The EDGE

Catch me if you can: targeting the mitochondrial permeability transition pore in myocardial infarction

A Linkermann, K Konstantinidis and R N Kitsis

Cell Death Differ 2016 23: 1-2; advance online publication, November 20, 2015; 10.1038/cdd.2015.151

Obituary

In memoriam: Prof Christopher J Froelich (1951–2015)

S S Metkar, J Pardo, G Anderluh, G Salvesen, J A Trapani and M M Simon

Cell Death Differ 2016 23: 3-4; 10.1038/cdd.2015.141

News-And-Commentaries

Autophagy and AML—food for thought

N Lalaoui, R Johnstone and P G Ekert

Cell Death Differ 2016 23: 5-6; advance online publication, October 30, 2015; 10.1038/cdd.2015.136

Chronic lymphocytic leukemia: looking into the dark side of the genome

R Valdés-Mas, J Gutiérrez-Abril, X S Puente and C López-Otín

Cell Death Differ 2016 23: 7-9; advance online publication, November 27, 2015; 10.1038/cdd.2015.155

Review

Programmed cell death 50 (and beyond)

R A Lockshin

Cell Death Differ 2016 23: 10-17; advance online publication, November 13, 2015; 10.1038/cdd.2015.126

Original Papers

Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons OPEN

B Oettinghaus, J M Schulz, L M Restelli, M Licci, C Savoia, A Schmidt, K Schmitt, A Grimm, L Morè, J Hench, M Tolnay, A Eckert, P D'Adamo, P Franken, N Ishihara, K Mihara, J Bischofberger, L Scorrano and S Frank

Cell Death Differ 2016 23: 18-28; advance online publication, April 24, 2015; 10.1038/cdd.2015.39

Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner

N Preyat, M Rossi, J Kers, L Chen, J Bertin, P J Gough, A Le Moine, A Rongvaux, F Van Gool and O Leo

Cell Death Differ 2016 23: 29-40; advance online publication, May 22, 2015; 10.1038/cdd.2015.60

The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland OPEN

F Schuler, F Baumgartner, V Klepsch, M Chamson, E Müller-Holzner, C J Watson, S Oh, L Hennighausen, P Tymoszuk, W Doppler and A Villunger

Cell Death Differ 2016 23: 41-51; advance online publication, June 5, 2015; 10.1038/cdd.2015.61

Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity

S Zhang, Q Qi, C B Chan, W Zhou, J Chen, H R Luo, C Appin, D J Brat and K Ye

Cell Death Differ 2016 23: 52-63; advance online publication, May 22, 2015; 10.1038/cdd.2015.66

Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death

U Beyer, S K Krönung, A Leha, L Walter and M Dobbelstein

Cell Death Differ 2016 23: 64-75; advance online publication, May 29, 2015; 10.1038/cdd.2015.68

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

D A Rodriguez, R Weinlich, S Brown, C Guy, P Fitzgerald, C P Dillon, A Oberst, G Quarato, J Low, J G Cripps, T Chen and D R Green

Cell Death Differ 2016 23: 76-88; advance online publication, May 29, 2015; 10.1038/cdd.2015.70

NF-κB pathway controls mitochondrial dynamics OPEN

M Laforge, V Rodrigues, R Silvestre, C Gautier, R Weil, O Corti and J Estaquier

Cell Death Differ 2016 23: 89-98; advance online publication, May 29, 2015; 10.1038/cdd.2015.42

Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes

C Mazzeo, V Calvo, R Alonso, I Mérida and M Izquierdo

Cell Death Differ 2016 23: 99-109; advance online publication, June 5, 2015; 10.1038/cdd.2015.72

HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism OPEN

E Conrad, T Polonio-Vallon, M Meister, S Matt, N Bitomsky, C Herbel, M Liebl, V Greiner, B Kriznik, S Schumacher, E Krieghoff-Henning and T G Hofmann

Cell Death Differ 2016 23: 110-122; advance online publication, June 26, 2015; 10.1038/cdd.2015.75

Stressed neurons protect themselves by a tissue-type plasminogen activator-mediated EGFR-dependent mechanism

E Lemarchand, E Maubert, B Haelewyn, C Ali, M Rubio and D Vivien

Cell Death Differ 2016 23: 123-131; advance online publication, June 12, 2015; 10.1038/cdd.2015.76

Stromal miR-200s contribute to breast cancer cell invasion through CAF activation and ECM remodeling OPEN

X Tang, Y Hou, G Yang, X Wang, S Tang, Y-E Du, L Yang, T Yu, H Zhang, M Zhou, S Wen, L Xu and M Liu

Cell Death Differ 2016 23: 132-145; advance online publication, June 12, 2015; 10.1038/cdd.2015.78

Tousled-like kinase mediated a new type of cell death pathway in Drosophila

Y Zhang, R Cai, R Zhou, Y Li and L Liu

Cell Death Differ 2016 23: 146-157; advance online publication, June 19, 2015; 10.1038/cdd.2015.77

The LIM protein Ajuba promotes adipogenesis by enhancing PPARγ and p300/CBP interaction

Q Li, H Peng, H Fan, X Zou, Q Liu, Y Zhang, H Xu, Y Chu, C Wang, K Ayyanathan, F J Rauscher, K Zhang and Z Hou

Cell Death Differ 2016 23: 158-168; advance online publication, June 26, 2015; 10.1038/cdd.2015.83

Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice

Z Tu, Q Wang, T Cui, J Wang, H Ran, H Bao, J Lu, B Wang, J P Lydon, F DeMayo, S Zhang, S Kong, X Wu and H Wang

Cell Death Differ 2016 23: 169-181; advance online publication, July 17, 2015; 10.1038/cdd.2015.98

Correspondence

The ATM–BID pathway plays a critical role in the DNA damage response by regulating mitochondria metabolism

A Gross, Y Zaltsman and M Maryanovich

Cell Death Differ 2016 23: 182; advance online publication, November 27, 2015; 10.1038/cdd.2015.154

Meeting-Report

9th Tuscany Retreat on Cancer Research: genetic profiling, resistance mechanisms and novel treatment concepts in cancer

L Peintner, F Novelli, A Smirnov, U Maurer, C Borner and S von Karstedt

Cell Death Differ 2016 23: 183-184; advance online publication, November 13, 2015; 10.1038/cdd.2015.148