Nature Reviews Microbiology contents January 2016 Volume 14 Number 1 pp 1-60

TABLE OF CONTENTS
January 2016 Volume 14 Number 1
Impact Factor 23.574 *	In this issue Research Highlights News and Analysis Reviews Perspectives Also this month Article series: Microbiome Article series: Vector-borne diseases  Featured article: Gut biogeography of the bacterial microbiota Gregory P. Donaldson, S. Melanie Lee & Sarkis K. Mazmanian
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RESEARCH HIGHLIGHTS Top Microbiome: Microbiota-based nutrition plans p1 | doi:10.1038/nrmicro.2015.10 This study investigates the links between diet, the gut microbiota and postprandial glycaemic responses (PPGRs), showing that differences in the gut microbiota are associated with the high interpersonal variability in the PPGRs to identical meals. PDF Bacterial physiology: Cropping up in an aerobic niche p2 | doi:10.1038/nrmicro.2015.11 This study identifies two new polyketide metabolites of Clostridium puniceum that enable this crop pathogen to thrive in its unusual aerobic niche while inhibiting the growth of other bacteria. PDF Viral infection: De-chaperoning antivirals p2 | doi:10.1038/nrmicro.2015.12 Two new studies show that Hsp70 inhibitors are promising candidates as antivirals against flaviviruses, including dengue virus (DENV), and Kaposi's sarcoma-associated herpesvirus (KSHV). PDF IN BRIEF Marine microbiology: Changing climate, changing plankton communities | Parasite biology: Hepatocyte receptor for Plasmodium | Viral infection: The next SARS? | Microbiome: Commensals promote anticancer immunotherapy PDF Microbiology EVENT The 2nd Microbiology and Immunology Conference (MIC 2016) 18.03.16 Los Angeles, USA More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Commitment issues in Plasmodium Ana Rita Gomes & Arthur M. Talman p4 | doi:10.1038/nrmicro.2015.9 Functional genomics has helped to identify global regulators of sexual differentiation in the malaria parasite. PDF
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REVIEWS		Top
Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy Pedro Escoll, Sonia Mondino, Monica Rolando & Carmen Buchrieser p5 | doi:10.1038/nrmicro.2015.1 Several bacterial pathogens have evolved the ability to subvert host cell functions. In this Review, Buchrieser and colleagues discuss the mechanisms used by bacteria to target eukaryotic organelles such as the nucleus, mitochondria, the endoplasmic reticulum and the Golgi apparatus, highlighting how these strategies potentiate bacterial infection. Abstract | Full Text | PDF
Article series: Microbiome Gut biogeography of the bacterial microbiota Gregory P. Donaldson, S. Melanie Lee & Sarkis K. Mazmanian p20 | doi:10.1038/nrmicro3552 The gut microbiota has a strong impact on host physiology. In this Review, Mazmanian and colleagues describe the mechanisms that control the biogeography of bacteria in the gut and discuss the importance of the spatial localization of the gut microbiota during health and disease. Abstract | Full Text | PDF
Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines Adrian O. Olivares, Tania A. Baker & Robert T. Sauer p33 | doi:10.1038/nrmicro.2015.4 AAA+ proteolytic machines unfold and degrade damaged and unneeded proteins in all domains of life. In this Review, Sauer and colleagues discuss the molecular mechanisms and structures of bacterial AAA+ machines, focusing on recent studies of ClpXP as a paradigm. Abstract | Full Text | PDF
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PERSPECTIVES		Top
OPINION Article series: Vector-borne diseases Dengue vaccine: hypotheses to understand CYD-TDV-induced protection Bruno Guy & Nicholas Jackson Published online: 07 December 2015 p45 | doi:10.1038/nrmicro.2015.2 Although there is currently no licensed vaccine against dengue virus (DENV), the chimeric yellow fever-DENV tetravalent dengue vaccine (CYD-TDV) has shown efficacy against DENV in two recent Phase III clinical trials. In this Opinion article, Guy and Jackson review the efficacy and safety data from these recent trials and discuss how interactions between the virus, pre-existing host immunity and vaccine-induced immune responses explain CYD-TDV-mediated protection. Abstract | Full Text | PDF
VIEWPOINT HIV reservoirs: what, where and how to target them Melissa J. Churchill, Steven G. Deeks, David M. Margolis, Robert F. Siliciano & Ronald Swanstrom Published online: 30 November 2015 p55 | doi:10.1038/nrmicro.2015.5 Viral reservoirs pose a major challenge in the efforts towards curing HIV. Here, Churchill, Deeks, Margolis, Siliciano and Swanstrom discuss the cells and tissues that constitute the viral reservoir, how best to measure it and how to target this source of persistent infection. Abstract | Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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