The EMBO Journal Table of Contents for 12 November 2015; Vol. 34, No. 22

12 November 2015 | Volume 34, Number 22 Submit Table of Contents Editorial Obituary Commentary News & Views Review Articles Resource Corrigendum Volume 34, Number 22 Editorial Reproducibility blues Bernd Pulverer Published online 04.11.2015 Obituary Gottfried Schatz (1936–2015)—mitochondrial pioneer and ambassador for science Volker Haucke and Benjamin S Glick Published online 26.10.2015 Commentary Focus: Study Design & Statistical Analysis: Statistical relevance—relevant statistics, part I As part of a new EMBO Journal statistics series, this commentary introduces key concepts in statistical analysis and discusses best practices in study design. Bernd Klaus Published online 21.09.2015 News & Views Assembly of the nucleolus: in need of revision A new study identifies a role for intron‐derived Alu elements in scaffolding the assembly of the nucleolus, thus shedding light on an abundant group of non‐coding RNAs. Maria Carmo‐Fonseca Published online 15.10.2015 Siglecs take a TOLL on inflammation: deciphering the Hsp70 riddle Recent work sheds light on the open question if extracellular heat shock proteins (HSPs) function as endogenous pro‐ or anti‐inflammatory signals. Stuart K Calderwood and Ayesha Murshid Published online 16.10.2015 Review Complement activation, regulation, and molecular basis for complement‐related diseases The complement system is an essential element of the innate immune response to pathogens. This review provides a comprehensive overview of the complement system with particular emphasis on understanding the role of complement proteins in health and disease. Goran Bajic, Søren E Degn, Steffen Thiel, and Gregers R Andersen Published online 21.10.2015 Articles Alu element‐containing RNAs maintain nucleolar structure and function The human genome encodes thousands of Alu repeats of unclear function. This study shows intronic Alu elements transcribed by RNA Pol II to be enriched in the nucleolus where they maintain nucleolar integrity and ensure pre‐rRNA synthesis. Maïwen Caudron‐Herger, Teresa Pankert, Jeanette Seiler, Attila Németh, Renate Voit, Ingrid Grummt, and Karsten Rippe Published online 13.10.2015 Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec‐5 and Siglec‐14 Recognition of Hsp70 by different leukocyte receptors has either pro‐ or anti‐inflammatory effects, helping to reconcile previous contradictory findings on the extracellular role of this chaperone. Jerry J Fong, Karthik Sreedhara, Liwen Deng, Nissi M Varki, Takashi Angata, Qinglian Liu, Victor Nizet, and Ajit Varki Published online 12.10.2015 H3K9 methylation extends across natural boundaries of heterochromatin in the absence of an HP1 protein Originally thought to be a stably bound protein required for heterochromatin formation, this study shows that HP1/Swi6 is highly dynamic and rather acts to prevent unwanted propagation of a silenced epigenetic state. Rieka Stunnenberg, Raghavendran Kulasegaran‐Shylini, Claudia Keller, Moritz A Kirschmann, Laurent Gelman, and Marc Bühler Published online 05.10.2015 The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes Transcription factor interplay triggered by brain injury compromises adult neurogenesis through derepression of astrocyte‐specific gene expression. Christian Bohrer, Sabrina Pfurr, Könül Mammadzada, Sebastian Schildge, Leandra Plappert, Miriam Hils, Lauriane Pous, Katharina S Rauch, Verónica I Dumit, Dietmar Pfeifer, Jörn Dengjel, Matthias Kirsch, Kristina Schachtrup, and Christian Schachtrup Published online 05.10.2015 Alzheimer's disease‐causing proline substitutions lead to presenilin 1 aggregation and malfunction Proper presenilin 1 folding and aggregation prevention in vivo is found to require the ER chaperone cyclophilin B, whose action on presenilin 1 is impaired by familial Alzheimer's disease‐associated mutations in the latter. Tziona Ben‐Gedalya, Lorna Moll, Michal Bejerano‐Sagie, Samuel Frere, Wayne A Cabral, Dinorah Friedmann‐Morvinski, Inna Slutsky, Tal Burstyn‐Cohen, Joan C Marini, and Ehud Cohen Published online 05.10.2015 Resource Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1 Ser111 modification of Rab8A, Rab8B and Rab13 represent some of only few PINK1‐dependent phosphorylation events and may regulate GTPase function during mitophagy. Yu‐Chiang Lai, Chandana Kondapalli, Ronny Lehneck, James B Procter, Brian D Dill, Helen I Woodroof, Robert Gourlay, Mark Peggie, Thomas J Macartney, Olga Corti, Jean‐Christophe Corvol, David G Campbell, Aymelt Itzen, Matthias Trost, and Miratul MK Muqit Published online 15.10.2015 Corrigendum The cis‐regulatory code of Hox function in Drosophila Sebastian Sorge, Nati Ha, Maria Polychronidou, Jana Friedrich, Daniela Bezdan, Petra Kaspar, Martin H Schaefer, Stephan Ossowski, Stefan R Henz, Juliane Mundorf, Jenny Rätzer, Fani Papagiannouli, and Ingrid Lohmann Published online 12.11.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.