 | RESEARCH HIGHLIGHTS | Top | Morphogens: How to grow wings
p1 | doi:10.1038/nrm.2015.10
Two studies provide novel insights into how the Dpp morphogen regulates fly wing growth.
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DNA replication: Quad-jumping
p2 | doi:10.1038/nrm.2015.13
The primase-polymerase PrimPol is required for bypassing G-quadruplexes in vertebrate cells by repriming replication downstream of the structures.
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Metabolism: Keeping insulin secretion in check
p2 | doi:10.1038/nrm.2015.21
The ubiquitin ligase COP1 promotes insulin secretion in mice by inducing the degradation of transcription factors ETV1, ETV4 and ETV5.
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Mechanisms of disease: Stopping traffic
p2 | doi:10.1038/nrm.2015.22
Cytoplasmic, but not nuclear, aggregates of [beta]-sheet proteins mediate toxic effects through impaired nucleo-cytoplasmic transport of mRNA and protein.
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Cytoskeleton: Centriole maturation to motherhood
p4 | doi:10.1038/nrm.2015.12
Cep135, Ana1 (Cep295) and Asterless (Cep152) are sequentially recruited to daughter centrioles to enable their maturation into duplication-competent mother centrioles.
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JOURNAL CLUB
Cell biology to disease and back
p4 | doi:10.1038/nrm.2015.9
M. Bishr Omary reminds us of the three articles that first uncovered a causative link between mutations in intermediate filaments (specifically, keratin 14) and human diseases.
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IN BRIEF
| Genome engineering: Structure-guided improvement of Cas9 specificity | Lipid metabolism: Lipid droplet growth in brown fat | RNA: Transcriptional mutagenesis by R-loops
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| | | | | | | | | REVIEWS | Top |  Article series: Technologies and techniques
Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation
Antonia A. Dominguez, Wendell A. Lim & Lei S. Qi
p5 | doi:10.1038/nrm.2015.2
The CRISPR-Cas9 system is a powerful, sequence-specific tool that was initially developed for gene and genome editing. The recent adoption of nuclease-deactivated Cas9 (dCas9) has enabled expansion of the use of the system to multiplexed and inducible transcription regulation, genome-wide screens and cell fate engineering.
Abstract | Full Text | PDF
| The molecular basis for centromere identity and function
Kara L. McKinley & Iain M. Cheeseman
p16 | doi:10.1038/nrm.2015.5
Most eukaryotic centromeres are defined epigenetically and require nucleosomes containing the histone H3 variant centromere protein A (CENP-A). We are now gaining insight into the mechanisms that regulate CENP-A deposition and positioning to specify and propagate centromeres during cell division, and into the function of centromeres in recruiting kinetochores to connect chromosomes to spindle microtubules.
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| Plant vascular development: from early specification to differentiation
Bert De Rybel, Ari Pekka Mähönen, Yrjö Helariutta & Dolf Weijers
p30 | doi:10.1038/nrm.2015.6
Recent studies in Arabidopsis thaliana have identified interconnected signalling networks that regulate plant vascular development. These findings have increased our understanding of vascular development from early cell specification during embryogenesis to the latest stages of differentiation of the phloem and xylem.
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| The exon junction complex as a node of post-transcriptional networks
Hervé Le Hir, Jérôme Sauliére & Zhen Wang
p41 | doi:10.1038/nrm.2015.7
In addition to its known roles in nonsense-mediated mRNA decay, recent findings show that the exon junction complex (EJC) participates in diverse mRNA maturation processes, including splicing, transport and translation. This multi-functionality is reflected by an increasing number of EJC-related disorders being discovered.
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| | | | | | PERSPECTIVES | Top | OPINION
Beyond β-catenin: prospects for a larger catenin network in the nucleus
Pierre D. McCrea & Cara J. Gottardi
p55 | doi:10.1038/nrm.2015.3
Catenins are typically considered to function at cell-cell junctions. However, it has recently become evident that multiple catenins can enter the nucleus and regulate gene expression. Thus, catenins might form complex networks, coupling membrane-associated signalling with transcriptional events.
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| Corrigendum: Transcriptional regulation of hepatic lipogenesis
Yuhui Wang, Jose Viscarra, Sun-Joong Kim & Hei Sook Sul
doi:10.1038/nrm.2015.23
Full Text | PDF
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