The EDGE

Serotonergic neurons derived from induced pluripotent stem cells (iPSCs): a new pathway for research on the biology and pharmacology of major depression

J Licinio and M-L Wong

Mol Psychiatry 2016 21: 1-2; 10.1038/mp.2015.201

Image

The different moods of human serotonergic neurons

K C Vadodaria, J Mertens, A Paquola, C Bardy, X Li, R Jappelli, L Fung, M C Marchetto, M Hamm, M Gorris, P Koch and F H Gage

Mol Psychiatry 2016 21: 3; 10.1038/mp.2015.202

News and Commentary

Psychiatric genetics in China: achievements and challenges

C Liu, D Saffen, T G Schulze, M Burmeister, P C Sham, Y-g Yao, P-H Kuo, C Chen, Y An, J Dai, W Yue, M X Li, H Xue, B Su, L Chen, Y Shi, M Qiao, T Liu, K Xia and R C K Chan

Mol Psychiatry 2016 21: 4-9; advance online publication, October 20, 2015; 10.1038/mp.2015.95

Expert Review

Molecular substrates of schizophrenia: homeostatic signaling to connectivity

M A Landek-Salgado, T E Faust and A Sawa

Mol Psychiatry 2016 21: 10-28; advance online publication, September 22, 2015; 10.1038/mp.2015.141

Review

The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders

D S Quintana, A J Guastella, L T Westlye and O A Andreassen

Mol Psychiatry 2016 21: 29-38; advance online publication, November 10, 2015; 10.1038/mp.2015.166

Immediate Communications

Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus OPEN

T Kasahara, A Takata, T M Kato, M Kubota-Sakashita, T Sawada, A Kakita, H Mizukami, D Kaneda, K Ozawa and T Kato

Mol Psychiatry 2016 21: 39-48; advance online publication, October 20, 2015; 10.1038/mp.2015.156

Generation of functional human serotonergic neurons from fibroblasts

K C Vadodaria, J Mertens, A Paquola, C Bardy, X Li, R Jappelli, L Fung, M C Marchetto, M Hamm, M Gorris, P Koch and F H Gage

Mol Psychiatry 2016 21: 49-61; advance online publication, October 27, 2015; 10.1038/mp.2015.161

Original Articles

Direct conversion of human fibroblasts to induced serotonergic neurons OPEN

Z Xu, H Jiang, P Zhong, Z Yan, S Chen and J Feng

Mol Psychiatry 2016 21: 62-70; advance online publication, July 28, 2015; 10.1038/mp.2015.101

Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study

M H Rapaport, A A Nierenberg, P J Schettler, B Kinkead, A Cardoos, R Walker and D Mischoulon

Mol Psychiatry 2016 21: 71-79; advance online publication, March 24, 2015; 10.1038/mp.2015.22

The impact of chronic stress on the rat brain lipidome

T G Oliveira, R B Chan, F V Bravo, A Miranda, R R Silva, B Zhou, F Marques, V Pinto, J J Cerqueira, G Di Paolo and N Sousa

Mol Psychiatry 2016 21: 80-88; advance online publication, March 10, 2015; 10.1038/mp.2015.14

Copy number variation in bipolar disorder OPEN

E K Green, E Rees, J T R Walters, K-G Smith, L Forty, D Grozeva, J L Moran, P Sklar, S Ripke, K D Chambert, G Genovese, S A McCarroll, I Jones, L Jones, M J Owen, M C O'Donovan, N Craddock and G Kirov

Mol Psychiatry 2016 21: 89-93; advance online publication, January 6, 2015; 10.1038/mp.2014.174

Common polygenic variation and risk for childhood-onset schizophrenia OPEN

K Ahn, S S An, Y Y Shugart and J L Rapoport

Mol Psychiatry 2016 21: 94-96; advance online publication, December 16, 2014; 10.1038/mp.2014.158

A_2A adenosine receptor deletion is protective in a mouse model of Tauopathy OPEN

C Laurent, S Burnouf, B Ferry, V L Batalha, J E Coelho, Y Baqi, E Malik, E Mariciniak, S Parrot, A Van der Jeugd, E Faivre, V Flaten, C Ledent, R D'Hooge, N Sergeant, M Hamdane, S Humez, C E Müller, L V Lopes, L Buée and D Blum

Mol Psychiatry 2016 21: 97-107; advance online publication, December 2, 2014; 10.1038/mp.2014.151

A novel Alzheimer disease locus located near the gene encoding tau protein

G Jun, C A Ibrahim-Verbaas, M Vronskaya, J-C Lambert, J Chung, A C Naj, B W Kunkle, L-S Wang, J C Bis, C Bellenguez, D Harold, K L Lunetta, A L Destefano, B Grenier-Boley, R Sims, G W Beecham, A V Smith, V Chouraki, K L Hamilton-Nelson, M A Ikram, N Fievet, N Denning, E R Martin, H Schmidt, Y Kamatani, M L Dunstan, O Valladares, A R Laza, D Zelenika, A Ramirez, T M Foroud, S-H Choi, A Boland, T Becker, W A Kukull, S J van der Lee, F Pasquier, C Cruchaga, D Beekly, A L Fitzpatrick, O Hanon, M Gill, R Barber, V Gudnason, D Campion, S Love, D A Bennett, N Amin, C Berr, Magda Tsolaki, J D Buxbaum, O L Lopez, V Deramecourt, N C Fox, L B Cantwell, L Tárraga, C Dufouil, J Hardy, P K Crane, G Eiriksdottir, D Hannequin, R Clarke, D Evans, T H Mosley, Jr., L Letenneur, C Brayne, W Maier, P De Jager, V Emilsson, J-F Dartigues, H Hampel, M I Kamboh, R F A G de Bruijn, C Tzourio, P Pastor, E B Larson, J I Rotter, M C O'Donovan, T J Montine, M A Nalls, S Mead, E M Reiman, P V Jonsson, C Holmes, P H St George-Hyslop, M Boada, P Passmore, J R Wendland, R Schmidt, K Morgan, A R Winslow, J F Powell, M Carasquillo, S G Younkin, J Jakobsdóttir, J S K Kauwe, K C Wilhelmsen, D Rujescu, M M Nöthen, A Hofman, L Jones, IGAP Consortium, J L Haines, B M Psaty, C Van Broeckhoven, P Holmans, L J Launer, R Mayeux, M Lathrop, A M Goate, V Escott-Price, S Seshadri, M A Pericak-Vance, P Amouyel, J Williams, C M van Duijn, G D Schellenberg and L A Farrer

Mol Psychiatry 2016 21: 108-117; advance online publication, March 17, 2015; 10.1038/mp.2015.23

Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder

A K Tilot, G Bebek, F Niazi, J B Altemus, T Romigh, T W Frazier and C Eng

Mol Psychiatry 2016 21: 118-125; advance online publication, March 10, 2015; 10.1038/mp.2015.17

Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID

B W M van Bon, B P Coe, R Bernier, C Green, J Gerdts, K Witherspoon, T Kleefstra, M H Willemsen, R Kumar, P Bosco, M Fichera, D Li, D Amaral, F Cristofoli, H Peeters, E Haan, C Romano, H C Mefford, I Scheffer, J Gecz, B B A de Vries and E E Eichler

Mol Psychiatry 2016 21: 126-132; advance online publication, February 24, 2015; 10.1038/mp.2015.5

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes OPEN

H Hu, S A Haas, J Chelly, H Van Esch, M Raynaud, A P M de Brouwer, S Weinert, G Froyen, S G M Frints, F Laumonnier, T Zemojtel, M I Love, H Richard, A-K Emde, M Bienek, C Jensen, M Hambrock, U Fischer, C Langnick, M Feldkamp, W Wissink-Lindhout, N Lebrun, L Castelnau, J Rucci, R Montjean, O Dorseuil, P Billuart, T Stuhlmann, M Shaw, M A Corbett, A Gardner, S Willis-Owen, C Tan, K L Friend, S Belet, K E P van Roozendaal, M Jimenez-Pocquet, M-P Moizard, N Ronce, R Sun, S O'Keeffe, R Chenna, A van Bömmel, J Göke, A Hackett, M Field, L Christie, J Boyle, E Haan, J Nelson, G Turner, G Baynam, G Gillessen-Kaesbach, U Müller, D Steinberger, B Budny, M Badura-Stronka, A Latos-Bieleńska, L B Ousager, P Wieacker, G Rodríguez Criado, M-L Bondeson, G Annerén, A Dufke, M Cohen, L Van Maldergem, C Vincent-Delorme, B Echenne, B Simon-Bouy, T Kleefstra, M Willemsen, J-P Fryns, K Devriendt, R Ullmann, M Vingron, K Wrogemann, T F Wienker, A Tzschach, H van Bokhoven, J Gecz, T J Jentsch, W Chen, H-H Ropers and V M Kalscheuer

Mol Psychiatry 2016 21: 133-148; advance online publication, February 3, 2015; 10.1038/mp.2014.193

Corrigendum

A_2A adenosine receptor deletion is protective in a mouse model of Tauopathy

Mol Psychiatry 2016 21: 149; advance online publication, July 28, 2015; 10.1038/mp.2015.115