Scientific Reports Biology Table of Contents e-alert: 15 December 2015

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15 December 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports       The discussion on Alzheimer’s Disease continues Nature Neuroscience presents a community forum on Alzheimer's Disease (AD) research. ACCESS NOW to view videos of our panel event at SfN 2015, read related articles for free, and discuss critical issues facing AD research today. Produced with support from Eli Lilly and Company and vTv Therapeutics         Biological Sciences               Erratum: Auxenochlorella protothecoides and Prototheca wickerhamii plastid genome sequences give insight into the origins of non-photosynthetic algae ▶     Dong Yan, Yun Wang, Tatsuya Murakami et al.                 Sex differences in social modulation of learning in rats ▶     Marta Mikosz, Aleksandra Nowak, Tomasz Werka et al.     In its simplest form, empathy can be characterized as the capacity to share the emotional experiences among individuals, a phenomenon known as emotional contagion. Recent …             Encoding of frequency-modulation (FM) rates in human auditory cortex ▶     Hidehiko Okamoto, Ryusuke Kakigi     Frequency-modulated sounds play an important role in our daily social life. However, it currently remains unclear whether frequency modulation rates affect neural activity in the …             Disassembly of the self-assembled, double-ring structure of proteasome α7 homo-tetradecamer by α6 ▶     Kentaro Ishii, Masanori Noda, Hirokazu Yagi et al.     The 20S core particle of the eukaryotic proteasome is composed of two α- and two β-rings, each of which is a hetero-heptamer composed of seven homologous but distinct subunits. …             Corrigendum: Contribution and distribution of inorganic ions and organic compounds to the osmotic adjustment in Halostachys caspica response to salt stress ▶     Youling Zeng, Ling Li, Ruirui Yang et al.                 Erratum: The effect of background music on episodic memory and autonomic responses: listening to emotionally touching music enhances facial memory capacity ▶     Alice Mado Proverbio, Valentina Lozano Nasi, Laura Alessandra Arcari et al.                 Corrigendum: Reducing the stress of drug administration: implications for the 3Rs ▶     Sarah A. Stuart, Emma S.J. Robinson                 Corrigendum: Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure ▶     Joachim M. Gerhold, Şirin Cansiz-Arda, Madis Lõhmus et al.                 Development of insect resistant maize plants expressing a chitinase gene from the cotton leaf worm, Spodoptera littoralis ▶     Gamal H. Osman, Shireen K. Assem, Rasha M. Alreedy et al.     Due to the importance of chitinolytic enzymes for insect, nematode and fungal growth, they are receiving attention concerning their development as biopesticides or chemical …             Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety ▶     Luca Carnevali, Federica Vacondio, Stefano Rossi et al.     In humans, chronic anxiety represents an independent risk factor for cardiac arrhythmias and sudden death. Here we evaluate in male Wistar rats bred for high (HAB) and low (LAB) …             Stochasticity in economic losses increases the value of reputation in indirect reciprocity ▶     Miguel dos Santos, Sarah Placì, Claus Wedekind     Recent theory predicts harsh and stochastic conditions to generally promote the evolution of cooperation. Here, we test experimentally whether stochasticity in economic losses …             Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium ▶     Chun-Yu Chen, Yann-Lii Leu, Yu Fang et al.     The leaves of Perilla frutescens (L.) Britt. have been traditionally used as an herbal medicine in East Asian countries to treat a variety diseases. In this present study, we …             Developmental validation of an X-Insertion/Deletion polymorphism panel and application in HAN population of China ▶     Suhua Zhang, Kuan Sun, Yingnan Bian et al.     InDels are short-length polymorphisms characterized by low mutation rates, high inter-population diversity, short amplicon strategy and simplicity of laboratory analysis. This …             Electroporation on microchips: the harmful effects of pH changes and scaling down ▶     Yang Li, Mengxi Wu, Deyao Zhao et al.     Electroporation has been widely used in delivering foreign biomolecules into cells, but there is still much room for improvement, such as cell viability and integrity. In this …             Identification of mycoparasitism-related genes in Clonostachys rosea 67-1 active against Sclerotinia sclerotiorum ▶     Zhan-Bin Sun, Man-Hong Sun, Shi-Dong Li     Clonostachys rosea is a mycoparasite that has shown great potential in controlling various plant fungal pathogens. In order to find mycoparasitism-related genes in C. rosea, the …             Akbu-LAAO exhibits potent anti-tumor activity to HepG2 cells partially through produced H2O2via TGF-β signal pathway ▶     Chunmei Guo, Shuqing Liu, Panpan Dong et al.     Previously, we characterized the biological properties of Akbu-LAAO, a novel L-amino acid oxidase from Agkistrodon blomhoffii ussurensis snake venom (SV). Current work …             Synergistic effect of ATP for RuvA–RuvB–Holliday junction DNA complex formation ▶     Takuma Iwasa, Yong-Woon Han, Ryo Hiramatsu et al.     The Escherichia coli RuvB hexameric ring motor proteins, together with RuvAs, promote branch migration of Holliday junction DNA. Zero mode waveguides (ZMWs) constitute of …             MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome ▶     Elena Chiavacci, Romina D’Aurizio, Elena Guzzolino et al.     Holt-Oram Syndrome (HOS) is an autosomal dominant heart-hand syndrome caused by mutations in the TBX5 gene, a transcription factor capable of regulating hundreds of …             Combination of NTP with cetuximab inhibited invasion/migration of cetuximab-resistant OSCC cells: Involvement of NF-κB signaling ▶     Jae Won Chang, Sung Un Kang, Yoo Seob Shin et al.     Although the epidermal growth factor receptor (EGFR) is an established target in head-and-neck cancer (HNC), resistance to EGFR-targeted therapy mediated by various mechanisms …             Origins of Cell-to-Cell Bioprocessing Diversity and Implications of the Extracellular Environment Revealed at the Single-Cell Level ▶     A. E. Vasdekis, A. M. Silverman, G. Stephanopoulos     Bioprocess limitations imposed by microbial cell-to-cell phenotypic diversity remain poorly understood. To address this, we investigated the origins of such culture diversity …             Methoprene-tolerant (Met) and Krüpple-homologue 1 (Kr-h1) are required for ovariole development and egg maturation in the brown plant hopper ▶     Xinda Lin, Yun Yao, Bo Wang     The brown plant hopper is one of the most destructive known pests of rice. We studied the roles of the JH receptor Met and the downstream transcription factor Kr-h1 in ovariole …             Comparison of the depolarization response of human mesenchymal stem cells from different donors ▶     Sarah Sundelacruz, Michael Levin, David L. Kaplan     Bioelectric signaling is currently being explored as a novel regulator of cell processes in non-excitable cells. In particular, stem cells have demonstrated increasing evidence …             Generosity motivated by acceptance - evolutionary analysis of an anticipation game ▶     I. Zisis, S. Di Guida, T. A. Han et al.     We here present both experimental and theoretical results for an Anticipation Game, a two-stage game wherein the standard Dictator Game is played after a matching phase wherein …             The Saccharomyces cerevisiae poly(A) binding protein Pab1 as a target for eliciting stress tolerant phenotypes ▶     Francesca Martani, Francesca Marano, Stefano Bertacchi et al.     When exploited as cell factories, Saccharomyces cerevisiae cells are exposed to harsh environmental stresses impairing titer, yield and productivity of the fermentative …             RNAi mediated inhibition of viroid infection in transgenic plants expressing viroid-specific small RNAs derived from various functional domains ▶     Charith Raj Adkar-Purushothama, Atsushi Kasai, Kohei Sugawara et al.     Previous attempts to develop RNAi-mediated viroid-resistant transgenic plants using nearly full-length Potato spindle tuber viroid (PSTVd) hairpin RNA (hpRNA) were successful; …             RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders ▶     Valérie Grandjean, Sandra Fourré, Diana Andrea Fernandes De Abreu et al.     The paternal heredity of obesity and diabetes induced by a high-fat and/or high-sugar diet (Western-like diet) has been demonstrated through epidemiological analysis of human …             Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells ▶     Yiqiang Zhang, Jiang F Zhong, Hongyu Qiu et al.     It has been believed that mammalian adult cardiomyocytes (ACMs) are terminally-differentiated and are unable to proliferate. Recently, using a bi-transgenic ACM fate mapping …             Simvastatin suppresses breast cancer cell proliferation induced by senescent cells ▶     Su Liu, Harpreet Uppal, Marco Demaria et al.     Cellular senescence suppresses cancer by preventing the proliferation of damaged cells, but senescent cells can also promote cancer though the pro-inflammatory …             Broadband activation by white-opsin lowers intensity threshold for cellular stimulation ▶     Subrata Batabyal, Gregory Cervenka, David Birch et al.     Photoreceptors, which initiate the conversion of ambient light to action potentials via retinal circuitry, degenerate in retinal diseases such as retinitis pigmentosa and age …             Resistance Mechanisms and Molecular Docking Studies of Four Novel QoI Fungicides in Peronophythora litchii ▶     Yuxin Zhou, Lei Chen, Jian Hu et al.     Peronophythora litchii is the causal agent of litchi downy blight. Enestroburin, SYP-1620, SYP-2815 and ZJ0712 are four novel QoI fungicides developed by China. Eight mutants of …             Long-term xeno-free culture of human pluripotent stem cells on hydrogels with optimal elasticity ▶     Akon Higuchi, Shih-Hsuan Kao, Qing-Dong Ling et al.     The tentative clinical application of human pluripotent stem cells (hPSCs), such as human embryonic stem cells and human induced pluripotent stem cells, is restricted by the …             Impact of oil spills on coral reefs can be reduced by bioremediation using probiotic microbiota ▶     Henrique Fragoso ados Santos, Gustavo Adolpho Santos Duarte, Caio TavoraCoelho da Costa Rachid et al.     Several anthropogenic factors, including contamination by oil spills, constitute a threat to coral reef health. Current methodologies to remediate polluted marine environments …             A novel single-chain antibody redirects adenovirus to IL13Rα2-expressing brain tumors ▶     Julius W. Kim, Jacob S. Young, Elena Solomaha et al.     The generation of a targeting agent that strictly binds to IL13Rα2 will significantly expand the therapeutic potential for the treatment of IL13Rα2-expressing cancers. In order …             Effects of green and red light in βL-crystallin and ovalbumin ▶     J. Horacio Espinoza, Elizabeth Reynaga-Hernández, Jaime Ruiz-García et al.     The effects of visible light on biological systems have been widely studied. In particular, the alterations of blue light on the ocular lens have recently attracted much …             PEGylated silica-enzyme nanoconjugates: a new frontier in large scale separation of α-amylase ▶     Seyed Mohsen Dehnavi, Gholamreza Pazuki, Manouchehr Vossoughi     High resolution is nearly lost at the expense of throughput in most conventional bioseparation methods. Nanoparticles, due to their high surface to volume ratio, are …             Direct Evidence that Myocardial Insulin Resistance following Myocardial Ischemia Contributes to Post-Ischemic Heart Failure ▶     Feng Fu, Kun Zhao, Jia Li et al.     A close link between heart failure (HF) and systemic insulin resistance has been well documented, whereas myocardial insulin resistance and its association with HF are …             Strategies for Early Vaccination During Novel Influenza Outbreaks ▶     M. Laskowski, Y. Xiao, N. Charland et al.     Ongoing research and technology developments hold the promise of rapid production and large-scale deployment of strain-specific or cross-protective vaccines for novel influenza …             Integrating longitudinal serum IL-17 and IL-23 follow-up, along with autoantibodies variation, contributes to predict bullous pemphigoid outcome ▶     Julie Plée, Sébastien Le Jan, Jérôme Giustiniani et al.     Bullous pemphigoid (BP) is an inflammatory autoimmune bullous disease involving cytokines and proteases in the process of blister formation. Recently, IL-17 and IL-23 were …             Regulation of Bacterial DNA Packaging in Early Stationary Phase by Competitive DNA Binding of Dps and IHF ▶     Sin Yi Lee, Ci Ji Lim, Peter Dröge et al.     The bacterial nucleoid, a bacterial genome packed by nucleoid binding proteins, forms the physical basis for cellular processes such as gene transcription and DNA replication. …             Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro ▶     Zhonghao Su, Jin Ye, Zhenxia Qin et al.     Madecassoside (MA), a triterpenoid saponin isolated from C. asitica, exerts various pharmacological activity including antioxidative and antinflammatory. Doxorubicin (DOX), a …             Differential Plasmodium falciparum surface antigen expression among children with Malarial Retinopathy ▶     Abdirahman I. Abdi, Symon M Kariuki, Michelle K. Muthui et al.     Retinopathy provides a window into the underlying pathology of life-threatening malarial coma (“cerebral malaria”), allowing differentiation between 1) coma caused by …             An efficient planar accordion-shaped micromixer: from biochemical mixing to biological application ▶     Armando Cosentino, Hojjat Madadi, Paola Vergara et al.     Micromixers are the key component that allow lab-on-a-chip and micro total analysis systems to reach the correct level of mixing for any given process. This paper proposes a …             Gene silencing of TACE enhances plaque stability and improves vascular remodeling in a rabbit model of atherosclerosis ▶     Xueqiang Zhao, Jing Kong, Yuxia Zhao et al.     We aimed to test the hypothesis that gene silencing of tumor necrosis factor alpha converting enzyme (TACE) may attenuate lesion inflammation and positive vascular remodeling and …             Zepto-molar electrochemical detection of Brucella genome based on gold nanoribbons covered by gold nanoblooms ▶     Amid Rahi, Naghmeh Sattarahmady, Hossein Heli     Gold nanoribbons covered by gold nanoblooms were sonoelectrodeposited on a polycrystalline gold surface at −1800 mV (vs. AgCl) with the assistance of ultrasound and co-occurrence …             Protective immune barrier against hepatitis B is needed in individuals born before infant HBV vaccination program in China ▶     Shigui Yang, Chengbo Yu, Ping Chen et al.     The hepatitis B prevalence rate in adults is still at a high to intermediate level in China. Our purpose was to explore the incidence rate and protective immune barrier against …             The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis ▶     Ruchi Bansal, Joop van Baarlen, Gert Storm et al.     Hepatic stellate cells (HSCs) known as “master producers” and macrophages as “master regulators”, are the key cell types that strongly contribute to the progression of liver …             Suspended sediments limit coral sperm availability ▶     Gerard F. Ricardo, Ross J. Jones, Peta L. Clode et al.     Suspended sediment from dredging activities and natural resuspension events represent a risk to the reproductive processes of coral, and therefore the ongoing maintenance of …             Anomalous Dynamics of a Lipid Recognition Protein on a Membrane Surface ▶     Eiji Yamamoto, Antreas C. Kalli, Takuma Akimoto et al.     Pleckstrin homology (PH) domains are lipid-binding modules present in peripheral membrane proteins which interact with phosphatidyl-inositol phosphates (PIPs) in cell membranes. …             Electrogenic transport and K+ ion channel expression by the human endolymphatic sac epithelium ▶     Sung Huhn Kim, Bo Gyung Kim, Jin Young Kim et al.     The endolymphatic sac (ES) is a cystic organ that is a part of the inner ear and is connected to the cochlea and vestibule. The ES is thought to be involved in inner ear ion …             Screening of the key volatile organic compounds of Tuber melanosporum fermentation by aroma sensory evaluation combination with principle component analysis ▶     Rui-Sang Liu, Guang-Huai Jin, Deng-Rong Xiao et al.     Aroma results from the interplay of volatile organic compounds (VOCs) and the attributes of microbial-producing aromas are significantly affected by fermentation conditions. …             Comparative genomics Lactobacillus reuteri from sourdough reveals adaptation of an intestinal symbiont to food fermentations ▶     Jinshui Zheng, Xin Zhao, Xiaoxi B. Lin et al.     Lactobacillus reuteri is a dominant member of intestinal microbiota of vertebrates, and occurs in food fermentations. The stable presence of L. reuteri in sourdough provides the …             miR-140-5p regulates adipocyte differentiation by targeting transforming growth factor-β signaling ▶     Xin Zhang, Ailing Chang, Yongmei Li et al.     Recent emerging studies of miRNAs in adipocyte commitment provide new insights to understand the molecular basis of adipogenesis. The current study indicated that miR-140-5p was …             Analysis of histone modifications at human ribosomal DNA in liver cancer cell ▶     Feng Yu, Xingyong Shen, Li Fan et al.     Human liver cancer is the cancer commonly seen clinically. The transcription of ribosomal DNA (rDNA) is a critical step for cells, and epigenetic marks such as post-translational …             The impact of rearing environment on the development of gut microbiota in tilapia larvae ▶     Christos Giatsis, Detmer Sipkema, Hauke Smidt et al.     This study explores the effect of rearing environment on water bacterial communities (BC) and the association with those present in the gut of Nile tilapia larvae (Oreochromis …             Enhanced performance of an innovative dengue IgG/IgM rapid diagnostic test using an anti-dengue EDI monoclonal antibody and dengue virus antigen ▶     Jihoo Lee, Young-Eun Kim, Hak-Yong Kim et al.     High levels of anti-dengue IgM or IgG can be detected using numerous rapid diagnostic tests (RDTs). However, the sensitivity and specificity of these tests are reduced by changes …             Functional trait responses to grazing are mediated by soil moisture and plant functional group identity ▶     Shuxia Zheng, Wenhuai Li, Zhichun Lan et al.     Abundant evidence has shown that grazing alters plant functional traits, community structure and ecosystem functioning of grasslands. Few studies, however, have tested how plant …             Novel green tissue-specific synthetic promoters and cis-regulatory elements in rice ▶     Rui Wang, Menglin Zhu, Rongjian Ye et al.     As an important part of synthetic biology, synthetic promoter has gradually become a hotspot in current biology. The purposes of the present study were to synthesize green …             Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy ▶     Patricio V. Sepulveda, Séverine Lamon, Adam Hagg et al.     Follistatin is an inhibitor of TGF-β superfamily ligands that repress skeletal muscle growth and promote muscle wasting. Accordingly, follistatin has emerged as a potential …             Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression ▶     Shui-Xing Yu, Chong-Tao Du, Wei Chen et al.     Inflammasomes are cytoplasmic, multiprotein complexes that trigger caspase-1 activation and IL-1β maturation in response to diverse stimuli. Although inflammasomes play important …             Repression of AKT signaling by ARQ 092 in cells and tissues from patients with Proteus syndrome ▶     Marjorie J. Lindhurst, Miranda R. Yourick, Yi Yu et al.     A somatic activating mutation in AKT1, c.49G>A, pGlu17Lys, that results in elevated AKT signaling in mutation-positive cells, is responsible for the mosaic overgrowth condition, …             Systematic investigation and microbial community profile of indole degradation processes in two aerobic activated sludge systems ▶     Qiao Ma, Yuanyuan Qu, Xuwang Zhang et al.     Indole is widely spread in various environmental matrices. Indole degradation by bacteria has been reported previously, whereas its degradation processes driven by aerobic …             Integrated analysis of global proteome, phosphoproteome, and glycoproteome enables complementary interpretation of disease-related protein networks ▶     Jong-Moon Park, Ji-Hwan Park, Dong-Gi Mun et al.     Multi-dimensional proteomic analyses provide different layers of protein information, including protein abundance and post-translational modifications. Here, we report an …             Improvement of genome assembly completeness and identification of novel full-length protein-coding genes by RNA-seq in the giant panda genome ▶     Meili Chen, Yibo Hu, Jingxing Liu et al.     High-quality and complete gene models are the basis of whole genome analyses. The giant panda (Ailuropoda melanoleuca) genome was the first genome sequenced on the basis of …             IFN-γ modulates Ly-49 receptors on NK cells in IFN-γ-induced pregnancy failure ▶     Zhong-Yin Li, Zhi-Hui Song, Chao-Yang Meng et al.     We have previously shown that interferon gamma (IFN-γ) induces aberrant CD49b+ natural killer (NK) cell recruitment by regulating CX3CL1 and eventually provokes foetal loss. In …             Fancb deficiency impairs hematopoietic stem cell function ▶     Wei Du, Surya Amarachintha, Ozlem Erden et al.     Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure, variable congenital malformations and a predisposition to malignancies. FANCB (also known as FAAP95…             Identification of climate factors related to human infection with avian influenza A H7N9 and H5N1 viruses in China ▶     Jing Li, Yuhan Rao, Qinglan Sun et al.     Human influenza infections display a strongly seasonal pattern. However, whether H7N9 and H5N1 infections correlate with climate factors has not been examined. Here, we analyzed …             The transcription factor ccaat/enhancer binding protein β (C/EBPβ) and miR-27a regulate the expression of porcine Dickkopf2 (DKK2) ▶     Hu Tao, Lei Wang, Jiawei Zhou et al.     Using Affymetrix porcine Gene-Chip analyses, we found that Dickkopf2 (DKK2), a WNT antagonist, is differentially expressed in pre-ovulatory follicles between Large White and …             Mitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells ▶     Moshe Giladi, Rosa S Schneiderman, Tali Voloshin et al.     Tumor Treating Fields (TTFields) are low intensity, intermediate frequency, alternating electric fields. TTFields are a unique anti-mitotic treatment modality delivered in a …             The Spatial and Temporal Transcriptomic Landscapes of Ginseng, Panax ginseng C. A. Meyer ▶     Kangyu Wang, Shicui Jiang, Chunyu Sun et al.     Ginseng, including Asian ginseng (Panax ginseng C. A. Meyer) and American ginseng (P. quinquefolius L.), is one of the most important medicinal herbs in Asia and North America, …             Identifying transcription start sites and active enhancer elements using BruUV-seq ▶     Brian Magnuson, Artur Veloso, Killeen S. Kirkconnell et al.     BruUV-seq utilizes UV light to introduce transcription-blocking DNA lesions randomly in the genome prior to bromouridine-labeling and deep sequencing of nascent RNA. By …             Quantitative analysis of changes in the phosphoproteome of maize induced by the plant hormone salicylic acid ▶     Liuji Wu, Xiuli Hu, Shunxi Wang et al.     Phytohormone salicylic acid (SA) plays an important role in regulating various physiological and biochemical processes. Our previous study identified several protein kinases …             Uncovering MicroRNA Regulatory Hubs that Modulate Plasma Cell Differentiation ▶     Dong-Yan Tsai, Kuo-Hsuan Hung, I-Ying Lin et al.     Using genome-wide approaches, we studied the microRNA (miRNA) expression profile during human plasma cell (PC) differentiation induced by stimulation of human blood B cells with …             Microspectrometric insights on the uptake of antibiotics at the single bacterial cell level ▶     Bertrand Cinquin, Laure Maigre, Elizabeth Pinet et al.     Bacterial multidrug resistance is a significant health issue. A key challenge, particularly in Gram-negative antibacterial research, is to better understand membrane permeation …             Electrophysiological effects of non-invasive Radio Electric Asymmetric Conveyor (REAC) on thalamocortical neural activities and perturbed experimental conditions ▶     Antonio G. Zippo, Salvatore Rinaldi, Giulio Pellegata et al.     The microwave emitting Radio Electric Asymmetric Conveyor (REAC) is a technology able to interact with biological tissues at low emission intensity (2 mW at the emitter and 2.4 …             A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys ▶     Eric J. Smith, Kara Olson, Lauric J. Haber et al.     Bispecific antibodies, while showing great therapeutic potential, pose formidable challenges with respect to their assembly, stability, immunogenicity, and pharmacodynamics. Here …             Transcriptome analysis identifies genes involved in adventitious branches formation of Gracilaria lichenoides in vitro ▶     Wenlei Wang, Huanqin Li, Xiangzhi Lin et al.     Tissue culture could solve the problems associated with Gracilaria cultivation, including the consistent supply of high-quality seed stock, strain improvement, and efficient mass …             Knockdown of a nutrient amino acid transporter gene LdNAT1 reduces free neutral amino acid contents and impairs Leptinotarsa decemlineata pupation ▶     Kai-Yun Fu, Wen-Chao Guo, Tursun Ahmat et al.     A Leptinotarsa decemlineata SLC6 NAT gene (LdNAT1) was cloned. LdNAT1 was highly expressed in the larval alimentary canal especially midgut. LdNAT1 mRNA levels were high right …             Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy ▶     Anna Baulies, Vicent Ribas, Susana Núñez et al.     The role of lysosomes in acetaminophen (APAP) hepatotoxicity is poorly understood. Here, we investigated the impact of genetic and drug-induced lysosomal cholesterol (LC) …             Infectious dengue vesicles derived from CD61+ cells in acute patient plasma exhibited a diaphanous appearance ▶     Alan Yi-Hui Hsu, Shang-Rung Wu, Jih-Jin Tsai et al.     The levels of neutralizing antibody to a pathogen are an effective indicator to predict efficacy of a vaccine in trial. And yet not all the trial vaccines are in line with the …             Variant fatty acid-like molecules Conjugation, novel approaches for extending the stability of therapeutic peptides ▶     Ying Li, Yuli Wang, Qunchao Wei et al.     The multiple physiological properties of glucagon-like peptide-1 (GLP-1) make it a promising drug candidate for the treatment of type 2 diabetes. However, the in vivo half-life …             Determination of the source of SHG verniers in zebrafish skeletal muscle ▶     William P. Dempsey, Nathan O. Hodas, Aaron Ponti et al.     SHG microscopy is an emerging microscopic technique for medically relevant imaging because certain endogenous proteins, such as muscle myosin lattices within muscle cells, are …             Radiobiological modeling analysis of the optimal fraction scheme in patients with peripheral non-small cell lung cancer undergoing stereotactic body radiotherapy ▶     Bao-Tian Huang, Jia-Yang Lu, Pei-Xian Lin et al.     This study aimed to determine the optimal fraction scheme (FS) in patients with small peripheral non-small cell lung cancer (NSCLC) undergoing stereotactic body radiotherapy …             Critical roles for murine Reck in the regulation of vascular patterning and stabilization ▶     Glícia Maria de Almeida, Mako Yamamoto, Yoko Morioka et al.     Extracellular matrix (ECM) is known to play several important roles in vascular development, although the molecular mechanisms behind these remain largely unknown. RECK, a tumor …             Difference in left renal vein pressure: an indicator for free of reconstruction after ligation in retroperitoneal tumor patients ▶     Chengli Miao, Mengmeng Xiao, Tengyan Li et al.     We hypothesized that the left renal vein pressure difference (ΔP) before and after the ligation can serve as an objective indicator for free of reconstruction after resection of …             Intrinsic Localized Modes in Proteins ▶     Adrien Nicolaï, Patrice Delarue, Patrick Senet     Protein dynamics is essential for proteins to function. Here we predicted the existence of rare, large nonlinear excitations, termed intrinsic localized modes (ILMs), of the main …             A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles ▶     Peilin Yu, Jin Li, Jialin Jiang et al.     Silica nanoparticles (NPs) have remarkable applications. However, accumulating evidence suggests NPs can cause cellular toxicity by inducing ROS production and increasing …             Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells ▶     Henning Gram Hansen, Claes Nymand Nilsson, Anne Mathilde Lund et al.     Chinese hamster ovary (CHO) cells are widely used as cell factories for the production of biopharmaceuticals. In contrast to the highly optimized production processes for …             Structural and functional interactions between six-transmembrane μ-opioid receptors and β2-adrenoreceptors modulate opioid signaling ▶     Alexander Samoshkin, Marino Convertino, Chi T. Viet et al.     The primary molecular target for clinically used opioids is the μ-opioid receptor (MOR). Besides the major seven-transmembrane (7TM) receptors, the MOR gene codes for …             Constructing 3D microtubule networks using holographic optical trapping ▶     J. Bergman, O. Osunbayo, M. Vershinin     Developing abilities to assemble nanoscale structures is a major scientific and engineering challenge. We report a technique which allows precise positioning and manipulation of …             Podocyte injury in diabetic nephropathy: implications of angiotensin II – dependent activation of TRPC channels ▶     Daria V. Ilatovskaya, Vladislav Levchenko, Andrea Lowing et al.     Injury to podocytes is considered a major contributor to diabetic kidney disease: their loss causes proteinuria and progressive glomerulosclerosis. Podocyte depletion may result …             Cross-species conservation of complementary amino acid-ribonucleobase interactions and their potential for ribosome-free encoding ▶     John G. D. Cannon, Rachel M. Sherman, Victoria M. Y. Wang et al.     The role of amino acid-RNA nucleobase interactions in the evolution of RNA translation and protein-mRNA autoregulation remains an open area of research. We describe the inference …             Effects of warming on ectomycorrhizal colonization and nitrogen nutrition of Picea asperata seedlings grown in two contrasting forest ecosystems ▶     Yuejiao Li, Didi Sun, Dandan Li et al.     Ectomycorrhiza (ECM) plays an important role in plant nitrogen (N) nutrition and regulates plant responded to climate warming. We conducted a field experiment in a natural forest …             Transgenic banana plants expressing Xanthomonas wilt resistance genes revealed a stable non-target bacterial colonization structure ▶     Jean Nimusiima, Martina Köberl, John Baptist Tumuhairwe et al.     Africa is among the continents where the battle over genetically modified crops is currently being played out. The impact of GM in Africa could potentially be very positive. In Ug…             Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice ▶     Patricia Pazos, Luis Lima, Sulay Tovar et al.     Brown and beige adipocytes recruitment in brown (BAT) or white adipose tissue, mainly in the inguinal fat pad (iWAT), meet the need for temperature adaptation in cold-exposure …             FgMon1, a guanine nucleotide exchange factor of FgRab7, is important for vacuole fusion, autophagy and plant infection in Fusarium graminearum ▶     Ying Li, Bing Li, Luping Liu et al.     The Ccz1-Mon1 protein complex, the guanine nucleotide exchange factor (GEF) of the late endosomal Rab7 homolog Ypt7, is required for the late step of multiple vacuole delivery …             Cartilage development requires the function of Estrogen-related receptor alpha that directly regulates sox9 expression in zebrafish ▶     Yong-Il Kim, Joon No Lee, Sushil Bhandari et al.     Estrogen-related receptor alpha (ESRRa) regulates a number of cellular processes including development of bone and muscles. However, direct evidence regarding its involvement in …             Proteomic analysis of symbiotic proteins of Glomus mosseae and Amorpha fruticosa ▶     Fuqiang Song, Dandan Qi, Xuan Liu et al.     Arbuscular mycorrhiza fungi (AMF) can colonize the roots of Amorpha fruticosa, a perennial leguminous woody shrub, and form arbuscular mycorrhiza (AM). AMF have significant …             Genome-wide SNP analysis explains coral diversity and recovery in the Ryukyu Archipelago ▶     Chuya Shinzato, Sutada Mungpakdee, Nana Arakaki et al.     Following a global coral bleaching event in 1998, Acropora corals surrounding most of Okinawa island (OI) were devastated, although they are now gradually recovering. In …             Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S ▶     Gordon Y. C. Cheung, Anthony J. Yeh, Dorothee Kretschmer et al.     Staphylococcus aureus δ-toxin is a member of the phenol-soluble modulin (PSM) peptide family. PSMs have multiple functions in staphylococcal pathogenesis; for example, they lyse …             A behavioral defect of temporal association memory in mice that partly lack dopamine reuptake transporter ▶     Shining Deng, Lingli Zhang, Tailin Zhu et al.     Temporal association memory, like working memory, is a type of episodic memory in which temporally discontinuous elements are associated. However, the mechanisms that govern this …             Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons ▶     Miguel Veas-Pérez de Tudela, Carolina Maestre, María Delgado-Esteban et al.     The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that regulates cell cycle progression in proliferating cells. To enter the S-phase, APC/C must be …             Nanoparticle-assisted optical tethering of endosomes reveals the cooperative function of dyneins in retrograde axonal transport ▶     Praveen D. Chowdary, Daphne L. Che, Luke Kaplan et al.     Dynein-dependent transport of organelles from the axon terminals to the cell bodies is essential to the survival and function of neurons. However, quantitative knowledge of …             The well-coordinated linkage between acidogenicity and aciduricity via insoluble glucans on the surface of Streptococcus mutans ▶     Lihong Guo, Jeffrey S. McLean, Renate Lux et al.     Streptococcus mutans is considered the principal cariogenic bacterium for dental caries. Despite the recognition of their importance for cariogenesis, the possible coordination …             Correlative cryo-fluorescence and cryo-scanning electron microscopy as a straightforward tool to study host-pathogen interactions ▶     Martin Strnad, Jana Elsterová, Jana Schrenková et al.     Correlative light and electron microscopy is an imaging technique that enables identification and targeting of fluorescently tagged structures with subsequent imaging at …             Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM) ▶     Megan L. Coghlan, Garth Maker, Elly Crighton et al.     Globally, there has been an increase in the use of herbal remedies including traditional Chinese medicine (TCM). There is a perception that products are natural, safe and …             A single-nucleotide exon found in Arabidopsis ▶     Lei Guo, Chun-Ming Liu     The presence of introns in gene-coding regions is one of the most mysterious evolutionary inventions in eukaryotic organisms. It has been proposed that, although sequences …             Context-dependent dynamic UV signaling in female three spine sticklebacks ▶     Meike Hiermes, Theo C. M. Bakker, Marion Mehlis et al.     Color signals, including ultraviolet (UV) signals, are widespread throughout the animal kingdom and color changes can be influenced by reproductive and motivational state. …             Polymorphisms of BCL2 and BAX Genes Associate with Outcomes in Advanced Non-small cell lung cancer Patients treated with platinum-based Chemotherapy ▶     Yu Peng, Linang Wang, Yi Qing et al.     Single-nucleotide polymorphisms (SNP) of the gene belonging to the BCL2 family are thought to play a role in chemotherapy resistance. This study investigated the association of …             CellMethy: Identification of a focal concordantly methylated pattern of CpGs revealed wide differences between normal and cancer tissues ▶     Fang Wang, Shaojun Zhang, Hongbo Liu et al.     DNA methylation patterns may serve as a key in determining cell phenotypes and functions. Adjacent CpG patterns may provide insight into methylation functional mechanisms. Some …             Antigen-dependent and –independent contributions to primary memory CD8 T cell activation and protection following infection ▶     Matthew D. Martin, Vladimir P. Badovinac     Memory CD8 T-cell activation, including expression of IFN-γ and granzymeB, can be induced by antigen (Ag)-dependent signals through the T-cell-receptor, or by pathogen-derived …             CRISPR/Cas9-mediated knockout of factors in non-homologous end joining pathway enhances gene targeting in silkworm cells ▶     Li Zhu, Hiroaki Mon, Jian Xu et al.     Gene targeting can be achieved by precise genetic modifications through homology-directed repair (HDR) after DNA breaks introduced by genome editing tools such as CRISPR/Cas9 …             Selection of reference genes for RT-qPCR analysis in a predatory biological control agent, Coleomegilla maculata (Coleoptera: Coccinellidae) ▶     Chunxiao Yang, Huipeng Pan, Jeffrey Edward Noland et al.     Reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) is a reliable technique for quantifying gene expression across various biological processes, of which …             Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode Schizophrenia: A Near-Infrared Spectroscopy Study ▶     Po-Han Chou, Wei-Hao Lin, Chih-Chien Lin et al.     A longer duration of untreated psychosis (DUP) has been associated with poor clinical outcomes in patients with schizophrenia (SZ); however, it remains unclear whether this is …             SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer ▶     Xiao-bin Lv, Lijuan Liu, Chun Cheng et al.     SUN2, a key component of LINC (linker of nucleoskeleton and cytoskeleton) complex located at the inner nuclear membrane, plays unknown role in lung cancer. We found that SUN2 …             Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives ▶     Kyle J. Korshavn, Milim Jang, Yeon Ju Kwak et al.     Both amyloid-β (Aβ) and transition metal ions are shown to be involved in the pathogenesis of Alzheimer’s disease (AD), though the importance of their interactions remains …             Biofortification of oilseed Brassica juncea with the anti-cancer compound glucoraphanin by suppressing GSL-ALK gene family ▶     Rehna Augustine, Naveen C. Bisht     Glucosinolates are amino acids derived secondary metabolites, invariably present in Brassicales, which have huge health and agricultural benefits. Sulphoraphane, the breakdown …             Only a minority of broad-range detoxification genes respond to a variety of phytotoxins in generalist Bemisia tabaci species ▶     Eyal Halon, Galit Eakteiman, Pnina Moshitzky et al.     Generalist insect can utilize two different modes for regulating their detoxification genes, the constitutive mode and the induced mode. Here, we used the Bemisia tabaci sibling …             NMR structure and function of Helicoverpa armigera sterol carrier protein-2, an important insecticidal target from the cotton bollworm ▶     Haihao Ma, Yuemin Ma, Xuehui Liu et al.     The cotton bollworm, Helicoverpa armigera, has developed strong resistance to many insecticides. Sterol Carrier Protein-2 (SCP-2) is an important non-specific lipid transfer …             Corresponding morphological and molecular indicators of crude oil toxicity to the developing hearts of mahi mahi ▶     Richard C. Edmunds, J. A. Gill, David H. Baldwin et al.     Crude oils from distinct geological sources worldwide are toxic to developing fish hearts. When oil spills occur in fish spawning habitats, natural resource injury assessments …             A G-protein-coupled receptor regulation pathway in cytochrome P450-mediated permethrin-resistance in mosquitoes, Culex quinquefasciatus ▶     Ting Li, Chuanwang Cao, Ting Yang et al.     Rhodopsin-like G protein-coupled receptors (GPCRs) are known to be involved in the GPCR signal transduction system and regulate many essential physiological processes in …             Discovery of Anti-inflammatory Ingredients in Chinese Herbal Formula Kouyanqing Granule based on Relevance Analysis between Chemical Characters and Biological Effects ▶     Hong Liu, Yan-fang Zheng, Chu-yuan Li et al.     Kouyanqing Granule (KYQG) is a traditional Chinese herbal formula composed of Flos lonicerae (FL), Radix scrophulariae (RS), Radix ophiopogonis (RO), Radix asparagi (RA), and …             Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway ▶     Min Liu, Youwei Xu, Xu Han et al.     The present work aimed to investigate the activities and underlying mechanisms of dioscin against alcoholic liver fibrosis (ALF). In vivo liver fibrosis in mice was induced by an …             Successful treatment of biofilm infections using shock waves combined with antibiotic therapy ▶     Divya Prakash Gnanadhas, Monalisha Elango, S. Janardhanraj et al.     Many bacteria secrete a highly hydrated framework of extracellular polymer matrix on suitable substrates and embed within the matrix to form a biofilm. Bacterial biofilms are …             Stronger warming effects on microbial abundances in colder regions ▶     Ji Chen, Yiqi Luo, Jianyang Xia et al.     Soil microbes play critical roles in regulating terrestrial carbon (C) cycle and its feedback to climate change. However, it is still unclear how the soil microbial community and …             Climate Change and the Evolution and Fate of the Tangier Islands of Chesapeake Bay, USA ▶     David M. Schulte, Karin M. Dridge, Mark H. Hudgins     Climate change and associated sea level rise (SLR) are already impacting low-lying coastal areas, including islands, throughout the world. Many of these areas are inhabited, many …             Circular analysis in complex stochastic systems ▶     Angelo Valleriani     Ruling out observations can lead to wrong models. This danger occurs unwillingly when one selects observations, experiments, simulations or time-series based on their outcome. In …             Antagonism of Nav channels and α1-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine ▶     Anne Virsolvy, Charlotte Farah, Nolwenn Pertuit et al.     Ranolazine is a recently developed drug used for the treatment of patients with chronic stable angina. It is a selective inhibitor of the persistent cardiac Na+ current (INa), …             Influence of ionic liquid and ionic salt on protein against the reactive species generated using dielectric barrier discharge plasma ▶     Pankaj Attri, Thapanut Sarinont, Minsup Kim et al.     The presence of salts in biological solution can affect the activity of the reactive species (RS) generated by plasma, and so they can also have an influence on the …             Is overexpression of TWIST, a transcriptional factor, a prognostic biomarker of head and neck carcinoma? Evidence from fifteen studies ▶     Xianlu Zhuo, Huanli Luo, Aoshuang Chang et al.     TWIST, a basic helix-loop-helix transcription factor, has been indicated to play a critical role in the progression of numerous malignant disorders. Published data on the …             Increased Variability of Genomic Transcription in Schizophrenia ▶     Fuquan Zhang, Yin Yao Shugart, Weihua Yue et al.     Schizophrenia (SZ) is a severe chronic mental disorder with a high heritability. Current microarray analyses typically focus on identifying differentially expressed genes or …             A method for reproducible measurements of serum BDNF: comparison of the performance of six commercial assays ▶     Alessio Polacchini, Giuliana Metelli, Ruggiero Francavilla et al.     Brain-Derived Neurotrophic Factor (BDNF) has attracted increasing interest as potential biomarker to support the diagnosis or monitor the efficacy of therapies in brain …             PTEN stabilizes TOP2A and regulates the DNA decatenation ▶     Xi Kang, Chang Song, Xiao Du et al.     PTEN is a powerful tumor suppressor that antagonizes the cytoplasmic PI3K-AKT pathway and suppresses cellular proliferation. PTEN also plays a role in the maintenance of genomic …             Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs ▶     Lanbo Shi, Hugh Salamon, Eliseo A. Eugenin et al.     To elucidate the little-known bioenergetic pathways of host immune cells in tuberculosis, a granulomatous disease caused by the intracellular pathogen Mycobacterium tuberculosis, …             Proteome Analysis of Renoprotection Mediated by a Novel Cyclic Helix B Peptide in Acute Kidney Injury ▶     Cheng Yang, Junjun Liu, Long Li et al.     We developed a novel, erythropoietin-derived, non-erythropoiesis, cyclic helix B peptide (CHBP) that displays potent renoprotection against acute kidney injury (AKI). To …             An optical biosensor assay for rapid dual detection of Botulinum neurotoxins A and E ▶     Christian Lévêque, Géraldine Ferracci, Yves Maulet et al.     The enzymatic activity of the pathogenic botulinum neurotoxins type A and E (BoNT/A and E) leads to potentially lethal paralytic symptoms in humans and their prompt detection is …             DNA methylation is stable during replication and cell cycle arrest ▶     Amy R. Vandiver, Adrian Idrizi, Lindsay Rizzardi et al.     DNA methylation is an epigenetic modification with important functions in development. Large-scale loss of DNA methylation is a hallmark of cancer. Recent work has identified …             Vasculogenic dynamics in 3D engineered tissue constructs ▶     Yaron J. Blinder, Alina Freiman, Noa Raindel et al.     Implantable 3D engineered vascular tissue constructs can be formed by co-culturing endothelial and fibroblast cells on macroporous scaffolds. Here we show that these constructs …             Erratum: Disadvantageous associations: Reversible spatial cueing effects in a discrimination task ▶     Daniele Nico, Elena Daprati                 Ca-α1T, a fly T-type Ca2+ channel, negatively modulates sleep ▶     Kyunghwa Jeong, Soyoung Lee, Haengsoo Seo et al.     Mammalian T-type Ca2+ channels are encoded by three separate genes (Cav3.1, 3.2, 3.3). These channels are reported to be sleep stabilizers important in the generation of the …             A simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks ▶     Suyu Mei, Hao Zhu     Signaling pathways play important roles in understanding the underlying mechanism of cell growth, cell apoptosis, organismal development and pathways-aberrant diseases. …             Efficient Structure Resonance Energy Transfer from Microwaves to Confined Acoustic Vibrations in Viruses ▶     Szu-Chi Yang, Huan-Chun Lin, Tzu-Ming Liu et al.     Virus is known to resonate in the confined-acoustic dipolar mode with microwave of the same frequency. However this effect was not considered in previous virus-microwave …             P accumulation and physiological responses to different high P regimes in Polygonum hydropiper for understanding a P-phytoremediation strategy ▶     Daihua Ye, Tingxuan Li, Dan Liu et al.     Phosphorus (P) accumulators used for phytoremediation vary in their potential to acquire P from different high P regimes. Growth and P accumulation in Polygonum hydropiper were …             A competitive photoelectrochemical immunosensor based on a CdS-induced signal amplification strategy for the ultrasensitive detection of dexamethasone ▶     Xueping Wang, Tao Yan, Yan Li et al.     A novel photoelectrochemical immunosensor based on the competitive strategy is proposed for the specific detection of dexamethasone (DXM). Graphitic carbon nitride coupled with …             Burst predicting neurons survive an in vitro glutamate injury model of cerebral ischemia ▶     Eric S. Kuebler, Joseph S. Tauskela, Amy Aylsworth et al.     Neuronal activity in vitro exhibits network bursts characterized by brief periods of increased spike rates. Recent work shows that a subpopulation of neurons reliably predicts …             Simple surface engineering of polydimethylsiloxane with polydopamine for stabilized mesenchymal stem cell adhesion and multipotency ▶     Yon Jin Chuah, Yi Ting Koh, Kaiyang Lim et al.     Polydimethylsiloxane (PDMS) has been extensively exploited to study stem cell physiology in the field of mechanobiology and microfluidic chips due to their transparency, low cost …             Distinct X-chromosome SNVs from some sporadic AD samples ▶     A. Gómez-Ramos, P. Podlesniy, E. Soriano et al.     Sporadic Alzheimer disease (SAD) is the most prevalent neurodegenerative disorder. With the development of new generation DNA sequencing technologies, additional genetic risk …             Sensitivity and specificity of Cobas TaqMan MTB real-time polymerase chain reaction for culture-proven Mycobacterium tuberculosis: meta-analysis of 26999 specimens from 17 Studies ▶     Nobuyuki Horita, Masaki Yamamoto, Takashi Sato et al.     Since 2010, studies on the diagnostic accuracy of COBAS TaqMan MTB (CTM) have been frequently reported with an unignorable discrepancy. The key inclusion criterion for this …             Single Cell Dynamics Causes Pareto-Like Effect in Stimulated T Cell Populations ▶     Jérémie Cosette, Alice Moussy, Fanny Onodi et al.     Cell fate choice during the process of differentiation may obey to deterministic or stochastic rules. In order to discriminate between these two strategies we used time-lapse …             Monomeric Garnet, a far-red fluorescent protein for live-cell STED imaging ▶     Anika Hense, Benedikt Prunsche, Peng Gao et al.     The advancement of far-red emitting variants of the green fluorescent protein (GFP) is crucially important for imaging live cells, tissues and organisms. Despite notable efforts, …             Mapping the genetic diversity of HLA haplotypes in the Japanese populations ▶     Woei-Yuh Saw, Xuanyao Liu, Chiea-Chuen Khor et al.     Japan has often been viewed as an Asian country that possesses a genetically homogenous community. The basis for partitioning the country into prefectures has largely been …             Stochastic Micro-Pattern for Automated Correlative Fluorescence - Scanning Electron Microscopy ▶     Isabell Begemann, Abhiyan Viplav, Christiane Rasch et al.     Studies of cellular surface features gain from correlative approaches, where live cell information acquired by fluorescence light microscopy is complemented by ultrastructural …             Energetics of Endotoxin Recognition in the Toll-Like Receptor 4 Innate Immune Response ▶     Teresa Paramo, Susana M. Tomasio, Kate L. Irvine et al.     Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS …             Regulation of Shootin1 Gene Expression Involves NGF-induced Alternative Splicing during Neuronal Differentiation of PC12 Cells ▶     Volkan Ergin, Mutlu Erdogan, Adnan Menevse     Shootin1 is a protein involved in neuronal polarization, and has been shown to be a key molecule for the positive/negative feedback loop for axon induction required during …             REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia ▶     Miguel A. S. Cavadas, Marion Mesnieres, Bianca Crifo et al.     The hypoxia-inducible factor (HIF) is a key regulator of the cellular response to hypoxia which promotes oxygen delivery and metabolic adaptation to oxygen deprivation. However, …             A20 regulates IL-1-induced tolerant production of CXC chemokines in human mesangial cells via inhibition of MAPK signaling ▶     Hongbo Luo, Yuming Liu, Qian Li et al.     Chemokines and chemokine receptors are involved in the resolution or progression of renal diseases. Locally secreted chemokines mediated leukocyte recruitment during the …             Identifying early-warning signals of critical transitions with strong noise by dynamical network markers ▶     Rui Liu, Pei Chen, Kazuyuki Aihara et al.     Identifying early-warning signals of a critical transition for a complex system is difficult, especially when the target system is constantly perturbed by big noise, which makes …             Emotional mimicry signals pain empathy as evidenced by facial electromyography ▶     Ya-Bin Sun, Yu-Zheng Wang, Jin-Yan Wang et al.     Facial mimicry has been suggested to be a behavioral index for emotional empathy. The present study is the first to investigate the link between facial muscle activity and …             Predicting cancerlectins by the optimal g-gap dipeptides ▶     Hao Lin, Wei-Xin Liu, Jiao He et al.     The cancerlectin plays a key role in the process of tumor cell differentiation. Thus, to fully understand the function of cancerlectin is significant because it sheds light on …             Specific quorum sensing-disrupting activity (AQSI) of thiophenones and their therapeutic potential ▶     Qian Yang, Anne Aamdal Scheie, Tore Benneche et al.     Disease caused by antibiotic resistant pathogens is becoming a serious problem, both in human and veterinary medicine. The inhibition of quorum sensing, bacterial cell-to-cell …             Experience-dependent emergence of beta and gamma band oscillations in the primary visual cortex during the critical period ▶     Guang Chen, Malte J. Rasch, Ran Wang et al.     Neural oscillatory activities have been shown to play important roles in neural information processing and the shaping of circuit connections during development. However, it …             The Cerato-Platanin protein Epl-1 from Trichoderma harzianum is involved in mycoparasitism, plant resistance induction and self cell wall protection ▶     Eriston Vieira Gomes, Mariana do Nascimento Costa, Renato Graciano de Paula et al.     Trichoderma harzianum species are well known as biocontrol agents against important fungal phytopathogens. Mycoparasitism is one of the strategies used by this fungus in the …             SMARCAL1 Negatively Regulates C-Myc Transcription By Altering The Conformation Of The Promoter Region ▶     Tapan Sharma, Ritu Bansal, Dominic Thangminlen Haokip et al.     SMARCAL1, a member of the SWI2/SNF2 protein family, stabilizes replication forks during DNA damage. In this manuscript, we provide the first evidence that SMARCAL1 is also a …             Quantifying replicative senescence as a tumor suppressor pathway and a target for cancer therapy ▶     Ignacio A. Rodriguez-Brenes, Dominik Wodarz, Natalia L. Komarova     To study quantitatively replicative senescence as a tumor suppressor mechanism, we investigate the distribution of a growing clonal cell population restricted by Hayflick’s …             Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices ▶     Emma J. Davies, Meng Dong, Matthias Gutekunst et al.     Precision-cut slices of in vivo tumours permit interrogation in vitro of heterogeneous cells from solid tumours together with their native microenvironment. They offer a low …             Chikusetsu saponin IVa confers cardioprotection via SIRT1/ERK1/2 and Homer1a pathway ▶     Jialin Duan, Ying Yin, Guo Wei et al.     Hyperglycemia-induced reactive oxygen species (ROS) generation and Ca2+ overload contribute to the development of diabetic cardiomyopathy. In this study, we aimed to study the …             Can live weight be used as a proxy for enteric methane emissions from pasture-fed sheep? ▶     J. M. Moorby, H. R. Fleming, V. J. Theobald et al.     To test the hypothesis that sheep live weight (LW) could be used to improve enteric methane (CH4) emission calculations, mature ewes of 4 different breeds representative of the UK…             Unfavorable Individuals in Social Gaming Networks ▶     Yichao Zhang, Guanrong Chen, Jihong Guan et al.     In social gaming networks, the current research focus has been on the origin of widespread reciprocal behaviors when individuals play non-cooperative games. In this paper, we …             The long-term fate of permafrost peatlands under rapid climate warming ▶     Graeme T. Swindles, Paul J. Morris, Donal Mullan et al.     Permafrost peatlands contain globally important amounts of soil organic carbon, owing to cold conditions which suppress anaerobic decomposition. However, climate warming and …             A neural coding scheme reproducing foraging trajectories ▶     Esther D. Gutiérrez, Juan Luis Cabrera     The movement of many animals may follow Lévy patterns. The underlying generating neuronal dynamics of such a behavior is unknown. In this paper we show that a novel discovery of …             Identification of Genes Associated with Smad3-dependent Renal Injury by RNA-seq-based Transcriptome Analysis ▶     Qin Zhou, Yuanyan Xiong, Xiao R. Huang et al.     Transforming growth factor-β/Smad3 signaling plays a critical role in the process of chronic kidney disease (CKD), but targeting Smad3 systematically may cause autoimmune disease …             A 3-day EGCG-supplementation reduces interstitial lactate concentration in skeletal muscle of overweight subjects ▶     Jasper Most, Judith G P van Can, Jan-Willem van Dijk et al.     Green tea, particularly epigallocatechin-3-gallate (EGCG), may affect body weight and composition, possibly by enhancing fat oxidation. The aim of this double-blind, randomized …             Unexpected diversity of Anopheles species in Eastern Zambia: implications for evaluating vector behavior and interventions using molecular tools ▶     Neil F. Lobo, Brandyce St. Laurent, Chadwick H. Sikaala et al.     The understanding of malaria vector species in association with their bionomic traits is vital for targeting malaria interventions and measuring effectiveness. Many entomological …             Transcriptome analysis of the key role of GAT2 gene in the hyper-accumulation of copper in the oyster Crassostrea angulata ▶     Bo Shi, Zekun Huang, Xu Xiang et al.     One paradigm of oysters as the hyper-accumulators of many toxic metals is the inter-individual variation of metals, but the molecular mechanisms remain very elusive. A …             Simulation of avascular tumor growth by agent-based game model involving phenotype-phenotype interactions ▶     Yong Chen, Hengtong Wang, Jiangang Zhang et al.     All tumors, both benign and metastatic, undergo an avascular growth stage with nutrients supplied by the surrounding tissue. This avascular growth process is much easier to carry …             Loss of synaptic Zn2+ transporter function increases risk of febrile seizures ▶     Michael S. Hildebrand, A. Marie Phillips, Saul A. Mullen et al.     Febrile seizures (FS) are the most common seizure syndrome and are potentially a prelude to more severe epilepsy. Although zinc (Zn2+) metabolism has previously been implicated …             Suppression of established hepatocarcinoma in adjuvant only immunotherapy: alum triggers anti-tumor CD8+ T cell response ▶     Bo Wang, Xuanyi Wang, Yumei Wen et al.     Dendritic cell-based immunotherapy is a new weapon in our battle against malignancies in human. Recent trials in human and research work in model animals have shown various …             Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis ▶     Juneyoung Lee, Eun Jeong Park, Yoshikazu Yuki et al.     Inflammatory bowel diseases (IBDs) accompany a critical loss of the frontline barrier function that is achieved primarily by intestinal epithelial cells (IECs). Although the …             Altered miRNA Signature of Developing Germ-cells in Infertile Patients Relates to the Severity of Spermatogenic Failure and Persists in Spermatozoa ▶     Xavier Muñoz, Ana Mata, Lluís Bassas et al.     The aim of this study was to assess the cellular miRNA expression behaviour in testes with spermatogenic failure (SpF). We performed a high-throughput screen of 623 mature miRNAs …             A novel multiplex isothermal amplification method for rapid detection and identification of viruses ▶     Dougbeh-Chris Nyan, Kevin L. Swinson     A rapid multiplex isothermal amplification assay has been developed for detection and identification of multiple blood-borne viruses that infect millions of people world-wide. …             A 1 MDa protein complex containing critical components of the Escherichia coli divisome ▶     Erik N. Trip, Dirk-Jan Scheffers     Cell division in bacteria is an essential process that is carried out at mid-cell by a group of cell division proteins referred to as the divisome. In Escherichia coli, over two …             Two-stage comprehensive evaluation of genetic susceptibility of common variants in FBXO38, AP3B2 and WHAMM to severe chronic periodontitis ▶     Dong Shang, Li Dong, Lingfang Zeng et al.     Chronic periodontitis is an oral disorder characterized with gingival inflammation and bone destruction. As the sixth-most prevalent condition affecting more than 743 million …             Knockdown of the partner protein OsNAR2.1 for high-affinity nitrate transport represses lateral root formation in a nitrate-dependent manner ▶     Shuangjie Huang, Si Chen, Zhihao Liang et al.     The morphological plasticity of root systems is critical for plant survival, and understanding the mechanisms underlying root adaptation to nitrogen (N) fluctuation is critical …             Network-Dependent Modulation of COMT and DRD2 Polymorphisms in Healthy Young Adults ▶     Fangshi Zhao, Xuejun Zhang, Wen Qin et al.     Nonlinear modulation of the dopamine signaling on brain functions can be estimated by the interaction effects of dopamine-related genetic variations. We aimed to explore the …             Identification of new genotype of Echovirus 19 from children with Acute Flaccid Paralysis in Pakistan ▶     Mehar Angez, Shahzad Shaukat, Rabaab Zahra et al.     Enteroviruses are known to cause childhood paralysis. The purpose of this study was to examine the genetic diversity and to determine the association of non-polio enteroviruses …             A Novel Class of HIV-1 Antiviral Agents Targeting HIV via a SUMOylation-Dependent Mechanism ▶     Ikenna G. Madu, Shirley Li, Baozong Li et al.     We have recently identified a chemotype of small ubiquitin-like modifier (SUMO)-specific protease (SENP) inhibitors. Prior to the discovery of their SENP inhibitory activity, …             Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing ▶     Shixuan Chen, Junbin Shi, Min Zhang et al.     The purpose of this study was to permit bone marrow mesenchymal stem cells (BMSCs) to reach their full potential in the treatment of chronic wounds. A biocompatible …             Impact of imidacloprid on new queens of imported fire ants, Solenopsis invicta (Hymenoptera: Formicidae) ▶     Lei Wang, Ling Zeng, Jian Chen     Neonicotinoid insecticides are commonly used in managing pest insects, including the imported fire ant, Solenopsis invicta Buren. There is increasing evidence that neonicotinoid …             Induction of autophagy improves embryo viability in cloned mouse embryos ▶     XingHui Shen, Na Zhang, ZhenDong Wang et al.     Autophagy is an essential cellular mechanism that degrades cytoplasmic proteins and organelles to recycle their components. Moreover, autophagy is essential for preimplantation …             A STRIPAK component Strip regulates neuronal morphogenesis by affecting microtubule stability ▶     Chisako Sakuma, Misako Okumura, Tomoki Umehara et al.     During neural development, regulation of microtubule stability is essential for proper morphogenesis of neurons. Recently, the striatin-interacting phosphatase and kinase …             Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation ▶     Pengxiang Chang, Suresh V. Kuchipudi, Kenneth H. Mellits et al.     Pigs are evidently more resistant to avian than swine influenza A viruses, mediated in part through frontline epithelial cells and alveolar macrophages (AM). Although porcine AM …             Drug-Drug Interaction Potentials of Tyrosine Kinase Inhibitors via Inhibition of UDP-Glucuronosyltransferases ▶     Nan Zhang, Yong Liu, Hyunyoung Jeong     Tyrosine kinase inhibitors (TKIs) are anticancer drugs that may be co-administered with other drugs. The aims of this study are to investigate the inhibitory effects of TKIs on UD…             Comparative transcriptomic analysis of silkworm-1Bmovo-1 and wild type silkworm ovary ▶     Renyu Xue, Xiaolong Hu, Liyuan Zhu et al.     The detailed molecular mechanism of Bmovo-1 regulation of ovary size is unclear. To uncover the mechanism of Bmovo-1 regulation of ovarian development and oogenesis using …             Seven gene deletions in seven days: Fast generation of Escherichia coli strains tolerant to acetate and osmotic stress ▶     Sheila I. Jensen, Rebecca M. Lennen, Markus J. Herrgård et al.     Generation of multiple genomic alterations is currently a time consuming process. Here, a method was established that enables highly efficient and simultaneous deletion of …             The Inevitability of Ethnocentrism Revisited: Ethnocentrism Diminishes As Mobility Increases ▶     Soham De, Michele J. Gelfand, Dana Nau et al.     Nearly all major conflicts across the globe, both current and historical, are characterized by individuals defining themselves and others by group membership. This existence of …             Gene expression changes triggered by end-of-day far-red light treatment on early developmental stages of Eustoma grandiflorum (Raf.) Shinn. ▶     Yoshihiro Takemura, Katsuou Kuroki, Masahiro Katou et al.     To better understand the molecular mechanisms related to growth promotion in the early developmental stages of Eustoma grandiflorum (Raf.) Shinn. under end-of-day far-red light …             Self-labelling enzymes as universal tags for fluorescence microscopy, super-resolution microscopy and electron microscopy ▶     Viktoria Liss, Britta Barlag, Monika Nietschke et al.     Research in cell biology demands advanced microscopy techniques such as confocal fluorescence microscopy (FM), super-resolution microscopy (SRM) and transmission electron …             Ultra-sensitive detection of tumorigenic cellular impurities in human cell-processed therapeutic products by digital analysis of soft agar colony formation ▶     Shinji Kusakawa, Satoshi Yasuda, Takuya Kuroda et al.     Contamination with tumorigenic cellular impurities is one of the most pressing concerns for human cell-processed therapeutic products (hCTPs). The soft agar colony formation …             Quantitating intracellular oxygen tension in vivo by phosphorescence lifetime measurement ▶     Yosuke Hirakawa, Toshitada Yoshihara, Mako Kamiya et al.     Hypoxia appears to have an important role in pathological conditions in many organs such as kidney; however, a method to quantify intracellular oxygen tension in vivo has not …             From cholera to corals: Viruses as drivers of virulence in a major coral bacterial pathogen ▶     Karen D. Weynberg, Christian R. Voolstra, Matthew J. Neave et al.     Disease is an increasing threat to reef-building corals. One of the few identified pathogens of coral disease is the bacterium Vibrio coralliilyticus. In Vibrio cholerae, …             Cognitive caching promotes flexibility in task switching: evidence from event-related potentials ▶     Florian Lange, Caroline Seer, Dorothea Müller et al.     Time-consuming processes of task-set reconfiguration have been shown to contribute to the costs of switching between cognitive tasks. We describe and probe a novel mechanism …             Impacts of impervious surface expansion on soil organic carbon – a spatially explicit study ▶     Yan Yan, Wenhui Kuang, Chi Zhang et al.     The rapid expansion of impervious surface areas (ISA) threatens soil organic carbon (SOC) pools in urbanized areas globally. The paucity of field observations on SOC under ISA …             APA-style human milk fat analogue from silkworm pupae oil: Enzymatic production and improving storage stability using alkyl caffeates ▶     Xi Liu, Xudong Wang, Na Pang et al.     Silkworm pupae oil derived from reeling waste is a rich source of α-linolenic acid (ALA), which has multipal applications. ALAs were added in sn-1, 3 positions in a …             Transcription Factor Runx3 Is Induced by Influenza A Virus and Double-Strand RNA and Mediates Airway Epithelial Cell Apoptosis ▶     Huachen Gan, Qin Hao, Steven Idell et al.     Influenza A virus (IAV) targets airway epithelial cells and exploits the host cell machinery to replicate, causing respiratory illness in annual epidemics and pandemics of …             The hematopoietic regulator, ELF-1, enhances the transcriptional response to Interferon-β of the OAS1 anti-viral gene ▶     Steven Larsen, Shota Kawamoto, Sei-ichi Tanuma et al.     Interferon (IFN) therapy is effective in treating cancers, haematological and virus induced diseases. The classical Jak/Stat pathway of IFN signal transduction leading to changes …             Haptic perception of force magnitude and its relation to postural arm dynamics in 3D ▶     Femke E. van Beek, Wouter M. Bergmann Tiest, Winfred Mugge et al.     In a previous study, we found the perception of force magnitude to be anisotropic in the horizontal plane. In the current study, we investigated this anisotropy in three …             Discovery of symbiotic nitrogen fixation and chemoautotrophy in cold-water corals ▶     Jack J. Middelburg, Christina E. Mueller, Bart Veuger et al.     Cold-water corals (CWC) are widely distributed around the world forming extensive reefs at par with tropical coral reefs. They are hotspots of biodiversity and organic matter …             Effects of sample storage and shell orientation on LA-ICPMS trace element measurements on deep-sea mussels ▶     Luciana Génio, Klaus Simon, Steffen Kiel et al.     Geochemical markers are being increasingly applied to fundamental questions in population and community ecology in marine habitats because they allow inferences on individuals …             Hypoxia facilitates neurogenic dural plasma protein extravasation in mice: a novel animal model for migraine pathophysiology ▶     Anika Hunfeld, Daniel Segelcke, Ingo Bäcker et al.     Migraine animal models generally mimic the onset of attacks and acute treatment processes. A guinea pig model used the application of meta-chlorophenylpiperazine (mCPP) to …             Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells ▶     Qianting Yang, Qian Xu, Qi Chen et al.     Interferon-gamma Release Assays (IGRAs) significantly increases the possibility for early diagnosis of tuberculosis, but IGRAs alone cannot discriminate active TB from LTBI. …             Phylogenetics reveals the crustacean order Amphionidacea to be larval shrimps (Decapoda: Caridea) ▶     Sammy De Grave, Tin-Yam Chan, Ka Hou Chu et al.     We present evidence that the single representative of the crustacean order Amphionidacea is a decapod shrimp and not a distinct order. After reviewing available morphological …             Cell cycle reactivation of cochlear progenitor cells in neonatal FUCCI mice by a GSK3 small molecule inhibitor ▶     M. Roccio, S. Hahnewald, M. Perny et al.     Due to the lack of regenerative capacity of the mammalian auditory epithelium, sensory hair cell loss results in permanent hearing deficit. Nevertheless, a population of tissue …             The Assessment of the Readiness of Molecular Biomarker-Based Mobile Health Technologies for Healthcare Applications ▶     Chu Qin, Lin Tao, Yik Hui Phang et al.     Mobile health technologies to detect physiological and simple-analyte biomarkers have been explored for the improvement and cost-reduction of healthcare services, some of which …             Erythropoietin alleviates hepatic insulin resistance via PPARγ-dependent AKT activation ▶     Zhijuan Ge, Pengzi Zhang, Ting Hong et al.     Erythropoietin (EPO) has beneficial effects on glucose metabolism and insulin resistance. However, the mechanism underlying these effects has not yet been elucidated. This study …             Contribution and Mobilization of Mesenchymal Stem Cells in a mouse model of carbon tetrachloride-induced liver fibrosis ▶     Yan Liu, Xue Yang, Yingying Jing et al.     Hepatic fibrosis is associated with bone marrow derived mesenchymal stem cells (BM-MSCs). In this study, we aimed to determine what role MSCs play in the process and how they …             Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia ▶     Francesco Fazio, Luana Lionetto, Martina Curto et al.     The kynurenine pathway of tryptophan metabolism has been implicated in the pathophysiology of psychiatric disorders, including schizophrenia. We report here that the kynurenine …                 Nature Publishing Group offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. 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