The EMBO Journal Table of Contents for 3 November 2015; Vol. 34, No. 21

3 November 2015 | Volume 34, Number 21 Submit Table of Contents News & Views Articles Volume 34, Number 21 News & Views Acetyl‐ed question in mitochondrial biology? New findings of very low acetylation stoichiometry on hepatic mitochondrial proteins question the widespread regulatory significance of SIRT3 deacylase‐targeted lysine acetylation in liver mitochondria. David B Lombard, Banaja P Dash, and Surinder Kumar Published online 14.09.2015 MicroRNAs in ALS: small pieces to the puzzle A new study finds a global decrease in microRNA levels to be a common hallmark of amyotrophic lateral sclerosis (ALS) and shows that enhancing microRNA biogenesis has beneficial effects on the neuromuscular function in mouse models of ALS. Silvia Bicker and Gerhard Schratt Published online 14.09.2015 Articles NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity The SMC5/6 complex subunit NSMCE2/MMS21 has an essential role in limiting recombination and facilitating chromosome segregation in mice, but does not require its SUMO ligase function to support normal murine development and life span. Ariana Jacome, Paula Gutierrez‐Martinez, Federica Schiavoni, Enrico Tenaglia, Paula Martinez, Sara Rodríguez‐Acebes, Emilio Lecona, Matilde Murga, Juan Méndez, Maria A Blasco, and Oscar Fernandez‐Capetillo Published online 06.10.2015 Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions Proteomics analyses show that mitochondrial lysine acetylation occurs as a low‐level non‐enzymatic protein lesion, and SIRT3 deacetylase functions as a protein repair factor removing acetylation lesions. Brian T Weinert, Tarek Moustafa, Vytautas Iesmantavicius, Rudolf Zechner, and Chunaram Choudhary Published online 09.09.2015 Dysregulated miRNA biogenesis downstream of cellular stress and ALS‐causing mutations: a new mechanism for ALS Amyotrophic Lateral Sclerosis‐causing mutations affect DICER complex activity and lead to altered miRNA biogenesis. Anna Emde, Chen Eitan, Lee‐Loung Liou, Ryan T Libby, Natali Rivkin, Iddo Magen, Irit Reichenstein, Hagar Oppenheim, Raya Eilam, Aurelio Silvestroni, Betty Alajajian, Iddo Z Ben‐Dov, Julianne Aebischer, Alon Savidor, Yishai Levin, Robert Sons, Scott M Hammond, John M Ravits, Thomas Möller, and Eran Hornstein Published online 01.09.2015 Distinct preoptic‐BST nuclei dissociate paternal and infanticidal behavior in mice Depending on mating status, male mice show paternal nurturing or aggression toward infant mice. The balance of paternal versus aggressive behavior is based on neural activity in the forebrain nuclei cMPOA and BSTrh. Yousuke Tsuneoka, Kenichi Tokita, Chihiro Yoshihara, Taiju Amano, Gianluca Esposito, Arthur J Huang, Lily MY Yu, Yuri Odaka, Kazutaka Shinozuka, Thomas J McHugh, and Kumi O Kuroda Published online 30.09.2015 Suppression of miR‐199a maturation by HuR is crucial for hypoxia‐induced glycolytic switch in hepatocellular carcinoma Hypoxia drives RNA‐binding protein HuR to block the processing of miR‐199a, thus relieving inhibition of key glycolytic genes Hk2 and Pkm2 and contributing to deregulated glucose metabolism in hepatocellular carcinoma cells. Ling‐Fei Zhang, Jia‐Tao Lou, Ming‐Hua Lu, Chunfang Gao, Shuang Zhao, Biao Li, Sheng Liang, Yong Li, Dangsheng Li, and Mo‐Fang Liu Published online 07.09.2015 Disruption of adaptor protein 2μ (AP‐2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing The endocytic adaptor protein 2 (AP‐2μ) promotes synaptic vesicle replenishment by facilitating the clearance of vesicular release sites. SangYong Jung, Tanja Maritzen, Carolin Wichmann, Zhizi Jing, Andreas Neef, Natalia H Revelo, Hanan Al‐Moyed, Sandra Meese, Sonja M Wojcik, Iliana Panou, Haydar Bulut, Peter Schu, Ralf Ficner, Ellen Reisinger, Silvio O Rizzoli, Jakob Neef, Nicola Strenzke, Volker Haucke, and Tobias Moser Published online 07.10.2015 Phospholipid methylation controls Atg32‐mediated mitophagy and Atg8 recycling The phosphatidylethanolamine (PE) methyltransferase Cho2 is repressed in yeast under non‐fermentable conditions, causing a decrease in the glutathione (GSH) levels and subsequent induction of the mitophagy protein Atg32. Kaori Sakakibara, Akinori Eiyama, Sho W Suzuki, Machiko Sakoh‐Nakatogawa, Nobuaki Okumura, Motohiro Tani, Ayako Hashimoto, Sachiyo Nagumo, Noriko Kondo‐Okamoto, Chika Kondo‐Kakuta, Eri Asai, Hiromi Kirisako, Hitoshi Nakatogawa, Osamu Kuge, Toshifumi Takao, Yoshinori Ohsumi, and Koji Okamoto Published online 05.10.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.