The EMBO Journal Table of Contents for 2 December 2015; Vol. 34, No. 23

2 December 2015 | Volume 34, Number 23 Submit Table of Contents News & Views Review Articles Volume 34, Number 23 News & Views MED23: a new Mediator of H2B monoubiquitylation New work reports a specific role for a subunit of the Mediator complex in stimulating histone modifications in actively transcribed genes via the recruitment of RNF20/40. Gundula Streubel and Adrian P Bracken Published online 05.10.2015 Review Long non‐coding RNAs in corticogenesis: deciphering the non‐coding code of the brain Aprea and Calegari review our emerging understanding of the genomic organization, evolutionary origin and function of long non‐coding RNAs in the mammalian brain, the organ where lncRNAs have the most peculiar features. Julieta Aprea and Federico Calegari Published online 29.10.2015 Articles The Mediator subunit MED23 couples H2B mono‐ubiquitination to transcriptional control and cell fate determination The Mediator subunit MED23 regulates histone 2B mono‐ubiquitylation via RNF20/40 recruitment, leading to transcriptional activation of target genes and illustrating a role for MED23 in myogenesis and tumorigenesis. Xiao Yao, Zhanyun Tang, Xing Fu, Jingwen Yin, Yan Liang, Chonghui Li, Huayun Li, Qing Tian, Robert G Roeder, and Gang Wang Published online 01.09.2015 A non‐canonical role of the p97 complex in RIG‐I antiviral signaling The p97/VCP complex suppresses antiviral signaling by bridging K63‐ubiquitinated RIG‐I and the E3 ligase RNF125 to promote K48‐ubiquitination and proteasomal degradation of RIG‐I. Qian Hao, Shi Jiao, Zhubing Shi, Chuanchuan Li, Xia Meng, Zhen Zhang, Yanyan Wang, Xiaomin Song, Wenjia Wang, Rongguang Zhang, Yun Zhao, Catherine CL Wong, and Zhaocai Zhou Published online 15.10.2015 Structural basis of membrane budding by the nuclear egress complex of herpesviruses The first high‐resolution crystal structure view of an oligomeric array formed by a membrane‐deforming protein explains virus‐mediated nuclear envelope budding of HSV‐1 capsids. Janna M Bigalke and Ekaterina E Heldwein Published online 28.10.2015 Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex Crystal structures show that heterodimerization forced by one subunit clamping tightly onto the other is essential for nuclear egress and virus production of human cytomegalovirus. Ming F Lye, Mayuri Sharma, Kamel El Omari, David J Filman, Jonathan P Schuermann, James M Hogle, and Donald M Coen Published online 28.10.2015 EglN2 associates with the NRF1‐PGC1α complex and controls mitochondrial function in breast cancer While prolyl hydroxylase EglN2/PHD1 is well known for its role in oxygen‐dependent degradation of HIF1α, this work reports a HIF1‐independent role for EglN2 in regulating mitochondrial function via the formation of a transcription regulatory complex with PGC1α and NRF1. Jing Zhang, Chengyang Wang, Xi Chen, Mamoru Takada, Cheng Fan, Xingnan Zheng, Haitao Wen, Yong Liu, Chenguang Wang, Richard G Pestell, Katherine M Aird, William G Kaelin, Jr, Xiaole Shirley Liu, and Qing Zhang Published online 22.10.2015 Oct4‐induced oligodendrocyte progenitor cells enhance functional recovery in spinal cord injury model Terminally differentiated somatic cells can be directly converted into induced oligodendrocyte progenitor cells by Oct4‐mediated direct reprogramming strategy. Jeong Beom Kim, Hyunah Lee, Marcos J Araúzo‐Bravo, Kyujin Hwang, Donggyu Nam, Myung Rae Park, Holm Zaehres, Kook In Park, and Seok‐Jin Lee Published online 23.10.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.