Nature Immunology Contents: December 2015 Volume 16 pp 1205 - 1292

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Advertisement  A*STAR Research - Highlighting the best of research at the Agency for Science, Technology and Research (A*STAR), Singapore's premier research organization  Recent Highlights Immunology: A clear view of immune cells | Dengue fever: Virus version control | Immunology: To fight or to tolerate?  Download the A*STAR Research app now!   TABLE OF CONTENTS December 2015 Volume 16, Issue 12 Obituary Commentary News and Views Research Highlights Articles Resource Corrigenda Subscribe   Facebook   RSS   Recommend to library   Twitter   Obituary Top William E. Paul 1936-2015   p1205 Ethan M Shevach and David H Margulies doi:10.1038/ni.3316 Commentary Top A 'rule of 3' to revive Greek science, research and innovation   pp1206 - 1208 George Kollias and John D Lambris doi:10.1038/ni.3322 If research and technology are to become the driving force for turning Greece into a productive society, evidence-based governance, strategic restructuring of infrastructure and a substantial inflow of fresh human capital is urgently needed. News and Views Top Biological sensors shed light on ligand geography   pp1209 - 1211 C Colin Brinkman and Jonathan S Bromberg doi:10.1038/ni.3315 Small, soluble, ubiquitous ligands are difficult to visualize. Schwab and colleagues have created a functional receptor reporter that gauges the in vivo concentration, location and biological action of sphingolipids. See also: Article by Ramos-Perez et al. Nr4a1 discloses the sympathetic side of monocytes   pp1211 - 1213 Marta Joana Costa Jordão and Marco Prinz doi:10.1038/ni.3317 The transcription factor Nr4a1 can negatively regulate norepinephrine production in the context of neuroinflammation and thereby prevent the ensuing neuroinflammatory cascade in a mouse model of experimental autoimmune encephalomyelitis. See also: Article by Shaked et al. Immunology JOBS of the week postdoc and technician positions in immunology and disease pathogenesis Medical University of South Carolina Immunology and Cell Biology Beth Israel Deaconess Med Ctr / Harvard Medical School Postdoctoral Fellow in HIV / SIV Immunology Beth Israel Deaconess Medical Center - Harvard Medical School Staff Scientist, Immunology Benaroya Research Institute at Virginia Mason (BRI) Faculty Position, Department of Microbiology and Immunology University of California - San Francisco More Science jobs from Immunology EVENT International Congress of Immunology 2016 21st Aug - 26th Aug 2016 South Wharf, Victoria, Australia More science events from Research Highlights Top Hairy guide to maintaining TRM cells | Salted inflammation | Viral anti-STING factors | Nerve sentries | Epigenetic silencing in tumors | MALT1 regulates LUBAC Advertisement Have Confidence in Your Western Blotting Results  Get the quantitation of digital imaging with the sensitivity of film. Introducing the ChemiDoc™ Touch Imaging System, the latest addition to the V3 Western Workflow™. By providing optimal exposure for all samples and detecting signals distributed over a much broader range than film, the ChemiDoc Touch Imager ensures the quality and reproducibility of your western blotting results.   Articles Top PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection   pp1215 - 1227 Yong Zhang, Dailing Mao, William T Roswit, Xiaohua Jin, Anand C Patel et al. doi:10.1038/ni.3279 Holtzman and colleagues identify PARP9-DTX3L as an E3 ubiquitin ligase complex that interacts with STAT1 to modify chromatin accessibility for expression in interferon-stimulated genes and to target viral proteases for degradation. Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation   pp1228 - 1234 Iftach Shaked, Richard N Hanna, Helena Shaked, Grzegorz Chodaczek, Heba N Nowyhed et al. doi:10.1038/ni.3321 Stress can induce expression of norepinephrine, which can enhance neuroinflammation. Shaked, Hedrick and colleagues show that the transcriptional repressor Nr4a1 limits this stress-induced response by suppressing expression of tyrosine hydroxylase required for the synthesis of norepinephrine. See also: News and Views by Jordão & Prinz Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma   pp1235 - 1244 Shlomi Finkin, Detian Yuan, Ilan Stein, Koji Taniguchi, Achim Weber et al. doi:10.1038/ni.3290 Ectopic lymphoid structures develop at sites of chronic inflammation and are generally thought to be beneficial in the control of cancer. Pikarsky and colleagues show that these structures can instead nurture liver tumor progenitor cells. A map of the distribution of sphingosine 1-phosphate in the spleen   pp1245 - 1252 Willy D Ramos-Perez, Victoria Fang, Diana Escalante-Alcalde, Michael Cammer and Susan R Schwab doi:10.1038/ni.3296 The lipid S1P confers signals that regulate leukocyte trafficking. Schwab and colleagues generate mice that can faithfully report the bioavailability of S1P within tissues and reveal how S1P gradients are shaped in the spleen. See also: News and Views by Brinkman & Bromberg K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8+ T cell activation   pp1253 - 1262 Mingjin Yang, Taoyong Chen, Xuelian Li, Zhou Yu, Songqing Tang et al. doi:10.1038/ni.3258 The molecular details of the control of TCR signaling are still being determined. Cao and colleagues report that the E3 ligase Nrdp1 negatively regulates activity of the signaling kinase Zap70 selectively in CD8+ T cells. The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation   pp1263 - 1273 Dan Lu, Liang Liu, Xin Ji, Yanan Gao, Xi Chen et al. doi:10.1038/ni.3278 Little is known about the phosphatases involved in the control of TH17 cells. Yin and colleagues demonstrate that the phosphatase DUSP2 targets the transcription activator STAT3 to regulate the differentiation and function of TH17 cells. Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8   pp1274 - 1281 Heping Xu, Virendra K Chaudhri, Zhiguo Wu, Konstantinos Biliouris, Krista Dienger-Stambaugh et al. doi:10.1038/ni.3287 Antigen-activated B cells differentiate into plasmablasts or germinal center B cells that undergo further affinity maturation. Singh and colleagues identify the antagonistic roles of transcription factors IRF4 and IRF8 that establish these opposing cell fates. Resource Top Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages   pp1282 - 1291 David Casero, Salemiz Sandoval, Christopher S Seet, Jessica Scholes, Yuhua Zhu et al. doi:10.1038/ni.3299 Long non-coding RNAs contribute to the regulation of gene expression. Crooks and colleagues profile the long non-coding RNA transcriptome during the specification and development of human lymphocytes. Corrigenda Top Corrigendum: The receptor NLRP3 is a transcriptional regulator of TH2 differentiation   p1292 Mélanie Bruchard, Cédric Rebé, Valentin Derangère, Dieudonnee Togbé, Bernhard Ryffel et al. doi:10.1038/ni1215-1292a Corrigendum: The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3   p1292 Manira Rayamajhi and Edward A Miao doi:10.1038/ni1215-1292b Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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