Nature Reviews Neuroscience contents January 2015 Volume 17 Number 1 pp 1-72

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Brain disorders across the lifespan This supplement outlines the overarching and intersecting priorities for addressing causes, prevention, treatment and rehabilitation, as well as best practices to promote global nervous-system health. Available free online. Financial support for publication has been provided by the Fogarty International Center
TABLE OF CONTENTS
January 2016 Volume 17 Number 1
Impact Factor 31.427 *	In this issue Research Highlights Reviews Perspectives Correspondence Also this month  Featured article: Tau in physiology and pathology Yipeng Wang & Eckhard Mandelkow
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RESEARCH HIGHLIGHTS Top Sensory systems: Tasting in the brain p1 | doi:10.1038/nrn.2015.17 A study in mice shows that manipulating the activity of the cortical fields associated with sweet and bitter tastes mediates the perception of taste and drives associated behaviours. PDF Synaptic physiology: Dual role for dopamine p2 | doi:10.1038/nrn.2015.4 Tonic and phasic patterns of dopamine release have opposing effects on Schaffer collateral stimulation-evoked CA1 activity. PDF Neural repair: Redirecting regeneration p2 | doi:10.1038/nrn.2015.5 In zebrafish, components of the extracellular matrix help to direct regenerating motor axons to their original targets. PDF Learning and memory: Face-to-face with fear generalization p3 | doi:10.1038/nrn.2015.9 Functional imaging has provided insight into the neuronal processes that regulate fear generalization in humans. PDF Glia: Astrocytic parenting? p4 | doi:10.1038/nrn.2015.14 By vesicular secretion of D-serine, astrocytes in the hippocampal neurogenic niche regulate dendritic maturation, spine formation and synapse formation of adult-born hippocampal neurons. PDF IN BRIEF Neuronal circuits: Anxiety control | Circadian rhythms: Melatonin influence on circadian rhythms | Neurotransmission: Acidification by optogenetics | Stem cells: Unlocking your full potential PDF
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REVIEWS		Top
Specification of synaptic connectivity by cell surface interactions Joris de Wit & Anirvan Ghosh p4 | doi:10.1038/nrn.2015.3 Cell surface molecule diversification has been proposed to confer specific surface identities on neuronal cell types, enabling the precise pattern of connectivity that is observed between CNS neurons. In this Review, de Wit and Ghosh explore the role of various protein superfamilies in the specification of such connectivity. Abstract | Full Text | PDF
Tau in physiology and pathology Yipeng Wang & Eckhard Mandelkow p22 | doi:10.1038/nrn.2015.1 Tau is a microtubule-stabilizing protein that aggregates in several neurodegenerative diseases. In this Review, Wang and Mandelkow describe the structure, expression and post-translational modifications of tau, and the functions of this protein in health and in disease. Abstract | Full Text | PDF
Applications of CRISPR–Cas systems in neuroscience Matthias Heidenreich & Feng Zhang p36 | doi:10.1038/nrn.2015.2 Recent years have seen several important advances in the tools available to interrogate the function of specific genes. Here, Heidenreich and Zhang describe the advantages of the precise and efficient CRISPR–Cas9 (clustered regularly interspaced short palindromic repeat–CRISPR-associated protein) system for gene editing and outline how this approach may benefit research into nervous system function and disease. Abstract | Full Text | PDF
Neurobiology of rodent self-grooming and its value for translational neuroscience Allan V. Kalueff et al. p45 | doi:10.1038/nrn.2015.8 Rodents spend a large proportion of their waking time engaged in self-grooming behaviour. In this Review, Kalueff and colleagues describe the characteristics and underlying neural circuitry of rodent self-grooming, and discuss its use as a measure of repetitive behaviour in models of psychiatric disease. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION From nerve net to nerve ring, nerve cord and brain — evolution of the nervous system Detlev Arendt, Maria Antonietta Tosches & Heather Marlow p61 | doi:10.1038/nrn.2015.15 The evolution of complex nervous systems is not well understood. In this Opinion article, Arendt and colleagues discuss comparative gene-expression data that suggest that the bilaterian brain emerged from the integration of distinct integrative centres present on opposite sides of a nerve net. Abstract | Full Text | PDF
CORRESPONDENCE		Top
What is being studied as mindfulness meditation? Megan S. Wheeler, Diane B. Arnkoff & Carol R. Glass p59 | doi:10.1038/nrn.2015.6 Full Text | PDF
Traits and states in mindfulness meditation Yi-Yuan Tang, Britta K. Hölzel & Michael I. Posner p59 | doi:10.1038/nrn.2015.7 Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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