Nature Reviews Cancer contents December 2015 Volume 15 Number 12 pp695-756

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TABLE OF CONTENTS
December 2015 Volume 15 Number 12
Impact Factor 37.4 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer Philip A. Watson, Vivek K. Arora & Charles L. Sawyers
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RESEARCH HIGHLIGHTS Top Microenvironment: Astrocytes silence PTEN to promote brain metastasis p695 | doi:10.1038/nrc4045 A paper in Nature reports that an astrocyte exosome-derived microRNA induces the loss of PTEN expression in disseminated tumour cells in the brain, thus promoting metastasis. PDF Metastasis: Directions to metastatic sites p696 | doi:10.1038/nrc4046 Why do some cancers only metastasize to certain organs? This question of organotropism is perplexing, and a team led by Lyden, Bromberg and Peinado have found that exosomes could be key. PDF Diagnosis: RNA-seq for blood-based pan-cancer diagnostics p696 | doi:10.1038/nrc4048 Best et al. describe a diagnostic platform based on platelet RNA sequencing and self-learning algorithms that discriminates patients with cancer from healthy controls, predicts the localization of the primary tumour and provides information on the molecular tumour phenotype. PDF Cancer genomics: The relevance of extensive editing in tumour transcriptomes p698 | doi:10.1038/nrc4044 Three studies demonstrate that adenosine-to-inosine RNA editing introduces transcriptome diversity in tumours from a range of cancer types and show that this diversity is both functionally important and clinically relevant. PDF Genome instability: Stress management by the FA pathway p699 | doi:10.1038/nrc4047 Schwab et al. show that the Fanconi anaemia pathway might prevent genome instability by stabilizing replication forks when actively transcribed DNA is encountered and by removing DNA-RNA hybrids. PDF IN BRIEF Skin cancer: Nicotinamide chemoprevention trial success | Tumour immunology: An epigenetic evasion mechanism | Prostate cancer: Radiosensitization through reduced DNA repair | Therapy: PDX trials | Immunotherapy: Skipping out epitopes | Wildlife cancer: Size isn't everything | Tumorigenesis: Tapeworm tumours PDF Cancer JOBS of the week Faculty Position in Mechanisms of Genomic Instability in Cancer University of Calgary, Cumming School of Medicine Postdoctoral studies in cancer biology (scholarship) - 2 positions Karolinska Institutet (KI) Cancer Evolution, Assistant Professor Temple University Faculty Positions in Cancer Pharmacology - Northwestern University Northwestern University Cancer Biologist Wake Forest Baptist School of Medicine More Science jobs from Cancer EVENT UK Breast Cancer Research Symposium 2016 22.07.15 London, UK More science events from
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REVIEWS		Top
Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer Philip A. Watson, Vivek K. Arora & Charles L. Sawyers p701 | doi:10.1038/nrc4016 This Review highlights emerging mechanisms of acquired resistance to agents targeting the androgen receptor in castration-resistant prostate cancer, which fall into the three broad categories of restored androgen receptor (AR) signalling, AR bypass signalling and complete AR independence. Abstract | Full Text | PDF
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response Oakley C. Olson & Johanna A. Joyce p712 | doi:10.1038/nrc4027 Increased activity and aberrant localization of cysteine cathepsin proteases within the tumour microenvironment have potent roles in driving cancer progression. This Review discusses the roles of cathepsins and provides a roadmap for the rational integration of cathepsin-targeting agents into clinical treatment. Abstract | Full Text | PDF
The mathematics of cancer: integrating quantitative models Philipp M. Altrock, Lin L. Liu & Franziska Michor p730 | doi:10.1038/nrc4029 This Review discusses mathematical modelling approaches in cancer research. These models can complement experimental and clinical studies, but can also challenge current paradigms, redefine our understanding of mechanisms driving tumorigenesis and shape future research. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Precision medicine for cancer with next-generation functional diagnostics Adam A. Friedman, Anthony Letai, David E. Fisher & Keith T. Flaherty p747 | doi:10.1038/nrc4015 Genome-based cancer therapeutic matching is limited by incomplete biological understanding of the relationship between phenotype and cancer genotype. This Opinion article proposes that this limitation can be addressed by functional testing of live patient tumour cells exposed to potential therapies. Abstract | Full Text | PDF
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