 |  |  |  |  | Table of ContentsNews & Views Articles |  Volume 34, Number 24 |
News & Views  | Volume‐regulated anion channels are known for their role in maintaining cell homeostasis but a new study finds that they also mediate the cellular uptake of platinum‐based chemotherapeutic drugs. Thomas Voets, Bernd Nilius, and Rudi Vennekens Published online 12.11.2015 |
 | A germline defect seen upon ablated tRNA processing in flies reveals that replication fork stress interferes with transcription of piRNA clusters, thus strengthening the link between piRNA formation and genomic stability. Soichiro Yamanaka and Haruhiko Siomi Published online 13.11.2015 |
 | According to current definitions of infectious proteins, microtubule‐associated tau protein cannot be classified as bona fide prion protein. Juan Carlos Polanco and Jürgen Götz |
Articles  | LRRC8 proteins were recently shown to constitute the elusive volume‐regulated anion channel VRAC. This study shows that VRAC subunits LRRC8A and LRRC8D regulate both cell volume and uptake of anti‐cancer drugs, thus modulating cellular tumour drug responses. Rosa Planells‐Cases, Darius Lutter, Charlotte Guyader, Nora M Gerhards, Florian Ullrich, Deborah A Elger, Asli Kucukosmanoglu, Guotai Xu, Felizia K Voss, S Momsen Reincke, Tobias Stauber, Vincent A Blomen, Daniel J Vis, Lodewyk F Wessels, Thijn R Brummelkamp, Piet Borst, Sven Rottenberg, and Thomas J Jentsch |
 | The loss of tRNA endonuclease RNase P causes female sterility in flies by inducing replication stress at tRNA loci, leading to a collapse of piRNA transcription and de‐repression of deleterious transposable elements. This finding reveals a new role for tRNAs in genome stability. Anahi Molla‐Herman, Ana Maria Vallés, Carine Ganem‐Elbaz, Christophe Antoniewski, and Jean‐René Huynh Published online 15.10.2015 |
 | While endogenous tau is needed for mutant tau‐mediated neurotoxicity, it is not required for misfolded tau propagation across synaptically connected neurons thus supporting the notion that tau does not strictly classify as a prion protein. Susanne Wegmann, Eduardo A Maury, Molly J Kirk, Lubna Saqran, Allyson Roe, Sarah L DeVos, Samantha Nicholls, Zhanyun Fan, Shuko Takeda, Ozge Cagsal‐Getkin, Christopher M William, Tara L Spires‐Jones, Rose Pitstick, George A Carlson, Amy M Pooler, and Bradley T Hyman Published online 04.11.2015 |
 | A 3.9‐Å cryo‐EM structure of the human ribosome bound to the HCV IRES‐reveals how this viral RNA element hijacks the translational machinery of the host cell to facilitate replication. Hiroshi Yamamoto, Marianne Collier, Justus Loerke, Jochen Ismer, Andrea Schmidt, Tarek Hilal, Thiemo Sprink, Kaori Yamamoto, Thorsten Mielke, Jörg Bürger, Tanvir R Shaikh, Marylena Dabrowski, Peter W Hildebrand, Patrick Scheerer, and Christian MT Spahn Published online 24.11.2015 |
 | By combining immuno‐labelling and negative‐stain EM this study reveals the subunit architecture of the spliceosomal B complex and assigns individual snRNP components to distinct domains. Norbert Rigo, Chengfu Sun, Patrizia Fabrizio, Berthold Kastner, and Reinhard Lührmann Published online 18.11.2015 |
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