Nature Reviews Genetics Contents December 2015 Volume 16 Number 12 pp 683-740

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TABLE OF CONTENTS
December 2015 Volume 16 Number 12
Impact Factor 36.978 *	In this issue Research Highlights Reviews Also this month Article series: Computational tools Single-cell omics  Featured article: Protective alleles and modifier variants in human health and disease Andrew R. Harper, Shalini Nayee & Eric J. Topol
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RESEARCH HIGHLIGHTS Top Functional genomics: The genetic essence of human cells p683 | doi:10.1038/nrg4037 PDF Technology: Dropping in on single-cell epigenetic profiles p684 | doi:10.1038/nrg4036 PDF Gene regulation: Nuclear seclusion — a novel mechanism of transcription factor regulation p684 | doi:10.1038/nrg4038 PDF Epigenetics: Fatherly histone influences p685 | doi:10.1038/nrg4032 PDF Evolution: Mix and re-match p686 | doi:10.1038/nrg4035 PDF Evolution: Filling gaps in early human history p686 | doi:10.1038/nrg4039 PDF Functional genomics: A novel CRISPR-Cas system for easier genome editing? p687 | doi:10.1038/nrg4033 PDF Cancer genetics: RNA-seq for blood-based pan-cancer diagnostics p688 | doi:10.1038/nrg4048 PDF IN BRIEF Human evolution: Tandem repeats and divergent gene expression | Small RNAs: One precursor, one siRNA | Techniques: Porcine endogenous retroviruses get the chop | Plant genetics: A clever TrAP circumvents host defence | RNA: Getting in shape — bacterial mRNA structure functions beyond information transfer | Epigenomics: Sex matters | Genetic variation: A new foundation for non-coding variant analysis PDF
REVIEWS		Top
Protective alleles and modifier variants in human health and disease Andrew R. Harper, Shalini Nayee & Eric J. Topol p689 | doi:10.1038/nrg4017 Many disease-associated genetic variants have been identified, but how genetic variation contributes to protection from disease is less well understood. In this Review, the authors discuss the identification and characterization of protective alleles and modifier variants, and the potential implications of these findings for disease prevention and drug development. Abstract | Full Text | PDF
Article series: Computational tools Human genotype-phenotype databases: aims, challenges and opportunities Anthony J. Brookes & Peter N. Robinson p702 | doi:10.1038/nrg3932 With biomedical datasets growing exponentially in size and number, efforts to increase their utility and availability are essential, but much work remains to maximize exploitability. This Review summarizes trends, developments and future perspectives in the rapidly advancing field of human genotype-phenotype databases. Abstract | Full Text | PDF
Article series: Single-cell omics Single-cell epigenomics: techniques and emerging applications Omer Schwartzman & Amos Tanay p716 | doi:10.1038/nrg3980 Various methodologies have been developed to characterize diverse features of chromatin, but understanding how epigenomic states contribute to cellular heterogeneity requires adoption of these techniques at the single-cell level. This article discusses the technological developments driving single-cell epigenomics, including the practical and bioinformatic challenges and emerging biological insights. Abstract | Full Text | PDF
Article series: Computational tools Methods and models for unravelling human evolutionary history Joshua G. Schraiber & Joshua M. Akey p727 | doi:10.1038/nrg4005 The rapid accumulation and increasing quality of human DNA sequence-variation data brought about by advances in genome-scale sequencing present opportunities to investigate human evolution. The authors discuss the statistical methods and models that can be used to gain insight into the evolution of human populations from analyses of large-scale genomic data sets, as well as the challenges associated with these approaches. Abstract | Full Text | PDF | Supplementary information
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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