Nature Communications - 18 November 2015

Advertisement Sputtered Metal Deep-UV Interference Filters Manufactured using single substrates of UV-grade fused silica and backed by warranty, these filters are available in 11 different passbands in a wide range of sizes, from 2mm-200mm. Laser damage thresholds >0.15 J/cm2 using a 355nm laser (10 ns pulse, 10 Hz), and suffer no degradation after 2 hours @ 300ºC. www.chroma.com     Weekly Content Alert Nature Communications is now fully open access. Read more. 18 November 2015  Featured image: Khristosov et al. report a strategy for the fabrication of three-dimensional, micron-sized, nanoporous single crystals of gold. Latest content: Articles Corrigenda Erratum Journal homepage Recommend to library Web feed   Advertisement Nature Energy: Call for Papers Launching in January 2016, Nature Energy is now open for submissions and inviting high-quality research from across the natural and social sciences. The journal will be dedicated to exploring all aspects of the on-going discussion of energy provision; from the generation and storage of energy, to its distribution and management, the needs and demands of the different actors, and the impacts that energy technologies and policies have on societies. Submit your next research paper to the journal.     Advertisement Science Masterclass The 2015 meeting between Nobel laureates and young researchers in Lindau, Germany cast a spotlight on super-resolution microscopy, as discussed in depth in this Nature Outlook, as well as fields as diverse as memory formation and the Higgs bosons.  Access the Outlook free online.  Produced with support from: Mars, Incorporated       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     On the decline of biodiversity due to area loss OPEN Petr Keil, David Storch and Walter Jetz Habitat loss typically results in biodiversity decline, yet predicting how different facets of biodiversity are affected is challenging. Here, the authors show that the geometry of area loss is crucial to predict loss of taxonomic, functional and phylogenetic diversity across three taxa on four continents. 17 November 2015 | doi: 10.1038/ncomms9837 Biological Sciences  Ecology  Paracingulate sulcus morphology is associated with hallucinations in the human brain OPEN Jane R. Garrison, Charles Fernyhough, Simon McCarthy-Jones, Mark Haggard, null null, Vaughan Carr, Ulrich Schall, Rodney Scott, Assen Jablensky, Bryan Mowry, Patricia Michie, Stanley Catts, Frans Henskens, Christos Pantelis, Carmel Loughland and Jon S. Simons Hallucinations can occur in both healthy individuals and patients with psychiatric disorders. Garrison et al. here report that specific brain morphology differences in the paracingulate sulcus (PCS) can determine the occurrence of hallucinations in schizophrenia, irrespective of sensory modality. 17 November 2015 | doi: 10.1038/ncomms9956 Biological Sciences  Neuroscience  Fennoscandian freshwater control on Greenland hydroclimate shifts at the onset of the Younger Dryas OPEN Francesco Muschitiello, Francesco S. R. Pausata, Jenny E. Watson, Rienk H. Smittenberg, Abubakr A. M. Salih, Stephen J. Brooks, Nicola J. Whitehouse, Artemis Karlatou-Charalampopoulou and Barbara Wohlfarth Resolving the sources and timing of freshwater forcing during the Last Termination is key to evaluate the North Atlantic Ocean response to freshwater perturbations. Here, the authors that the North Atlantic climate system was highly sensitive to Scandinavian meltwater discharge shortly before the Younger Dryas. 17 November 2015 | doi: 10.1038/ncomms9939 Earth Sciences  Climate science  Oceanography  Direct visualization of dispersed lipid bicontinuous cubic phases by cryo-electron tomography OPEN Davide Demurtas, Paul Guichard, Isabelle Martiel, Raffaele Mezzenga, Cécile Hébert and Laurent Sagalowicz Dispersed lipid self-assembly can form various types of particles, including cubosomes, which are useful for drug delivery. Here, Demurtas et al. visualize their three-dimensional structure, showing two continuous water channels separated by lipid bilayers and the mechanism of particle stabilization. 17 November 2015 | doi: 10.1038/ncomms9915 Chemical Sciences  Biotechnology  Materials science  Genomic and transcriptomic evidence for scavenging of diverse organic compounds by widespread deep-sea archaea OPEN Meng Li, Brett J. Baker, Karthik Anantharaman, Sunit Jain, John A. Breier and Gregory J. Dick The contribution of marine archaea to the ocean's carbon cycle is unclear. Here, Li et al. analyse the genomes and transcriptomes from five deep-sea archaeal groups to reveal their metabolic characteristics, suggesting a crucial role in modulating the carbon cycle in deep oceans. 17 November 2015 | doi: 10.1038/ncomms9933 Biological Sciences  Ecology  Microbiology  Oceanography  Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue OPEN Hideya Sakaguchi, Taisuke Kadoshima, Mika Soen, Nobuhiro Narii, Yoshihito Ishida, Masatoshi Ohgushi, Jun Takahashi, Mototsugu Eiraku and Yoshiki Sasai In vitro differentiation of human pluripotent stem cells (hPSCs) has enabled the generation of neuroectodermal tissues. Here, Sakaguchi et al. use a modified neocortical induction method to generate functional hippocampal granule and pyramidal-like neurons, as well as dorsomedial telencephalic tissues from hPSCs. 17 November 2015 | doi: 10.1038/ncomms9896 Biological Sciences  Cell biology  Developmental biology  Auditory sequence processing reveals evolutionarily conserved regions of frontal cortex in macaques and humans OPEN Benjamin Wilson, Yukiko Kikuchi, Li Sun, David Hunter, Frederic Dick, Kenny Smith, Alexander Thiele, Timothy D. Griffiths, William D. Marslen-Wilson and Christopher I. Petkov This study uses functional magnetic resonance imaging in humans and monkeys to show similar ventral frontal and opercular cortical responses when processing sequences of auditory nonsense words. The study indicates that this frontal region is involved in evaluating the order of incoming sounds in a sequence, a process that may be conserved in primates. 17 November 2015 | doi: 10.1038/ncomms9901 Biological Sciences  Neuroscience  Aneuploidy causes premature differentiation of neural and intestinal stem cells OPEN Delphine Gogendeau, Katarzyna Siudeja, Davide Gambarotto, Carole Pennetier, Allison J. Bardin and Renata Basto It is unclear why certain tissues are more susceptible to the consequences of aneuploidy. Here, in Drosophila, Gogendeau et al. identify aneuploidy as the cause of lengthened G1 and premature differentiation in both neural and adult intestinal stem cells, which prevents cells with abnormal genomes from cycling. 17 November 2015 | doi: 10.1038/ncomms9894 Biological Sciences  Cell biology  Developmental biology  Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney OPEN Angshumoy Roy, Vijetha Kumar, Barry Zorman, Erica Fang, Katherine M. Haines, HarshaVardhan Doddapaneni, Oliver A. Hampton, Simon White, Abhishek A. Bavle, Nimesh R. Patel, Karen W. Eldin, M. John Hicks, Dinesh Rakheja, Patrick J. Leavey, Stephen X. Skapek, James F. Amatruda, Jed G. Nuchtern, Murali M. Chintagumpala, David A. Wheeler, Sharon E. Plon et al. The genetic basis of clear cell sarcomas of the kidney is not well understood. In this study, Roy et al. perform whole-exome and RNA sequencing of these tumours and identify recurrent internal tandem duplications in BCOR, a key constituent of a variant polycomb repressive complex. 17 November 2015 | doi: 10.1038/ncomms9891 Biological Sciences  Cancer  Genetics  MicroRNA–mRNA interactions underlying colorectal cancer molecular subtypes OPEN Laura Cantini, Claudio Isella, Consalvo Petti, Gabriele Picco, Simone Chiola, Elisa Ficarra, Michele Caselle and Enzo Medico Colorectal cancer subtypes can be distinguished by their different biological and molecular properties. Here the authors present microRNA Master Regulator Analysis, a tool to identify microRNAs driving subtype-specific gene expression and cancer variation. 17 November 2015 | doi: 10.1038/ncomms9878 Biological Sciences  Bioinformatics  Genetics  Molecular biology  Transient misfolding dominates multidomain protein folding OPEN Alessandro Borgia, Katherine R. Kemplen, Madeleine B. Borgia, Andrea Soranno, Sarah Shammas, Bengt Wunderlich, Daniel Nettels, Robert B. Best, Jane Clarke and Benjamin Schuler Single molecule kinetics investigations and molecular simulations are useful tools in elucidating protein assembly mechanisms. Here, the authors use these to show that even naturally occurring tandem repeats undergo transient misfolding and that assembly is much more complex than we previously understood. 17 November 2015 | doi: 10.1038/ncomms9861 Biological Sciences  Biochemistry  Biophysics  Molecular biology  The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis Chong Shen, Shailendra S. Rathore, Haijia Yu, Daniel R. Gulbranson, Rui Hua, Chen Zhang, Nathan E. Schoppa and Jingshi Shen Munc18-1 binds trans-SNARE complexes and promotes membrane fusion in vitro. Here the authors provide genetic evidence that this trans-SNARE-regulating function plays an essential role in synaptic releases in neurons, and show that this function is disrupted by a disease-causing Munc18-1 mutation. 17 November 2015 | doi: 10.1038/ncomms9852 Biological Sciences  Cell biology  Neuroscience  Ultrafast response of monolayer molybdenum disulfide photodetectors OPEN Haining Wang, Changjian Zhang, Weimin Chan, Sandip Tiwari and Farhan Rana Two-dimensional transition-metal dichalcogenides are useful for optoelectronic applications, but the ultimate limit on the speed of photodetector operation is unknown. Here, the authors show that the optical response time of monolayer molybdenum disulfide can be as short as three picoseconds. 17 November 2015 | doi: 10.1038/ncomms9831 Physical Sciences  Applied physics  Materials science  Optical physics  The antisymmetry of distortions OPEN Brian K. VanLeeuwen and Venkatraman Gopalan In a material system, a distortion constitutes a change from one stable state to another via a pathway built from a combination of atomic trajectories. Here, the authors present a distortion reversal antisymmetry operation which fully describes the symmetry of such pathways. 17 November 2015 | doi: 10.1038/ncomms9818 Physical Sciences  Condensed matter  Realization of a vertical topological p–n junction in epitaxial Sb2Te3/Bi2Te3 heterostructures OPEN Markus Eschbach, Ewa Młyńczak, Jens Kellner, Jörn Kampmeier, Martin Lanius, Elmar Neumann, Christian Weyrich, Mathias Gehlmann, Pika Gospodarič, Sven Döring, Gregor Mussler, Nataliya Demarina, Martina Luysberg, Gustav Bihlmayer, Thomas Schäpers, Lukasz Plucinski, Stefan Blügel, Markus Morgenstern, Claus M. Schneider and Detlev Grützmacher et al. Topological insulators possess dispersionless electronic surface states with perpendicular spin-momentum locking which may be utilised in spintronic devices. Here, the authors demonstrate p–n junctions formed from two topological insulator thin films, tuning the junction type by film thickness. 17 November 2015 | doi: 10.1038/ncomms9816 Physical Sciences  Condensed matter  Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila OPEN Renaud Caous, Aude Pascal, Pierre Romé, Laurent Richard-Parpaillon, Roger Karess and Régis Giet Drosophila aurA mutants develop brain tumours which are associated with defective mitotic spindle assembly. Caous et al. show that these mutants are surprisingly insensitive to tumour-suppressive spindle assembly checkpoint inactivation, due to a checkpoint-independent delay in cyclin B degradation. 16 November 2015 | doi: 10.1038/ncomms9879 Biological Sciences  Cancer  Cell biology  Charge density wave transition in single-layer titanium diselenide OPEN P Chen, Y. -H. Chan, X. -Y. Fang, Y Zhang, M Y Chou, S. -K. Mo, Z Hussain, A. -V. Fedorov and T. -C. Chiang Single molecular layers of TiSe2 are promising for advanced electronic applications, and it is therefore important to characterize their phases. Here, the authors use ARPES to detect a charge density wave transition without Fermi surface nesting and that takes place at a temperature higher than in bulk. 16 November 2015 | doi: 10.1038/ncomms9943 Physical Sciences  Condensed matter  Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction OPEN Annemarie Horn, Janosch Hennig, Yasar L. Ahmed, Gunter Stier, Klemens Wild, Michael Sattler and Irmgard Sinning The chloroplast signal recognition particle delivers LHCPs to the thylakoid membrane by interaction of cpSRP43 with the Alb3 insertase. Here the authors decipher the specific recognition of the Alb3 C-terminal tail within the interface of two communicating chromodomains by structural biochemistry. 16 November 2015 | doi: 10.1038/ncomms9875 Biological Sciences  Biochemistry  Plant sciences  Scalable amplification of strand subsets from chip-synthesized oligonucleotide libraries OPEN Thorsten L. Schmidt, Brian J. Beliveau, Yavuz O. Uca, Mark Theilmann, Felipe Da Cruz, Chao-Ting Wu and William M. Shih Synthetic oligonucleotides are the main cost factor for studies in DNA nanotechnology. Here, the authors present a selective oligonucleotide amplification method, based on three rounds of rolling-circle amplification, that produces nanomole amounts of single-stranded oligonucleotides per millilitre reaction. 16 November 2015 | doi: 10.1038/ncomms9634 Biological Sciences  Biotechnology  Molecular biology  Nanotechnology  Direct observation and imaging of a spin-wave soliton with p-like symmetry OPEN S. Bonetti, R. Kukreja, Z. Chen, F. Macià, J. M. Hernàndez, A. Eklund, D. Backes, J. Frisch, J. Katine, G. Malm, S. Urazhdin, A. D. Kent, J. Stöhr, H. Ohldag and H. A. Dürr Injecting spin-polarized current into a ferromagnetic thin film via a nanocontact is expected to generate a radially-symmetric spin wave soliton. Here, the authors use time-resolved x-ray microscopy and micromagnetic simulations to demonstrate the occurrence of p-like symmetry associated with non-uniform magnetic fields in the nanocontact region. 16 November 2015 | doi: 10.1038/ncomms9889 Physical Sciences  Condensed matter  Graphene liquid crystal retarded percolation for new high-k materials OPEN Jinkai Yuan, Alan Luna, Wilfrid Neri, Cécile Zakri, Tanja Schilling, Annie Colin and Philippe Poulin It is commonly believed that graphene flakes form electrical percolation networks at low concentration, and thus can be used as conductive materials. Here, Yuan et al. show in graphene polymer composites that the transition to liquid crystals hinders the formation of percolated networks, resulting in high-k materials. 16 November 2015 | doi: 10.1038/ncomms9700 Physical Sciences  Applied physics  Materials science  Physical chemistry  Comprehensive functional characterization of cancer–testis antigens defines obligate participation in multiple hallmarks of cancer OPEN Kimberly E. Maxfield, Patrick J. Taus, Kathleen Corcoran, Joshua Wooten, Jennifer Macion, Yunyun Zhou, Mark Borromeo, Rahul K. Kollipara, Jingsheng Yan, Yang Xie, Xian-Jin Xie and Angelique W. Whitehurst Proteins usually expressed solely in the testes are often found over-expressed in cancer and are termed cancer testis antigens. Here, the authors use a comprehensive screening strategy to identify 26 cancer-testis antigens that promote tumorigenic behaviour. 16 November 2015 | doi: 10.1038/ncomms9840 Biological Sciences  Cancer  Developmental biology  Increased tolerance to humans among disturbed wildlife OPEN Diogo S. M. Samia, Shinichi Nakagawa, Fausto Nomura, Thiago F. Rangel and Daniel T. Blumstein Some animal species tolerate the presence of humans better than others. In a meta-analysis, Samia et al. find that populations of wildlife exposed to greater levels of human disturbance are more tolerant than undisturbed populations, with large birds in urbanized areas showing the highest levels of tolerance. 16 November 2015 | doi: 10.1038/ncomms9877 Biological Sciences  Ecology  Scalable, full-colour and controllable chromotropic plasmonic printing OPEN Jiancai Xue, Zhang-Kai Zhou, Zhiqiang Wei, Rongbin Su, Juan Lai, Juntao Li, Chao Li, Tengwei Zhang and Xue-Hua Wang Plasmonics offers an alternative approach to robust colour printing, but real applications require a full-colour and scalable process. Here, the authors develop such an approach by combining plasmonic broadband absorbers with conjugate twin-phase modulation, demonstrating its potential for anticounterfeiting technology. 16 November 2015 | doi: 10.1038/ncomms9906 Physical Sciences  Optical physics  Upper Palaeolithic genomes reveal deep roots of modern Eurasians OPEN Eppie R. Jones, Gloria Gonzalez-Fortes, Sarah Connell, Veronika Siska, Anders Eriksson, Rui Martiniano, Russell L. McLaughlin, Marcos Gallego Llorente, Lara M. Cassidy, Cristina Gamba, Tengiz Meshveliani, Ofer Bar-Yosef, Werner Müller, Anna Belfer-Cohen, Zinovi Matskevich, Nino Jakeli, Thomas F. G. Higham, Mathias Currat, David Lordkipanidze, Michael Hofreiter et al. Upper Palaeolithic and Mesolithic genomes from western Europe and the Caucasus reveal a previously undescribed strand of Eurasian ancestry with a deep divergence from other hunter-gatherer genomes. This had a profound impact on ancient and modern populations from the Atlantic to Central Asia. 16 November 2015 | doi: 10.1038/ncomms9912 Biological Sciences  Evolution  Genetics  Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm–egg fusion in mice OPEN Naokazu Inoue, Yoshihisa Hagihara, Danelle Wright, Takahisa Suzuki and Ikuo Wada Sperm-egg fusion is facilitated by the sperm-specific receptor IZUMO1 and the egg-specific counter-receptor JUNO. Here Inoue et al. show that JUNO first binds to monomeric IZUMO1; IZUMO1 then dimerizes and excludes JUNO from the sperm-egg interface, suggesting the existence of a IZUMO1 dimer receptor. 16 November 2015 | doi: 10.1038/ncomms9858 Biological Sciences  Cell biology  Developmental biology  Enhanced wetting of Cu on ZnO by migration of subsurface oxygen vacancies OPEN Igor Beinik, Matti Hellström, Thomas N. Jensen, Peter Broqvist and Jeppe V. Lauritsen Comprehensive elucidation of metal-support interactions is important for controlling and improving their performances in a range of pertinent technologies. Here, the authors reveal how subsurface defects influence the adhesion and wetting of a metal on the surface of a metal oxide. 16 November 2015 | doi: 10.1038/ncomms9845 Physical Sciences  Catalysis  Condensed matter  Materials science  Identification and characterization of multiple rubisco activases in chemoautotrophic bacteria OPEN Yi-Chin Candace Tsai, Maria Claribel Lapina, Shashi Bhushan and Oliver Mueller-Cajar The CO2-fixing enzyme rubisco requires motor proteins known as rubisco activases to remove inhibitors bound to its active site. Here the authors describe a new class of rubisco activase present in chemoautotrophic bacteria that belongs to the MoxR family of AAA+ ATPases. 16 November 2015 | doi: 10.1038/ncomms9883 Biological Sciences  Biochemistry  Microbiology  Plant sciences  Magnon dark modes and gradient memory OPEN Xufeng Zhang, Chang-Ling Zou, Na Zhu, Florian Marquardt, Liang Jiang and Hong X. Tang Yttrium iron garnet is a ferrimagnetic insulator which demonstrates robust photon-spin coupling in hybrid microwave cavity systems. Here, the authors demonstrate a magnon gradient memory based on the dark modes of a strongly-coupled system of multiple yttrium iron garnet spheres. 16 November 2015 | doi: 10.1038/ncomms9914 Physical Sciences  Condensed matter  The full repertoire of Drosophila gustatory receptors for detecting an aversive compound OPEN Jaewon Shim, Youngseok Lee, Yong Taek Jeong, Yonjung Kim, Min Goo Lee, Craig Montell and Seok Jun Moon It remains unclear whether any set of the 68 gustatory receptors expressed in Drosophila comprise a cation channel that responds to an aversive chemical. Here the authors identify three gustatory receptors that are both necessary and sufficient to form a channel that confers sensitivity to a noxious tastant. 16 November 2015 | doi: 10.1038/ncomms9867 Biological Sciences  Neuroscience  Active porous transition towards spatiotemporal control of molecular flow in a crystal membrane OPEN Yuichi Takasaki and Satoshi Takamizawa Valve functionality is an essential tool for flow regulation in microfluidic systems. Here, the authors employ porous crystals which undergo mechanical reorientation of their internal subnanometer channels in order to manipulate spatiotemporal flow. 16 November 2015 | doi: 10.1038/ncomms9934 Chemical Sciences  Inorganic chemistry  Materials science  Nanotechnology  Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3 Imtiyaz Yaseen, Prabhjot Kaur, Vinay Kumar Nandicoori and Sanjeev Khosla Epigenetic modulation of hosts by pathogenic bacteria is underexplored. Here, Yaseen et al. show that protein Rv1988 from Mycobacterium tuberculosis enhances microbial survival by methylating histone H3 in the host cell nucleus and thus altering host gene expression. 16 November 2015 | doi: 10.1038/ncomms9922 Biological Sciences  Genetics  Microbiology  Efficient near-infrared up-conversion photoluminescence in carbon nanotubes OPEN Naoto Akizuki, Shun Aota, Shinichiro Mouri, Kazunari Matsuda and Yuhei Miyauchi Photoluminescent objects absorb light and then relax by emitting photons, usually with a lower energy. Here, the authors show that carbon nanotubes also emit larger energy photons thanks to one-phonon-assisted up-conversion, suggesting that nanotubes could be used as near-infrared up-converters. 16 November 2015 | doi: 10.1038/ncomms9920 Physical Sciences  Materials science  Optical physics  Physical chemistry  Combined effects of recent Pacific cooling and Indian Ocean warming on the Asian monsoon OPEN Hiroaki Ueda, Youichi Kamae, Masamitsu Hayasaki, Akio Kitoh, Shigeru Watanabe, Yurisa Miki and Atsuki Kumai Unique cooling in the tropical Pacific and warming in the Indian Ocean over the past 15 years is postulated to have an effect on Asian rainfall. Here, based on a numerical modelling experiment, the authors investigate this relationship and provide insight into the atmospheric dynamics at play. 13 November 2015 | doi: 10.1038/ncomms9854 Earth Sciences  Atmospheric science  Oceanography  Structure and dynamics of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA OPEN Yuan-Chao Lou, Tsai-Hsuan Weng, Yi-Chuan Li, Yi-Fen Kao, Wei-Feng Lin, Hwei-Ling Peng, Shan-Ho Chou, Chwan-Deng Hsiao and Chinpan Chen PmrA is a regulator of genes that are associated with antibiotic resistance. Here, the authors report the structure of the protein bound to DNA, and use NMR data to propose a mechanism for the regulation of gene transcription. 13 November 2015 | doi: 10.1038/ncomms9838 Biological Sciences  Biochemistry  Molecular biology  Sialic acid-dependent cell entry of human enterovirus D68 OPEN Yue Liu, Ju Sheng, Jim Baggen, Geng Meng, Chuan Xiao, Hendrik J. Thibaut, Frank J. M. van Kuppeveld and Michael G. Rossmann The human enterovirus D68 (EV-D68) is a causative agent of childhood respiratory infections, but despite its prevalence the exact mechanism mediating its cell entry have not been fully established. Here, the authors show how EV-D68 binds to sialic acid on the cell surface to initiate infection. 13 November 2015 | doi: 10.1038/ncomms9865 Biological Sciences  Virology  Fluid shear triggers microvilli formation via mechanosensitive activation of TRPV6 OPEN Shigenori Miura, Koji Sato, Midori Kato-Negishi, Tetsuhiko Teshima and Shoji Takeuchi Microvilli on epithelial cells can sense the surrounding fluid environment, but the regulatory mechanism behind their formation is mostly unknown. Here Miura et al. show that fluid shear stress serves as a trigger for microvilli formation via activation of the calcium ion channel TRPV6. 13 November 2015 | doi: 10.1038/ncomms9871 Biological Sciences  Cell biology  Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture OPEN Agla J. Fridriksdottir, Jiyoung Kim, René Villadsen, Marie Christine Klitgaard, Branden M. Hopkinson, Ole William Petersen and Lone Rønnov-Jessen Culturing normal primary breast cells that express the oestrogen receptor is difficult. Here, the authors isolate oestrogen receptor positive normal breast cells using the cell surface markers CD166 and CD117, and show that the cultures can be repeatedly passaged and retain oestrogen receptor protein expression. 13 November 2015 | doi: 10.1038/ncomms9786 Biological Sciences  Cancer  Cell biology  Analysing black phosphorus transistors using an analytic Schottky barrier MOSFET model OPEN Ashish V. Penumatcha, Ramon B. Salazar and Joerg Appenzeller Conventional models of transistors are not applicable to devices made from nanomaterials because their operation is dominated by gate-dependent transmission through a Schottkybarrier. Here, the authors develop an analytical model and compare it to data taken from ultrathin silicon field-effect transistors. 13 November 2015 | doi: 10.1038/ncomms9948 Physical Sciences  Applied physics  Materials science  Nanotechnology  Formin and capping protein together embrace the actin filament in a ménage à trois OPEN Shashank Shekhar, Mikael Kerleau, Sonja Kühn, Julien Pernier, Guillaume Romet-Lemonne, Antoine Jégou and Marie-France Carlier Formins promote actin filament polymerization and capping protein blocks polymerization; both proteins are thought to exclude each other from barbed ends. Here the authors show that both proteins can simultaneously bind barbed ends in a ternary complex while enhancing each other's dissociation from the barbed end. 13 November 2015 | doi: 10.1038/ncomms9730 Biological Sciences  Biochemistry  Biophysics  Single-molecule visualization of a formin-capping protein ‘decision complex’ at the actin filament barbed end OPEN Jeffrey P. Bombardier, Julian A. Eskin, Richa Jaiswal, Ivan R. Corrêa, Ming-Qun Xu, Bruce L. Goode and Jeff Gelles Formins promote the polymerization of actin filaments at barbed ends and capping protein prevents polymerization. Here the authors use single molecule imaging to directly visualize a decision complex consisting of the formin mDia1 and capping protein bound simultaneously to the filament barbed end and the dynamic mechanisms by which it forms and dissociates. 13 November 2015 | doi: 10.1038/ncomms9707 Biological Sciences  Biochemistry  Biophysics  Ultrafast collisional ion heating by electrostatic shocks OPEN A. E. Turrell, M. Sherlock and S. J. Rose Short pulses of high intensity laser light usually heat the ions in dense plasmas indirectly via collisions with the electrons. Here, the authors identify an extremely rapid alternative heating mechanism based on ion-ion collisions. 13 November 2015 | doi: 10.1038/ncomms9905 Physical Sciences  Fluids and plasma physics  Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers OPEN Bennie Lemmens, Robin van Schendel and Marcel Tijsterman Barriers to DNA replication are potent sources of genome instability. Here, the authors provide a mechanistic model for how a single persistent G-quadruplex structure generates multiple substrates for polymerase theta-mediated end-joining, thus causing multiple deletions during animal development. 13 November 2015 | doi: 10.1038/ncomms9909 Biological Sciences  Genetics  Molecular biology  Reversibility and criticality in amorphous solids OPEN Ido Regev, John Weber, Charles Reichhardt, Karin A. Dahmen and Turab Lookman The onset of yield, where a material starts to deform irreversibly, remains poorly understood for amorphous materials. Here, the authors use computer simulations that reveal how depinning-like processes in amorphous materials can result in large cooperative displacements of atoms during yield and cause irreversible, chaotic behaviour. 13 November 2015 | doi: 10.1038/ncomms9805 Physical Sciences  Materials science  Compensating for population sampling in simulations of epidemic spread on temporal contact networks OPEN Mathieu Génois, Christian L. Vestergaard, Ciro Cattuto and Alain Barrat Data describing human interaction suffer from incomplete sampling of population, affecting the reliability of studies on contagion spreading. Here, the authors present a systematic method to resample data and generate surrogate datasets of the unknown contacts, which approximate well the complete datasets. 13 November 2015 | doi: 10.1038/ncomms9860 Physical Sciences  Theoretical physics  Bird embryos uncover homology and evolution of the dinosaur ankle OPEN Luis Ossa-Fuentes, Jorge Mpodozis and Alexander O Vargas The anklebone of dinosaurs presents the ‘ascending process’ (ASC), a projection also found in modern birds, yet the ASC in birds has unique developmental characteristics. Here, the authors show that the ASC in six birds develops from an ancient element of the tetrapod ankle in a way that resembles basal tetrapods. 13 November 2015 | doi: 10.1038/ncomms9902 Biological Sciences  Evolution  Palaeontology  The molecular architecture of the Dam1 kinetochore complex is defined by cross-linking based structural modelling OPEN Alex Zelter, Massimiliano Bonomi, Jae ook Kim, Neil T. Umbreit, Michael R. Hoopmann, Richard Johnson, Michael Riffle, Daniel Jaschob, Michael J. MacCoss, Robert L. Moritz and Trisha N. Davis The Dam1 complex binds kinetochores to microtubules during mitosis. Here the authors combine cross-linking/mass spectrometry with structural modelling to derive a structure for the Dam1 complex that changes when bound to microtubules; further, they provide a mechanism for regulation by Aurora B kinase. 12 November 2015 | doi: 10.1038/ncomms9673 Biological Sciences  Biochemistry  Subwavelength imaging through ion-beam-induced upconversion OPEN Zhaohong Mi, Yuhai Zhang, Sudheer Kumar Vanga, Ce-Belle Chen, Hong Qi Tan, Frank Watt, Xiaogang Liu and Andrew A. Bettiol Combining high-resolution microscopic techniques with luminescent probes is important for biological imaging. Here, Mi et al. demonstrate subwavelength imaging by combining lanthanide-doped upconversion nanocrystals with ionoluminescence, revealing cellular structure and particle spatial distribution at high resolution. 12 November 2015 | doi: 10.1038/ncomms9832 Physical Sciences  Materials science  Nanotechnology  Optical physics  X-ray photoemission analysis of clean and carbon monoxide-chemisorbed platinum(111) stepped surfaces using a curved crystal OPEN Andrew L. Walter, Frederik Schiller, Martina Corso, Lindsay R. Merte, Florian Bertram, Jorge Lobo-Checa, Mikhail Shipilin, Johan Gustafson, Edvin Lundgren, Anton X. Brión-Ríos, Pepa Cabrera-Sanfelix, Daniel Sánchez-Portal and J. Enrique Ortega Systematic variation of surface sites may allow for more efficient testing of surface chemical reactions. Here, the authors use a platinum curved crystal and, by carrying out photoemission scans, are able to systematically address the fundamental CO-chemisorption process on a ‘tunable’ vicinal surface. 12 November 2015 | doi: 10.1038/ncomms9903 Chemical Sciences  Physical chemistry  MYC-induced reprogramming of glutamine catabolism supports optimal virus replication OPEN Minh Thai, Shivani K. Thaker, Jun Feng, Yushen Du, Hailiang Hu, Ting Ting Wu, Thomas G. Graeber, Daniel Braas and Heather R. Christofk Viruses can reprogram glutamine metabolism of host cells to support bioenergetics demands of viral replication. Here the authors show that adenoviral infection leads to enhanced glutamine metabolism through virus-mediated activation of MYC, which is required for optimal progeny virion generation. 12 November 2015 | doi: 10.1038/ncomms9873 Biological Sciences  Virology  Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM OPEN Moritz Pfreundschuh, David Alsteens, Ralph Wieneke, Cheng Zhang, Shaun R. Coughlin, Robert Tampé, Brian K. Kobilka and Daniel J. Müller Functional analysis of membrane proteins would benefit from the combination of imaging with ligand characterisation. Here, Pfreundschuh et al. use specialised atomic force microscopy tips to image and quantify the binding of two ligands at the same time. 12 November 2015 | doi: 10.1038/ncomms9857 Biological Sciences  Biophysics  Global biomass production potentials exceed expected future demand without the need for cropland expansion OPEN Wolfram Mauser, Gernot Klepper, Florian Zabel, Ruth Delzeit, Tobias Hank, Birgitta Putzenlechner and Alvaro Calzadilla Global demand for agricultural biomass is expected to exceed potential supply over the next few decades. Here, Mauser et al. show that by improving the management and efficiency of farmlands, global biomass has the potential to substantially exceed these estimates without the need for cropland expansion. 12 November 2015 | doi: 10.1038/ncomms9946 Biological Sciences  Ecology  Plant sciences  Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases OPEN Rubén M. Buey, Rodrigo Ledesma-Amaro, Adrián Velázquez-Campoy, Mónica Balsera, Mónica Chagoyen, José M. de Pereda and José L. Revuelta IMP dehydrogenase (IMPDH) plays essential roles in purine metabolism and cell proliferation. Here Buey et al. describe a guanine nucleotides regulated molecular mechanism for allosteric communication between the regulatory and catalytic domains of IMPDH. 12 November 2015 | doi: 10.1038/ncomms9923 Biological Sciences  Biochemistry  Biophysics    Nature Communications JOBS of the week Research Technician University of Liverpool Junior Research Group Eberhard Karls Universität Tübingen Postdoctoral Scientist John Innes Centre (JIC) Postdoctoral Research Scientist The Babraham Institute Research Associate / Postdoctoral Fellow Brigham and Women's Hospital/Harvard Medical School Postdoctoral Fellowship Linköping University (LiU) Technician University of Glasgow Group Leader Position Cancer Research Center of Toulouse Tenured / Tenure-Track Faculty Northeastern University Director of Fellowships Human Frontier Science Program (HFSP) More Science jobs from Nature Communications EVENT Toulouse Onco Week 2016 02.02.16 Toulouse, France More science events from       Latest Corrigenda     Corrigendum: Graphene-enabled electrically switchable radar-absorbing surfaces Osman Balci, Emre O. Polat, Nurbek Kakenov and Coskun Kocabas 16 November 2015 | doi: 10.1038/ncomms10000 Physical Sciences  Applied physics  Materials science  Optical physics      Corrigendum: Phase steps and resonator detuning measurements in microresonator frequency combs Pascal Del’Haye, Aurélien Coillet, William Loh, Katja Beha, Scott B. Papp and Scott A. Diddams 16 November 2015 | doi: 10.1038/ncomms10011 Physical Sciences  Optical physics        Latest Erratum     Erratum: Structural isomerism in gold nanoparticles revealed by X-ray crystallography OPEN Shubo Tian, Yi-Zhi Li, Man-Bo Li, Jinyun Yuan, Jinlong Yang, Zhikun Wu and Rongchao Jin 17 November 2015 | doi: 10.1038/ncomms10012 Chemical Sciences  Catalysis  Inorganic chemistry  Nanotechnology        Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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