Nature Reviews Microbiology contents December 2015 Volume 13 Number 12 pp 737-794

TABLE OF CONTENTS
December 2015 Volume 13 Number 12
Impact Factor 23.574 *	In this issue Research Highlights News and Analysis Progress Reviews Perspectives Also this month Article series: New technologies: methods and applications  Featured article: Live from under the lens: exploring microbial motility with dynamic imaging and microfluidics Kwangmin Son, Douglas R. Brumley & Roman Stocker
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RESEARCH HIGHLIGHTS Top Biofilms: Electrifying long-range signalling p737 | doi:10.1038/nrmicro3588 This study identifies a physiological role for bacterial ion channels, showing that they can propagate electrical signals throughout biofilms in a long-range process that coordinates the metabolic responses of the microbial community. PDF Structural biology: How CRISPR captures spacer invaders p738 | doi:10.1038/nrmicro3585 Two X-ray crystallography studies reveal the mechanism underlying spacer acquisition by CRISPR-Cas systems. PDF Parasite biology: A perfectly timed escape p738 | doi:10.1038/nrmicro3586 This study shows that processing of merozoite surface protein 1 (MSP1) by the Plasmodium subtilisin-like serine protease SUB1 enables MSP1 to interact with the host cell cytoskeleton, enabling parasite egress from red blood cells. PDF IN BRIEF Bacterial genomics: The Bronze Age: a time before bubonic plague | Viral infection: Highly flexible influenza polymerase | Microbiome: Commensal bacterium prevents wasting | Archaeal genomics: A new phylum for methanogens | Fungal biology: To mate or tomato? | Techniques & applications: Scaling up spatial imaging of the gut microbiota PDF
NEWS AND ANALYSIS		Top
GENOME WATCH It's diversity all the way down Sophia David & James Hadfield p740 | doi:10.1038/nrmicro3587 This month's Genome Watch highlights how single-cell transcriptomic analysis of infected macrophages has provided insight into the diversity in host-pathogen interactions. PDF
PROGRESS		Top
Modulation of p53 during bacterial infections Christine Siegl & Thomas Rudel p741 | doi:10.1038/nrmicro3537 It has recently been suggested that p53, which regulates the survival and metabolism of host cells, is commonly manipulated by intracellular bacterial pathogens. In this Progress article, Siegl and Rudel discuss mechanisms of p53 manipulation and consider the consequences for pathogenesis. Abstract | Full Text | PDF
REVIEWS		Top
c-di-GMP signalling and the regulation of developmental transitions in streptomycetes Matthew J. Bush, Natalia Tschowri, Susan Schlimpert, Klas Flärdh & Mark J. Buttner p749 | doi:10.1038/nrmicro3546 Streptomycetes have a complex life cycle that involves several regulated developmental transitions. In this Review, Buttner and colleagues discuss the factors that have recently been shown to regulate these transitions, including a novel role for the second messenger c-di-GMP. Abstract | Full Text | PDF
Article series: New technologies: methods and applications Live from under the lens: exploring microbial motility with dynamic imaging and microfluidics Kwangmin Son, Douglas R. Brumley & Roman Stocker p761 | doi:10.1038/nrmicro3567 Stocker and colleagues review how combining dynamic imaging techniques with microfluidics has furthered our understanding of the hydrodynamic signature of individual microorganisms, the mechanics of their locomotion, and the effects of surfaces, fluid flow and crowded habitats on microbial motility. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
TIMELINE A century of the phage: past, present and future George P. C. Salmond & Peter C. Fineran p777 | doi:10.1038/nrmicro3564 Phages were discovered 100 years ago, and since then phage research has transformed fundamental and translational biosciences. In this Timeline, Salmond and Fineran discuss a century of phage research, describing the roles of phages in ecosystems and in driving bacterial evolution and virulence, and highlight their impact as a source of novel reagents that revolutionized molecular biology and biotechnology. Abstract | Full Text | PDF
TIMELINE Article series: New technologies: methods and applications Twenty years of bacterial genome sequencing Nicholas J. Loman & Mark J. Pallen p787 | doi:10.1038/nrmicro3565 The first bacterial genome sequence was published 20 years ago. In this Timeline, Loman and Pallen review the first two decades of bacterial genome sequencing, discussing how advances in sequencing technologies and bioinformatics have furthered our understanding of the biology, diversity and evolution of bacteria. Abstract | Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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