Nature Reviews Neuroscience contents February 2016 Volume 17 Number 2 pp 73-134

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TABLE OF CONTENTS
February 2016 Volume 17 Number 2
Impact Factor 31.427 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Rediscovering area CA2: unique properties and functions Serena M. Dudek, Georgia M. Alexander & Shannon Farris
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RESEARCH HIGHLIGHTS Top Techniques: Wide of the mark p73 | doi:10.1038/nrn.2016.6 A new study shows that the transient manipulation of neural activity can sometimes have 'off-target' effects, making it challenging to determine the specific neural circuit that generates a particular behaviour. PDF Neurogenetics: Restoring levels p74 | doi:10.1038/nrn.2015.20 The behavioural phenotype in a mouse model of MECP2 (methyl-CpG-binding protein 2) duplication syndrome can be rescued in adulthood by normalizing MeCP2 levels. PDF Neurodegenerative disease: Forming fragments p74 | doi:10.1038/nrn.2015.25 Parkinson disease-associated mutations in the gene encoding vacuolar protein sorting-associated protein 35 increase the turnover of dynamin-like protein 1 in the mitochondrial membrane of neurons, leading to mitochondrial fission and neuronal death. PDF Neuronal circuits: Patch work in the striatum p75 | doi:10.1038/nrn.2015.23 The endogenous opioid enkephalin acts through δ-opioid receptors to suppress local inhibition of dorsal striatum patch output neurons. PDF Neurological disorders: A second wave p76 | doi:10.1038/nrn.2016.5 In mice, an early ablation of myelinating oligodendrocytes can trigger a secondary, CD4+ T cell-associated demyelination 30 weeks later, suggesting a possible mechanism for the onset of demyelinating diseases such as multiple sclerosis. PDF IN BRIEF Hippocampal processing: A new direction | Learning and memory: Mnemonic modifications | Reward: Top-down control | Emotion: Fear factors PDF Neuroscience JOBS of the week Faculty Position in the Department of Neuroscience Job Mayo Clinic PhD Students in Molecular Medicine – Translational Neuroscience Danish Research Institute for Translational Neuroscience (DANDRITE) / Nordic EMBL Partnership Tenure-track Faculty Position in Stroke Recovery / Brain Repair / Neuroscience University of Ottawa Director of the Programme in Neuroscience and Behavioural Disorders Duke-National University of Singapore Medical School (Duke-NUS) ULB Neuroscience Institute PhD Programme Université Libre de Bruxelles (ULB) More Science jobs from Neuroscience EVENT Applying Computational Modelling to Clinical Neuroscience 06.04.16 Buckinghamshire, UK More science events from
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REVIEWS		Top
The right time to learn: mechanisms and optimization of spaced learning Paul Smolen, Yili Zhang & John H. Byrne p77 | doi:10.1038/nrn.2015.18 Training involving repeated long inter-trial intervals — spaced training — leads to more robust memory formation for many types of learning than does training involving short or no intervals. This Review examines the learning theories and the molecular and cellular mechanisms that may account for the effectiveness of spaced training. Abstract | Full Text | PDF
Rediscovering area CA2: unique properties and functions Serena M. Dudek, Georgia M. Alexander & Shannon Farris p89 | doi:10.1038/nrn.2015.22 CA2 has several characteristics that distinguishes it from CA1 and CA3. In this Review, Dudek and colleagues discuss an updated definition of the CA2 boundaries, and provide an overview of the unique synaptic properties and behavioural functions of this region. Abstract | Full Text | PDF
Autoimmune synaptopathies Sarah J. Crisp, Dimitri M. Kullmann & Angela Vincent p103 | doi:10.1038/nrn.2015.27 Autoantibodies against neuromuscular junction targets are a well-established cause of myasthenic syndromes, and autoantibodies against CNS targets have also been associated with disease. In this Review, Vincent and colleagues discuss key examples of such autoantibodies, and the mechanisms by which they lead to neurological dysfunction. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Should I stop or should I go? The role of complexin in neurotransmitter release Thorsten Trimbuch & Christian Rosenmund p118 | doi:10.1038/nrn.2015.16 Synaptic vesicle exocytosis is tightly regulated by a number of synaptic proteins, including complexin; however, several alternative models of complexin function have been presented. Trimbuch and Rosenmund propose that a better understanding of the properties of different domains of complexin may help to shed light on its function. Abstract | Full Text | PDF
OPINION Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis Giles E. Hardingham & Kim Q. Do p125 | doi:10.1038/nrn.2015.19 Impaired interneuron function is widely believed to contribute to schizophrenia pathophysiology. Hardingham and Do describe converging evidence suggesting that NMDA receptor (NMDAR) hypofunction and oxidative stress during development contribute to interneuron dysfunction and schizophrenia pathophysiology. Abstract | Full Text | PDF
Erratum: Neurobiology of rodent self-grooming and its value for translational neuroscience Allan V. Kalueff et al. p118 | doi:10.1038/nrn.2015.28 Full Text | PDF
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