Nature Biotechnology Contents: Volume 33 pp 1113 - 1212

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Advertisement Harness the power of biomarker and CDx strategies for clinical trial success. Access leading-edge technologies, scientific experts and Genomics Know-How®. Partner with experts to realize efficiencies, mitigate risks and improve clinical outcomes. Learn More TABLE OF CONTENTS November 2015 Volume 33, Issue 11 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Advertisement   Ready for a glimpse of tomorrow? Visit KAUST Discovery today KAUST Discovery highlights the cutting-edge research, technologies and innovations emerging from the King Abdullah University of Science and Technology. http://discovery.kaust.edu.sa Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Nature Microbiology: Call for Papers Launching in January 2016, Nature Microbiology is now open for submissions and inviting high-quality submissions. The journal will cover all aspects of microorganisms be it their evolution, physiology and cell biology, their interactions with each other, with a host, with an environment, or their societal significance.  Submit your next research paper to the journal.     Editorial Top An unusual business   p1113 doi:10.1038/nbt.3409 And the 2015 Nobel Prize for Pharmacoeconomics goes to.... Martin Shkreli News Top Drug makers target ubiquitin proteasome pathway anew   pp1115 - 1117 Cormac Sheridan doi:10.1038/nbt1115-1115 FDA raps liquid biopsy firm   p1117 doi:10.1038/nbt1115-1117 Amgen bulks out cardio package   p1118 doi:10.1038/nbt1115-1118a UK funding agencies weigh in on human germline editing   pp1118 - 1119 Melanie Senior doi:10.1038/nbt1115-1118b MD Anderson catches immune-oncology wave   p1119 doi:10.1038/nbt1115-1119 AbbVie buys last available priority voucher for $350 million   p1120 Chris Morrison doi:10.1038/nbt1115-1120 Hatteras rounds up $90 million to lead biotech rebound in North Carolina   pp1121 - 1122 Deborah Erickson doi:10.1038/nbt1115-1121 First moss-made drug   p1122 doi:10.1038/nbt1115-1122a Seek 1 million US citizens   p1122 doi:10.1038/nbt1115-1122b Industrial biotechs turn greenhouse gas into feedstock opportunity   pp1123 - 1125 Mark Peplow doi:10.1038/nbt1115-1123 Around the world in a month   p1124 doi:10.1038/nbt1115-1124 First Rounders Podcast: William Rutter   p1125 doi:10.1038/nbt.3395 Sexed-up beer   p1125 doi:10.1038/nbt1115-1125 Data Page Drug pipeline: 3Q15   p1126 Laura DeFrancesco doi:10.1038/nbt.3405 3Q15—biotech in the balance   p1127 Walter Yang doi:10.1038/nbt.3407 News Feature Breathing easier with combinations   pp1128 - 1130 Anna Azvolinsky doi:10.1038/nbt.3397 The first approved combination therapy against cystic fibrosis will open up an increasing proportion of patients for treatment. As Anna Azvolinsky reports, companies are banking on it. Enhanced MALDI-TOF MS Performance and Flexibility From a linear-only system to a unique QIT-TOF configuration to a high-resolution, high-energy TOF-TOF, Shimadzu's suite of MALDI mass spectrometers easily meets the needs of researchers with varying applications and budgets. Mine your data using our comprehensive software solutions. Learn more. Ultra-Sensitive Biomarker Assay Service from PBL Assay Science  Dedicated assay team to execute & develop fit-for-purpose Single Molecule Array (SIMOA™) immunoassays: IL-6, IL-10, IL-17A, IL-23, IP-10, TNFa, TRAIL, 3-plexes, custom fg/ml sensitivities for analytes in serum, plasma, & other matrices Multiplexing capabilities  Let PBL help with your complex assay needs.  Bioentrepreneur Top Data page Top US universities, institutes for life sciences in 2014   p1131 Brady Huggett doi:10.1038/nbt.3394 Opinion and Comment Top Correspondence Recasting Asilomar's lessons for human germline editing   pp1132 - 1134 Henry I Miller doi:10.1038/nbt.3402 Using GlycoDelete to produce proteins lacking plant-specific N-glycan modification in seeds   pp1135 - 1137 Robin Piron, Francis Santens, Annelies De Paepe, Ann Depicker and Nico Callewaert doi:10.1038/nbt.3359 Features Top Patents The ownership question of plant gene and genome intellectual properties   pp1138 - 1143 Osmat A Jefferson, Deniz Kollhofer, Thomas H Ehrich and Richard A Jefferson doi:10.1038/nbt.3393 The restructuring of the crop agriculture industry over the past two decades has enabled patent holders to exclude, prevent and deter others from using certain research tools and delay or block further follow-on inventions. Recent patents in infectious disease diagnostics and treatment   p1144 doi:10.1038/nbt.3414 News and Views Top Putting induced pluripotent stem cells to the test   pp1145 - 1146 Ludovic Vallier doi:10.1038/nbt.3401 Human induced pluripotent stem cells are found to be nearly identical to embryonic stem cells, supporting their suitability for clinical applications. See also: Research by Choi et al. Big thinking for adjuvants   pp1146 - 1148 Eric L Dane and Darrell J Irvine doi:10.1038/nbt.3398 Particles formed by polymeric adjuvants preferentially localize to the lymph node and elicit robust immunity. See also: Research by Lynn et al. Biological synthesis unbounded?   pp1148 - 1149 Brian F Pfleger and Kristala L J Prather doi:10.1038/nbt.3399 Chemical synthesis of specialty and commodity products still reigns supreme but greener, metabolic engineering approaches are gaining ground. Scaling up phenotyping studies   pp1150 - 1151 Karen L Svenson doi:10.1038/nbt.3400 A well-designed mouse phenotyping study adds to the catalog of mammalian gene function. Research Highlights   p1151 doi:10.1038/nbt.3396 Biotechnology JOBS of the week Computational Toxicologist Environmental Protection Agency Professor (Open Rank) – Department of Bioengineering University of Illinois Professor and Chair University of Florida Postdoctoral Fellow Translational Oncology Helmholtz Association More Science jobs from Biotechnology EVENT XII International Symposium of Plant Biotechnology April 5, 2016 Villa Clara, Cuba More science events from Computational Biology Top Analysis Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes   pp1152 - 1158 Sachet A Shukla, Michael S Rooney, Mohini Rajasagi, Grace Tiao, Philip M Dixon et al. doi:10.1038/nbt.3344 An analysis of the HLA class I loci in 7,930 tumor samples detects recurrent mutation 'hotspots' in these genes. Research Top Brief Communications Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease   pp1159 - 1161 James E Dahlman, Omar O Abudayyeh, Julia Joung, Jonathan S Gootenberg, Feng Zhang et al. doi:10.1038/nbt.3390 Varying the length of sgRNAs allows knocking out and activating different genes in the same cell using catalytically active Cas9. DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins   pp1162 - 1164 Je Wook Woo, Jungeun Kim, Soon Il Kwon, Claudia Corvalan, Seung Woo Cho et al. doi:10.1038/nbt.3389 CRISPR-Cas9 genome editing is achieved in Arabidopsis, tobacco, lettuce and rice without introducing foreign DNA into the plants. Articles Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state   pp1165 - 1172 Assaf Rotem, Oren Ram, Noam Shoresh, Ralph A Sperling, Alon Goren et al. doi:10.1038/nbt.3383 Chromatin state is analyzed for the first time in single cells, revealing new cell subpopulations. A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs   pp1173 - 1181 Jiho Choi, Soohyun Lee, William Mallard, Kendell Clement, Guidantonio Malagoli Tagliazucchi et al. doi:10.1038/nbt.3388 Human induced pluripotent stem cells show no consistent differences from human embryonic stem cells in a study that controls for several sources of variability. See also: News and Views by Vallier A qPCR ScoreCard quantifies the differentiation potential of human pluripotent stem cells   pp1182 - 1192 Alexander M Tsankov, Veronika Akopian, Ramona Pop, Sundari Chetty, Casey A Gifford et al. doi:10.1038/nbt.3387 A qPCR ScoreCard assay provides a faster, more quantitative and scalable alternative to the teratoma assay for evaluating human stem cell lines. Nephron organoids derived from human pluripotent stem cells model kidney development and injury   pp1193 - 1200 Ryuji Morizane, Albert Q Lam, Benjamin S Freedman, Seiji Kishi, M Todd Valerius et al. doi:10.1038/nbt.3392 Human pluripotent stem cells are differentiated into renal vesicles that spontaneously form kidney organoids. In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity   pp1201 - 1210 Geoffrey M Lynn, Richard Laga, Patricia A Darrah, Andrew S Ishizuka, Alexandra J Balaci et al. doi:10.1038/nbt.3371 Vaccine efficacy is enhanced by optimizing the design of polymeric particles for adjuvant and antigen delivery. See also: News and Views by Dane & Irvine Careers and Recruitment Top Third-quarter biotech job picture   p1211 Michael Francisco doi:10.1038/nbt.3406 People People   p1212 doi:10.1038/nbt.3411 Advertisement Nature Plants: Call for Papers Nature Plants launched in January and covers all aspects of plants be it their evolution, genetics, development or metabolism, their interactions with the environment, or their societal significance. The journal welcomes high quality submissions and encourages you and your colleagues to consider submitting your next research paper to the journal.  Submit your next research paper to the journal.     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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