Scientific Reports Biology Table of Contents e-alert: 22 December 2015

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22 December 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         Small steps can lead to big impact - Tips for promoting your research Our Author Tips site guides you through simple steps you can take to disseminate your research through the use of social media and online communities. Learn about blogging, enhancing your online profile, and how your peers are using social media to engage in scientific conversation.            Biological Sciences               Comparison of catch per unit effort among four minnow trap models in the three-spined stickleback (Gasterosteus aculeatus) fishery ▶     Alexandre Budria, Jacquelin DeFaveri, Juha Merilä     Minnow traps are commonly used in the stickleback (Gasterostidae) fishery, but the potential differences in catch per unit effort (CPUE) among different minnow trap models are …             Oxytocin Protects Hippocampal Memory and Plasticity from Uncontrollable Stress ▶     Sun-Young Lee, Seong-Hae Park, ChiHye Chung et al.     The hippocampus is vulnerable to uncontrollable stress and is enriched with oxytocin receptors, but their interactive influences on hippocampal functioning are unknown. This …             A Novel Recombinant Enterovirus Type EV-A89 with Low Epidemic Strength in Xinjiang, China ▶     Qin Fan, Yong Zhang, Lan Hu et al.     Enterovirus A89 (EV-A89) is a novel member of the EV-A species. To date, only one full-length genome sequence (the prototype strain) has been published. Here, we report the …             Dirty deeds and dirty bodies: Embodiment of the Macbeth effect is mapped topographically onto the somatosensory cortex ▶     Michael Schaefer, Michael Rotte, Hans-Jochen Heinze et al.     The theory of embodied cognition claims that knowledge is represented in modal systems derived from perception. Recent behavioral studies found evidence for this hypothesis, for …             Constructive remodeling of a synthetic endothelial extracellular matrix ▶     Sewoon Han, Yoojin Shin, Hyo Eun Jeong et al.     The construction of well-controllable in vitro models of physiological and pathological vascular endothelium remains a fundamental challenge in tissue engineering and drug …             The yield of mechanically harvested rapeseed (Brassica napus L.) can be increased by optimum plant density and row spacing ▶     Jie Kuai, Yingying Sun, Qingsong Zuo et al.     To determine the effects of plant density and row spacing on the mechanical harvesting of rapeseed (Brassica napus L.), field experiments were conducted. Higher plant density …             Responses of community-level plant-insect interactions to climate warming in a meadow steppe ▶     Hui Zhu, Xuehui Zou, Deli Wang et al.     Climate warming may disrupt trophic interactions, consequently influencing ecosystem functioning. Most studies have concentrated on the temperature-effects on plant-insect …             High risk of plant invasion in the understory of eucalypt plantations in South China ▶     Dongmei Jin, Yong Huang, Xi-Le Zhou et al.     Eucalypt plantations expand rapidly out of their natural distribution zones, thus inducing a concern on their effects on biodiversity and ecosystem functions. We compare the …             Enzymatic cellulose oxidation is linked to lignin by long-range electron transfer ▶     Bjørge Westereng, David Cannella, Jane Wittrup Agger et al.     Enzymatic oxidation of cell wall polysaccharides by lytic polysaccharide monooxygenases (LPMOs) plays a pivotal role in the degradation of plant biomass. While experiments have …             Ultrasound-aided Multi-parametric Photoacoustic Microscopy of the Mouse Brain ▶     Bo Ning, Naidi Sun, Rui Cao et al.     High-resolution quantitative imaging of cerebral oxygen metabolism in mice is crucial for understanding brain functions and formulating new strategies to treat neurological …             G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation ▶     Mei-Ren Pan, Ming-Chuan Hsu, Li-Tzong Chen et al.     Methylation of histone H3-lysine 9 (H3K9) and H3K27 by the methyltransferase G9a and polycomb repressive complex 2 (PRC2) inhibits transcription of target genes. A crosstalk …             The molecular mechanism of photochemical internalization of cell penetrating peptide-cargo-photosensitizer conjugates ▶     Takashi Ohtsuki, Shunya Miki, Shouhei Kobayashi et al.     In many drug delivery strategies, an inefficient transfer of macromolecules such as proteins and nucleic acids to the cytosol often occurs because of their endosomal entrapment. …             From red to green: the propidium iodide-permeable membrane of Shewanella decolorationis S12 is repairable ▶     Yonggang Yang, Yinbo Xiang, Meiying Xu     Viability is a common issue of concern in almost all microbial processes. Fluorescence-based assays are extensively used in microbial viability assessment, especially for …             Characterization and Biotechnological Potential Analysis of a New Exopolysaccharide from the Arctic Marine Bacterium Polaribacter sp. SM1127 ▶     Mei-Ling Sun, Fang Zhao, Mei Shi et al.     Although many kinds of exopolysaccharides (EPSs) from microorganisms have been used in industry, the exploration and utilization of EPSs from polar microorganisms is still rather …             Thrombopoietin induces production of nucleated thrombocytes from liver cells in Xenopus laevis ▶     Yuta Tanizaki, Megumi Ichisugi, Miyako Obuchi-Shimoji et al.     The development of mammalian megakaryocytes (MKs) and platelets, which are thought to be absent in non-mammals, is primarily regulated by the thrombopoietin (TPO)/Mpl system. …             Co-dispersal of the blood fluke Schistosoma japonicum and Homo sapiens in the Neolithic Age ▶     Mingbo Yin, Hong-Xiang Zheng, Jing Su et al.     The global spread of human infectious diseases is of considerable public health and biomedical interest. Little is known about the relationship between the distribution of …             The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis ▶     Giorgio Oliviero, Nayla Munawar, Ariane Watson et al.     PCGF1 encodes one of six human Polycomb RING finger homologs that are linked to transcriptional repression and developmental gene regulation. Individual PCGF proteins define …             Network-assisted analysis of primary Sjögren’s syndrome GWAS data in Han Chinese ▶     Kechi Fang, Kunlin Zhang, Jing Wang     Primary Sjögren’s syndrome (pSS) is a complex autoimmune disorder. So far, genetic research in pSS has lagged far behind and the underlying biological mechanism is unclear. …             High total antioxidant capacity of the porcine seminal plasma (SP-TAC) relates to sperm survival and fertility ▶     Isabel Barranco, Asta Tvarijonaviciute, Cristina Perez-Patiño et al.     The study attempted to clarify the role of total antioxidant capacity of seminal plasma (SP-TAC) on boar sperm survival and fertility after artificial insemination (AI). SP-TAC …             Language modulates brain activity underlying representation of kinship terms ▶     Haiyan Wu, Yue Ge, Honghong Tang et al.     Kinship terms have been found to be highly diverse across languages. Here we investigated the brain representation of kinship terms in two distinct populations, native Chinese …             An ancestral host defence peptide within human β-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule ▶     Ersilia Nigro, Irene Colavita, Daniela Sarnataro et al.     Host defence peptides (HDPs) are critical components of innate immunity. Despite their diversity, they share common features including a structural signature, designated “γ-core …             Identification, characterization and molecular analysis of the viable but nonculturable Rhodococcus biphenylivorans ▶     Xiaomei Su, Faqian Sun, Yalin Wang et al.     Numerous bacteria, including pollutant-degrading bacteria can enter the viable but nonculturable state (VBNC) when they encounter harsh environmental conditions. VBNC bacteria, …             Crystal Structure of Human SSRP1 Middle Domain Reveals a Role in DNA Binding ▶     Wenjuan Zhang, Fuxing Zeng, Yiwei Liu et al.     SSRP1 is a subunit of the FACT complex, an important histone chaperone required for transcriptional regulation, DNA replication and damage repair. SSRP1 also plays important …             T cell responses are elicited against Respiratory Syncytial Virus in the absence of signalling through TLRs, RLRs and IL-1R/IL-18R ▶     Michelle Goritzka, Catherine Pereira, Spyridon Makris et al.     Pattern recognition receptors (PRRs) and cytokine receptors are key players in the initiation of immune responses to infection. PRRs detecting viral RNA, such as toll like …             Identification of Nα-acetyl-α-lysine as a probable thermolyte and its accumulation mechanism in Salinicoccus halodurans H3B36 ▶     Kai Jiang, Yanfen Xue, Yanhe Ma     Salinicoccus halodurans H3B36 is a moderate halophile that was isolated from a 3.2-m-deep sediment sample in Qaidam Basin, China. Our results suggest that Nα-acetyl-α-lysine can …             Contact rate modulates foraging efficiency in leaf cutting ants ▶     S. Bouchebti, S. Ferrere, K. Vittori et al.     Lane segregation is rarely observed in animals that move in bidirectional flows. Consequently, these animals generally experience a high rate of head-on collisions during their …             Enhanced Osteogenesis by Reduced Graphene Oxide/Hydroxyapatite Nanocomposites ▶     Jong Ho Lee, Yong Cheol Shin, Sang-Min Lee et al.     Recently, graphene-based nanomaterials, in the form of two dimensional substrates or three dimensional foams, have attracted considerable attention as bioactive scaffolds to …             The Roles of MicroRNA-122 Overexpression in Inhibiting Proliferation and Invasion and Stimulating Apoptosis of Human Cholangiocarcinoma Cells ▶     Ning Liu, Fan Jiang, Tian-Lin He et al.     Our study investigated whether microRNA-122 (miR-122) played important roles in the proliferation, invasion and apoptosis of human cholangiocarcinoma (CC) cells. QBC939 and RBE …             Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance ▶     Kyle Caution, Mikhail A. Gavrilin, Mia Tazi et al.     Inflammasomes are multiprotein complexes that include members of the NOD-like receptor family and caspase-1. Caspase-1 is required for the fusion of the Legionella vacuole with …             A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes ▶     Martijn W. Vos, Will J. R. Stone, Karin M. Koolen et al.     Current first-line treatments for uncomplicated falciparum malaria rapidly clear the asexual stages of the parasite, but do not fully prevent parasite transmission by mosquitoes. …             Non-Faradaic Electrochemical Detection of Exocytosis from Mast and Chromaffin Cells Using Floating-Gate MOS Transistors ▶     Krishna Jayant, Amit Singhai, Yingqiu Cao et al.     We present non-faradaic electrochemical recordings of exocytosis from populations of mast and chromaffin cells using chemoreceptive neuron MOS (CνMOS) transistors. In comparison …             Comparative transcriptome analysis of different chemotypes elucidates withanolide biosynthesis pathway from medicinal plant Withania somnifera ▶     Parul Gupta, Ridhi Goel, Aditya Vikram Agarwal et al.     Withania somnifera is one of the most valuable medicinal plants synthesizing secondary metabolites known as withanolides. Despite pharmaceutical importance, limited information …             PI3K/Akt signaling pathway triggers P2X7 receptor expression as a pro-survival factor of neuroblastoma cells under limiting growth conditions ▶     Rosa Gómez-Villafuertes, Paula García-Huerta, Juan Ignacio Díaz-Hernández et al.     The expression of purinergic P2X7 receptor (P2X7R) in neuroblastoma cells is associated to accelerated growth rate, angiogenesis, metastasis and poor prognosis. Noticeably, P2X7R …             Single-target high-throughput transcription analyses reveal high levels of alternative splicing present in the FPPS/GGPPS from Plasmodium falciparum ▶     Heloisa B. Gabriel, Mauro F. de Azevedo, Giuseppe Palmisano et al.     Malaria is a tropical disease with significant morbidity and mortality. A better understanding of the metabolism of its most important etiological agent, Plasmodium falciparum, …             Transcriptome analysis reveals mucin 4 to be highly associated with periodontitis and identifies pleckstrin as a link to systemic diseases ▶     Anna Lundmark, Haleh Davanian, Tove Båge et al.     The multifactorial chronic inflammatory disease periodontitis, which is characterized by destruction of tooth-supporting tissues, has also been implicated as a risk factor for …             miRNA-132-3p inhibits osteoblast differentiation by targeting Ep300 in simulated microgravity ▶     Zebing Hu, Yixuan Wang, Zhongyang Sun et al.     Recent studies have demonstrated that miRNAs can play important roles in osteoblast differentiation and bone formation. However, the function of miRNAs in bone loss induced by …             Antibiotic regimen based on population analysis of residing persister cells eradicates Staphylococcus epidermidis biofilms ▶     Shoufeng Yang, Iain D. Hay, David R. Cameron et al.     Biofilm formation is a major pathogenicity strategy of Staphylococcus epidermidis causing various medical-device infections. Persister cells have been implicated in treatment …             Spatially modulated structural colour in bird feathers ▶     Andrew J. Parnell, Adam L. Washington, Oleksandr O. Mykhaylyk et al.     Eurasian Jay (Garrulus glandarius) feathers display periodic variations in the reflected colour from white through light blue, dark blue and black. We find the structures …             Serological Measures of Trachoma Transmission Intensity ▶     Diana L. Martin, Ryan Wiegand, Brook Goodhew et al.     Ocular infection with Chlamydia trachomatis can lead to trachoma, a leading infectious cause of blindness. Trachoma is targeted for elimination by 2020. Clinical grading for …             Genome-wide association study reveals two loci for serum magnesium concentrations in European-American children ▶     Xiao Chang, Joseph Glessner, Adrienne Tin et al.     Magnesium ions are essential to the basic metabolic processes in the human body. Previous genetic studies indicate that serum magnesium levels are highly heritable, and a few …             Apocynin suppression of NADPH oxidase reverses the aging process in mesenchymal stem cells to promote osteogenesis and increase bone mass ▶     Jinlong Sun, Leiguo Ming, Fengqing Shang et al.     Because of the reduced potential for osteogenesis in aging bone marrow stromal cells, the balance of bone metabolism becomes disrupted, leading to various bone diseases. An …             Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus ▶     Xiaomin Su, Hui Yan, Yugang Huang et al.     We here found that intestinal epithelial Paneth cells secrete FABP4, adipsin and adiponectin in both mice and human. Deletion of Paneth cell results in the decrease of FABP4, …             An integrated statistical model for enhanced murine cardiomyocyte differentiation via optimized engagement of 3D extracellular matrices ▶     Jangwook P. Jung, Dongjian Hu, Ibrahim J. Domian et al.     The extracellular matrix (ECM) impacts stem cell differentiation, but identifying formulations supportive of differentiation is challenging in 3D models. Prior efforts involving …             Did Large-Scale Vaccination Drive Changes in the Circulating Rotavirus Population in Belgium? ▶     Virginia E. Pitzer, Joke Bilcke, Elisabeth Heylen et al.     Vaccination can place selective pressures on viral populations, leading to changes in the distribution of strains as viruses evolve to escape immunity from the vaccine. …             The temporal topography of the N-Methyl- N-nitrosourea induced photoreceptor degeneration in mouse retina ▶     Ye Tao, Tao Chen, Wei Fang et al.     Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by the progressive photoreceptors apoptosis. The N-Methyl- N-nitrosourea (MNU) is an …             Biofunctionalization of Selenium Nanoparticle with Dictyophora Indusiata Polysaccharide and Its Antiproliferative Activity through Death-Receptor and Mitochondria-Mediated Apoptotic Pathways ▶     Wenzhen Liao, Zhiqiang Yu, Zehua Lin et al.     Bio-functionalized nanoparticles with semiconducting/metallic core encapsulated in a bio- or bio-derived materials are promising for applications in biology and especially in …             Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study ▶     Yoonsu Cho, So-Youn Shin, Sungho Won et al.     Mendelian randomisation studies from Asia suggest detrimental influences of alcohol on cardiovascular risk factors, but such associations are observed mainly in men. The absence …             BODIPY-Based Fluorescent Probes for Sensing Protein Surface-Hydrophobicity ▶     Nethaniah Dorh, Shilei Zhu, Kamal B. Dhungana et al.     Mapping surface hydrophobic interactions in proteins is key to understanding molecular recognition, biological functions, and is central to many protein misfolding diseases. …             TMV mutants with poly(A) tracts of different lengths demonstrate structural variations in 3′UTR affecting viral RNAs accumulation and symptom expression ▶     Song Guo, Elzbieta Kierzek, Gang Chen et al.     The upstream pseudoknots domain (UPD) of Tobacco mosaic virus (TMV) is located at the 3′-untranslated region (UTR). It plays an important role in virus replication and …             Corrigendum: Crystal structure of caspase recruiting domain (CARD) of apoptosis repressor with CARD (ARC) and its implication in inhibition of apoptosis ▶     Tae-ho Jang, Seong Hyun Kim, Jae-Hee Jeong et al.                 Corrigendum: Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model ▶     Zhihui Yang, Ping Wang, Drake Morgan et al.                 Compact Wireless Microscope for In-Situ Time Course Study of Large Scale Cell Dynamics within an Incubator ▶     Di Jin, Dennis Wong, Junxiang Li et al.     Imaging of live cells in a region of interest is essential to life science research. Unlike the traditional way that mounts CO2 incubator onto a bulky microscope for observation, …             Identification of a novel antimicrobial peptide from amphioxus Branchiostoma japonicum by in silico and functional analyses ▶     Haohan Liu, Miaomiao Lei, Xiaoyuan Du et al.     The emergence of multi-drug resistant (MDR) microbes leads to urgent demands for novel antibiotics exploration. We demonstrated a cDNA from amphioxus Branchiostoma japonicum, …             Bioinformatical parsing of folding-on-binding proteins reveals their compositional and evolutionary sequence design ▶     Mohanalakshmi Narasumani, Paul M Harrison     Intrinsic disorder occurs when (part of) a protein remains unfolded during normal functioning. Intrinsically-disordered regions can contain segments that ‘fold on binding’ to …             PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm ▶     Rumiko Ono, Tsuneyasu Kaisho, Takashi Tanaka     Understanding the regulatory mechanisms for the NF-κB transcription factor is key to control inflammation. IκBα maintains NF-κB in an inactive form in the cytoplasm of …             De novo assembly and characterization of root transcriptome in two distinct morphotypes of vetiver, Chrysopogon zizaniodes (L.) Roberty ▶     Debasis Chakrabarty, Puneet Singh Chauhan, Abhishek Singh Chauhan et al.     Vetiver, a perennial C4 grass, has long been known for its multifarious uses in perfumery, medicine and environmental protection. Two distinct vetiver morphotypes have been …             Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells ▶     Toru Kamitani, Hirofumi Sakaguchi, Atsushi Tamura et al.     Tricellulin (also known as MARVELD2) is considered as a central component of tricellular tight junctions and is distributed among various epithelial tissues. Although mutations …             TRPV4 associates environmental temperature and sex determination in the American alligator ▶     Ryohei Yatsu, Shinichi Miyagawa, Satomi Kohno et al.     Temperature-dependent sex determination (TSD), commonly found among reptiles, is a sex determination mode in which the incubation temperature during a critical temperature …             Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity ▶     Alicia Amadoz, Patricia Sebastian-Leon, Enrique Vidal et al.     Many complex traits, as drug response, are associated with changes in biological pathways rather than being caused by single gene alterations. Here, a predictive framework is …             The colour of an avifauna: A quantitative analysis of the colour of Australian birds ▶     Kaspar Delhey     Animal coloration is a poorly-understood aspect of phenotypic variability. Here I expand initial studies of the colour gamut of birds by providing the first quantitative …             Effects of storage on mixed-culture biological electrodes ▶     Soroush Saheb Alam, Frank Persson, Britt-Marie Wilén et al.     Storage methods are important to preserve the viability and biochemical characteristics of microbial cultures between experiments or during periods when bioreactors are inactive. …             A functional polymorphism in IFNAR1 gene is associated with susceptibility and severity of HFMD with EV71 infection ▶     Rongrong Zou, Guoliang Zhang, Shaoyuan Li et al.     Enterovirus 71 (EV71), one of the major pathogens of Hand, foot and mouth disease (HFMD), results in millions of infections and hundreds of deaths each year in Southeast Asia. …             From an imbalance to a new imbalance: Italian-style gluten-free diet alters the salivary microbiota and metabolome of African celiac children ▶     Danilo Ercolini, Ruggiero Francavilla, Lucia Vannini et al.     Fourteen Saharawi celiac children following an African-style gluten-free diet for at least two years were subjected to a change of diet to an Italian-style gluten-free diet for …             Staphylococcus aureus forms spreading dendrites that have characteristics of active motility ▶     Eric J. G. Pollitt, Shanika A. Crusz, Stephen P. Diggle     Staphylococcus aureus is historically regarded as a non-motile organism. More recently it has been shown that S. aureus can passively move across agar surfaces in a process …             A toxic endophyte-infected grass helps reverse degradation and loss of biodiversity of over-grazed grasslands in northwest China ▶     Xiang Yao, Michael J. Christensen, Gensheng Bao et al.     Overgrazing of China’s grasslands is increasingly causing biodiversity to decline. In degenerated grasslands of northwest China endophyte (Epichloё gansuensis) infected …             The capacity to maintain ion and water homeostasis underlies interspecific variation in Drosophila cold tolerance ▶     Heath A. MacMillan, Jonas L. Andersen, Shireen A. Davies et al.     Many insects, including Drosophila, succumb to the physiological effects of chilling at temperatures well above those causing freezing. Low temperature causes a loss of …             Corrigendum: Donkey genome and insight into the imprinting of fast karyotype evolution ▶     Jinlong Huang, Yiping Zhao, Dongyi Bai et al.                 Genome-wide analysis of tomato long non-coding RNAs and identification as endogenous target mimic for microRNA in response to TYLCV infection ▶     Jinyan Wang, Wengui Yu, Yuwen Yang et al.     Recently, a large number of long noncoding RNAs (lncRNAs) have emerged as important regulators of many biological processes in animals and plants. However, how lncRNAs function …             Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E ▶     K. A. Smith, B. Zhou, S. Avdulov et al.     The epithelial to mesenchymal transition (EMT) imparts disease-defining properties to epithelial cells in cancer and organ fibrosis. Prior studies identify EMT control points at …             Comparison of owner-reported behavioral characteristics among genetically clustered breeds of dog (Canis familiaris). ▶     Akiko Tonoike, Miho Nagasawa, Kazutaka Mogi et al.     During the domestication process, dogs were selected for their suitability for multiple purposes, resulting in a variety of behavioral characteristics. In particular, the ancient …             Deformability of Tumor Cells versus Blood Cells ▶     Josephine Shaw Bagnall, Sangwon Byun, Shahinoor Begum et al.     The potential for circulating tumor cells (CTCs) to elucidate the process of cancer metastasis and inform clinical decision-making has made their isolation of great importance. …             Erratum: Tristetraprolin regulation of interleukin-22 production ▶     Lorena Härdle, Malte Bachmann, Franziska Bollmann et al.                 Secretome analysis of chickpea reveals dynamic extracellular remodeling and identifies a Bet v1-like protein, CaRRP1 that participates in stress response ▶     Sonika Gupta, Vijay Wardhan, Amit Kumar et al.     Secreted proteins maintain cell structure and biogenesis besides acting in signaling events crucial for cellular homeostasis during stress adaptation. To understand the …             Mechanism for attenuated outward conductance induced by mutations in the cytoplasmic pore of Kir2.1 channels ▶     Hsueh-Kai Chang, Masayuki Iwamoto, Shigetoshi Oiki et al.     Outward currents through Kir2.1 channels regulate the electrical properties of excitable cells. These currents are subject to voltage-dependent attenuation by the binding of …             Cancer associated missense mutations in BAP1 catalytic domain induce amyloidogenic aggregation: A new insight in enzymatic inactivation ▶     Sushmita Bhattacharya, Pranita Hanpude, Tushar Kanti Maiti     BRCA1 associated protein 1 (BAP1) is a nuclear deubiquitinase that regulates tumor suppressor activity and widely involves many cellular processes ranging from cell cycle …             Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells ▶     Jing Qu, Rya Ero, Chen Feng et al.     Kindlins are FERM-containing cytoplasmic proteins that regulate integrin-mediated cell-cell and cell-extracellular matrix (ECM) attachments. Kindlin-3 is expressed in …             Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration ▶     Jui-Chung Wu, Yu-Chen Chen, Chih-Ting Kuo et al.     Directed cell migration requires dynamical control of the protein complex within focal adhesions (FAs) and this control is regulated by signaling events involving tyrosine …             Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion ▶     Xiang-Qun Xie, Peng Yang, Yu Zhang et al.     Hematopoietic stem cells (HSCs) have emerged as promising therapeutic cell sources for high-risk hematological malignancies and immune disorders. However, their clinical use is …             Characterization and Comparative Analysis of the Milk Transcriptome in Two Dairy Sheep Breeds using RNA Sequencing ▶     Aroa Suárez-Vega, Beatriz Gutiérrez-Gil, Christophe Klopp et al.     This study presents a dynamic characterization of the sheep milk transcriptome aiming at achieving a better understanding of the sheep lactating mammary gland. Transcriptome …             Hidden Markov induced Dynamic Bayesian Network for recovering time evolving gene regulatory networks ▶     Shijia Zhu, Yadong Wang     Dynamic Bayesian Networks (DBN) have been widely used to recover gene regulatory relationships from time-series data in computational systems biology. Its standard assumption is …             Functional characterization of NADPH-cytochrome P450 reductase from Bactrocera dorsalis: Possible involvement in susceptibility to malathion ▶     Yong Huang, Xue-Ping Lu, Luo-Luo Wang et al.     NADPH cytochrome P450 reductase (CPR) is essential for cytochrome P450 catalysis, which is important in the detoxification and activation of xenobiotics. In this study, two …             Zinc enhancement of cytidine deaminase activity highlights a potential allosteric role of loop-3 in regulating APOBEC3 enzymes ▶     Ailie Marx, Meytal Galilee, Akram Alian     The strong association of APOBEC3 cytidine deaminases with somatic mutations leading to cancers accentuates the importance of their tight intracellular regulation to minimize …             Prion protein localizes at the ciliary base during neural and cardiovascular development, and its depletion affects α-tubulin post-translational modifications ▶     Sophie Halliez, Séverine Martin-Lannerée, Bruno Passet et al.     Although conversion of the cellular form of the prion protein (PrPC) into a misfolded isoform is the underlying cause of prion diseases, understanding PrPC physiological …             A Fluorescent Tile DNA Diagnocode System for In Situ Rapid and Selective Diagnosis of Cytosolic RNA Cancer Markers ▶     Kyung Soo Park, Seung Won Shin, Min Su Jang et al.     Accurate cancer diagnosis often requires extraction and purification of genetic materials from cells, and sophisticated instrumentations that follow. Otherwise in order to …             Archaeal and bacterial communities across a chronosequence of drained lake basins in arctic alaska ▶     J. Kao-Kniffin, B.J. Woodcroft, S.M. Carver et al.     We examined patterns in soil microbial community composition across a successional gradient of drained lake basins in the Arctic Coastal Plain. Analysis of 16S rRNA gene …             Minimal domain of bacterial phytochrome required for chromophore binding and fluorescence ▶     Konstantin A. Rumyantsev, Daria M. Shcherbakova, Natalia I. Zakharova et al.     Fluorescent proteins (FP) are used to study various biological processes. Recently, a series of near-infrared (NIR) FPs based on bacterial phytochromes was developed. Finding …             Monitor unit optimization in stereotactic body radiotherapy for small peripheral non-small cell lung cancer patients ▶     Bao-Tian Huang, Zhu Lin, Pei-Xian Lin et al.     The increasingly attractive stereotactic body radiotherapy (SBRT) treatment for stage I lung cancer is concomitant with a large amount of monitor units (MU), leading to excessive …             “Cation-Stitching Cascade”: exquisite control of terpene cyclization in cyclooctatin biosynthesis ▶     Hajime Sato, Kazuya Teramoto, Yui Masumoto et al.     Terpene cyclization is orchestrated by terpene cyclases, which are involved in the biosynthesis of various cyclic natural products, but understanding the origin and mechanism of …             Novel mechanism of harmaline on inducing G2/M cell cycle arrest and apoptosis by up-regulating Fas/FasL in SGC-7901 cells ▶     Yihai Wang, Chunhua Wang, Chenguang Jiang et al.     Harmaline (HAR), a natural occurrence β-carboline alkaloid, was isolated from the seeds of Peganum harmala and exhibited potent antitumor effect. In this study, the anti-gastric …             The northern limit of corals of the genus Acropora in temperate zones is determined by their resilience to cold bleaching ▶     Tomihiko Higuchi, Sylvain Agostini, Beatriz Estela Casareto et al.     The distribution of corals in Japan covers a wide range of latitudes, encompassing tropical to temperate zones. However, coral communities in temperate zones contain only a small …             Neck Circumference and Incidence of Diabetes Mellitus over 10 Years in the Korean Genome and Epidemiology Study (KoGES) ▶     Nam H. Cho, Tae Jung Oh, Kyoung Min Kim et al.     Neck circumference, a proxy for upper-body fat, may be a unique fat depot that indicates metabolic risk beyond whole body fat. We investigated whether neck circumference is …             Testing the fecundity advantage hypothesis with Sitobion avenae, Rhopalosiphum padi, and Schizaphis graminum (Hemiptera: Aphididae) feeding on ten wheat accessions ▶     Xiang-Shun Hu, Xiao-Feng Liu, Thomas Thieme et al.     The fecundity advantage hypothesis suggests that females with a large body size produce more offspring than smaller females. We tested this hypothesis by exploring the …             Association of Interleukin-23 receptor gene polymorphisms with susceptibility to Crohn’s disease: A meta-analysis ▶     Wang-Dong Xu, Qi-Bing Xie, Yi Zhao et al.     Studies investigating the association between Interleukin-23 receptor (IL-23R) gene polymorphisms and Crohn’s disease (CD) report conflicting results. Thus, a meta-analysis was …             Iron oxide nanoparticle-mediated hyperthermia stimulates dispersal in bacterial biofilms and enhances antibiotic efficacy ▶     Thuy-Khanh Nguyen, Hien T. T. Duong, Ramona Selvanayagam et al.     The dispersal phase that completes the biofilm lifecycle is of particular interest for its potential to remove recalcitrant, antimicrobial tolerant biofilm infections. Here we …             Glycolysis, but not Mitochondria, responsible for intracellular ATP distribution in cortical area of podocytes ▶     Shota Ozawa, Shuko Ueda, Hiromi Imamura et al.     Differentiated podocytes, a type of renal glomerular cells, require substantial levels of energy to maintain glomerular physiology. Mitochondria and glycolysis are two major …             Resistance to dual-gene Bt maize in Spodoptera frugiperda: selection, inheritance, and cross-resistance to other transgenic events ▶     Oscar F. Santos-Amaya, João V. C. Rodrigues, Thadeu C. Souza et al.     Transgenic crop “pyramids” producing two or more Bacillus thuringiensis (Bt) toxins active against the same pest are used to delay evolution of resistance in insect pest …             Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies ▶     Ana Andjelković, Marcos T. Oliveira, Giuseppe Cannino et al.     The mitochondrial alternative oxidase, AOX, carries out the non proton-motive re-oxidation of ubiquinol by oxygen in lower eukaryotes, plants and some animals. Here we created a …             Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance ▶     Chong Yew Tan, Samuel Virtue, Steven Murfitt et al.     The non-essential fatty acids, C18:1n9, C16:0, C16:1n7, C18:0 and C18:1n7 account for over 75% of fatty acids in white adipose (WAT) triacylglycerol (TAG). The relative …             The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia ▶     Matteo Allegretti, Maria Rosaria Ricciardi, Roberto Licchetta et al.     Aberrant activation of the PI3K/Akt/mTOR pathway is a common feature of acute myeloid leukemia (AML) patients contributing to chemoresistance, disease progression and …             Social density processes regulate the functioning and performance of foraging human teams ▶     Andrew J. King, Julia P. Myatt, Ines Fürtbauer et al.     Social density processes impact the activity and order of collective behaviours in a variety of biological systems. Much effort has been devoted to understanding how density of …             The N-terminal domain of the thermo-regulated surface protein PrpA of Enterococcus faecium binds to fibrinogen, fibronectin and platelets ▶     Ana M. Guzmán Prieto, Rolf T. Urbanus, Xinglin Zhang et al.     Enterococcus faecium is a commensal of the mammalian gastrointestinal tract, but is also found in non-enteric environments where it can grow between 10 °C and 45 °C. E. faecium …             Genetic dissection of heterosis using epistatic association mapping in a partial NCII mating design ▶     Jia Wen, Xinwang Zhao, Guorong Wu et al.     Heterosis refers to the phenomenon in which an F1 hybrid exhibits enhanced growth or agronomic performance. However, previous theoretical studies on heterosis have been based on …             Classical ROS-dependent and early/rapid ROS-independent release of Neutrophil Extracellular Traps triggered by Leishmania parasites ▶     Natalia C. Rochael, Anderson B. Guimarães-Costa, Michelle T. C. Nascimento et al.     Neutrophil extracellular traps (NETs) extruded from neutrophils upon activation are composed of chromatin associated with cytosolic and granular proteins, which ensnare and kill …             A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast ▶     Genrikh V. Serpionov, Alexander I. Alexandrov, Yuri N. Antonenko et al.     Several neurodegenerative amyloidoses, including Huntington disease, are caused by expansion of polyglutamine (polyQ) stretches in otherwise unrelated proteins. In a yeast model, …             IL-8 as mediator in the microenvironment-leukaemia network in acute myeloid leukaemia ▶     Alexander Kuett, Christina Rieger, Deborah Perathoner et al.     The bone marrow microenvironment is physiologically hypoxic with areas being as low as 1% O2, e.g. the stem cell niche. Acute myeloid leukaemia (AML) blasts misuse these bone …             Metabolomic analysis with GC-MS to reveal potential metabolites and biological pathways involved in Pb & Cd stress response of radish roots ▶     Yan Wang, Liang Xu, Hong Shen et al.     The radish (Raphanus sativus L.) is an important root vegetable crop. In this study, the metabolite profiling analysis of radish roots exposed to lead (Pb) and cadmium (Cd) …             HIV-1 CCR5 gene therapy will fail unless it is combined with a suicide gene ▶     Aridaman Pandit, Rob J. de Boer     Highly active antiretroviral therapy (ART) has successfully turned Human immunodeficiency virus type 1 (HIV-1) from a deadly pathogen into a manageable chronic infection. ART is …             Identification of a highly efficient stationary phase promoter in Bacillus subtilis ▶     Xiaoxia Yu, Jiangtao Xu, Xiaoqing Liu et al.     A promoter that enabled high-level expression of the target gene during the stationary phase in the absence of an inducer would facilitate the efficient production of …             Pathway-Based Genome-Wide Association Studies for Two Meat Production Traits in Simmental Cattle ▶     Huizhong Fan, Yang Wu, Xiaojing Zhou et al.     Most single nucleotide polymorphisms (SNPs) detected by genome-wide association studies (GWAS), explain only a small fraction of phenotypic variation. Pathway-based GWAS were …             Treating Colon Cancer Cells with FK228 Reveals a Link between Histone Lysine Acetylation and Extensive Changes in the Cellular Proteome ▶     Tian-yun Wang, Yan-long Jia, Xi Zhang et al.     The therapeutic value of FK228 as a cancer treatment option is well known, and various types of cancer have been shown to respond to this drug. However, the complete mechanism of …             A functional 4-hydroxybenzoate degradation pathway in the phytopathogen Xanthomonas campestris is required for full pathogenicity ▶     Jia-Yuan Wang, Lian Zhou, Bo Chen et al.     Plants contain significant levels of natural phenolic compounds essential for reproduction and growth, as well as defense mechanisms against pathogens. Xanthomonas campestris pv. …             Evolution of cellular morpho-phenotypes in cancer metastasis ▶     Pei-Hsun Wu, Jude M. Phillip, Shyam B. Khatau et al.     Intratumoral heterogeneity greatly complicates the study of molecular mechanisms driving cancer progression and our ability to predict patient outcomes. Here we have developed an …             PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response ▶     Ananya Gupta, Muhammad Mosaraf Hossain, Danielle E. Read et al.     The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of …             Hypericin-photodynamic therapy induces human umbilical vein endothelial cell apoptosis ▶     Qian Zhang, Zhuo-heng Li, Yuan-yuan Li et al.     The conventional photosensitizers used in photodynamic therapy (PDT), such as haematoporphyrin (HP), have not yet reached satisfactory therapeutic effects on port-wine stains …             TALEN-mediated homologous recombination in Daphnia magna ▶     Takashi Nakanishi, Yasuhiko Kato, Tomoaki Matsuura et al.     Transcription Activator-Like Effector Nucleases (TALENs) offer versatile tools to engineer endogenous genomic loci in various organisms. We established a homologous recombination …             DockTope: a Web-based tool for automated pMHC-I modelling ▶     Maurício Menegatti Rigo, Dinler Amaral Antunes, Martiela Vaz de Freitas et al.     The immune system is constantly challenged, being required to protect the organism against a wide variety of infectious pathogens and, at the same time, to avoid autoimmune …             Identification of potential mitochondrial CLPXP protease interactors and substrates suggests its central role in energy metabolism ▶     Fabian Fischer, Julian D. Langer, Heinz D. Osiewacz     Maintenance of mitochondria is achieved by several mechanisms, including the regulation of mitochondrial proteostasis. The matrix protease CLPXP, involved in protein quality …             Owning the body in the mirror: The effect of visual perspective and mirror view on the full-body illusion ▶     Catherine Preston, Benjamin J. Kuper-Smith, H. Henrik Ehrsson     Mirrors allow us to view our own body from a third-person (observer) perspective. However, how viewing ourselves through a mirror affects central body representations compared …             TRAIL-R2 Superoligomerization Induced by Human Monoclonal Agonistic Antibody KMTR2 ▶     Taro Tamada, Daisuke Shinmi, Masahiro Ikeda et al.     The fully human monoclonal antibody KMTR2 acts as a strong direct agonist for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAIL-R2), which is …             Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis ▶     Rakesh K. Arya, Akhilesh Singh, Navneet K. Yadav et al.     Major challenges for current therapeutic strategies against breast cancer are associated with drug-induced toxicities. Considering the immense potential of bioactive …             Functional tooth restoration utilising split germs through re-regionalisation of the tooth-forming field ▶     Naomi Yamamoto, Masamitsu Oshima, Chie Tanaka et al.     The tooth is an ectodermal organ that arises from a tooth germ under the regulation of reciprocal epithelial-mesenchymal interactions. Tooth morphogenesis occurs in the …             Effect of edge pruning on structural controllability and observability of complex networks ▶     Simachew Abebe Mengiste, Ad Aertsen, Arvind Kumar     Controllability and observability of complex systems are vital concepts in many fields of science. The network structure of the system plays a crucial role in determining its …             Predicting the impact of promoter variability on regulatory outputs ▶     Naomi N. Kreamer, Rob Phillips, Dianne K. Newman et al.     The increased availability of whole genome sequences calls for quantitative models of global gene expression, yet predicting gene expression patterns directly from genome …             SMC1B is present in mammalian somatic cells and interacts with mitotic cohesin proteins ▶     Linda Mannini, Francesco Cucco, Valentina Quarantotti et al.     Cohesin is an evolutionarily conserved protein complex that plays a role in many biological processes: it ensures faithful chromosome segregation, regulates gene expression and …             Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors ▶     Katie J. Herbst-Robinson, Li Liu, Michael James et al.     Senile plaques comprised of Aβ peptides are a hallmark of Alzheimer’s disease (AD) brain, as are activated glia that release inflammatory molecules, including eicosanoids. …             Comparative transcriptome analysis of grapevine in response to copper stress ▶     Xiangpeng Leng, Haifeng Jia, Xin Sun et al.     Grapevine is one of the most economically important and widely cultivated fruit crop worldwide. With the industrialization and the popular application of cupric fungicides in …             Heterogeneous distribution of dye-labelled biomineralizaiton proteins in calcite crystals ▶     Chuang Liu, Liping Xie, Rongqing Zhang     Biominerals are highly ordered crystals mediated by organic matters especially proteins in organisms. However, how specific proteins are distributed inside biominerals are not …             Immobilization of myoglobin on Au nanoparticle-decorated carbon nanotube/polytyramine composite as a mediator-free H2O2 and nitrite biosensor ▶     A. T. Ezhil Vilian, Vediyappan Veeramani, Shen-Ming Chen et al.     A novel composite film was designed for use as a highly selective mediator-free amperometric biosensor, and a method was created for accomplishing direct electrochemistry of …             PRINT: A Protein Bioconjugation Method with Exquisite N-terminal Specificity ▶     Surojit Sur, Yuan Qiao, Anja Fries et al.     Chemical conjugation is commonly used to enhance the pharmacokinetics, biodistribution, and potency of protein therapeutics, but often leads to non-specific modification or loss …             Relation of retinal blood flow and retinal oxygen extraction during stimulation with diffuse luminance flicker ▶     Stefan Palkovits, Michael Lasta, Reinhard Told et al.     Cerebral and retinal blood flow are dependent on local neuronal activity. Several studies quantified the increase in cerebral blood flow and oxygen consumption during activity. …             Measurement of the Nucleus Area and Nucleus/Cytoplasm and Mitochondria/Nucleus Ratios in Human Colon Tissues by Dual-Colour Two-Photon Microscopy Imaging ▶     Chang Su Lim, Eun Sun Kim, Ji Yeon Kim et al.     We developed two-photon (TP) probes for DNA (ABI-Nu), cytoplasm (Pyr-CT), and mitochondria (BF-MT). We found that ABI-Nu binds to AT in the minor groove, while ABI-Nu and BF-MT …             Elevation of serum interleukins 8, 4, and 1β levels in patients with gastrointestinal low-grade B-cell lymphoma ▶     Tomoko Miyata-Takata, Katsuyoshi Takata, Tomohiro Toji et al.     Proinflammatory cytokines that are produced by helper T cells (Th) regulate immune reactions, facilitate class switching of B cells, and prolong the lifespan of B and T cells. …             Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA ▶     Serena Vella, Ilaria Penna, Luca Longo et al.     High Risk Neuroblastoma (HR-NB) is a pediatric cancer characterized by high malignancy and remarkable cell heterogeneity within the tumour nodules. In a recent study, we …             Effects of electrical stimulation on rat limb regeneration, a new look at an old model ▶     Liudmila P. Leppik, Dara Froemel, Andrei Slavici et al.     Limb loss is a devastating disability and while current treatments provide aesthetic and functional restoration, they are associated with complications and risks. The optimal …             Secreted multifunctional Glyceraldehyde-3-phosphate dehydrogenase sequesters lactoferrin and iron into cells via a non-canonical pathway ▶     Anoop S. Chauhan, Pooja Rawat, Himanshu Malhotra et al.     Lactoferrin is a crucial nutritionally important pleiotropic molecule and iron an essential trace metal for all life. The current paradigm is that living organisms have evolved …             GC-elements controlling HRAS transcription form i-motif structures unfolded by heterogeneous ribonucleoprotein particle A1 ▶     Giulia Miglietta, Susanna Cogoi, Erik B. Pedersen et al.     HRAS is regulated by two neighbouring quadruplex-forming GC-elements (hras-1 and hras-2), located upstream of the major transcription start sites (doi: 10.1093/nar/gku 5784). In …             Principles of using Cold Atmospheric Plasma Stimulated Media for Cancer Treatment ▶     Dayun Yan, Annie Talbot, Niki Nourmohammadi et al.     To date, the significant anti-cancer capacity of cold atmospheric plasma (CAP) on dozens of cancer cell lines has been demonstrated in vitro and in mice models. Conventionally, …             Substrate-Mediated Laser Ablation under Ambient Conditions for Spatially-Resolved Tissue Proteomics ▶     Benoit Fatou, Maxence Wisztorski, Cristian Focsa et al.     Numerous applications of ambient Mass Spectrometry (MS) have been demonstrated over the past decade. They promoted the emergence of various micro-sampling techniques such as …             The effect of androgens on ovarian follicle maturation: Dihydrotestosterone suppress FSH-stimulated granulosa cell proliferation by upregulating PPARγ-dependent PTEN expression. ▶     Mei-Jou Chen, Chia-Hung Chou, Shee-Uan Chen et al.     Intraovarian hyperandrogenism is one of the determining factors of follicular arrest in women with polycystic ovary syndrome (PCOS). Using androgenized rat models, we …             A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins ▶     Domenico Azarnia Tehran, Giulia Zanetti, Oneda Leka et al.     Botulinum neurotoxins (BoNTs) form a large class of potent and deadly neurotoxins. Given their growing number, it is of paramount importance to discover novel inhibitors …             Unveiling Bacterial Interactions through Multidimensional Scaling and Dynamics Modeling ▶     Pedro Dorado-Morales, Cristina Vilanova, Carlos P. Garay et al.     We propose a new strategy to identify and visualize bacterial consortia by conducting replicated culturing of environmental samples coupled with high-throughput sequencing and …             Stochasticity and homeostasis in the E. coli replication and division cycle ▶     Aileen Adiciptaningrum, Matteo Osella, M. Charl Moolman et al.     How cells correct for stochasticity to coordinate the chromosome replication and cellular division cycle is poorly understood. We used time-lapse microscopy and fluorescently …             Development of a mono-promoter-driven CRISPR/Cas9 system in mammalian cells ▶     Shin Yoshioka, Wataru Fujii, Tetsuhiro Ogawa et al.     The CRISPR/Cas9 system has been used for spatio-temporal gene modification through the ubiquitous expression of gRNA by an RNA polymerase III promoter and the controlled …             Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin ▶     Joseph F. Nabhan, Renea L. Gooch, Eugene L. Piatnitski Chekler et al.     Friedreich’s Ataxia is a genetic disease caused by expansion of an intronic trinucleotide repeat in the frataxin (FXN) gene yielding diminished FXN expression and consequently …             Hepatocystin is Essential for TRPM7 Function During Early Embryogenesis ▶     Jeffrey D. Overton, Yuko Komiya, Courtney Mezzacappa et al.     Mutations in protein kinase C substrate 80K-H (PRKCSH), which encodes for an 80 KDa protein named hepatocystin (80K-H, PRKCSH), gives rise to polycystic liver disease (PCLD). …             Reverse Engineering Applied to Red Human Hair Pheomelanin Reveals Redox-Buffering as a Pro-Oxidant Mechanism ▶     Eunkyoung Kim, Lucia Panzella, Raffaella Micillo et al.     Pheomelanin has been implicated in the increased susceptibility to UV-induced melanoma for people with light skin and red hair. Recent studies identified a UV-independent pathway …             RNA-sequencing Reveals Global Transcriptomic Changes in Nicotiana tabacum Responding to Topping and Treatment of Axillary-shoot Control Chemicals ▶     Sanjay K. Singh, Yongmei Wu, Jayadri S. Ghosh et al.     Removal of terminal buds (topping) and control of the formation of axillary shoots (suckers) are common agronomic practices that significantly impact the yield and quality of …             Biotechnological production of 1,2,4-butanetriol: An efficient process to synthesize energetic material precursor from renewable biomass ▶     Yujin Cao, Wei Niu, Jiantao Guo et al.     1,2,4-Butanetriol (BT) is a valuable chemical with extensive applications in many different fields. The traditional chemical routes to synthesize BT suffer from many drawbacks, …             Nudix hydrolases degrade protein-conjugated ADP-ribose ▶     Casey M. Daniels, Puchong Thirawatananond, Shao-En Ong et al.     ADP-ribosylation refers to the transfer of the ADP-ribose group from NAD+ to target proteins post-translationally, either attached singly as mono(ADP-ribose) (MAR) or in …             Efficient generation of region-specific forebrain neurons from human pluripotent stem cells under highly defined condition ▶     Fang Yuan, Kai-Heng Fang, Shi-Ying Cao et al.     Human pluripotent stem cells (hPSCs) have potential to differentiate to unlimited number of neural cells, which provide powerful tools for neural regeneration. To date, most …             Tongue Epithelium Cells from shRNA Mediated Transgenic Goat Show High Resistance to Foot and Mouth Disease Virus ▶     Wenting Li, Kejun Wang, Shimeng Kang et al.     Foot and mouth disease induced by foot and mouth disease virus (FMDV) is severe threat to cloven-hoofed domestic animals. The gene 3Dpol in FMDV genome encodes the viral RNA …             Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64+ cells ▶     Stephanie Vogel, Elena Grabski, Daniela Buschjäger et al.     Treatment of PBMC with the CD4-specific mAb BT-061 induces CD4 down-modulation of T cells. Here we report that addition of BT-061 to purified T cells did not confer this effect, …             Familiarity affects other-regarding preferences in pet dogs ▶     Mylene Quervel-Chaumette, Rachel Dale, Sarah Marshall-Pescini et al.     Other-regarding preferences are considered to be the foundation of human cooperation. However, the evolutionary origin of this behavior in humans remains poorly understood. So …             Sustained intraocular VEGF neutralization results in retinal neurodegeneration in the Ins2Akita diabetic mouse ▶     Jose R. Hombrebueno, Imran HA. Ali, Heping Xu et al.     Current therapies that target vascular endothelial growth factor (VEGF) have become a mainstream therapy for the management of diabetic macular oedema. The treatment involves …             Rat and human STINGs profile similarly towards anticancer/antiviral compounds ▶     Heng Zhang, Min-Jie Han, Jianli Tao et al.     Cyclic dinucleotides (CDNs) and antitumor/antiviral agents (DMXAA and CMA) trigger STING-dependent innate immunity activation. Accumulative evidences have showed that DMXAA and …             Dysfunctional vestibular system causes a blood pressure drop in astronauts returning from space ▶     Emma Hallgren, Pierre-François Migeotte, Ludmila Kornilova et al.     It is a challenge for the human body to maintain stable blood pressure while standing. The body’s failure to do so can lead to dizziness or even fainting. For decades it has been …             Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation and Damage In Exhaustive Exercise ▶     Wladimir Rafael Beck, José Diego Botezelli, José Rodrigo Pauli et al.     It is well documented that exhaustive physical exercise leads to inflammation and skeletal muscle tissue damage. With this in mind, melatonin has been acutely administered before …             Proteome Analysis of Ground State Pluripotency ▶     Sara Taleahmad, Mehdi Mirzaei, Lindsay M. Parker et al.     The differentiation potential of pluripotent embryonic stem cells (ESCs) can be manipulated via serum and medium conditions for direct cellular development or to maintain a naïve …             Lacritin Salvages Human Corneal Epithelial Cells from Lipopolysaccharide Induced Cell Death ▶     Venkat Rao Vantaku, Geetika Gupta, Krishna Chaitanya Rapalli et al.     Innate immunity of the corneal epithelium is conferred by proteinaceous secretions from the epithelium and associated lacrimal and meibomian glands. Lacritin, an eye-specific …             Corrigendum: Amino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression ▶     Megumi Tasaka-Fujita, Nao Sugiyama, Wonseok Kang et al.                 The global landscape of cognition: hierarchical aggregation as an organizational principle of human cortical networks and functions ▶     P. Taylor, J. N. Hobbs, J. Burroni et al.     Though widely hypothesized, limited evidence exists that human brain functions organize in global gradients of abstraction starting from sensory cortical inputs. Hierarchical …             GFP-complementation assay to detect functional CPP and protein delivery into living cells ▶     Nadia Milech, Brooke AC Longville, Paula T Cunningham et al.     Efficient cargo uptake is essential for cell-penetrating peptide (CPP) therapeutics, which deliver widely diverse cargoes by exploiting natural cell processes to penetrate the …             Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq ▶     Luis R. Saraiva, Ximena Ibarra-Soria, Mona Khan et al.     The mouse olfactory mucosa is a complex chemosensory tissue composed of multiple cell types, neuronal and non-neuronal. We have here applied RNA-seq hierarchically, in three …             High glucose environment inhibits cranial neural crest survival by activating excessive autophagy in the chick embryo ▶     Xiao-Yu Wang, Shuai Li, Guang Wang et al.     High glucose levels induced by maternal diabetes could lead to defects in neural crest development during embryogenesis, but the cellular mechanism is still not understood. In …             Interaction of MDM33 with mitochondrial inner membrane homeostasis pathways in yeast ▶     Till Klecker, Megan Wemmer, Mathias Haag et al.     Membrane homeostasis affects mitochondrial dynamics, morphology, and function. Here we report genetic and proteomic data that reveal multiple interactions of Mdm33, a protein …             TALENs-mediated gene disruption of FLT3 in leukemia cells: Using genome-editing approach for exploring the molecular basis of gene abnormality ▶     Jue Wang, Tongjuan Li, Mi Zhou et al.     Novel analytic tools are needed to elucidate the molecular basis of leukemia-relevant gene mutations in the post-genome era. We generated isogenic leukemia cell clones in which …             A unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain glycoside hydrolase family 3 β-N-acetylglucosaminidase ▶     Zhen Qin, Yibei Xiao, Xinbin Yang et al.     Glycoside hydrolase (GH) family 3 β-N-acetylglucosaminidases widely exist in the filamentous fungi, which may play a key role in chitin metabolism of fungi. A multi-domain GH …             Remote coral reefs can sustain high growth potential and may match future sea-level trends ▶     Chris T. Perry, Gary N. Murphy, Nicholas A. J. Graham et al.     Climate-induced disturbances are contributing to rapid, global-scale changes in coral reef ecology. As a consequence, reef carbonate budgets are declining, threatening reef …             The impact of natural modes in plasmonic imaging ▶     Angela Demetriadou     Plasmonic imaging is crucial for understanding cellular behaviours for biological sciences, where is used to image and track organelles in cells, such as DNA and virus molecules. …             Collembola at three alpine subarctic sites resistant to twenty years of experimental warming ▶     Juha M. Alatalo, Annika K. Jägerbrand, Peter Čuchta     This study examined the effects of micro-scale, site and 19 and 21 years of experimental warming on Collembola in three contrasting alpine subarctic plant communities (poor …             TATA boxes in gene transcription and poly (A) tails in mRNA stability: New perspective on the effects of berberine ▶     Zhi-Yi Yuan, Xi Lu, Fan Lei et al.     Berberine (BBR) is a natural compound with variable pharmacological effects and a broad panel of target genes. We investigated berberine’s pharmacological activities from the …             Are Immune Modulating Single Nucleotide Polymorphisms Associated with Necrotizing Enterocolitis? ▶     Ashanti L. Franklin, Mariam Said, Clint D. Cappiello et al.     Necrotizing enterocolitis (NEC) is a devastating gastrointestinal emergency. The purpose of this study is to determine if functional single nucleotide polymorphisms (SNPs) in …             Smokeless tobacco consumption impedes metabolic, cellular, apoptotic and systemic stress pattern: A study on Government employees in Kolkata, India ▶     Sushobhan Biswas, Krishnendu Manna, Ujjal Das et al.     Smokeless tobacco (SLT) remains a threat amongst a large population across the globe and particularly in India. The oral use of tobacco has been implicated to cause physiological …             Insulin-like growth factor binding protein-3 is a new predictor of radiosensitivity on esophageal squamous cell carcinoma ▶     Li-Ling Luo, Lei Zhao, Ying-Xue Wang et al.     Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in radiosensitivity of esophageal squamous cell carcinoma (ESCC). However, the underlying mechanism …             A white spot syndrome virus microRNA promotes the virus infection by targeting the host STAT ▶     Qian Ren, Ying Huang, Yaodong He et al.     JAK/STAT pathway plays an important role in invertebrates during virus infection. However the microRNA (miRNA)-mediated regulation of JAK/STAT is not intensively investigated. …             In vivo cellular imaging of various stress/response pathways using AAV following axonal injury in mice ▶     Kosuke Fujita, Koji M Nishiguchi, Yu Yokoyama et al.     Glaucoma, a leading cause of blindness worldwide, is instigated by various factors, including axonal injury, which eventually leads to a progressive loss of retinal ganglion …             Telomere mean length in patients with diabetic retinopathy ▶     Rupali Sharma, Amod Gupta, M. Thungapathra et al.     Telomere regression has been shown to be associated with several complex disorders like diabetes mellitus, cancer, cataract etc. Diabetic retinopathy develops as a complication …             Evaluating the potential impact of proton carriers on syntrophic propionate oxidation ▶     Natacha M. S. Juste-Poinapen, Mark S. Turner, Korneel Rabaey et al.     Anaerobic propionic acid degradation relies on interspecies electron transfer (IET) between propionate oxidisers and electron acceptor microorganisms, via either molecular …             A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2 ▶     Zeyun Mi, Jiwei Ding, Quan Zhang et al.     Human BST-2 inhibits HIV-1 replication by tethering nascent virions to the cell surface. HIV-1 codes Vpu that counteracts BST-2 by down-regulating this restriction factor from …             Physiological response to elevated temperature and pCO2 varies across four Pacific coral species: Understanding the unique host+symbiont response ▶     Kenneth D. Hoadley, D. Tye Pettay, Andréa G. Grottoli et al.     The physiological response to individual and combined stressors of elevated temperature and pCO2 were measured over a 24-day period in four Pacific corals and their respective …             Subsite-specific contributions of different aromatic residues in the active site architecture of glycoside hydrolase family 12 ▶     Xiaomei Zhang, Shuai Wang, Xiuyun Wu et al.     The active site architecture of glycoside hydrolase (GH) is a contiguous subregion of the enzyme constituted by residues clustered in the three-dimensional space, recognizing the …             Development of a pneumatically driven active cover lid for multi-well microplates for use in perfusion three-dimensional cell culture ▶     Song-Bin Huang, Dean Chou, Yu-Han Chang et al.     Before microfluidic-based cell culture models can be practically utilized for bioassays, there is a need for a transitional cell culture technique that can improve conventional …             Usefulness of serum interleukin-18 in predicting cardiovascular mortality in patients with chronic kidney disease – systems and clinical approach ▶     Dorota Formanowicz, Maria Wanic-Kossowska, Elżbieta Pawliczak et al.     The aim of this study was to check if serum interleukin-18 (IL-18) predicts 2-year cardiovascular mortality in patients at various stages of chronic kidney disease (CKD) and …             Thermodynamic Insights and Conceptual Design of Skin-Sensitive Chitosan Coated Ceramide/PLGA Nanodrug for Regeneration of Stratum Corneum on Atopic Dermatitis ▶     Sang-Myung Jung, Gwang Heum Yoon, Hoo Chul Lee et al.     Atopic dermatitis (AD) is a complex skin disease primarily characterized by psoriasis of the stratum corneum. AD drugs have usually been used in acidic and hydrophilic solvents …             Population genetic analysis reveals cryptic sex in the phytopathogenic fungus Alternaria alternata ▶     Jing-Wen Meng, Wen Zhu, Meng-Han He et al.     Reproductive mode can impact population genetic dynamics and evolutionary landscape of plant pathogens as well as on disease epidemiology and management. In this study, we …             Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B ▶     Sandra Pacios, Wenmei Xiao, Marcelo Mattos et al.     Bacterial pathogens stimulate periodontitis, the most common osteolytic disease in humans and the most common cause of tooth loss in adults. Previous studies identified …             Reading direction causes spatial biases in mental model construction in language understanding ▶     Antonio Román, Andrea Flumini, Pilar Lizano et al.     Correlational evidence suggests that the experience of reading and writing in a certain direction is able to induce spatial biases at both low-level perceptuo-motor skills and …             Successive site translocating inoculation potentiates DNA/recombinant vaccinia vaccination ▶     Yanqin Ren, Na Wang, Weiguo Hu et al.     DNA vaccines have advantages over traditional vaccine modalities; however the relatively low immunogenicity restrains its translation into clinical use. Further optimizations are …             Effect of handedness on brain activity patterns and effective connectivity network during the semantic task of Chinese characters ▶     Qing Gao, Junping Wang, Chunshui Yu et al.     Increasing efforts have been denoted to elucidating the effective connectivity (EC) among brain regions recruited by certain language task; however, it remains unclear the impact …             Comprehensive study of liposome-assisted synthesis of membrane proteins using a reconstituted cell-free translation system ▶     Tatsuya Niwa, Yoshihiro Sasaki, Eri Uemura et al.     Membrane proteins play pivotal roles in cellular processes and are key targets for drug discovery. However, the reliable synthesis and folding of membrane proteins are …             Two domain-disrupted hda6 alleles have opposite epigenetic effects on transgenes and some endogenous targets ▶     Shoudong Zhang, Xiangqiang Zhan, Xiaoming Xu et al.     HDA6 is a RPD3-like histone deacetylase. In Arabidopsis, it mediates transgene and some endogenous target transcriptional gene silencing (TGS) via histone deacetylation and DNA …             Rapid loss of antipredatory behaviour in captive-bred birds is linked to current avian invasions ▶     Martina Carrete, José L. Tella     Despite the importance of behaviour in conservation biology, there have been few studies that address behaviour in areas such as invasion ecology. There is an urgent need to …             Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression ▶     Verena Schwartz, Katharina Friedrich, Georg Polleichtner et al.     Acid-sensing ion channels (ASICs) are voltage-independent proton-gated amiloride sensitive sodium channels, belonging to the DEG/ENaC gene family. Six different ASICs have been …             Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-α-induced hepatic insulin resistance ▶     Hongye Zhao, Xiuqing Huang, Juan Jiao et al.     Protein phosphatase 4 (PP4) was shown to participate in multiple cellular processes, including DNA damage response, cell cycle and embryo development. Recent studies demonstrated …             Novel Compound Heterozygous CBS Mutations Cause Homocystinuria in a Han Chinese Family ▶     Bo Gong, Liping Liu, Zhiwei Li et al.     The cystathionine β-synthase (CBS) gene has been shown to be related to homocystinuria. This study was aimed to detect the mutations in CBS in a Han Chinese family with …             Sildenafil Therapy Normalizes the Aberrant Metabolomic Profile in the Comt−/− Mouse Model of Preeclampsia/Fetal Growth Restriction ▶     Joanna L. Stanley, Karolina Sulek, Irene J. Andersson et al.     Preeclampsia (PE) and fetal growth restriction (FGR) are serious complications of pregnancy, associated with greatly increased risk of maternal and perinatal morbidity and …             NGS-based Molecular diagnosis of 105 eyeGENE® probands with Retinitis Pigmentosa ▶     Zhongqi Ge, Kristen Bowles, Kerry Goetz et al.     The National Ophthalmic Disease Genotyping and Phenotyping Network (eyeGENE®) was established in an effort to facilitate basic and clinical research of human inherited eye …             A Large-scale Survey of CRF55_01B from Men-Who-Have-Sex-with-Men in China: implying the Evolutionary History and Public Health Impact ▶     Xiaoxu Han, Yutaka Takebe, Weiqing Zhang et al.     The HIV-1 epidemic among men-who-have-sex-with-men (MSM) continues to expand in China, involving the co-circulation of several different lineages of HIV-1 strains, including …             MycoCAP - Mycobacterium Comparative Analysis Platform ▶     Siew Woh Choo, Mia Yang Ang, Avirup Dutta et al.     Mycobacterium spp. are renowned for being the causative agent of diseases like leprosy, Buruli ulcer and tuberculosis in human beings. With more and more mycobacterial genomes …             Physical activity in adulthood: genes and mortality ▶     Sira Karvinen, Katja Waller, Mika Silvennoinen et al.     Observational studies report a strong inverse relationship between leisure-time physical activity and all-cause mortality. Despite suggestive evidence from population-based …             A combined system of microbial fuel cell and intermittently aerated biological filter for energy self-sufficient wastewater treatment ▶     Yue Dong, Yujie Feng, Youpeng Qu et al.     Energy self-sufficiency is a highly desirable goal of sustainable wastewater treatment. Herein, a combined system of a microbial fuel cell and an intermittently aerated …             Comparative study of diversity based on heat tolerant-related morpho-physiological traits and molecular markers in tall fescue accessions ▶     Xiaoyan Sun, Yan Xie, Yufang Bi et al.     Heat stress is a critical challenge to tall fescue (Festuca arundinacea Schreb.) in many areas of the globe and variations in genetic structure and functional traits is for the …             Dissociating sensory from decision processes in human perceptual decision making ▶     Pim Mostert, Peter Kok, Floris P. de Lange     A key question within systems neuroscience is how the brain translates physical stimulation into a behavioral response: perceptual decision making. To answer this question, it is …             DeFiNe: an optimisation-based method for robust disentangling of filamentous networks ▶     David Breuer, Zoran Nikoloski     Thread-like structures are pervasive across scales, from polymeric proteins to root systems to galaxy filaments, and their characteristics can be readily investigated in the …             A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation ▶     Hiroaki Fujimori, Akira Sato, Sota Kikuhara et al.     A comprehensive genome-wide screen of radiosensitization targets in HeLa cells was performed using a shRNA-library/functional cluster analysis and DNMT3B was identified as a …             A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions ▶     Thomas Bertero, Katherine A. Cottrill, Sofia Annis et al.     The molecular origins of fibrosis affecting multiple tissue beds remain incompletely defined. Previously, we delineated the critical role of the control of extracellular matrix …             A simple coculture system shows mutualism between anaerobic faecalibacteria and epithelial Caco-2 cells ▶     Mehdi Sadaghian Sadabad, Julius Z. H. von Martels, Muhammed Tanweer Khan et al.     Most gut bacteria are obligate anaerobes and are important for human health. However, little mechanistic insight is available on the health benefits of specific anaerobic gut …             Variants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in China ▶     Xingyuan Jiao, Ying Wu, Liansuo Zhou et al.     The role of FEN1 genetic variants on gallstone and gallbladder cancer susceptibility is unknown. FEN1 SNPs were genotyped using the polymerase chain reaction-restriction fragment …             6-Amidopyrene as a label-assisted laser desorption/ionization (LA-LDI) enhancing tag: development of photoaffinity pyrene derivative ▶     Kozo Yoneda, Yaping Hu, Masaki Kita et al.     Pyrene-conjugated compounds are detected by label-assisted laser desorption/ionization mass spectrometry (LA-LDI MS) without matrixes. We found that 6-amidopyrene derivatives …             The Influence of OLR1 and PCSK9 Gene Polymorphisms on Ischemic Stroke: Evidence from a Meta-Analysis ▶     Anthony Au, Lyn R. Griffiths, Kian-Kai Cheng et al.     Both OLR1 and PCSK9 genes are associated with atherosclerosis, cardiovascular disease and ischemic stroke. The overall prevalence of PCSK9 rs505151 and OLR1 rs11053646 variants …             Annexin A1 Deficiency does not Affect Myofiber Repair but Delays Regeneration of Injured Muscles ▶     Evgenia Leikina, Aurelia Defour, Kamran Melikov et al.     Repair and regeneration of the injured skeletal myofiber involves fusion of intracellular vesicles with sarcolemma and fusion of the muscle progenitor cells respectively. In vitro…             Heterogeneity in the spread and control of infectious disease: consequences for the elimination of canine rabies ▶     Elaine A. Ferguson, Katie Hampson, Sarah Cleaveland et al.     Understanding the factors influencing vaccination campaign effectiveness is vital in designing efficient disease elimination programmes. We investigated the importance of spatial …             Increased co-expression of genes harboring the damaging de novo mutations in Chinese schizophrenic patients during prenatal development ▶     Qiang Wang, Miaoxin Li, Zhenxing Yang et al.     Schizophrenia is a heritable, heterogeneous common psychiatric disorder. In this study, we evaluated the hypothesis that de novo variants (DNVs) contribute to the pathogenesis of …             Distinct promoter activation mechanisms modulate noise-driven HIV gene expression ▶     Arvind K. Chavali, Victor C. Wong, Kathryn Miller-Jensen     Latent human immunodeficiency virus (HIV) infections occur when the virus occupies a transcriptionally silent but reversible state, presenting a major obstacle to cure. There is …             A Microperfusion and In-Bore Oxygenator System Designed for Magnetic Resonance Microscopy Studies on Living Tissue Explants ▶     Jeremy J. Flint, Kannan Menon, Brian Hansen et al.     Spectrometers now offer the field strengths necessary to visualize mammalian cells but were not designed to accommodate imaging of live tissues. 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