkul et al.     Epidemiological studies have indicated diabetes mellitus (DM) as a risk of cholangiocarcinoma (CCA), however, the effects and mechanisms of high glucose on progression of CCA …             Tomato yellow leaf curl virus (TYLCV-IL): a seed-transmissible geminivirus in tomatoes ▶     Eui-Joon Kil, Sunhoo Kim, Ye-Ji Lee et al.     Tomato yellow leaf curl virus (TYLCV) is one of the most well-known tomato-infecting begomoviruses and transmitted by Bemisia tabaci. Seed transmission has previously been …             Thermodynamics and kinetics of amphotericin B self-association in aqueous solution characterized in molecular detail ▶     Joanna Zielińska, Miłosz Wieczór, Tomasz Bączek et al.     Amphotericin B (AmB) is a potent but toxic drug commonly used to treat systemic mycoses. Its efficiency as a therapeutic agent depends on its ability to discriminate between …             A Generic Platform for Cellular Screening Against Ubiquitin Ligases ▶     Timurs Maculins, Nikki Carter, Thierry Dorval et al.     Ubiquitin signalling regulates most aspects of cellular life, thus deregulation of ubiquitylation has been linked with a number of diseases. E3 ubiquitin ligases provide …             Diversity and interactions of microbial functional genes under differing environmental conditions: insights from a membrane bioreactor and an oxidation ditch ▶     Yu Xia, Man Hu, Xianghua Wen et al.     The effect of environmental conditions on the diversity and interactions of microbial communities has caused tremendous interest in microbial ecology. Here, we found that with …             A highly selective and sensitive near-infrared fluorescent probe for imaging of hydrogen sulphide in living cells and mice ▶     Ling Zhang, Xi Emily Zheng, Fang Zou et al.     Hydrogen sulphide (H2S), the third endogenous gaseous signalling molecule, has attracted attention in biochemical research. The selective detection of H2S in living systems is …             Sensillar expression and responses of olfactory receptors reveal different peripheral coding in two Helicoverpa species using the same pheromone components ▶     Hetan Chang, Mengbo Guo, Bing Wang et al.     Male moths efficiently recognize conspecific sex pheromones thanks to their highly accurate and specific olfactory system. The Heliothis/Helicoverpa species are regarded as good …             Molecular switches of the κ opioid receptor triggered by 6′-GNTI and 5′-GNTI ▶     Jianxin Cheng, Xianqiang Sun, Weihua Li et al.     The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating neurological diseases. κOR selective 6′-GNTI was …             The musk chemical composition and microbiota of Chinese forest musk deer males ▶     Diyan Li, Binlong Chen, Long Zhang et al.     Male musk deer secrete musk from the musk gland located between their naval and genitals. Unmated male forest musk deer generate a greater amount of musk than mated males, …             Altered functional connectivity in persistent developmental stuttering ▶     Yang Yang, Fanlu Jia, Wai Ting Siok et al.     Persistent developmental stuttering (PDS) is a speech disorder that impairs communication skills. Despite extensive research, the core causes of PDS are elusive. Converging …             “Click on the bidirectional switch”: the aptasensor for simultaneous detection of lysozyme and ATP with high sensitivity and high selectivity ▶     Feng Chen, Changqun Cai, Xiaoming Chen et al.     A bifunctional and simple aptasensor was designed to one-spot simultaneously detect two analytes, lysozyme and ATP. The aptasensor was obtained by the electronic interaction …             Increased nuclear stiffness via FAK-ERK1/2 signaling is necessary for synthetic mechano-growth factor E peptide-induced tenocyte migration ▶     Bingyu Zhang, Qing Luo, Zhen Chen et al.     We have previously reported that a synthetic mechano-growth factor (MGF) C-terminal E-domain with 25 amino acids (MGF-C25E) promotes rat tenocyte migration through the FAK-ERK1/2 …             Evidence for genetic regulation of mRNA expression of the dosage-sensitive gene retinoic acid induced-1 (RAI1) in human brain ▶     Li Chen, Yu Tao, Fan Song et al.     RAI1 (retinoic acid induced-1) is a dosage-sensitive gene that causes Smith-Magenis syndrome (SMS) when mutated or deleted and Potocki-Lupski Syndrome (PTLS) when duplicated, …             Association between the DOCK7, PCSK9 and GALNT2 Gene Polymorphisms and Serum Lipid levels ▶     Tao Guo, Rui-Xing Yin, Feng Huang et al.     This study was to determine the association between several single nucleotide polymorphisms (SNPs) in the dedicator of cytokinesis 7 (DOCK7), proprotein convertase …             Overexpression of ThVHAc1 and its potential upstream regulator, ThWRKY7, improved plant tolerance of Cadmium stress ▶     Guiyan Yang, Chao Wang, Yucheng Wang et al.     As one of the most toxic heavy metals in the environment, cadmium (Cd) poses a severe threat to plant growth. We previously reported that overexpression of the Tamarix hispida …             Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production ▶     Soren Hayrabedyan, Krassimira Todorova, Asma Jabeen et al.     Sertoli cells, can function as non-professional tolerogenic antigen-presenting cells, and sustain the blood-testis barrier formed by their tight junctions. The NOD-like receptor …             17beta-estradiol counteracts neuropathic pain: a behavioural, immunohistochemical, and proteomic investigation on sex-related differences in mice ▶     Valentina Vacca, Sara Marinelli, Luisa Pieroni et al.     Sex differences play a role in pain sensitivity, efficacy of analgesic drugs and prevalence of neuropathic pain, even if the underlying mechanisms are far from being understood. …             Deciphering the streamlined genome of Streptomyces xiamenensis 318 as the producer of the anti-fibrotic drug candidate xiamenmycin ▶     Min-Juan XU, Jia-Hua WANG, Xu-Liang BU et al.     Streptomyces xiamenensis 318, a moderate halophile isolated from a mangrove sediment, produces the anti-fibrotic compound xiamenmycin. The whole genome sequence of strain 318 was …             Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology ▶     Yuanyuan Li, Darren B. Leneghan, Kazutoyo Miura et al.     Transmission-blocking vaccines (TBV) target the sexual-stages of the malaria parasite in the mosquito midgut and are widely considered to be an essential tool for malaria …             Comparative transcriptomic analysis uncovers the complex genetic network for resistance to Sclerotinia sclerotiorum in Brassica napus ▶     Jian Wu, Qing Zhao, Qingyong Yang et al.     Sclerotinia stem rot caused by Sclerotinia sclerotiorum is one of the most devastating diseases in many important crops including Brassica napus worldwide. Quantitative …             The Impact of Dietary Energy Intake Early in Life on the Colonic Microbiota of Adult Mice ▶     Jinyu Xu, Jeffrey D. Galley, Michael T. Bailey et al.     The complex and dynamic interactions between diet, gut microbiota (GM) structure and function, and colon carcinogenesis are only beginning to be elucidated. We examined the …             Discovering and validating between-subject variations in plasma lipids in healthy subjects ▶     Husna Begum, Bowen Li, Guanghou Shui et al.     Lipid levels are commonly used in clinical settings as disease biomarkers, and the advent of mass spectrometry-based (MS) lipidomics heralds the possibility of identifying …             Anaerobic decomposition of humic substances by Clostridium from the deep subsurface ▶     Akio Ueno, Satoru Shimizu, Shuji Tamamura et al.     Decomposition of humic substances (HSs) is a slow and cryptic but non-negligible component of carbon cycling in sediments. Aerobic decomposition of HSs by microorganisms in the …             Carbon: nitrogen stoichiometry following afforestation: a global synthesis ▶     Xia Xu, Dejun Li, Xiaoli Cheng et al.     Though carbon (C): nitrogen (N) stoichiometry has been widely studied in terrestrial ecosystems, little is known about its variation following afforestation. By synthesizing the …             Extraction, purification and anti-fatigue activity of γ-aminobutyric acid from mulberry (Morus alba L.) leaves ▶     Hengwen Chen, Xuanhui He, Yan Liu et al.     Mulberry (Morus alba L.) is a tree species of Moraceae widely distributed in Southern China. In the present study, the white crystal of γ-aminobutyric acid (GABA) was purified …             Inner membrane fusion mediates spatial distribution of axonal mitochondria ▶     Yiyi Yu, Hao-Chih Lee, Kuan-Chieh Chen et al.     In eukaryotic cells, mitochondria form a dynamic interconnected network to respond to changing needs at different subcellular locations. A fundamental yet unanswered question …             Revealing Potential Biomarkers of Functional Dyspepsia by Combining 1H NMR Metabonomics Techniques and an Integrative Multi-objective Optimization Method ▶     Qiaofeng Wu, Meng Zou, Mingxiao Yang et al.     Metabonomics methods have gradually become important auxiliary tools for screening disease biomarkers. However, recognition of metabolites or potential biomarkers closely related …             Efficacy and safety of dulaglutide in patients with type 2 diabetes: a meta-analysis and systematic review ▶     Lin Zhang, Mei Zhang, Yuwei Zhang et al.     A meta-analysis was conducted to assess the clinical efficacy and safety of dulaglutide in patients with type 2 diabetes mellitus (T2DM). Medline, Embase, Cochrane Library and …             CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells ▶     Xiao-Li Xu, Qi-chao Bao, Jian-Min Jia et al.     Heat-shock protein 90 (Hsp90) is highly expressed in many tumor cells and is associated with the maintenance of malignant phenotypes. Targeting Hsp90 has had therapeutic success …             Development of a self-administered web-based test for longitudinal cognitive assessment ▶     Luis Ruano, Andreia Sousa, Milton Severo et al.     Sequential testing with brief cognitive tools has been recommended to improve cognitive screening and monitoring, however the few available tools still depend on an external …             Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish ▶     Chunsheng Liu, Guanyong Su, John P. Giesy et al.     Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been frequently detected in environmental media and has adverse health effect on wildlife and humans. It has been implicated to …             Pathway of FeEDTA transformation and its impact on performance of NOx removal in a chemical absorption-biological reduction integrated process ▶     Wei Li, Jingkai Zhao, Lei Zhang et al.     A novel chemical absorption-biological reduction (CABR) integrated process, employing ferrous ethylenediaminetetraacetate (Fe(II)EDTA) as a solvent, is deemed as a potential …             Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes ▶     Shunsuke Funakoshi, Kenji Miki, Tadashi Takaki et al.     Human pluripotent stem cell-derived cardiomyocytes (CMs) are a promising tool for cardiac cell therapy. Although transplantation of induced pluripotent stem cell (iPSC)-derived …             Runx2-Modified Adipose-Derived Stem Cells Promote Tendon Graft Integration in Anterior Cruciate Ligament Reconstruction ▶     Xin Zhang, Yong Ma, Xin Fu et al.     Runx2 is a powerful osteo-inductive factor and adipose-derived stem cells (ADSCs) are multipotent. However, it is unknown whether Runx2-overexpressing ADSCs (Runx2-ADSCs) could …             Macroevolution of hyperdiverse flightless beetles reflects the complex geological history of the Sunda Arc ▶     Rene Tänzler, Matthew H. Van Dam, Emmanuel F. A. Toussaint et al.     The Sunda Arc forms an almost continuous chain of islands and thus a potential dispersal corridor between mainland Southeast Asia and Melanesia. However, the Sunda Islands have …             Unearthing the Antibacterial Mechanism of Medicinal Clay: A Geochemical Approach to Combating Antibiotic Resistance ▶     Keith D. Morrison, Rajeev Misra, Lynda B. Williams     Natural antibacterial clays, when hydrated and applied topically, kill human pathogens including antibiotic resistant strains proliferating worldwide. Only certain clays are …             Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation. ▶     Allison Agus, Jérémy Denizot, Jonathan Thévenot et al.     Recent advances have shown that the abnormal inflammatory response observed in CD involves an interplay among intestinal microbiota, host genetics and environmental factors. The …             Reptile Toll-like receptor 5 unveils adaptive evolution of bacterial flagellin recognition ▶     Carlos G. P. Voogdt, Lieneke I. Bouwman, Marja J. L. Kik et al.     Toll-like receptors (TLR) are ancient innate immune receptors crucial for immune homeostasis and protection against infection. TLRs are present in mammals, birds, amphibians and …             Autophosphorylation at Thr279 of Entamoeba histolytica atypical kinase EhAK1 is required for activity and regulation of erythrophagocytosis ▶     M Shahid Mansuri, Mrigya Babuta, Mohammad Sabir Ali et al.     Phagocytosis plays a key role in survival and pathogenicity of Entamoeba histolytica. We have recently demonstrated that an atypical kinase EhAK1 is involved in phagocytosis in …             Molecular mapping and characterization of the silkworm apodal mutant ▶     Peng Chen, Xiao-Ling Tong, Ming-Yue Fu et al.     The morphological diversity of insects is important for their survival; in essence, it results from the differential expression of genes during development of the insect body. …             Visualisation of newly synthesised collagen in vitro and in vivo ▶     Corien Oostendorp, Peter J.E. Uijtdewilligen, Elly M. Versteeg et al.     Identifying collagen produced de novo by cells in a background of purified collagenous biomaterials poses a major problem in for example the evaluation of tissue-engineered …             Targeted pruning of a neuron’s dendritic tree via femtosecond laser dendrotomy ▶     Mary Ann Go, Julian Min Chiang Choy, Alexandru Serban Colibaba et al.     Neurons are classified according to action potential firing in response to current injection. While such firing patterns are shaped by the composition and distribution of ion …             Corrigendum: Efficient amplification of self-gelling polypod-like structured DNA by rolling circle amplification and enzymatic digestion ▶     Tomoya Yata, Yuki Takahashi, Mengmeng Tan et al.                 Drug response in organoids generated from frozen primary tumor tissues ▶     Alex J. Walsh, Rebecca S. Cook, Melinda E. Sanders et al.     Primary tumor organoids grown in three-dimensional culture provide an excellent platform for studying tumor progression, invasion, and drug response. However, organoid generation …             Corrigendum: Gene expression profiling of pre-eclamptic placentae by RNA sequencing ▶     Tea Kaartokallio, Alejandra Cervera, Anjuska Kyllönen et al.                 Comparative transcriptome analysis reveals insights into the streamlined genomes of haplosclerid demosponges ▶     Christine Guzman, Cecilia Conaco     Sponges (Porifera) are one of the most ancestral metazoan groups. They are characterized by a simple body plan lacking the true tissues and organ systems found in other animals. …             Corrigendum: Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation ▶     Yifan Wang, Yanchong Zhang, Wen Hu et al.                 Coral mucus fuels the sponge loop in warm- and cold-water coral reef ecosystems ▶     Laura Rix, Jasper M. de Goeij, Christina E. Mueller et al.     Shallow warm-water and deep-sea cold-water corals engineer the coral reef framework and fertilize reef communities by releasing coral mucus, a source of reef dissolved organic …             Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors ▶     Maria V. Yelshanskaya, Kei Saotome, Appu K. Singh et al.     AMPA subtype ionotropic glutamate receptors (iGluRs) mediate the majority of fast neurotransmission across excitatory synapses in the central nervous system. Each AMPA receptor …             A comprehensive characterization of simple sequence repeats in pepper genomes provides valuable resources for marker development in Capsicum ▶     Jiaowen Cheng, Zicheng Zhao, Bo Li et al.     The sequences of the full set of pepper genomes including nuclear, mitochondrial and chloroplast are now available for use. However, the overall of simple sequence repeats (SSR) …             Mathematical modelling of transcriptional heterogeneity identifies novel markers and subpopulations in complex tissues ▶     Niya Wang, Eric P. Hoffman, Lulu Chen et al.     Tissue heterogeneity is both a major confounding factor and an underexploited information source. While a handful of reports have demonstrated the potential of supervised …             An authenticity survey of herbal medicines from markets in China using DNA barcoding ▶     Jianping Han, Xiaohui Pang, Baosheng Liao et al.     Adulterant herbal materials are a threat to consumer safety. In this study, we used DNA barcoding to investigate the proportions and varieties of adulterant species in …             Is costly punishment altruistic? Exploring rejection of unfair offers in the Ultimatum Game in real-world altruists ▶     Kristin M. Brethel-Haurwitz, Sarah A. Stoycos, Elise M. Cardinale et al.     In the Ultimatum Game (UG), incurring a cost to punish inequity is commonly termed altruistic punishment. This behaviour is thought to benefit others if the defector becomes more …             Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription ▶     Hui Han, Jialin Fan, Yue Xiong et al.     Gene apterous (ap), chip (chi) and beadex (bx) play important roles in the dorsal-ventral compartmentalization in Drosophila wing discs. Meanwhile, Notch signaling is essential …             TGF-β1 Upregulates the Expression of Triggering Receptor Expressed on Myeloid Cells 1 in Murine Lungs ▶     Li Peng, Yong Zhou, Liang Dong et al.     Triggering receptor expressed on myeloid cells 1 (TREM-1) increases the expression of TGF-β family genes, which are known as profibrogenic cytokines in the pathogenesis of …             Insect stereopsis demonstrated using a 3D insect cinema ▶     Vivek Nityananda, Ghaith Tarawneh, Ronny Rosner et al.     Stereopsis - 3D vision – has become widely used as a model of perception. However, all our knowledge of possible underlying mechanisms comes almost exclusively from vertebrates. …             Adipose triglyceride lipase (Atgl) mediates the antibiotic jinggangmycin-stimulated reproduction in the brown planthopper, Nilaparvata lugens Stål ▶     Yi-Ping Jiang, Lei Li, Zong-Yu Liu et al.     The antibiotic jinggangmycin (JGM) is an agrochemical product widely used in China for controlling rice sheath blight, Rhizoctonia solani. Unexpectedly, it stimulates …             Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities ▶     Terumasa Ikeda, Eugene Boon Beng Ong, Nobumoto Watanabe et al.     APOBEC1 (A1) proteins from lagomorphs and rodents have deaminase-dependent restriction activity against HIV-1, whereas human A1 exerts a negligible effect. To investigate these …             Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales) ▶     Chunmei Chen, Qingyi Tong, Hucheng Zhu et al.     Chemical investigation on the methanol extract of Chaetomium globosum TW1-1, a fungus isolated from the common pillbug (Armadillidium vulgare), has resulted in the isolation of …             Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation ▶     Gibok Lee, Hyung-Sik Won, Yoon-Mi Lee et al.     Prolyl hydroxylase domain protein 2 (PHD2) belongs to an evolutionarily conserved superfamily of 2-oxoglutarate and Fe(II)-dependent dioxygenases that mediates homeostatic …             Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction ▶     Michelle Vincendeau, Kamyar Hadian, Ana C. Messias et al.     The IκB kinase (IKK) complex acts as the gatekeeper of canonical NF-κB signaling, thereby regulating immunity, inflammation and cancer. It consists of the catalytic subunits IKKα …             GeNN: a code generation framework for accelerated brain simulations ▶     Esin Yavuz, James Turner, Thomas Nowotny     Large-scale numerical simulations of detailed brain circuit models are important for identifying hypotheses on brain functions and testing their consistency and plausibility. An …             Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA ▶     Asako Shimoda, Koji Ueda, Shin Nishiumi et al.     CagA, encoded by cytotoxin-associated gene A (cagA), is a major virulence factor of Helicobacter pylori, a gastric pathogen involved in the development of upper gastrointestinal …             Corrigendum: Plant-microbe rhizosphere interactions mediated by Rehmannia glutinosa root exudates under consecutive monoculture ▶     Linkun Wu, Juanying Wang, Weimin Huang et al.                 Corrigendum: Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis ▶     Tomoyo Taniguchi, Eiji Miyauchi, Shota Nakamura et al.                 Genome-wide identification of DNA methylation provides insights into the association of gene expression in rice exposed to pesticide atrazine ▶     Yi Chen Lu, Sheng Jun Feng, Jing Jing Zhang et al.     Atrazine (ATR) is a pesticide widely used for controlling weeds for crop production. Crop contamination with ATR negatively affects crop growth and development. This study …             Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators ▶     Katsuya Iuchi, Akemi Imoto, Naomi Kamimura et al.     We previously showed that H2 acts as a novel antioxidant to protect cells against oxidative stress. Subsequently, numerous studies have indicated the potential applications of H2 …             Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilatation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway ▶     Yi Sun, Chi-Wai Lau, Yingli Jia et al.     Mammalian urea transporters (UTs), UT-A and UT-B, are best known for their role in urine concentration. UT-B is especially distributed in multiple extrarenal tissues with …             Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape ▶     Thomas Peacock, Kolli Reddy, Joe James et al.     H9N2 avian influenza virus is a major cause of poultry production loss across Asia leading to the wide use of vaccines. Efficacy of vaccines is often compromised due to the rapid …             MicroRNAs in Honey Bee Caste Determination ▶     Regan Ashby, Sylvain Forêt, Iain Searle et al.     The cellular mechanisms employed by some organisms to produce contrasting morphological and reproductive phenotypes from the same genome remains one of the key unresolved issues …             Ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade ▶     Luanqing Che, Yan Jin, Chao Zhang et al.     Ozone is a common environmental air pollutant leading to respiratory illness. The mechanisms regulating ozone-induced airway inflammation remain poorly understood. We hypothesize …             Crystal structures of Mycobacterium tuberculosis HspAT and ArAT reveal structural basis of their distinct substrate specificities ▶     Nazia Nasir, Avishek Anant, Rajan Vyas et al.     Aminotransferases of subfamily Iβ, which include histidinol phosphate aminotransferases (HspATs) and aromatic amino acid aminotransferases (ArATs), are structurally similar but …             Potential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights ▶     Priyanka Singh, Ramesha H. Jayaramaiah, Sachin B. Agawane et al.     Medicinally important genus Ocimum harbors a vast pool of chemically diverse metabolites. Current study aims at identifying anti-diabetic candidate compounds from Ocimum species. …             Water Dynamics in Shewanella oneidensis at Ambient and High Pressure using Quasi-Elastic Neutron Scattering ▶     Fabrizia Foglia, Rachael Hazael, Giovanna G. Simeoni et al.     Quasielastic neutron scattering (QENS) is an ideal technique for studying water transport and relaxation dynamics at pico- to nanosecond timescales and at length scales relevant …             Clinical features, Outcomes and Molecular Profiles of Drug Resistance in Tuberculous Meningitis in non-HIV Patients ▶     Jingya Zhang, Xuejiao Hu, Xin Hu et al.     Tuberculous meningitis continues to be a serious problem for physicians because it is difficult to make an early diagnosis and the consequences of delaying treatment are severe. …             Effect of calcium cyanamide, ammonium bicarbonate and lime mixture, and ammonia water on survival of Ralstonia solanacearum and microbial community ▶     Lijuan Liu, Chengliang Sun, Xingxing Liu et al.     The inorganic nitrogenous amendments calcium cyanamide (CC), ammonia water (AW), and a mixture of ammonium bicarbonate with lime (A+L) are popularly used as fumigants to control …             Corrigendum: Zebrafish Models for Human Acute Organophosphorus Poisoning ▶     Melissa Faria, Natàlia Garcia-Reyero, Francesc Padrós et al.                 The First Two Clostridium difficile Ribotype 027/ST1 Isolates Identified in Beijing, China–an Emerging Problem or a Neglected Threat? ▶     Jing-Wei Cheng, Meng Xiao, Timothy Kudinha et al.     Clostridium difficile hyper-virulent ribotype 027 strain has become a significant concern globally, but has rarely been reported in Asian countries including China. Recently, a …             Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways ▶     Xiao Yong Qiao, Ying Nie, Ya Xian Ma et al.     Physical exercise is able to improve skeletal health. However, the mechanisms are poorly known. Irisin, a novel exercise-induced myokine, secreted by skeletal muscle in response …             Habituation of visual adaptation ▶     Xue Dong, Yi Gao, Lili Lv et al.     Our sensory system adjusts its function driven by both shorter-term (e.g. adaptation) and longer-term (e.g. learning) experiences. Most past adaptation literature focuses on …             Extracellular ATP mediates inflammatory responses in colitis via P2 × 7 receptor signaling ▶     Ping Wan, Xiaopeng Liu, Yan Xiong et al.     Extracellular purinergic products, particularly ATP, have recently been implicated to regulate immune cell functions and contribute to aberrant inflammatory responses of immune …             HIV-1 gp120 induces type-1 programmed cell death through ER stress employing IRE1α, JNK and AP-1 pathway ▶     Ankit Shah, Naveen K. Vaidya, Hari K. Bhat et al.     The ER stress-mediated apoptosis has been implicated in several neurodegenerative diseases; however, its role in HIV/neuroAIDS remains largely unexplored. The present study was …             Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists ▶     Valentina Sepe, Carmen Festa, Barbara Renga et al.     Bile acids are the endogenous modulators of the nuclear receptor FXR and the membrane receptor GPBAR1. FXR represents a promising pharmacological target for the treatment of …             Theropod courtship: large scale physical evidence of display arenas and avian-like scrape ceremony behaviour by Cretaceous dinosaurs ▶     Martin G. Lockley, Richard T. McCrea, Lisa G. Buckley et al.     Relationships between non-avian theropod dinosaurs and extant and fossil birds are a major focus of current paleobiological research. Despite extensive phylogenetic and …             Elderly male smokers with right lung tumors are viable candidates for KRAS mutation screening ▶     Yang Yang, Chun Shi, Hui Sun et al.     Genetic aberrations in tumor driver genes provide specific molecular targets for therapeutic intervention, which can greatly improve therapeutic outcomes. Here, we analyzed the …             High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells ▶     Yu-Ching Chen, Sarah Statt, Reen Wu et al.     Epithelial–mesenchymal transition (EMT) is implicated in bronchial remodeling and loss of lung function in chronic inflammatory airway diseases. Previous studies showed the …             Coralline algal physiology is more adversely affected by elevated temperature than reduced pH ▶     Román Manuel Vásquez-Elizondo, Susana Enríquez     In this study we analyzed the physiological responses of coralline algae to ocean acidification (OA) and global warming, by exposing algal thalli of three species with …             CrossNorm: a novel normalization strategy for microarray data in cancers ▶     Lixin Cheng, Leung-Yau Lo, Nelson L. S. Tang et al.     Normalization is essential to get rid of biases in microarray data for their accurate analysis. Existing normalization methods for microarray gene expression data commonly assume …             Climate-driven sympatry may not lead to foraging competition between congeneric top-predators ▶     Megan A. Cimino, Mark A. Moline, William R. Fraser et al.     Climate-driven sympatry may lead to competition for food resources between species. Rapid warming in the West Antarctic Peninsula (WAP) is coincident with increasing gentoo …             Transcriptome and biomineralization responses of the pearl oyster Pinctada fucata to elevated CO2 and temperature ▶     Shiguo Li, Chuang Liu, Jingliang Huang et al.     Ocean acidification and global warming have been shown to significantly affect the physiological performances of marine calcifiers; however, the underlying mechanisms remain …             Impaired encoding of rapid pitch information underlies perception and memory deficits in congenital amusia ▶     Philippe Albouy, Marion Cousineau, Anne Caclin et al.     Recent theories suggest that the basis of neurodevelopmental auditory disorders such as dyslexia or specific language impairment might be a low-level sensory dysfunction. In the …             Corrigendum: Identification of novel alleles of the rice blast resistance gene Pi54 ▶     Kumar Vasudevan, Wilhelm Gruissem, Navreet K. Bhullar                 Corrigendum: 3D Structural Fluctuation of IgG1 Antibody Revealed by Individual Particle Electron Tomography ▶     Xing Zhang, Lei Zhang, Huimin Tong et al.                 Corrigendum: Bub1 is required for maintaining cancer stem cells in breast cancer cell lines ▶     Jeong Yoon Han, Yu Kyeong Han, Ga-Young Park et al.                 Rational design of ultrastable and reversibly photoswitchable fluorescent proteins for super-resolution imaging of the bacterial periplasm ▶     Mariam El Khatib, Alexandre Martins, Dominique Bourgeois et al.     Phototransformable fluorescent proteins are central to several nanoscopy approaches. As yet however, there is no available variant allowing super-resolution imaging in cell …             Discovering new mTOR inhibitors for cancer treatment through virtual screening methods and in vitro assays ▶     Ling Wang, Lei Chen, Miao Yu et al.     Mammalian target of rapamycin (mTOR) is an attractive target for new anticancer drug development. We recently developed in silico models to distinguish mTOR inhibitors and …             Exceptional preservation reveals gastrointestinal anatomy and evolution in early actinopterygian fishes ▶     Thodoris Argyriou, Marcus Clauss, Erin E. Maxwell et al.     Current knowledge about the evolutionary morphology of the vertebrate gastrointestinal tract (GIT) is hindered by the low preservation potential of soft tissues in fossils. …             The recent ancestry of Middle East respiratory syndrome coronavirus in Korea has been shaped by recombination ▶     Jin Il Kim, You-Jin Kim, Philippe Lemey et al.     Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe cases of human respiratory disease. Since 2012, the victims have mainly come from the Middle East countries …             Overexpression of SIRT6 in the hippocampal CA1 impairs the formation of long-term contextual fear memory ▶     Xi Yin, Yuan Gao, Hai-Shui Shi et al.     Histone modifications have been implicated in learning and memory. Our previous transcriptome data showed that expression of sirtuins 6 (SIRT6), a member of Histone deacetylases …             Distribution, function and evolution characterization of microsatellite in Sargassum thunbergii (Fucales, Phaeophyta) transcriptome and their application in marker development ▶     Fuli Liu, Zimin Hu, Wenhui Liu et al.     Using transcriptome data to mine microsatellite and develop markers has growingly become prevalent. However, characterizing the possible function of microsatellite is relatively …             Intracellular Doppler Signatures of Platinum Sensitivity Captured by Biodynamic Profiling in Ovarian Xenografts ▶     Daniel Merrill, Ran An, Hao Sun et al.     Three-dimensional (3D) tissue cultures are replacing conventional two-dimensional (2D) cultures for applications in cancer drug development. However, direct comparisons of in …             VIP treatment prevents embryo resorption by modulating efferocytosis and activation profile of maternal macrophages in the CBAxDBA resorption prone model ▶     Lucila Gallino, Guillermina Calo, Vanesa Hauk et al.     Successful embryo implantation occurs followed by a local pro-inflammatory response subsequently shifted toward a tolerogenic one. VIP (vasoactive intestinal peptide) has …             NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity ▶     Chenyu Li, Yajun Zhang, Qiaoyun Yang et al.     Nucleolar and spindle-associated protein (NuSAP) is a microtubule-associated protein that functions as a microtubule stabiliser. Depletion of NuSAP leads to severe mitotic …             Testis-enriched heat shock protein A2 (HSPA2): Adaptive advantages of the birds with internal testes over the mammals with testicular descent ▶     Abinash Padhi, Mona M. Ghaly, Li Ma     The molecular chaperone heat shock protein A2 (HSPA2), a member of the 70 kDa heat shock protein (HSP70) family, plays an important role in spermatogenesis and male fertility. …             Intravital imaging of Ca2+ signals in lymphocytes of Ca2+ biosensor transgenic mice: indication of autoimmune diseases before the pathological onset ▶     Soichiro Yoshikawa, Takako Usami, Junichi Kikuta et al.     Calcium ion (Ca2+) signaling is a typical phenomenon mediated through immune receptors, such as the B-cell antigen receptor (BCR), and it is important for their biological …             The soluble form of BMPRIB is a novel therapeutic candidate for treating bone related disorders ▶     Kengo Yamawaki, Yuichiro Kondo, Tsutomu Okada et al.     Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the TGF-beta superfamily. Recently, several soluble BMP receptors, such as ActRIIA-Fc, …             Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu ▶     Jiamei Chen, Wei Gao, Ping Zhou et al.     Chinese medicine, Fuzhenghuayu (FZHY), appears to prevent fibrosis progression and improve liver function in humans. Here we found that FZHY enhanced hepatocyte differentiation …             miRNA Digger: a comprehensive pipeline for genome-wide novel miRNA mining ▶     Lan Yu, Chaogang Shao, Xinghuo Ye et al.     MicroRNAs (miRNAs) are important regulators of gene expression. The recent advances in high-throughput sequencing (HTS) technique have greatly facilitated large-scale detection …             Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation ▶     Ayano Takagi, Shinji Kume, Motoyuki Kondo et al.     Autophagy is an intracellular degradation system activated, across species, by starvation. Although accumulating evidence has shown that mammalian autophagy is involved in …             Mitochondrial genome evolution and tRNA truncation in Acariformes mites: new evidence from eriophyoid mites ▶     Xiao-Feng Xue, Jing-Feng Guo, Yan Dong et al.     The subclass Acari (mites and ticks) comprises two super-orders: Acariformes and Parasitiformes. Most species of the Parasitiformes known retained the ancestral pattern of …             Hybridization following population collapse in a critically endangered antelope ▶     Pedro Vaz Pinto, Pedro Beja, Nuno Ferrand et al.     Population declines may promote interspecific hybridization due to the shortage of conspecific mates (Hubb’s ‘desperation’ hypothesis), thus greatly increasing the risk of …             Corrigendum: Down-regulation of miR-206 is associated with Hirschsprung disease and suppresses cell migration and proliferation in cell models ▶     Ankur Sharan, Hairong Zhu, Hua Xie et al.                 Genome-wide identification of calcium-dependent protein kinases in soybean and analyses of their transcriptional responses to insect herbivory and drought stress ▶     Christian Hettenhausen, Guiling Sun, Yanbiao He et al.     Calcium-dependent protein kinases (CDPKs) are plant-specific calcium sensors that play important roles in various aspects of plant physiology. Here, we investigated phylogenic …             Embelin binds to human neuroserpin and impairs its polymerisation ▶     Giorgia Saga, Fabio Sessa, Alberto Barbiroli et al.     Neuroserpin (NS) is a serpin inhibitor of tissue plasminogen activator (tPA) in the brain. The polymerisation of NS pathologic mutants is responsible for a genetic dementia known …             Presence of unique glyoxalase III proteins in plants indicates the existence of shorter route for methylglyoxal detoxification ▶     Ajit Ghosh, Hemant R Kushwaha, Mohammad R Hasan et al.     Glyoxalase pathway, comprising glyoxalase I (GLY I) and glyoxalase II (GLY II) enzymes, is the major pathway for detoxification of methylglyoxal (MG) into D-lactate involving …             A transcriptome-wide, organ-specific regulatory map of Dendrobium officinale, an important traditional Chinese orchid herb ▶     Yijun Meng, Dongliang Yu, Jie Xue et al.     Dendrobium officinale is an important traditional Chinese herb. Here, we did a transcriptome-wide, organ-specific study on this valuable plant by combining RNA, small RNA (sRNA) …             Genome-wide analysis of the AP2/ERF family in Musa species reveals divergence and neofunctionalisation during evolution ▶     Deepika Lakhwani, Ashutosh Pandey, Yogeshwar Vikram Dhar et al.     AP2/ERF domain containing transcription factor super family is one of the important regulators in the plant kingdom. The involvement of AP2/ERF family members has been elucidated …             Automatic stage identification of Drosophila egg chamber based on DAPI images ▶     Dongyu Jia, Qiuping Xu, Qian Xie et al.     The Drosophila egg chamber, whose development is divided into 14 stages, is a well-established model for developmental biology. However, visual stage determination can be a …             NAADP-Dependent Ca2+ Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis ▶     Annarita Favia, Irene Pafumi, Marianna Desideri et al.     A novel transduction pathway for the powerful angiogenic factor VEGF has been recently shown in endothelial cells to operate through NAADP-controlled intracellular release of Ca2+…             Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway ▶     Junichi Maruyama, Yumie Kobayashi, Tsuyoshi Umeda et al.     The With No lysine [K] (WNK)-Ste20-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase 1 (OSR1) pathway has been reported to be a crucial signaling …             Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities ▶     Ana Teresa Pinto, Marta Laranjeiro Pinto, Ana Patrícia Cardoso et al.     In order to improve the efficacy of conventional radiotherapy, attention has been paid to immune cells, which not only modulate cancer cell response to therapy but are also …             RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits ▶     Li Yan, Yaomin Chen, Wubo Li et al.     Alzheimer’s disease (AD) is the most common form of dementia in the elderly. It is generally believed that β-amyloidogenesis, tau-hyperphosphorylation, and synaptic loss underlie …             PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress ▶     Mei-Ling Kuo, Mabel Bin-Er Lee, Michelle Tang et al.     Ribonucleotide reductase small subunit B (RRM2B) is a stress response protein that protects normal human fibroblasts from oxidative stress. However, the underlying mechanism that …             Next-Generation Bacillus anthracis Live Attenuated Spore Vaccine Based on the htrA- (High Temperature Requirement A) Sterne Strain ▶     Theodor Chitlaru, Ma’ayan Israeli, Erez Bar-Haim et al.     Anthrax is a lethal disease caused by the gram-positive spore-producing bacterium Bacillus anthracis. Live attenuated vaccines, such as the nonencapsulated Sterne strain, do not …             Two kinds of common prenatal screening tests for Down’s syndrome: a systematic review and meta-analysis ▶     Yuan Yao, Yang Liao, Mei Han et al.     As the chromosomal examination of foetal cells for the prenatal diagnosis of Down’s syndrome (DS) carries a risk of inducing miscarriage, serum screening tests are commonly used …             Anti-inflammatory effects of indirubin derivatives on influenza A virus-infected human pulmonary microvascular endothelial cells ▶     Hoi-Hin Kwok, Po-Ying Poon, Siu-Ping Fok et al.     Influenza A virus (IAV) poses global threats to human health. Acute respiratory distress syndrome and multi-organ dysfunction are major complications in patients with severe …             Both diet and gene mutation induced obesity affect oocyte quality in mice ▶     Yan-Jun Hou, Cheng-Cheng Zhu, Xing Duan et al.     Obesity was shown to cause reproductive dysfunctions such as reduced conception, infertility and early pregnancy loss. However, the possible effects of obesity on oocyte quality …             Novel mutations in CRYGD are associated with congenital cataracts in Chinese families ▶     Guoxing Yang, Zhimin Chen, Wulin Zhang et al.     Congenital cataract disease is a clinically and genetically heterogeneous lens disorder. The purpose of this study was to identify the genetic defects and to investigate the …             Exon-centric regulation of ATM expression is population-dependent and amenable to antisense modification by pseudoexon targeting ▶     Jana Kralovicova, Marcin Knut, Nicholas C. P. Cross et al.     ATM is an important cancer susceptibility gene that encodes a critical apical kinase of the DNA damage response (DDR) pathway. We show that a key nonsense-mediated RNA decay s…             Effects of calcitriol on random skin flap survival in rats ▶     Kai-liang Zhou, Yi-hui Zhang, Ding-sheng Lin et al.     Calcitriol, a metabolite of vitamin D, is often used in osteoporosis clinics. However, the material has other bioactivities; for example, it accelerates angiogenesis, has …             Factors controlling soil organic carbon stability along a temperate forest altitudinal gradient ▶     Qiuxiang Tian, Hongbo He, Weixin Cheng et al.     Changes in soil organic carbon (SOC) stability may alter carbon release from the soil and, consequently, atmospheric CO2 concentration. The mean annual temperature (MAT) can …             Evidence for the presence of biogenic magnetic particles in the nocturnal migratory brown planthopper, Nilaparvata lugens ▶     Weidong Pan, Guijun Wan, Jingjing Xu et al.     Biogenic magnetic particles have been detected in some migratory insects, which implies the basis of magnetoreception mechanism for orientation and navigation. Here, the biogenic …             Aim-less translation: loss of Saccharomyces cerevisiae mitochondrial translation initiation factor mIF3/Aim23 leads to unbalanced protein synthesis ▶     Anton Kuzmenko, Ksenia Derbikova, Roger Salvatori et al.     The mitochondrial genome almost exclusively encodes a handful of transmembrane constituents of the oxidative phosphorylation (OXPHOS) system. Coordinated expression of these …             Neural mechanisms supporting evaluation of others’ errors in real-life like conditions ▶     Iiro P. Jääskeläinen, Hanna-Leena Halme, Yigal Agam et al.     The ability to evaluate others’ errors makes it possible to learn from their mistakes without the need for first-hand trial-and-error experiences. Here, we compared functional …             Receptor for detection of a Type II sex pheromone in the winter moth Operophtera brumata ▶     Dan-Dan Zhang, Hong-Lei Wang, Anna Schultze et al.     How signal diversity evolves under stabilizing selection in a pheromone-based mate recognition system is a conundrum. Female moths produce two major types of sex pheromones, …             Probiotic treatment reduces appetite and glucose level in the zebrafish model ▶     Silvia Falcinelli, Ana Rodiles, Suraj Unniappan et al.     The gut microbiota regulates metabolic pathways that modulate the physiological state of hunger or satiety. Nutrients in the gut stimulate the release of several appetite …             The role of dung beetles in reducing greenhouse gas emissions from cattle farming ▶     Eleanor M. Slade, Terhi Riutta, Tomas Roslin et al.     Agriculture is one of the largest anthropogenic sources of greenhouse gases (GHGs), with dairy and beef production accounting for nearly two-thirds of emissions. Several recent …             Comparison of bacterial communities of conventional and A-stage activated sludge systems ▶     Alejandro Gonzalez-Martinez, Alejandro Rodriguez-Sanchez, Tommaso Lotti et al.     The bacterial community structure of 10 different wastewater treatment systems and their influents has been investigated through pyrosequencing, yielding a total of 283486 reads. …             Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator ▶     Chihiro Kitatsuji, Kozue Izumi, Shusuke Nambu et al.     The Bradyrhizobium japonicum transcriptional regulator Irr (iron response regulator) is a key regulator of the iron homeostasis, which is degraded in response to heme binding via …             Potent Antibacterial Nanoparticles against Biofilm and Intracellular Bacteria ▶     Haibo Mu, Jiangjiang Tang, Qianjin Liu et al.     The chronic infections related to biofilm and intracellular bacteria are always hard to be cured because of their inherent resistance to both antimicrobial agents and host …             Restriction of protein synthesis abolishes senescence features at cellular and organismal levels ▶     Yuki Takauji, Takumi Wada, Asuka Takeda et al.     Cellular senescence or its equivalence is induced by treatment of cells with an appropriate inducer of senescence in various cell types. Mild restriction of cytoplasmic protein …             Farnesoid X receptor activation promotes cell proliferation via PDK4-controlled metabolic reprogramming ▶     Yang Xie, Hong Wang, Xuefang Cheng et al.     Farnesoid X receptor (FXR) plays a pivotal role in the regulation of various metabolic pathways as well as liver regeneration. However, the casual link between cell proliferative …             State-dependent and cell type-specific temporal processing in auditory thalamocortical circuit ▶     Shuzo Sakata     Ongoing spontaneous activity in cortical circuits defines cortical states, but it still remains unclear how cortical states shape sensory processing across cortical laminae and …             Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells ▶     Sicong Hou, Tomoya Isaji, Qinglei Hang et al.     An aberrant expression of integrin β1 has been implicated in breast cancer progression. Here, we compared the cell behaviors of wild-type (WT), β1 gene deleted (KO), and β1 gene …             Curcumin modulates cell death and is protective in Huntington’s disease model ▶     Anjalika Chongtham, Namita Agrawal     Huntington’s disease (HD) is a progressive, dominantly inherited neurological disorder caused by an abnormal expansion of polyglutamine (polyQ) repeat within the Huntingtin (Htt) …             Genetic diversity and natural selection footprints of the glycine amidinotransferase gene in various human populations ▶     Asifullah Khan, Lei Tian, Chao Zhang et al.     The glycine amidinotransferase gene (GATM) plays a vital role in energy metabolism in muscle tissues and is associated with multiple clinically important phenotypes. However, the …             Variability of Action Potentials Within and Among Cardiac Cell Clusters Derived from Human Embryonic Stem Cells ▶     Renjun Zhu, Michal A. Millrod, Elias T. Zambidis et al.     Electrophysiological variability in cardiomyocytes derived from pluripotent stem cells continues to be an impediment for their scientific and translational applications. We …             EBP50 induces apoptosis in macrophages by upregulating nitric oxide production to eliminate intracellular Mycobacterium tuberculosis ▶     Yang Guo, Yating Deng, Zikun Huang et al.     Mycobacterium bovis BCG is known to have the capacity to inhibit the positioning of iNOS on BCG-containing phagosomes by interfering with EBP50, a scaffolding protein that …             Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q ▶     Kyoung Joo Cho, So Young Cheon, Gyung Whan Kim     Apoptosis signal-regulating kinase-1 (ASK1), an early signaling element in the cell death pathway, has been hypothesized to participate in the pathology of neurodegenerative …             Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells ▶     Giovanna Talarico, Stefania Orecchioni, Katiuscia Dallaglio et al.     Metformin can induce breast cancer (BC) cell apoptosis and reduce BC local and metastatic growth in preclinical models. Since Metformin is frequently used along with Aspirin or …             Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh ▶     A. S. Noman, M. Uddin, M. Z. Rahman et al.     Dysregulation of Hedgehog (Hh) signaling pathway has been documented in mammary gland development and breast cancer (BC) progression. Despite the remarkable progress in …             Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer ▶     Magali Michaut, Suet-Feung Chin, Ian Majewski et al.     Invasive lobular carcinoma (ILC) is the second most frequently occurring histological breast cancer subtype after invasive ductal carcinoma (IDC), accounting for around 10% of …             Transgenic FingRs for Live Mapping of Synaptic Dynamics in Genetically-Defined Neurons ▶     Jong-Hyun Son, Matthew D. Keefe, Tamara J. Stevenson et al.     Tools for genetically-determined visualization of synaptic circuits and interactions are necessary to build connectomics of the vertebrate brain and to screen synaptic properties …             Mineral and organic growing media have distinct community structure, stability and functionality in soilless culture systems ▶     Oliver Grunert, Emma Hernandez-Sanabria, Ramiro Vilchez-Vargas et al.     The choice of soilless growing medium for plant nutrition, growth and support is crucial for improving the eco-sustainability of the production in horticultural systems. As our …             Generation and Characterization of a MYF5 Reporter Human iPS Cell Line Using CRISPR/Cas9 Mediated Homologous Recombination ▶     Jianbo Wu, Samuel D. Hunt, Haipeng Xue et al.     Human iPS cells hold great promise for disease modeling and treatment of degenerative disorders including muscular dystrophies. Although a few research groups have used them for …             A diffusion model for the coordination of DNA replication in Schizosaccharomyces pombe ▶     T. Pichugina, T. Sugawara, A. Kaykov et al.     The locations of proteins and epigenetic marks on the chromosomal DNA sequence are believed to demarcate the eukaryotic genome into distinct structural and functional domains …             How type 1 fimbriae help Escherichia coli to evade extracellular antibiotics ▶     Ima Avalos Vizcarra, Vahid Hosseini, Philip Kollmannsberger et al.     To survive antibiotics, bacteria use two different strategies: counteracting antibiotic effects by expression of resistance genes or evading their effects e.g. by persisting …             Maize pan-transcriptome provides novel insights into genome complexity and quantitative trait variation ▶     Minliang Jin, Haijun Liu, Cheng He et al.     Gene expression variation largely contributes to phenotypic diversity and constructing pan-transcriptome is considered necessary for species with complex genomes. However, the …             Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice ▶     James Dachtler, Christina Elliott, R. John Rodgers et al.     Disrupted-in-Schizophrenia 1 (DISC1) is a risk factor for schizophrenia and affective disorders. The full-length DISC1 protein consists of an N-terminal ‘head’ domain and a …             Structural Variant Detection by Large-scale Sequencing Reveals New Evolutionary Evidence on Breed Divergence between Chinese and European Pigs ▶     Pengju Zhao, Junhui Li, Huimin Kang et al.     In this study, we performed a genome-wide SV detection among the genomes of thirteen pigs from diverse Chinese and European originated breeds by next genetation sequencing, and …             Immune cell impact of three differently coated lipid nanocapsules: pluronic, chitosan and polyethylene glycol ▶     Cristiano Farace, Paola Sánchez-Moreno, Marco Orecchioni et al.     Lipid nanocapsules (NCs) represent promising tools in clinical practice for diagnosis and therapy applications. However, the NC appropriate functionalization is essential to …             Bcl6 Sets a Threshold for Antiviral Signaling by Restraining IRF7 Transcriptional Program ▶     Feng Xu, Yanhua Kang, Ningtong Zhuang et al.     The coordination of restraining and priming of antiviral signaling constitute a fundamental aspect of immunological functions. However, we currently know little about the …             Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway ▶     Yu-Wei Fang, Sung-Sen Yang, Chih-Jen Cheng et al.     The mechanism by which chronic metabolic acidosis (CMA) regulates sodium (Na+)-chloride (Cl−) cotransporter (NCC) in the renal distal convoluted tubules remains unexplored. We …             Potency of umbilical cord blood- and Wharton’s jelly-derived mesenchymal stem cells for scarless wound healing ▶     Hanako Doi, Yuriko Kitajima, Lan Luo et al.     Postnatally, scars occur as a consequence of cutaneous wound healing. Scarless wound healing is highly desired for patients who have undergone surgery or trauma, especially to …             AGE-RAGE signal generates a specific NF-κB RelA “barcode” that directs collagen I expression ▶     Yunqian Peng, Ji-Min Kim, Hal-Sol Park et al.     Advanced glycation end products (AGEs) are sugar-modified biomolecules that accumulate in the body with advancing age, and are implicated in the development of multiple …             A Flow-Through Cell Electroporation Device for Rapidly and Efficiently Transfecting Massive Amounts of Cells in vitro and ex vivo ▶     Deyao Zhao, Dong Huang, Yang Li et al.     Continuous cell electroporation is an appealing non-viral approach for genetically transfecting a large number of cells. Yet the traditional macro-scale devices suffer from the …             Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia ▶     Ines Yang, Sabrina Woltemate, M. Blanca Piazuelo et al.     Inhabitants of Túquerres in the Colombian Andes have a 25-fold higher risk of gastric cancer than inhabitants of the coastal town Tumaco, despite similar H. pylori prevalences. …             Resistin, a fat-derived secretory factor, promotes metastasis of MDA-MB-231 human breast cancer cells through ERM activation ▶     Jung Ok Lee, Nami Kim, Hye Jeong Lee et al.     Resistin, an adipocyte-secreted factor, is known to be elevated in breast cancer patients. However, the molecular mechanism by which resistin acts is not fully understood. The …             The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL ▶     Christin Ungewiss, Zain H. Rizvi, Jonathon D. Roybal et al.     Tumor cell metastasis is a complex process that has been mechanistically linked to the epithelial-mesenchymal transition (EMT). The double-negative feedback loop between the …             Topographic confinement of epithelial clusters induces epithelial-to-mesenchymal transition in compliant matrices ▶     Samila Nasrollahi, Amit Pathak     Epithelial cells disengage from their clusters and become motile by undergoing epithelial-to-mesenchymal transition (EMT), an essential process for both embryonic development and …             Shift from complementarity to facilitation on P uptake by intercropped wheat neighboring with faba bean when available soil P is depleted ▶     Chunjie Li, Yan Dong, Haigang Li et al.     Rhizosphere processes stimulate overyielding and facilitative phosphorus (P) uptake in cereal/legume intercropping systems. However, little is known about when and how …             Pigeons home faster through polluted air ▶     Zhongqiu Li, Franck Courchamp, Daniel T. Blumstein     Air pollution, especially haze pollution, is creating health issues for both humans and other animals. However, remarkably little is known about how animals behaviourally respond …             Treponema pallidum (syphilis) antigen TpF1 induces angiogenesis through the activation of the IL-8 pathway ▶     Tommaso Pozzobon, Nicola Facchinello, Fleur Bossi et al.     Over 10 million people every year become infected by Treponema pallidum and develop syphilis, a disease with broad symptomatology that, due to the difficulty to eradicate the …             Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease ▶     Liang Zhang, Sergey Trushin, Trace A. Christensen et al.     Altered brain metabolism is associated with progression of Alzheimer’s Disease (AD). Mitochondria respond to bioenergetic changes by continuous fission and fusion. To account for …             Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment ▶     Hailati Aini, Keiji Itaka, Ayano Fujisawa et al.     Osteoarthritis (OA) is a chronic degenerative joint disease and a major health problem in the elderly population. No disease-modifying osteoarthritis drug (DMOAD) has been made …             Blood-based gene expression signatures of medication-free outpatients with major depressive disorder: integrative genome-wide and candidate gene analyses ▶     Hiroaki Hori, Daimei Sasayama, Toshiya Teraishi et al.     Several microarray-based studies have investigated gene expression profiles in major depressive disorder (MDD), yet with highly variable findings. We examined blood-based …             Allelopathic interactions between the brown algal genus Lobophora (Dictyotales, Phaeophyceae) and scleractinian corals ▶     Christophe Vieira, Olivier P. Thomas, Gérald Culioli et al.     Allelopathy has been recently suggested as a mechanism by which macroalgae may outcompete corals in damaged reefs. Members of the brown algal genus Lobophora are commonly …             Shifts in methanogen community structure and function across a coastal marsh transect: effects of exotic Spartina alterniflora invasion ▶     Junji Yuan, Weixin Ding, Deyan Liu et al.     Invasion of Spartina alterniflora in coastal areas of China increased methane (CH4) emissions. To elucidate the underlying mechanisms, we measured CH4 production potential, …             An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces ▶     Masakazu Nakadai, Shuta Tomida, Kazuhisa Sekimizu     Druggable sites on protein-protein interfaces are difficult to predict. To survey inhibitor-binding sites onto which residues are superimposed at protein-protein interfaces, we …             Off like a shot: scaling of ballistic tongue projection reveals extremely high performance in small chameleons ▶     Christopher V. Anderson     Stretching elastic tissues and using their recoil to power movement allows organisms to release energy more rapidly than by muscle contraction directly, thus amplifying power …             Interspecific hybridization, polyploidization, and backcross of Brassica oleracea var. alboglabra with B. rapa var. purpurea morphologically recapitulate the evolution of Brassica vegetables ▶     Xiaohui Zhang, Tongjin Liu, Xixiang Li et al.     Brassica oleracea and B. rapa are two important vegetable crops. Both are composed of dozens of subspecies encompassing hundreds of varieties and cultivars. Synthetic B. napus …             Talaromyces neofusisporus and T. qii, two new species of section Talaromyces isolated from plant leaves in Tibet, China ▶     Qi-Ming Wang, Yong-Hong Zhang, Bo Wang et al.     Two new species isolated from plant leaves belonging to Talaromyces section Talaromyces are reported, namely T. neofusisporus (ex-type AS3.15415 T = CBS 139516 T) and T. qii …             Uncovering system-specific stress signatures in primate teeth with multimodal imaging ▶     Christine Austin, Tanya M. Smith, Ramin M. Z. Farahani et al.     Early life stress can disrupt development and negatively impact long-term health trajectories. Reconstructing histories of early life exposure to external stressors is hampered …             Detachment of surface membrane invagination systems by cationic amphiphilic drugs ▶     Sangar Osman, Kirk A. Taylor, Natalie Allcock et al.     Several cell types develop extensive plasma membrane invaginations to serve a specific physiological function. For example, the megakaryocyte demarcation membrane system (DMS) …             Sex differences in behavioural and neural responsiveness to mate calls in a parrot ▶     Hiroko Eda-Fujiwara, Ryohei Satoh, Yuka Hata et al.     Vocalisation in songbirds and parrots has become a prominent model system for speech and language in humans. We investigated possible sex differences in behavioural and neural …             Allosteric effects of chromophore interaction with dimeric near-infrared fluorescent proteins engineered from bacterial phytochromes ▶     Olesya V. Stepanenko, Mikhail Baloban, Grigory S. Bublikov et al.     Fluorescent proteins (FPs) engineered from bacterial phytochromes attract attention as probes for in vivo imaging due to their near-infrared (NIR) spectra and use of available in …             MYB96 shapes the circadian gating of ABA signaling in Arabidopsis ▶     Hong Gil Lee, Paloma Mas, Pil Joon Seo     Circadian clocks regulate the rhythms of biological activities with a period of approximately 24-hours and synchronize plant metabolism and physiology with the environmental …             Nesterenkonia sp. strain F, a halophilic bacterium producing acetone, butanol, and ethanol under aerobic conditions ▶     Hamid Amiri, Reza Azarbaijani, Laleh Parsa Yeganeh et al.     The moderately halophilic bacterium Nesterenkonia sp. strain F, which was isolated from Aran-Bidgol Lake (Iran), has the ability to produce acetone, butanol, and ethanol (ABE) as …             Dissecting the structural basis of MEIG1 interaction with PACRG ▶     Wei Li, Ninad M. Walavalkar, William A. Buchwald et al.     The product of the meiosis-expressed gene 1 (MEIG1) is found in the cell bodies of spermatocytes and recruited to the manchette, a structure unique to elongating spermatids, by …             Effects of Testosterone Administration on Strategic Gambling in Poker Play ▶     Jack van Honk, Geert-Jan Will, David Terburg et al.     Testosterone has been associated with economically egoistic and materialistic behaviors, but -defensibly driven by reputable status seeking- also with economically fair, generous …             Cryptic effects of habitat declines: coral-associated fishes avoid coral-seaweed interactions due to visual and chemical cues ▶     Rohan M. Brooker, Simon J. Brandl, Danielle L. Dixson     Seaweed-dominated coral reefs are becoming increasingly common as environmental conditions shift away from those required by corals and toward those ideal for rampant seaweed …             MicroRNA-induced negative regulation of TLR-5 in grass carp, Ctenopharyngodon idella ▶     Xiao-Yan Xu, Yu-Bang Shen, Jian-Jun Fu et al.     MicroRNAs (miRNAs) are endogenous small non-coding RNAs that play crucial roles in numerous biological processes. However, the role of miRNAs in antibacterial defence in fish has …             PARP6 is a Regulator of Hippocampal Dendritic Morphogenesis ▶     Jeffrey Y. Huang, Kang Wang, Anke Vermehren-Schmaedick et al.     Mono-ADP-ribosylation (MARylation) of mammalian proteins was first described as a post-translational modification catalyzed by bacterial toxins. It is now known that endogenous …             Amy63, a novel type of marine bacterial multifunctional enzyme possessing amylase, agarase and carrageenase activities ▶     Ge Liu, Shimei Wu, Weihua Jin et al.     A multifunctional enzyme is one that performs multiple physiological functions, thus benefiting the organism. Characterization of multifunctional enzymes is important for …             Noisy decision thresholds can account for suboptimal detection of low coherence motion ▶     Nicholas S. C. Price, John B. VanCuylenberg     Noise in sensory signals can vary over both space and time. Moving random dot stimuli are commonly used to quantify how the visual system accounts for spatial noise. In these …             Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses ▶     Oriana Rossi, Lisette A. van Berkel, Florian Chain et al.     Faecalibacterium prausnitzii strain A2-165 was previously reported to have anti-inflammatory properties and prevent colitis in a TNBS model. We compared the immunomodulatory …             The DSF type quorum sensing signalling system RpfF/R regulates diverse phenotypes in the opportunistic pathogen Cronobacter ▶     Angela Suppiger, Athmanya Konegadde Eshwar, Roger Stephan et al.     Several bacterial pathogens produce diffusible signal factor (DSF)-type quorum sensing (QS) signals to control biofilm formation and virulence. Previous work showed that in …             The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models ▶     Yuqin Shu, Qiyong Lou, Ziru Dai et al.     Prolactin (PRL) is an anterior pituitary hormone with a broad range of functions. Its ability to stimulate lactogenesis, maternal behavior, growth and development, …             Impact of multiple bird partners on the seed dispersal effectiveness of China’s relic trees ▶     Ning Li, Xin-hai Li, Shu-qing An et al.     Frugivorous birds generally exhibit an unequal contribution to dispersal effectiveness of plant species as a function of their habitat adaptation and body size. In our study, we …             Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice ▶     Abhijnan Chattopadhyay, Decha Pinkaew, Hung Q. Doan et al.     Fortilin, a pro-survival molecule, inhibits p53-induced apoptosis by binding to the sequence-specific DNA-binding domain of the tumor suppressor protein and preventing it from …             Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease ▶     Xiao-qin Wu, Yang Yang, Wan-xia Li et al.     Activation of Kupffer cells (KCs) plays a central role in the pathogenesis of alcoholic liver disease (ALD). C57BL/6 mice fed EtOH-containing diet showed a mixed induction of …             Structural basis of lantibiotic recognition by the nisin resistance protein from Streptococcus agalactiae ▶     Sakshi Khosa, Benedikt Frieg, Daniel Mulnaes et al.     Lantibiotics are potent antimicrobial peptides. Nisin is the most prominent member and contains five crucial lanthionine rings. Some clinically relevant bacteria express …             Functional Analysis of Esterase TCE2 Gene from Tetranychus cinnabarinus (Boisduval) involved in Acaricide Resistance ▶     Li Shi, Peng Wei, Xiangzun Wang et al.     The carmine spider mite, Tetranychus cinnabarinus is an important pest of crops and vegetables worldwide, and it has the ability to develop resistance against acaricides rapidly. …             Characterization of vegetative inflorescence (mc-vin) mutant provides new insight into the role of MACROCALYX in regulating inflorescence development of tomato ▶     Fernando J. Yuste-Lisbona, Muriel Quinet, Antonia Fernández-Lozano et al.     Inflorescence development is a key factor of plant productivity, as it determines flower number. Therefore, understanding the mechanisms that regulate inflorescence architecture …             Altered Phenylpropanoid Metabolism in the Maize Lc-Expressed Sweet Potato (Ipomoea batatas) Affects Storage Root Development ▶     Hongxia Wang, Jun Yang, Min Zhang et al.     There is no direct evidence of the effect of lignin metabolism on early storage root development in sweet potato. In this study, we found that heterologous expression of the …             Emotional Intent Modulates The Neural Substrates Of Creativity: An fMRI Study of Emotionally Targeted Improvisation in Jazz Musicians ▶     Malinda J. McPherson, Frederick S. Barrett, Monica Lopez-Gonzalez et al.     Emotion is a primary motivator for creative behaviors, yet the interaction between the neural systems involved in creativity and those involved in emotion has not been studied. …             Visualization of Assembly Intermediates and Budding Vacuoles of Singapore Grouper Iridovirus in Grouper Embryonic Cells ▶     Yang Liu, Bich Ngoc Tran, Fan Wang et al.     Iridovirid infection is associated with the catastrophic loss in aquaculture industry and the population decline of wild amphibians and reptiles, but none of the iridovirid life …             Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers ▶     Aritro Nath, Christina Chan     Reprogramming of cellular metabolism is a hallmark feature of cancer cells. While a distinct set of processes drive metastasis when compared to tumorigenesis, it is yet unclear …             Temporally Coordinated Deep Brain Stimulation in the Dorsal and Ventral Striatum Synergistically Enhances Associative Learning ▶     Husam A. Katnani, Shaun R. Patel, Churl-Su Kwon et al.     The primate brain has the remarkable ability of mapping sensory stimuli into motor behaviors that can lead to positive outcomes. We have previously shown that during the …             Emulating short-term synaptic dynamics with memristive devices ▶     Radu Berdan, Eleni Vasilaki, Ali Khiat et al.     Neuromorphic architectures offer great promise for achieving computation capacities beyond conventional Von Neumann machines. The essential elements for achieving this vision are …             The long-term effects of planting and harvesting on secondary forest dynamics under climate change in northeastern China ▶     Jing Yao, Xingyuan He, Hongshi He et al.     Unlike the virgin forest in the Changbaishan Nature Reserve in northeastern China, little research on a landscape scale has been conducted on secondary forests in the region …             Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits ▶     Yuetiva Deming, Jian Xia, Yefei Cai et al.     Genome-wide association studies of 146 plasma protein levels in 818 individuals revealed 56 genome-wide significant associations (28 novel) with 47 analytes. Loci associated with …             Effects of sediment influx on the settlement and survival of canopy-forming macrophytes ▶     Hayato Watanabe, Miku Ito, Akira Matsumoto et al.     Kelp forests on coastal rocky shores are negatively impacted by sudden sediment loads that can occur with storms and floods. Using laboratory experiments, we studied the effects …             Structural characterization of eRF1 mutants indicate a complex mechanism of stop codon recognition ▶     Shubhadra Pillay, Yan Li, Leo E Wong et al.     Eukarya translation termination requires the stop codon recognizing protein eRF1. In contrast to the multiple proteins required for translation termination in Bacteria, eRF1 …             Elevated serum complement factors 3 and 4 are strong inflammatory markers of the metabolic syndrome development: a longitudinal cohort study ▶     Zhenfang Liu, Qin Tang, Jing Wen et al.     An epidemiological design, consisting of cross-sectional (n = 2376) and cohort (n = 976) studies, was adopted to investigate the association between complement factors 3 (C3) and …             Cryotherapy Reduces Inflammatory Response Without Altering Muscle Regeneration Process and Extracellular Matrix Remodeling of Rat Muscle ▶     Gracielle Vieira Ramos, Clara Maria Pinheiro, Sabrina Peviani Messa et al.     The application of cryotherapy is widely used in sports medicine today. Cooling could minimize secondary hypoxic injury through the reduction of cellular metabolism and injury …             Snord116 is critical in the regulation of food intake and body weight ▶     Yue Qi, Louise Purtell, Melissa Fu et al.     Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans. Recent clinical reports have suggested that micro-deletion of the Snord116 gene cluster can …             Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum ▶     Synne Jenum, S. Dhanasekaran, Rakesh Lodha et al.     The World Health Organization (WHO) calls for an accurate, rapid, and simple point-of-care (POC) test for the diagnosis of pediatric tuberculosis (TB) in order to make progress …             Evaluation of force generation mechanisms in natural, passive hydraulic actuators ▶     A. Le Duigou, M. Castro     Pine cones are well known natural actuators that can move their scales upon humidity gradient. The mechanism manifests itself through a displacement easily observable by the …             Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells ▶     Min Ae Han, Dong Hee Lee, Seon Min Woo et al.     Galangin, bioflavonoids, has been shown anti-cancer properties in various cancer cells. In this study, we investigated whether galangin could enhance TRAIL-mediated apoptosis in …             Overexpression of HER-2 in MDA-MB-435/LCC6 Tumours is Associated with Higher Metabolic Activity and Lower Energy Stress ▶     Wieslawa H. Dragowska, Mihaela Ginj, Piotr Kozlowski et al.     Overexpresssion of HER-2 in the MDA-MB-435/LCC6 (LCC6HER-2) tumour model is associated with significantly increased hypoxia and reduced necrosis compared to isogenic control …             FTO modulates fibrogenic responses in obstructive nephropathy ▶     Chao-Yung Wang, Shian-Sen Shie, Ming-Lung Tsai et al.     Genome-wide association studies have shown that variants in fat mass and obesity-associated (FTO) gene are robustly associated with body mass index and obesity. These FTO …             Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study ▶     Hudson Reddon, Hertzel C. Gerstein, James C. Engert et al.     Physical activity (PA) has been shown to reduce the impact of FTO variation and obesity genetic risk scores (GRS) on BMI. We examined this interaction using a quantitative …             A new hexapeptide from the leader peptide of rMnSOD enters cells through the oestrogen receptor to deliver therapeutic molecules ▶     Antonella Borrelli, Antonietta Schiattarella, Roberto Mancini et al.     A 24-amino acid leader peptide of a new human recombinant manganese superoxide dismutase can enter cells and carry molecules. Here, we demonstrated that six of the 24 amino acids …             Sequence and gene expression evolution of paralogous genes in willows ▶     Srilakshmy L. Harikrishnan, Pascal Pucholt, Sofia Berlin     Whole genome duplications (WGD) have had strong impacts on species diversification by triggering evolutionary novelties, however, relatively little is known about the balance …             Effects of Spaceflight on Bone Microarchitecture in the Axial and Appendicular Skeleton in Growing Ovariectomized Rats ▶     Jessica A. Keune, Adam J. Branscum, Urszula T. Iwaniec et al.     This study investigated the effects of a 14-day spaceflight on bone mass, density and microarchitecture in weight bearing (femur and humerus) and non-weight bearing (2nd lumbar …             Parallel Analysis of 124 Universal SNPs for Human Identification by Targeted Semiconductor Sequencing ▶     Suhua Zhang, Yingnan Bian, Zheren Zhang et al.     SNPs, abundant in human genome with lower mutation rate, are attractive to genetic application like forensic, anthropological and evolutionary studies. Universal SNPs showing …             Gene map of large yellow croaker (Larimichthys crocea) provides insights into teleost genome evolution and conserved regions associated with growth ▶     Shijun Xiao, Panpan Wang, Yan Zhang et al.     The genetic map of a species is essential for its whole genome assembly and can be applied to the mapping of important traits. In this study, we performed RNA-seq for a family of …             Population dynamics and associated factors of cereal aphids and armyworms under global change ▶     Leyun Wang, Cang Hui, Hardev S. Sandhu et al.     Studying the impacts of global change, which comprises largely climate and landscape changes, on agricultural pests is crucial for developing sustainable pest management. This …             Linking the sender to the receiver: vocal adjustments by bats to maintain signal detection in noise ▶     Jinhong Luo, Holger R. Goerlitz, Henrik Brumm et al.     Short-term adjustments of signal characteristics allow animals to maintain reliable communication in noise. Noise-dependent vocal plasticity often involves simultaneous changes …             Architecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications ▶     Ken-ichiro Matsunaga, Michiko Kimoto, Charlotte Hanson et al.     We present a remodeling method for high-affinity unnatural-base DNA aptamers to augment their thermal stability and nuclease resistance, for use as drug candidates targeting …             Genome-wide analysis of microRNAs identifies the lipid metabolism pathway to be a defining factor in adipose tissue from different sheep ▶     Xiangyang Miao, Qingmiao Luo, Xiaoyu Qin et al.     MicroRNAs are short (17–24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability …             Disparate metabolic response to fructose feeding between different mouse strains ▶     M. K. Montgomery, C. E. Fiveash, J. P. Braude et al.     Diets enriched in fructose (FR) increase lipogenesis in the liver, leading to hepatic lipid accumulation and the development of insulin resistance. Previously, we have shown that …             Directly interrogating single quantum dot labelled UvrA2 molecules on DNA tightropes using an optically trapped nanoprobe ▶     Michelle Simons, Mark R. Pollard, Craig D. Hughes et al.     In this study we describe a new methodology to physically probe individual complexes formed between proteins and DNA. By combining nanoscale, high speed physical force …             Contributions of multiple refugia during the last glacial period to current mainland populations of Korean pine (Pinus koraiensis) ▶     Lei Bao, Ayijiamali Kudureti, Weining Bai et al.     The northern microrefugia that existed during the Last Glacial Maximum (LGM) are a key factor in the demographic history of species. Pinus koraiensis has a unique distribution in …             Horizontal functional gene transfer from bacteria to fishes ▶     Bao-Fa Sun, Tong Li, Jin-Hua Xiao et al.     Invertebrates can acquire functional genes via horizontal gene transfer (HGT) from bacteria but fishes are not known to do so. We provide the first reliable evidence of one HGT …             Cell Nucleus-Targeting Zwitterionic Carbon Dots ▶     Yun Kyung Jung, Eeseul Shin, Byeong-Su Kim     An innovative nucleus-targeting zwitterionic carbon dot (CD) vehicle has been developed for anticancer drug delivery and optical monitoring. The zwitterionic functional groups of …             Vitamin D3 pretreatment regulates renal inflammatory responses during lipopolysaccharide-induced acute kidney injury ▶     Shen Xu, Yuan-Hua Chen, Zhu-Xia Tan et al.     Vitamin D receptor (VDR) is highly expressed in human and mouse kidneys. Nevertheless, its functions remain obscure. This study investigated the effects of vitamin D3 (VitD3) …             Early recurrence and ongoing parietal driving during elementary visual processing ▶     Gijs Plomp, Alexis Hervais-Adelman, Laura Astolfi et al.     Visual stimuli quickly activate a broad network of brain areas that often show reciprocal structural connections between them. Activity at short latencies (<100 ms) is thought to …             MicroRNA-214 Mediates Isoproterenol-induced Proliferation and Collagen Synthesis in Cardiac Fibroblasts ▶     Min Sun, Haiyi Yu, Youyi Zhang et al.     The action of β-adrenergic receptors (β-ARs) induces cardiac fibroblast (CF) proliferation and collagen synthesis and is a major source of the cardiac fibrosis caused by various …             An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility ▶     Adam Bartok, Krisztina Fehér, Andrea Bodor et al.     The voltage-gated Kv1.3 K+ channel plays a key role in the activation of T lymphocytes. Kv1.3 blockers selectively suppress immune responses mediated by effector memory T cells, …             Experimental evidence of the synergistic effects of warming and invasive algae on a temperate reef-builder coral ▶     Diego K Kersting, Emma Cebrian, Clara Casado et al.     In the current global climate change scenario, stressors overlap in space and time, and knowledge on the effects of their interaction is highly needed to understand and predict …             Gut bacterial diversity of the tribes of India and comparison with the worldwide data ▶     Madhusmita Dehingia, Kanchal Thangjam devi, Narayan C. Talukdar et al.     The gut bacteria exert phenotypic traits to the host but the factors which determine the gut bacterial profile (GBP) is poorly understood. This study aimed to understand the …             Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells ▶     Wenzhe Ma, Senling Feng, Xiaojun Yao et al.     Multidrug resistance (MDR) is the major obstacle to the successful chemotherapy treatment of many cancers. Here we found that nobiletin, a citrus methoxyflavone, significantly …             Contractile dynamics change before morphological cues during florescence illumination ▶     S. G. Knoll, W. W. Ahmed, T. A. Saif     Illumination can have adverse effects on live cells. However, many experiments, e.g. traction force microscopy, rely on fluorescence microscopy. Current methods to assess …             Characterization of marine diatom-infecting virus promoters in the model diatom Phaeodactylum tricornutum ▶     Takashi Kadono, Arisa Miyagawa-Yamaguchi, Nozomu Kira et al.     Viruses are considered key players in phytoplankton population control in oceans. However, mechanisms that control viral gene expression in prominent microalgae such as diatoms …             3D Image-Guided Automatic Pipette Positioning for Single Cell Experiments in vivo ▶     Brian Long, Lu Li, Ulf Knoblich et al.     We report a method to facilitate single cell, image-guided experiments including in vivo electrophysiology and electroporation. Our method combines 3D image data acquisition, …             Tractography-based Parcellation of the Human Middle Temporal Gyrus ▶     Jinping Xu, Jiaojian Wang, Lingzhong Fan et al.     The middle temporal gyrus (MTG) participates in a variety of functions, suggesting the existence of distinct functional subregions. In order to further delineate the functions of …             Efficient chemo-enzymatic gluten detoxification: reducing toxic epitopes for celiac patients improving functional properties ▶     Miguel Ribeiro, Fernando M. Nunes, Sofia Guedes et al.     Protein engineering of gluten, the exogenous effector in celiac disease, seeking its detoxification by selective chemical modification of toxic epitopes is a very attractive …             Disruption of OsEXO70A1 Causes Irregular Vascular Bundles and Perturbs Mineral Nutrient Assimilation in Rice ▶     Bin Tu, Li Hu, Weilan Chen et al.     Normal uptake, transportation, and assimilation of primary nutrients are essential to plant growth. Tracheary elements (TEs) are tissues responsible for the transport of water …             Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1 ▶     Shinn-Jong Jiang, Je-Wen Liou, Chun-Chun Chang et al.     Chemokine CXCL8 is crucial for regulation of inflammatory and immune responses via activating its cognate receptor CXCR1. In this study, molecular docking and binding free energy …             Long-term Autophagy and Nrf2 Signaling in the Hippocampi of Developing Mice after Carbon Ion Exposure ▶     Fei Ye, Ting Zhao, Xiongxiong Liu et al.     To explore charged particle radiation-induced long-term hippocampus damage, we investigated the expression of autophagy and antioxidant Nrf2 signaling-related proteins in the …             Functions of miR-146a and miR-222 in Tumor-associated Macrophages in Breast Cancer ▶     Yanshuang Li, Lianmei Zhao, Bianhua Shi et al.     Tumor-associated macrophages (TAMs) play critical roles in promoting tumor progression and invasion. However, the molecular mechanisms underlying TAM regulation remain to be …             Secreted Factors from Human Vestibular Schwannomas Can Cause Cochlear Damage ▶     Sonam Dilwali, Lukas D. Landegger, Vitor Y. R. Soares et al.     Vestibular schwannomas (VSs) are the most common tumours of the cerebellopontine angle. Ninety-five percent of people with VS present with sensorineural hearing loss (SNHL); the …             Body part-centered and full body-centered peripersonal space representations ▶     Andrea Serino, Jean-Paul Noel, Giulia Galli et al.     Dedicated neural systems represent the space surrounding the body, termed Peripersonal space (PPS), by integrating visual or auditory stimuli occurring near the body with …             Natural History of Non-Small-Cell Lung Cancer with Bone Metastases ▶     Santini Daniele, Barni Sandro, Intagliata Salvatore et al.     We conducted a large, multicenter, retrospective survey aimed to explore the impact of tumor bone involvement in Non-Small Cell Lung Cancer.Data on clinical-pathology, skeletal …             Ecological consequences of long-term browning in lakes ▶     Craig E. Williamson, Erin P. Overholt, Rachel M. Pilla et al.     Increases in terrestrially-derived dissolved organic matter (DOM) have led to the browning of inland waters across regions of northeastern North America and Europe. Short-term …             Competitive allele-specific TaqMan PCR (Cast-PCR) is a sensitive, specific and fast method for BRAF V600 mutation detection in Melanoma patients ▶     Raffaela Barbano, Barbara Pasculli, Michelina Coco et al.     BRAF codon 600 mutation testing of melanoma patients is mandatory for the choice of the most appropriate therapy in the clinical setting. Competitive allele specific TaqMan PCR …             Torque-induced precession of bacterial flagella ▶     Yuji Shimogonya, Yoichiro Sawano, Hiromichi Wakebe et al.     The bacterial flagellar motor is an ion-driven rotary machine in the cell envelope of bacteria. Using a gold nanoparticle as a probe, we observed the precession of flagella …             HIV-1 Protease Dimerization Dynamics Reveals a Transient Druggable Binding Pocket at the Interface ▶     Fabio Pietrucci, Attilio Vittorio Vargiu, Agata Kranjc     The binding mechanism of HIV-1 protease monomers leading to the catalytically competent dimeric enzyme has been investigated by means of state-of-the-art atomistic simulations. …             Hierarchy is Detrimental for Human Cooperation ▶     Katherine A. Cronin, Daniel J. Acheson, Penélope Hernández et al.     Studies of animal behavior consistently demonstrate that the social environment impacts cooperation, yet the effect of social dynamics has been largely excluded from studies of …             Quantifying electron transfer reactions in biological systems: what interactions play the major role? ▶     Emil Sjulstok, Jógvan Magnus Haugaard Olsen, Ilia A. Solov’yov     Various biological processes involve the conversion of energy into forms that are usable for chemical transformations and are quantum mechanical in nature. Such processes involve …             Renal Denervation Findings on Cardiac and Renal Fibrosis in Rats with Isoproterenol Induced Cardiomyopathy ▶     Qian Liu, Qi Zhang, Kai Wang et al.     Cardio-renal fibrosis plays key roles in heart failure and chronic kidney disease. We sought to determine the effects of renal denervation (RDN) on cardiac and renal fibrosis in …             Global insights into acetic acid resistance mechanisms and genetic stability of Acetobacter pasteurianus strains by comparative genomics ▶     Bin Wang, Yanchun Shao, Tao Chen et al.     Acetobacter pasteurianus (Ap) CICC 20001 and CGMCC 1.41 are two acetic acid bacteria strains that, because of their strong abilities to produce and tolerate high concentrations …             Developmental genes significantly afflicted by aberrant promoter methylation and somatic mutation predict overall survival of late-stage colorectal cancer ▶     Ning An, Xue Yang, Shujun Cheng et al.     Carcinogenesis is an exceedingly complicated process, which involves multi-level dysregulations, including genomics (majorly caused by somatic mutation and copy number …                 All content now open access including archives! Nature Communications is an open access journal that publishes high-quality research from all areas of the natural sciences. Papers published by the journal represent important advances of significance to specialists within each subject area including the life sciences. Visit the website to explore ALL the content available within your field.         • Careers & Jobs           naturejobs.com Science jobs of the week       MRC Postdoctoral Scientist (CSC 74)     Medical Research Council            Biostatistician     The Henry M.Jackson Foundation            Postdoctoral Fellow / Doctoral Student     Helmholtz Association            Research Associate     University College London (UCL)            Charity Officer     Myrovlytis Trust            Research Associate (Fixed Term)     University of Cambridge            Postdoctoral Fellow     Wellcome Trust Sanger Institute            Postdoc Position     Weill Cornell College of Medicine            Postdoctoral Researcher     INSERM U1100            Research Scientist     MIT          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. Keep up-to-date with the latest sector trends, vote in our reader poll and sign-up to receive the monthly Naturejobs newsletter.           • Scientific Reports events Directory featured events           natureevents directory featured events         Physical Biology of the Cell     18th September 2016 Woods Hole, USA         Natureevents Directory is the premier resource for scientists looking for the latest scientific conferences, courses, meetings and symposia. Featured across Nature Publishing Group journals and centrally at natureevents.com it is an essential reference guide to scientific events worldwide.                 Your email address is in the Scientific Reports: Biology mailing list. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For other enquiries, please contact our customer feedback department Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's offices: Principal offices: London - New York - Tokyo Worldwide offices: Basingstoke - Boston - Buenos Aires - Delhi - Hong Kong - Madrid - Melbourne - Munich - Paris - San Francisco - Seoul - Washington DC Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.