Nature Communications - 16 December 2015

Advertisement Sputtered Metal Deep-UV Interference Filters Manufactured using single substrates of UV-grade fused silica and backed by warranty, these filters are available in 11 different passbands in a wide range of sizes, from 2mm-200mm. Laser damage thresholds >0.15 J/cm2 using a 355nm laser (10 ns pulse, 10 Hz), and suffer no degradation after 2 hours @ 300ºC.  www.chroma.com     Weekly Content Alert Nature Communications is now fully open access. Read more. 16 December 2015  Featured image: Conrad et al. present an electrostatic actuator with improved performance, composed of repeated actuator cells containing titanium aluminide electrodes. Latest content: Editorial Articles Corrigenda Errata Journal homepage Recommend to library Web feed       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Editorial View all Editorials     Transparent peer review at Nature Communications OPEN Authors of papers submitted from January 2016 will be given the option to publish the peer review history of their paper 14 December 2015 | doi: 10.1038/ncomms10277       Latest Articles View all Articles     Free mate choice enhances conservation breeding in the endangered giant panda OPEN Meghan S. Martin-Wintle, David Shepherdson, Guiquan Zhang, Hemin Zhang, Desheng Li, Xiaoping Zhou, Rengui Li and Ronald R. Swaisgood Ex situ conservation breeding programmes for endangered species are expensive, and not always guaranteed to succeed. Here, Martin-Wintle et al. show that when captive giant pandas are given the opportunity to choose their preferred mate, copulation and birth rates increase significantly. 15 December 2015 | doi: 10.1038/ncomms10125 Biological Sciences  Ecology  Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction OPEN Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson and Frank J. Gonzalez The nuclear farnesoid X receptor (FXR) is activated by bile acids and influences energy metabolism. Here, the authors report a small molecule inhibitor of FXR, glycine-ß-muricholic acid, which inhibits FXR in the intestine and improves metabolic homeostasis by repressing intestinal ceramide synthesis. 15 December 2015 | doi: 10.1038/ncomms10166 Biological Sciences  Medical research  Tracking molecular resonance forms of donor–acceptor push–pull molecules by single-molecule conductance experiments OPEN Henriette Lissau, Riccardo Frisenda, Stine T. Olsen, Martyn Jevric, Christian R. Parker, Anders Kadziola, Thorsten Hansen, Herre S. J. van der Zant, Mogens Brøndsted Nielsen and Kurt V. Mikkelsen Donor-acceptor molecules are important components for molecular electronics applications. Here, the authors show that donor-acceptor molecular wires exhibit changes in conductivity under the influence of small changes in the environment. 15 December 2015 | doi: 10.1038/ncomms10233 Chemical Sciences  Organic chemistry  Physical chemistry  Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts OPEN Jean Albrengues, Thomas Bertero, Eloise Grasset, Stephanie Bonan, Majdi Maiel, Isabelle Bourget, Claude Philippe, Cecilia Herraiz Serrano, Samia Benamar, Olivier Croce, Victoria Sanz-Moreno, Guerrino Meneguzzi, Chloe C. Feral, Gael Cristofari and Cedric Gaggioli Carcinoma-associated fibroblasts are key components of solid tumours and associated with poor clinical outcome. Here the authors show that the cytokine LIF initiates an epigenetic switch which results in the sustained invasive activity of the tumour cells. 15 December 2015 | doi: 10.1038/ncomms10204 Biological Sciences  Cancer  Molecular biology  Breaking of the site-bond percolation universality in networks OPEN Filippo Radicchi and Claudio Castellano The percolation transition has been regarded as model-independent, namely determined by the geometry of a system but otherwise identical for bond or site percolation models. Here, the authors show the violation of this assumption both analytically and numerically for networks with null percolation thresholds. 15 December 2015 | doi: 10.1038/ncomms10196 Physical Sciences  Theoretical physics  Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts OPEN Francesca Fasanelli, Laura Baglietto, Erica Ponzi, Florence Guida, Gianluca Campanella, Mattias Johansson, Kjell Grankvist, Mikael Johansson, Manuela Bianca Assumma, Alessio Naccarati, Marc Chadeau-Hyam, Ugo Ala, Christian Faltus, Rudolf Kaaks, Angela Risch, Bianca De Stavola, Allison Hodge, Graham G. Giles, Melissa C. Southey, Caroline L. Relton et al. Smoking tobacco is known to alter DNA methylation. Here, the authors show that hypomethylation of smoke-related genes is associated with future increase in lung cancer risk. 15 December 2015 | doi: 10.1038/ncomms10192 Biological Sciences  Genetics  An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding OPEN Patrick Sweeney and Yunlei Yang The ventral hippocampus connects to the hypothalamus and has been implicated in feeding behaviours. Here, the authors use a combination of optogenetics and DREADD strategies to dissect the underlying circuit, showing that projections from the vHC to the lateral septum work to regulate feeding suppression. 15 December 2015 | doi: 10.1038/ncomms10188 Biological Sciences  Neuroscience  SCFβ-TRCP promotes cell growth by targeting PR-Set7/Set8 for degradation OPEN Zhiwei Wang, Xiangpeng Dai, Jiateng Zhong, Hiroyuki Inuzuka, Lixin Wan, Xiaoning Li, Lixia Wang, Xiantao Ye, Liankun Sun, Daming Gao, Lee Zou and Wenyi Wei The Set8-Set7 methyltransferase plays a critical role in cell cycle progression and tumorigenesis, and is degraded through modification by the E3 ubiquitin ligase CRL4Cdt2. Here Wang et al. identify SCFβ-TRCP as an additional E3 ubiquitin ligase that marks Set8 for degradation in response to DNA damage. 15 December 2015 | doi: 10.1038/ncomms10185 Biological Sciences  Cell biology  Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes OPEN Johan Siewiera, Jordi Gouilly, Hocine-Rachid Hocine, Géraldine Cartron, Claude Levy, Reem Al-Daccak and Nabila Jabrane-Ferrat Decidual natural killer (NK) cells from the pregnant uterus play an important role in the physiology of pregnancy and differ functionally from peripheral blood NK cells. Siewiera et al. reveal that this is partly due to the differential expression of splice variants of natural cytotoxicity receptors by these two cell subsets. 15 December 2015 | doi: 10.1038/ncomms10183 Biological Sciences  Immunology  Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy OPEN P. Rocheteau, L. Chatre, D. Briand, M. Mebarki, G. Jouvion, J. Bardon, C. Crochemore, P. Serrani, P. P. Lecci, M. Latil, B. Matot, P. G. Carlier, N. Latronico, C. Huchet, A. Lafoux, T. Sharshar, M. Ricchetti and F. Chrétien Sepsis patients often develop muscle atrophy that can last for years. Here the authors show in a mouse model that sepsis causes long-term impairment of the satellite cells, affecting mitochondrial function and energy metabolism, and that injection of mesenchymal stem cells restores satellite cell metabolism and muscle regeneration. 15 December 2015 | doi: 10.1038/ncomms10145 Biological Sciences  Cell biology  Immunology  Medical research  Basal body multipotency and axonemal remodelling are two pathways to a 9+0 flagellum OPEN R. J. Wheeler, E. Gluenz and K. Gull Whether basal bodies are pre-committed to form 9+2 motile or 9+0 sensory axonemes and whether interconversion occurs between the two types of axonemes is not clear. Here, the authors used the unicellular eukaryote Leishmania as a model system to demonstrate that 9+0 axonemes can be formed de novo or by restructuring of 9+2 axonemes. 15 December 2015 | doi: 10.1038/ncomms9964 Biological Sciences  Cell biology  Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex OPEN Yohei Shinmyo, M. Asrafuzzaman Riyadh, Giasuddin Ahmed, Iftekhar Bin Naser, Mahmud Hossain, Hirohide Takebayashi, Hiroshi Kawasaki, Kunimasa Ohta and Hideaki Tanaka During neural development thalamocortical axons follow corticofugal projections into the neocortex. Here, using a combination of knock down and rescue experiments, the authors show that Draxin expression in neocortical cells promotes thalamic axon projections from the internal capsule. 14 December 2015 | doi: 10.1038/ncomms10232 Biological Sciences  Cell biology  Neuroscience  Topological states on the gold surface OPEN Binghai Yan, Benjamin Stadtmüller, Norman Haag, Sebastian Jakobs, Johannes Seidel, Dominik Jungkenn, Stefan Mathias, Mirko Cinchetti, Martin Aeschlimann and Claudia Felser The surfaces of noble metals possess Shockley states which exhibit Rashba-type spin splitting and spin-momentum locking. Here, the authors use ab initio methods and photoemission spectroscopy to demonstrate how such Shockley states may be reinterpreted as topologically protected surface states. 14 December 2015 | doi: 10.1038/ncomms10167 Physical Sciences  Condensed matter  Ultra-narrow metallic armchair graphene nanoribbons OPEN Amina Kimouche, Mikko M. Ervasti, Robert Drost, Simo Halonen, Ari Harju, Pekka M. Joensuu, Jani Sainio and Peter Liljeroth Graphene nanoribbons have potential applications as nanoscale wires, though experimentally studied ribbons display wide bandgaps. Here, the authors synthesise the narrowest armchair graphene nanoribbon predicted to have metallic behaviour and show these ribbons—5 carbon atoms wide—indeed display almost metallic behaviour. 14 December 2015 | doi: 10.1038/ncomms10177 Chemical Sciences  Materials science  Nanotechnology  Amygdala lesions in rhesus macaques decrease attention to threat OPEN Olga Dal Monte, Vincent D. Costa, Pamela L. Noble, Elisabeth A. Murray and Bruno B. Averbeck The amygdala in the medial temporal lobe of the human and non-human primate brain is known to process salient social stimuli and to mediate threat discrimination. Here, Dal Monte et al. show that rhesus monkeys with amygdala lesions have deficits in detecting threat signals and directing attention to the eye region of a conspecific's face. 14 December 2015 | doi: 10.1038/ncomms10161 Biological Sciences  Neuroscience  The experimental power of FR900359 to study Gq-regulated biological processes OPEN Ramona Schrage, Anna-Lena Schmitz, Evelyn Gaffal, Suvi Annala, Stefan Kehraus, Daniela Wenzel, Katrin M. Büllesbach, Tobias Bald, Asuka Inoue, Yuji Shinjo, Ségolène Galandrin, Naveen Shridhar, Michael Hesse, Manuel Grundmann, Nicole Merten, Thomas H. Charpentier, Matthew Martz, Adrian J. Butcher, Tanja Slodczyk, Sylvain Armando et al. Pertussis toxin is used extensively for perturbing Gαi/o pathways in the study of physiology and disease, but an equivalent inhibitor of Gαq signalling is not currently available to the research community. Here the authors characterize FR900359 as a specific Gq inhibitor and demonstrate its utility to dissect GPCR signalling and its potential to inhibit melanoma cells. 14 December 2015 | doi: 10.1038/ncomms10156 Biological Sciences  Cancer  Cell biology  Testing necessary regional frontal contributions to value assessment and fixation-based updating OPEN Avinash R. Vaidya and Lesley K. Fellows In value-based decisions, the longer one fixates on an option, the more likely one is to choose it. Here, the authors compare the performance of people with focal frontal lobe damage in a simple choice task and show that damage to the dorsomedial PFC leads to exaggerated fixation-related value updating. 14 December 2015 | doi: 10.1038/ncomms10120 Biological Sciences  Neuroscience  RCAN1 links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in Down syndrome OPEN Ami Patel, Naoya Yamashita, Maria Ascaño, Daniel Bodmer, Erica Boehm, Chantal Bodkin-Clarke, Yun Kyoung Ryu and Rejji Kuruvilla Down syndrome is associated with both central and peripheral nervous system dysfunction. Here, the authors report reduced sympathetic neural innervation in human Down syndrome tissues and a mouse model, and propose a role for RCAN1 trisomy in disrupted NGF receptor trafficking and neurotrophic support. 14 December 2015 | doi: 10.1038/ncomms10119 Biological Sciences  Neuroscience  Spin-orbit engineering in transition metal dichalcogenide alloy monolayers OPEN Gang Wang, Cedric Robert, Aslihan Suslu, Bin Chen, Sijie Yang, Sarah Alamdari, Iann C. Gerber, Thierry Amand, Xavier Marie, Sefaattin Tongay and Bernhard Urbaszek Single atomic layers of transition metal dichalcogenides are semiconductors with possible applications in spintronics. Here, the authors demonstrate tuning of the spin-orbit splitting in molybdenum tungsten diselenide by altering the alloy’s composition, impacting valley polarization and light emission yield. 14 December 2015 | doi: 10.1038/ncomms10110 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Positive-bias gate-controlled metal–insulator transition in ultrathin VO2 channels with TiO2 gate dielectrics OPEN Takeaki Yajima, Tomonori Nishimura and Akira Toriumi Oxide materials that undergo a metal to insulator transition under an applied electric field could extend the functionality of electronic devices. Here, the authors induce a phase transition in vanadium dioxide via a titanium dioxide gate, and thus modulate the current flowing through the channel. 14 December 2015 | doi: 10.1038/ncomms10104 Physical Sciences  Applied physics  Materials science  Flexible thin-film black gold membranes with ultrabroadband plasmonic nanofocusing for efficient solar vapour generation OPEN Kyuyoung Bae, Gumin Kang, Suehyun K. Cho, Wounjhang Park, Kyoungsik Kim and Willie J. Padilla Efficient steam generation under solar irradiation is of interest for energy harvesting applications. Here, Bae et al. develop a plasmonic nanofocusing film consisting of metal coated alumina nanowires to efficiently generate solar vapour with an efficiency up to 57% at 20 kWm−2. 14 December 2015 | doi: 10.1038/ncomms10103 Physical Sciences  Applied physics  Materials science  Nanotechnology  Inverted polymer fullerene solar cells exceeding 10% efficiency with poly(2-ethyl-2-oxazoline) nanodots on electron-collecting buffer layers OPEN Sungho Nam, Jooyeok Seo, Sungho Woo, Wook Hyun Kim, Hwajeong Kim, Donal D. C. Bradley and Youngkyoo Kim Forming a dipole layer at the electron-collecting interface is a proposed method of efficiency enhancement in solar cells. Here, Nam et al. report the use of PEOz as a dipole layer, which increases the work function at the electron-collecting interface within the polymer solar cell leading to an efficiency of 10.7%. 14 December 2015 | doi: 10.1038/ncomms9929 Physical Sciences  Materials science  Nanotechnology  Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits OPEN Jennifer E. Murray, Aude Belin-Rauscent, Marine Simon, Chiara Giuliano, Marianne Benoit-Marand, Barry J. Everitt and David Belin Drug seeking behaviour has habitual neural substrates. Here, Murray et al. show that the basolateral amygdala and central nucleus of the amygdala are necessary to recruit and maintain, respectively, the intrastriatal functional transition that underlies cocaine seeking habits. 14 December 2015 | doi: 10.1038/ncomms10088 Biological Sciences  Neuroscience  Efficient quasi-monoenergetic ion beams from laser-driven relativistic plasmas OPEN Sasi Palaniyappan, Chengkun Huang, Donald C. Gautier, Christopher E. Hamilton, Miguel A. Santiago, Christian Kreuzer, Adam B. Sefkow, Rahul C. Shah and Juan C. Fernández Table-top laser-plasma ion accelerators have many potential applications, but achieving simultaneous narrow energy spread and high efficiency remains a challenge. Here, the authors produce ion beams with up to 18 MeV per nucleon whilst keeping the energy spread reduced through a self-organized process. 11 December 2015 | doi: 10.1038/ncomms10170 Physical Sciences  Atomic and molecular physics  Fluids and plasma physics  A new tool called DISSECT for analysing large genomic data sets using a Big Data approach OPEN Oriol Canela-Xandri, Andy Law, Alan Gray, John A. Woolliams and Albert Tenesa Availability of computing power can limit computational analysis of large genetic and genomic datasets. Here, Canela-Xandri, et al. describe a software called DISSECT that is capable of analyzing large-scale genetic data by distributing the work across thousands of networked computers. 11 December 2015 | doi: 10.1038/ncomms10162 Biological Sciences  Bioinformatics  Genetics  Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory–inhibitory synapse formation in the mature cortex OPEN Saurav Seshadri, Travis Faust, Koko Ishizuka, Kristen Delevich, Youjin Chung, Sun-Hong Kim, Martis Cowles, Minae Niwa, Hanna Jaaro-Peled, Toshifumi Tomoda, Cary Lai, E. S. Anton, Bo Li and Akira Sawa Neuregulin-1 and DISC1 signalling pathways have both been linked to neurodevelopment and schizophrenia. Here, Seshadri et al. demonstrate that DISC1 negatively regulates NRG1-induced ErbB4 signalling in adult cortical interneurons both in vitro and in vivo, possibly via competitive binding to PSD95. 11 December 2015 | doi: 10.1038/ncomms10118 Biological Sciences  Cell biology  Neuroscience  The genetic basis of natural variation in mushroom body size in Drosophila melanogaster OPEN Liesbeth Zwarts, Lies Vanden Broeck, Elisa Cappuyns, Julien F. Ayroles, Michael M. Magwire, Veerle Vulsteke, Jason Clements, Trudy F. C. Mackay and Patrick Callaerts The mushroom bodies (MBs) in an insect brain integrate and process sensory information. Using fully sequenced/inbred lines of the Drosophila Genetic Reference Panel, this study performs genome wide association analyses and identifies candidate genes affecting MB size, and uses RNAi to functionally validate the identified loci. 11 December 2015 | doi: 10.1038/ncomms10115 Biological Sciences  Genetics  Neuroscience  Structure of a bacterial type III secretion system in contact with a host membrane in situ OPEN Andrea Nans, Mikhail Kudryashev, Helen R. Saibil and Richard D. Hayward Bacterial type III secretion systems (T3SSs) inject virulence effector proteins into eukaryotic cells and are activated by host membrane contact. Here the authors report the in situ structure of the Chlamydia trachomatis T3SS in the presence or absence of host membrane, and observe compaction of the basal body embedded in the bacterial envelope. 11 December 2015 | doi: 10.1038/ncomms10114 Biological Sciences  Biophysics  Microbiology  Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage OPEN Efrat Dvash, Michal Har-Tal, Sara Barak, Ofir Meir and Menachem Rubinstein Chemotherapeutic agents elicit ER and oxidative stress as part of their mode of action. Here the authors show that chemotherapy and ER stress trigger MGST2-based biosynthesis of LTC4, whose inhibition abolishes chemotherapy- and ER stress-triggered oxidative stress and DNA damage, resulting in the attenuation of cell death. 11 December 2015 | doi: 10.1038/ncomms10112 Biological Sciences  Cancer  Cell biology  Molecular biology  Acceptorless dehydrogenation of small molecules through cooperative base metal catalysis OPEN Julian G. West, David Huang and Erik J. Sorensen Acceptorless dehydrogenation of simple alkanes and alcohols provides useful functionality and typically requires precious metal catalysts. Here, the authors dehydrogenate unactivated alkanes and alcohols at room temperature using earth-abundant metals with hydrogen as the sole by-product. 11 December 2015 | doi: 10.1038/ncomms10093 Chemical Sciences  Catalysis  Organic chemistry  Avalanching strain dynamics during the hydriding phase transformation in individual palladium nanoparticles OPEN A. Ulvestad, M. J. Welland, S. S. E. Collins, R. Harder, E. Maxey, J. Wingert, A. Singer, S. Hy, P. Mulvaney, P. Zapol and O. G. Shpyrko Phase transformations in nanoparticles can have a large effect on the performance of electrochemical devices and are strongly determined by parameters such as surface energy and faceting. Here, the authors study the hydriding phase transformation in individual palladium nanocubes and uncover individual structure-function relationships. 11 December 2015 | doi: 10.1038/ncomms10092 Chemical Sciences  Materials science  Nanotechnology  Physical chemistry  A small-gap electrostatic micro-actuator for large deflections OPEN Holger Conrad, Harald Schenk, Bert Kaiser, Sergiu Langa, Matthieu Gaudet, Klaus Schimmanz, Michael Stolz and Miriam Lenz Most electrostatic actuators suffer from an operational instability, the so-called pull-in effect. Here, the authors report an electrostatic actuator concept which makes the huge electrostatic forces within nanometre small electrode separation accessible for large deflections. 11 December 2015 | doi: 10.1038/ncomms10078 Physical Sciences  Applied physics  Nanotechnology  Physical chemistry  Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1 Liang Zhou, Kun Sun, Yu Zhao, Suyang Zhang, Xuecong Wang, Yuying Li, Leina Lu, Xiaona Chen, Fengyuan Chen, Xichen Bao, Xihua Zhu, Lijun Wang, Ling-Yin Tang, Miguel A. Esteban, Chi-Chiu Wang, Ralf Jauch, Hao Sun and Huating Wang Long intervening noncoding RNAs (lincRNAs) are an emerging class of molecular regulators with diverse functions. Here the authors identify Linc-YY1, a novel lincRNA transcribed from the noncoding region of the mouse YY1 gene, that binds to YY1 protein and thereby regulates skeletal muscle differentiation and regeneration. 11 December 2015 | doi: 10.1038/ncomms10026 Biological Sciences  Cell biology  Medical research  Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition Sergio Casas-Tintó, Fidel-Nicolás Lolo and Eduardo Moreno Slow-dividing ‘loser’ cells are outcompeted by more robust ‘winner’ cells and eliminated by macrophage-like haemocytes in the fruit fly larva. Here the authors show that the dying loser cells secrete the enzyme Tyrosyl-tRNA synthetase that upon Mmp2-mediated cleavage acts as a haemocyte chemoattractant. 11 December 2015 | doi: 10.1038/ncomms10022 Biological Sciences  Developmental biology  Jurassic climate mode governed by ocean gateway OPEN Christoph Korte, Stephen P. Hesselbo, Clemens V. Ullmann, Gerd Dietl, Micha Ruhl, Günter Schweigert and Nicolas Thibault Dynamics of the Laurasian Seaway are thought to have had wide effects on oceanography and climate in the mid-Mesozoic. Here, the authors show evidence for seawater temperature change, ascribed to tectonic uplift that impeded poleward oceanic heat transport and triggered a cool climate mode in the earliest Middle Jurassic. 11 December 2015 | doi: 10.1038/ncomms10015 Earth Sciences  Climate science  Oceanography  The impact of climate change on photovoltaic power generation in Europe OPEN Sonia Jerez, Isabelle Tobin, Robert Vautard, Juan Pedro Montávez, Jose María López-Romero, Françoise Thais, Blanka Bartok, Ole Bøssing Christensen, Augustin Colette, Michel Déqué, Grigory Nikulin, Sven Kotlarski, Erik van Meijgaard, Claas Teichmann and Martin Wild Renewables are key for abating climate change, but also potentially vulnerable to it. Here, the authors show that the power supply from a well-developed European fleet of photovoltaic installations may undergo decreases during the 21st century, but with limited changes in amplitude and temporal stability. 11 December 2015 | doi: 10.1038/ncomms10014 Earth Sciences  Climate science  Materials science  A universal self-charging system driven by random biomechanical energy for sustainable operation of mobile electronics OPEN Simiao Niu, Xiaofeng Wang, Fang Yi, Yu Sheng Zhou and Zhong Lin Wang Triboelectric nanogenerators utilize triboelectrification for harvesting energy from ambient mechanical motions. Here, the authors report an integrated triboelectric nanogenerator system using only human biomechanical energy to generate mW-level DC electricity that is enough to continuously drive various commercial mobile electronics. 11 December 2015 | doi: 10.1038/ncomms9975 Physical Sciences  Materials science  Multitrophic diversity in a biodiverse forest is highly nonlinear across spatial scales OPEN Andreas Schuldt, Tesfaye Wubet, François Buscot, Michael Staab, Thorsten Assmann, Martin Böhnke-Kammerlander, Sabine Both, Alexandra Erfmeier, Alexandra-Maria Klein, Keping Ma, Katherina Pietsch, Sabrina Schultze, Christian Wirth, Jiayong Zhang, Pascale Zumstein and Helge Bruelheide Measurements of biodiversity may differ according to the extent of area sampled, although how this changes across taxa is not well understood. Here, Schuldt et al. find that the diversity of plants, arthropods and microorganisms in a heterogeneous subtropical forest is highly nonlinear across spatial scales. 10 December 2015 | doi: 10.1038/ncomms10169 Biological Sciences  Ecology  Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels OPEN Sylvain Rama, Mickaël Zbili, Andrzej Bialowas, Laure Fronzaroli-Molinieres, Norbert Ankri, Edmond Carlier, Vincenzo Marra and Dominique Debanne 'Digital' spike-evoked transmission can be facilitated by slow subthreshold 'analogue' depolarisation of the presynaptic neuron. Here, the authors identify a novel, rapid form of digital-analogue facilitation in mammalian neurons whereby presynaptic hyperpolarisation enables de-inactivation of axonal Nav channels. 10 December 2015 | doi: 10.1038/ncomms10163 Biological Sciences  Neuroscience  Cellobiohydrolase 1 from Trichoderma reesei degrades cellulose in single cellobiose steps OPEN Sonia K. Brady, Sarangapani Sreelatha, Yinnian Feng, Shishir P. S. Chundawat and Matthew J Lang Cellobiohydrolases are promising tools in biofuel production by hydrolysing cellulose into cellobiose. Here the authors use optical tweezers to show that Cellobiohydrolase 1 from Tricodermia reesei functions processively against moderate load, and likely uses multiple energy sources to fuel each step along the cellulose fibre. 10 December 2015 | doi: 10.1038/ncomms10149 Biological Sciences  Biophysics  Engulfment pathways promote programmed cell death by enhancing the unequal segregation of apoptotic potential OPEN Sayantan Chakraborty, Eric J. Lambie, Samik Bindu, Tamara Mikeladze-Dvali and Barbara Conradt Programed cell death occurs in a stereotypic fashion during C. elegans development, and it is thought that engulfment promotes programmed cell death. Here the authors present evidence that a signaling function of the conserved engulfment pathways, not the process of engulfment itself, promotes apoptotic cell death. 10 December 2015 | doi: 10.1038/ncomms10126 Biological Sciences  Cell biology  Developmental biology  Mechanisms of assembly and genome packaging in an RNA virus revealed by high-resolution cryo-EM OPEN Emma L. Hesketh, Yulia Meshcheriakova, Kyle C. Dent, Pooja Saxena, Rebecca F. Thompson, Joseph J. Cockburn, George P. Lomonossoff and Neil A. Ranson Little is known about how the plant-infecting cowpea mosaic virus (CPMV)—an invaluable tool in several biotechnology applications—packages its single-strand RNA genome into the capsid. Here the authors present two high-resolution cryo-EM structures of CPMV and a new model for RNA recognition and capsid assembly. 10 December 2015 | doi: 10.1038/ncomms10113 Biological Sciences  Biotechnology  Virology  Humidity trends imply increased sensitivity to clouds in a warming Arctic OPEN Christopher J. Cox, Von P. Walden, Penny M. Rowe and Matthew D. Shupe The cloud radiative effect (CRE) in the Arctic plays an important role in the amount of infrared radiation that reaches the surface. Here, the authors show that interplay between temperature and humidity controls CRE through competing influences in two semi-transparent wavelength ranges. 10 December 2015 | doi: 10.1038/ncomms10117 Earth Sciences  Atmospheric science  Climate science  A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance OPEN Natsumi Ageta-Ishihara, Maya Yamazaki, Kohtarou Konno, Hisako Nakayama, Manabu Abe, Kenji Hashimoto, Tomoki Nishioka, Kozo Kaibuchi, Satoko Hattori, Tsuyoshi Miyakawa, Kohichi Tanaka, Fathul Huda, Hirokazu Hirai, Kouichi Hashimoto, Masahiko Watanabe, Kenji Sakimura and Makoto Kinoshita Glutamate transporters mediate neurotransmitter reuptake at glutamatergic synapses. Here the authors show that CDC42 effector protein CDC42EP4 supports efficient glutamate clearance by promoting the tethering of a glutamate transporter GLAST to perisynaptic clusters of septins in Bergmann glia. 10 December 2015 | doi: 10.1038/ncomms10090 Biological Sciences  Cell biology  Neuroscience  Atlantic multi-decadal oscillation covaries with Agulhas leakage OPEN Arne Biastoch, Jonathan V. Durgadoo, Adele K. Morrison, Erik van Sebille, Wilbert Weijer and Stephen M. Griffies The long-term quantification of the Angulas Leakage is difficult due to its highly variable spatio-temporal nature and sparse observations. Here, the authors combine sea surface temperature with a series of ocean and climate model simulations to construct a 145-year long time series of Agulhas leakage. 10 December 2015 | doi: 10.1038/ncomms10082 Earth Sciences  Climate science  Oceanography  Left–right asymmetric cell intercalation drives directional collective cell movement in epithelial morphogenesis OPEN Katsuhiko Sato, Tetsuya Hiraiwa, Emi Maekawa, Ayako Isomura, Tatsuo Shibata and Erina Kuranaga Coordinated epithelial movement during embryogenesis drives complex tissue formation, but how this movement is coordinated to maintain epithelial integrity is not clear. Here the authors show that left-right asymmetry in cell intercalation drives clockwise rotation of epithelia in Drosophila genital development. 10 December 2015 | doi: 10.1038/ncomms10074 Biological Sciences  Biophysics  Developmental biology  Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis OPEN Smitha Pillai, Jonathan Nguyen, Joseph Johnson, Eric Haura, Domenico Coppola and Srikumar Chellappan TANK binding kinase 1 (TBK1) is a non-canonical IκB kinase that regulates immunity via NF-κB. Here Pillai et al. show that TBK1 localizes to centrosomes during mitosis, and regulates microtubule dynamics and spindle formation by phosphorylating the centrosomal protein CEP170 and the mitotic apparatus protein NuMa. 10 December 2015 | doi: 10.1038/ncomms10072 Biological Sciences  Cell biology  Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane OPEN Mehdi Damaghi, Narges K. Tafreshi, Mark C. Lloyd, Robert Sprung, Veronica Estrella, Jonathan W. Wojtkowiak, David L. Morse, John M. Koomen, Marilyn M. Bui, Robert A Gatenby and Robert J Gillies The protein LAMP2 functions to protect lysosomal membranes from acid proteolysis. In this study, the authors show that malignant cells adapt to the acidic tumour microenvironment by redirecting LAMP2 from lysosomes to the plasma membrane. 10 December 2015 | doi: 10.1038/ncomms9752 Biological Sciences  Cancer  Cell biology  Long-term neural and physiological phenotyping of a single human OPEN Russell A. Poldrack, Timothy O. Laumann, Oluwasanmi Koyejo, Brenda Gregory, Ashleigh Hover, Mei-Yen Chen, Krzysztof J. Gorgolewski, Jeffrey Luci, Sung Jun Joo, Ryan L. Boyd, Scott Hunicke-Smith, Zack Booth Simpson, Thomas Caven, Vanessa Sochat, James M. Shine, Evan Gordon, Abraham Z. Snyder, Babatunde Adeyemo, Steven E. Petersen, David C. Glahn et al. Large-scale, multimodal phenotypic characterisation is a valuable tool to explore brain function. Poldrack et al. collect and relate MRI, psychological, physiological, metabolic and gene expression data from a single human over an 18 month period, providing a rich resource for future studies. 09 December 2015 | doi: 10.1038/ncomms9885 Biological Sciences  Neuroscience  Systems biology  Conformational gating of DNA conductance OPEN Juan Manuel Artés, Yuanhui Li, Jianqing Qi, M. P. Anantram and Joshua Hihath DNA could find a role in molecular electronics. Here, the authors show that the conductance of DNA can be reversibly changed by an order of magnitude when its conformation is changed from one form to another by controlling its chemical environment. 09 December 2015 | doi: 10.1038/ncomms9870 Physical Sciences  Biophysics  Nanotechnology  Physical chemistry  Nanoscale origins of the damage tolerance of the high-entropy alloy CrMnFeCoNi OPEN ZiJiao Zhang, M. M. Mao, Jiangwei Wang, Bernd Gludovatz, Ze Zhang, Scott X. Mao, Easo P. George, Qian Yu and Robert O. Ritchie Single-phase high-entropy alloys, such as CrMnFeCoNi, display excellent ductility and fracture toughness. Here, the authors use in situ mechanical loading in an aberration-corrected transmission electron microscope to probe the atomistic to micro-scale mechanisms underlying these properties. 09 December 2015 | doi: 10.1038/ncomms10143 Physical Sciences  Materials science  Linker histone H1 and H3K56 acetylation are antagonistic regulators of nucleosome dynamics OPEN Morgan Bernier, Yi Luo, Kingsley C. Nwokelo, Michelle Goodwin, Sarah J. Dreher, Pei Zhang, Mark R. Parthun, Yvonne Fondufe-Mittendorf, Jennifer J. Ottesen and Michael G. Poirier The linker histone H1 is highly abundant and regulates DNA accessibility by compacting chromatin. Here the authors analyze transcription factor binding to nucleosomes and show that histone H1 suppresses unwrapping but does not directly block the binding of transcription factors. 09 December 2015 | doi: 10.1038/ncomms10152 Biological Sciences  Biochemistry  Molecular biology  Host–guest chemistry for tuning colloidal solubility, self-organization and photoconductivity of inorganic-capped nanocrystals OPEN Maryna I. Bodnarchuk, Sergii Yakunin, Laura Piveteau and Maksym V. Kovalenko The high polarity of colloidal inorganic-ligand-functionalized nanocrystals can be problematic for their processing, limiting their optoelectronic applications. Here, by complexation with macrocycles, the authors enabled broad amphiphilicity of such nanocrystals and processing from a variety of solvents. 09 December 2015 | doi: 10.1038/ncomms10142 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas OPEN Kui Wu, Xin Zhang, Fuqiang Li, Dakai Xiao, Yong Hou, Shida Zhu, Dongbing Liu, Xiaofei Ye, Mingzhi Ye, Jie Yang, Libin Shao, Hui Pan, Na Lu, Yuan Yu, Liping Liu, Jin Li, Liyan Huang, Hailing Tang, Qiuhua Deng, Yue Zheng et al. Despite lung adenocarcinoma having a high global mortality, the genetic mutations present in Asian patients are uncharacterized. Here the authors use genomic and transcriptomic analysis to identify thirteen significantly affected genes, including RHPN2, GLI3, MRC2, TP53 and IQGAP3. 09 December 2015 | doi: 10.1038/ncomms10131 Biological Sciences  Cancer  Genetics  TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair OPEN Yuji Ogura, Sajedah M. Hindi, Shuichi Sato, Guangyan Xiong, Shizuo Akira and Ashok Kumar TAK1 is a MEK kinase family member that activates pro-survival NF-kB signalling but also pro-apoptotic caspase signalling in various cell types. Here the authors show that satellite-cell specific deletion of TAK1 in mice depletes the muscle stem cell pool and thus limits myofibre regeneration after injury. 09 December 2015 | doi: 10.1038/ncomms10123 Biological Sciences  Medical research  Cold-sensing regulates Drosophila growth through insulin-producing cells OPEN Qiaoran Li and Zhefeng Gong Animal body size is influenced by climate, but the cellular mechanisms regulating this response are unclear. Here, the authors identify a neuronal circuit composed of a group of cold-sensing neurons and insulin-producing cells that mediates the effects of temperature on Drosophila growth. 09 December 2015 | doi: 10.1038/ncomms10083 Biological Sciences  Neuroscience  Signal transduction in light–oxygen–voltage receptors lacking the adduct-forming cysteine residue OPEN Estella F. Yee, Ralph P. Diensthuber, Anand T. Vaidya, Peter P. Borbat, Christopher Engelhard, Jack H. Freed, Robert Bittl, Andreas Möglich and Brian R. Crane Light-oxygen-voltage receptors sense blue light through the photochemical generation of a covalent adduct between a flavin-nucleotide chromophore and a strictly conserved cysteine residue. Here, the authors show that these proteins can react to light even when devoid of the adduct-forming cysteine. 09 December 2015 | doi: 10.1038/ncomms10079 Chemical Sciences  Biochemistry  Chemical biology  Molecular biology  PLK1 regulation of PCNT cleavage ensures fidelity of centriole separation during mitotic exit OPEN Jaeyoun Kim, Kwanwoo Lee and Kunsoo Rhee Separase-mediated cleavage of pericentrin is an essential step for centriole separation during mitotic exit. Here, Kim et al. show that pericentrin has to be phosphorylated by PLK1 in order to be cleaved by separase, which provides an additional layer of regulation for centriole separation during mitotic exit. 09 December 2015 | doi: 10.1038/ncomms10076 Biological Sciences  Cell biology  The microscopic structure of charge density waves in underdoped YBa2Cu3O6.54 revealed by X-ray diffraction OPEN E. M. Forgan, E. Blackburn, A. T. Holmes, A. K. R. Briffa, J. Chang, L. Bouchenoire, S. D. Brown, Ruixing Liang, D. Bonn, W. N. Hardy, N. B. Christensen, M. V. Zimmermann, M. Hücker and S. M. Hayden Near to the superconducting state, cuprates display spatially-periodic charge density variations. Here, the authors use x-ray diffraction to determine the microscopic structure, showing how charge density waves in underdoped YBa2Cu3O6.54 break the symmetry of the superconducting layers. 09 December 2015 | doi: 10.1038/ncomms10064 Physical Sciences  Condensed matter  A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing OPEN Tyler S. Alioto, Ivo Buchhalter, Sophia Derdak, Barbara Hutter, Matthew D. Eldridge, Eivind Hovig, Lawrence E. Heisler, Timothy A. Beck, Jared T. Simpson, Laurie Tonon, Anne-Sophie Sertier, Ann-Marie Patch, Natalie Jäger, Philip Ginsbach, Ruben Drews, Nagarajan Paramasivam, Rolf Kabbe, Sasithorn Chotewutmontri, Nicolle Diessl, Christopher Previti et al. Cancer genetics has benefited from the advent of next generation sequencing, yet a comparison of sequencing and analysis techniques is lacking. Here, the authors sequence a normal-tumour pair and perform data analysis at multiple institutes and highlight some of the pitfalls associated with the different methods. 09 December 2015 | doi: 10.1038/ncomms10001 Biological Sciences  Bioinformatics  Cancer  Genetics    Nature Communications JOBS of the week Postdoctoral Scientist John Innes Centre (JIC) Post-Doctoral Research Fellow Massachusetts General Hospital & Harvard Medical School Postdoctoral Fellow: Neurocognitive Aging National Institute on Aging (NIA), National Institutes of Health (NIH) Laboratory Technician University of Leeds Doctoral Researchers University of Göttingen - CRC 990 Principal / Senior Research Fellow University of Strathclyde Group Leader Positions, Tenure Track Friedrich Miescher Institute for Biomedical Research (FMI) 12 Fully Funded Ph.D. Student Positions Cologne Graduate School of Ageing Research (CGA) Two Professors Umeå University Postdoctoral Program Novartis Institutes for BioMedical Research More Science jobs from Nature Communications EVENT Mechanisms and Barriers in Nanomedicine 14.07.16 Breckenridge, USA More science events from       Latest Corrigenda     Corrigendum: TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression Ken-ichi Takayama, Aya Misawa, Takashi Suzuki, Kiyoshi Takagi, Yoshihide Hayashizaki, Tetsuya Fujimura, Yukio Homma, Satoru Takahashi, Tomohiko Urano and Satoshi Inoue 14 December 2015 | doi: 10.1038/ncomms10265 Biological Sciences  Cancer      Corrigendum: A fast and unbiased procedure to randomize ecological binary matrices with fixed row and column totals Giovanni Strona, Domenico Nappo, Francesco Boccacci, Simone Fattorini and Jesus San-Miguel-Ayanz 10 December 2015 | doi: 10.1038/ncomms10226 Biological Sciences  Ecology      Corrigendum: Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients Elad Ziv, Eric Dean, Donglei Hu, Alessandro Martino, Daniel Serie, Karen Curtin, Daniele Campa, Blake Aftab, Paige Bracci, Gabriele Buda, Yi Zhao, Jennifer Caswell-Jin, Robert Diasio, Charles Dumontet, Marek Dudziński, Laura Fejerman, Alexandra Greenberg, Scott Huntsman, Krzysztof Jamroziak, Artur Jurczyszyn et al. 09 December 2015 | doi: 10.1038/ncomms10203 Biological Sciences  Cancer  Genetics        Latest Errata     Erratum: The genomics of ecological vicariance in threespine stickleback fish OPEN Marius Roesti, Benjamin Kueng, Dario Moser and Daniel Berner 15 December 2015 | doi: 10.1038/ncomms10229 Biological Sciences  Ecology  Evolution  Genetics      Erratum: Cooper pair splitting in parallel quantum dot Josephson junctions OPEN R. S. Deacon, A. Oiwa, J. Sailer, S. Baba, Y. Kanai, K. Shibata, K. Hirakawa and S. Tarucha 14 December 2015 | doi: 10.1038/ncomms10299 Physical Sciences  Applied physics  Nanotechnology      Erratum: Lateral forces on circularly polarizable particles near a surface OPEN Francisco J. Rodríguez-Fortuño, Nader Engheta, Alejandro Martínez and Anatoly V. Zayats 14 December 2015 | doi: 10.1038/ncomms10263 Physical Sciences  Nanotechnology  Optical physics  Theoretical physics      Advertisement Nature Genetics and Nature Reviews Cancer present: NUCLEAR REPROGRAMMING AND THE CANCER GENOME 2016 Sponsored by CapitalBio Corporation February 21-23, 2016 | La Jolla, CA, USA REGISTER NOW!   Advertisement The discussion on Alzheimer’s Disease continues Nature Neuroscience presents a community forum on Alzheimer's Disease (AD) research. ACCESS NOW to view videos of our panel event at SfN 2015, read related articles for free, and discuss critical issues facing AD research today. 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