Nature Reviews Molecular Cell Biology contents December 2015 Volume 16 Number 12 pp 699-761

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TABLE OF CONTENTS
December 2015 Volume 16 Number 12
Impact Factor 37.806 *	In this issue Research Highlights Progress Reviews Perspectives Also this month Article series: Technologies and techniques Featured article: The expanding world of small RNAs in plants Filipe Borges & Robert A. Martienssen
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RESEARCH HIGHLIGHTS Top Cell signalling: How mTORC1 senses leucine p699 | doi:10.1038/nrm4088 Sestrin 2 has been shown to function as a leucine sensor for the mTORC1 signalling pathway. PDF DNA damage response: H1 - a linker of ubiquitylation and repair p700 | doi:10.1038/nrm4090 PDF Autophagy: Nuclear autophagy in tumour suppression p700 | doi:10.1038/nrm4091 Autophagy-induced degradation of the nuclear lamina protects cells from tumorigenesis PDF Chromosome biology: Moving a TAD closer to unravelling chromosome architecture p701 | doi:10.1038/nrm4092 Analyses of Drosophila melanogaster polytene chromosomes elucidate the interconnections between gene expression, genome organization into topologically associated domains (TADs) and the structures of euchromatin and heterochromatin. PDF Proteomics: Strength in numbers p702 | doi:10.1038/nrm4086 A novel protocol for protein interactome analysis in three dimensions identifies the crucial role of highly abundant, weak interactions. PDF Cell division: Hippo regulates cell division p702 | doi:10.1038/nrm4089 The Hippo signalling pathway regulates spindle orientation and asymmetric cell division PDF IN BRIEF Stem cells: Histone mark of stemness | Chromatin: R loops regulate chromatin remodelling | Ubiquitylation: Maintenance of nutrient homeostasis PDF Molecular Cell Biology JOBS of the week Post-Doctoral Fellow University of Massachusett Medical School Molecular Biologist California Institute of Technology Post-doctoral position in virus-host interactions and liver disease Inserm Postdoctoral Fellows Icahn School of Medicine at Mount Sinai Postdoctoral Scientist German Cancer Research Center (DKFZ). More Science jobs from Molecular Cell Biology EVENT The 2nd International Conference on Advances in Biophysics (ICAB 2016) 18.03.16 Los Angeles, USA More science events from
PROGRESS		Top
DNA N6-methyladenine: a new epigenetic mark in eukaryotes? Yang Shi et al. p705 | doi:10.1038/nrm4076 Recent studies have changed our understanding of the prevalence and biological significance of DNA N 6-adenine methylation (6mA) in eukaryotes. This modification is involved in regulating transcription, transposable elements and epigenetic inheritance, and thus can be considered to be a eukaryotic epigenetic mark. Abstract | Full Text | PDF
REVIEWS		Top
Control of microtubule organization and dynamics: two ends in the limelight Anna Akhmanova & Michel O. Steinmetz p711 | doi:10.1038/nrm4084 Microtubule plus ends and minus ends accumulate specific sets of proteins that can regulate microtubule dynamics, connect microtubules to cellular structures and recruit signalling molecules that collectively control cellular behaviour. Our knowledge of the factors that associate with microtubule ends, and the mechanisms through which they do this, has strongly increased in recent years. Abstract | Full Text | PDF
The expanding world of small RNAs in plants Filipe Borges & Robert A. Martienssen p727 | doi:10.1038/nrm4085 Plant genomes encode diverse small RNAs, such as microRNAs, secondary siRNAs, heterochromatic siRNAs and various RNA-dependent RNA polymerases, DICER proteins and ARGONAUTE proteins. Together, these constitute several genetic and epigenetic silencing pathways with diverse cellular and developmental functions, in processes including reproductive transitions, genomic imprinting and paramutation. Abstract | Full Text | PDF
Glycosylation-directed quality control of protein folding Chengchao Xu & Davis T. W. Ng p742 | doi:10.1038/nrm4073 Membrane and soluble secretory proteins are glycosylated in the endoplasmic reticulum. The addition of N-linked glycans is important for protein folding and quality control, whereas O-linked mannoses have distinct functions in protein quality control. Recent studies have revealed the complexity of these glycan-directed modifications in protein biogenesis and degradation. Abstract | Full Text | PDF
PERSPECTIVES		Top
INNOVATION Article series: Technologies and techniques The systematic analysis of protein-lipid interactions comes of age Antoine-Emmanuel Saliba, Ivana Vonkova & Anne-Claude Gavin p753 | doi:10.1038/nrm4080 Lipids tailor membrane identities and function as molecular hubs in all cellular processes. The development of pioneering technologies, including affinity-purification lipidomics and the liposome microarray-based assay (LiMA), will enable researchers to decipher protein-lipid interactions and enhance our understanding of how lipids modulate protein function and structure. Abstract | Full Text | PDF | Supplementary information
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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