Nature Cell Biology contents: February 2016 Volume 18 Number 2, pp 139 - 234

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TABLE OF CONTENTS February 2016 Volume 18, Issue 2 News and Views Articles Letter Corrigendum Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement All content now free to access including archives! Nature Communications is an open access journal that publishes high-quality research from all areas of the natural sciences. Papers published by the journal represent important advances of significance to specialists within each subject area including the life sciences. Visit the website to explore ALL the content available within your field.    News and Views Top A twist in zygotic reprogramming   pp139 - 140 Daniel M. Messerschmidt doi:10.1038/ncb3304 The first hours of mammalian embryogenesis are devoted to extensive epigenetic reprogramming. One hallmark is active demethylation of the paternal genome by Tet (ten-eleven translocation) enzymes. However, the process is now shown to be Tet-independent at first, with Tet enzymes only counteracting hitherto underappreciated de novo DNA methylation activity in later zygotic stages. See also: Letter by Amouroux et al. Ramping up degradation for proliferation   pp141 - 142 Jon M. Huibregtse and Andreas Matouschek doi:10.1038/ncb3306 The control of proteasome-mediated protein degradation is thought to occur mainly at the level of polyubiquitylation of the substrate. However, the proteasome can also be regulated directly, as now demonstrated by a study in which DYRK2-mediated phosphorylation of the 19S subunit Rpt3 is found to increase proteasome activity. See also: Article by Guo et al. Actin puts the squeeze on Drosophila glue secretion   pp142 - 144 Christien J. Merrifield doi:10.1038/ncb3305 An actin filament coat promotes cargo expulsion from large exocytosing vesicles, but the mechanisms of coat formation and force generation have been poorly characterized. Elegant imaging studies of the Drosophila melanogaster salivary gland now reveal how actin and myosin are recruited, and show that myosin II forms a contractile 'cage' that facilitates exocytosis. See also: Article by Rousso et al. Cell Biology JOBS of the week Postdoctoral Fellow in bioinformatics and stem cell biology The University of Texas Medical School At Houston Postdoctoral Research, Ocular Stem Cell Biology University of California San Diego Health System Postdoc in angiogenesis and cell signaling Karolinska Institutet (KI) PhD programs of the Faculty of Medicine Geneva University of Geneva, Faculty of Medicine PhD Student (f / m) in Functional Neuroproteomics German Center for Neurodegenerative Deseases More Science jobs from Cell Biology EVENT Physical Biology of the Cell 18.09.16 Woods Hole, USA More science events from Articles Top Human keratinocytes have two interconvertible modes of proliferation   pp145 - 156 Amit Roshan, Kasumi Murai, Joanna Fowler, Benjamin D. Simons, Varvara Nikolaidou-Neokosmidou et al. doi:10.1038/ncb3282 By tracking the division outcomes of thousands of single cells, Jones and colleagues show that primary human keratinocyte proliferation in culture is either expanding, producing proliferating progeny, or balanced, thereby producing proliferating and differentiating progeny. A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors   pp157 - 167 Mario Buono, Raffaella Facchini, Sahoko Matsuoka, Supat Thongjuea, Dominique Waithe et al. doi:10.1038/ncb3299 Nerlov and colleagues show that expression of mKitL by cortical vascular endothelial cells is important for DN1 progenitor maintenance, whereas expression of mKitL by cortical thymic epithelial cells is required for maintaining DN2 progenitor cells. Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction   pp168 - 180 Craig S. Nowell, Pascal D. Odermatt, Luca Azzolin, Sylke Hohnel, Erwin F. Wagner et al. doi:10.1038/ncb3290 Nowell et al. report that chronic inflammation of the corneal epithelium activates β-catenin signalling through YAP/TAZ-dependent mechanotransduction, leading to epidermal differentiation on the ocular surface and corneal squamous cell metaplasia. Orchestrated content release from Drosophila glue-protein vesicles by a contractile actomyosin network   pp181 - 190 Tal Rousso, Eyal D. Schejter and Ben-Zion Shilo doi:10.1038/ncb3288 Rousso et al. describe the dynamics of exocytosis in the Drosophila salivary gland. They show that Dia and Rok regulate the formation of an actomyosin coat around the vesicle, with a contractile myosin II case-like structure driving content release. See also: News and Views by Merrifield Locally excitable Cdc42 signals steer cells during chemotaxis   pp191 - 201 Hee Won Yang, Sean R. Collins and Tobias Meyer doi:10.1038/ncb3292 Meyer and colleagues use fluorescent biosensors to demonstrate that chemotactic steering and cell polarization are controlled by locally excitable Cdc42 signalling. Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis   pp202 - 212 Xing Guo, Xiaorong Wang, Zhiping Wang, Sourav Banerjee, Jing Yang et al. doi:10.1038/ncb3289 Dixon and colleagues and Guo and colleagues find that phosphorylation of the 19S proteasome subunit Rpt3 by DYRK2 increases proteasome activity and promotes cell proliferation, whereas loss of Rpt3 phosphorylation inhibits tumour formation in mice. See also: News and Views by Huibregtse & Matouschek The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer   pp213 - 224 Aifu Lin, Chunlai Li, Zhen Xing, Qingsong Hu, Ke Liang et al. doi:10.1038/ncb3295 Yang and colleagues identify a lncRNA that controls HIF1α signalling to stabilize HIF1α under normoxic conditions, and promotes breast cancer tumorigenesis. Letter Top De novo DNA methylation drives 5hmC accumulation in mouse zygotes   pp225 - 233 Rachel Amouroux, Buhe Nashun, Kenjiro Shirane, Shoma Nakagawa, Peter W. S. Hill et al. doi:10.1038/ncb3296 Using ultrasensitive mass spectrometry of wild-type and mutant early mouse zygotes, Hajkova and colleagues show that 5mC loss and 5hmC accumulation are uncoupled during zygotic epigenetic reprogramming. See also: News and Views by Messerschmidt Corrigendum Top Corrigendum: Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells   p234 Pablo Vargas, Paolo Maiuri, Marine Bretou, Pablo J. Saez, Paolo Pierobon et al. doi:10.1038/ncb3301 Top Advertisement Nature Conference on Tissue Engineering and Regenerative Medicine  Presented by: State Key Laboratory of Ophthalmology | Zhongshan Ophthalmic Center | Sun Yat-sen University Nature Materials | Nature Reviews Materials April 7-9, 2016 | Ocean Hotel, Guangzhou, China  Register now!   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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