Nature Reviews Immunology Contents November 2015 Volume 15 Number 11 pp 665-724

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TABLE OF CONTENTS
November 2015 Volume 15 Number 11
Impact Factor 34.985 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: γδ T cells in cancer Bruno Silva-Santos, Karine Serre & Håkan Norell
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RESEARCH HIGHLIGHTS Top Neutrophils: Growing old disgracefully? p665 | doi:10.1038/nri3924 The microbiota drives ageing and the acquisition of pro-inflammatory functions in circulating neutrophils. PDF T cells: Nutrients guide differentiation p666 | doi:10.1038/nri3923 Stimulation of naive CD4+ T cells in glutamine-deprived conditions favours differentiation into regulatory T cells. PDF Dendritic cells: Perforin protection p666 | doi:10.1038/nri3926 Perforin-positive dendritic cells protect against metabolic syndrome and autoimmunity. PDF Phagocytosis: Mitochondria and phagosomes: better together p667 | doi:10.1038/nri3931 The kinases MST1 and MST2, which are activated by Toll-like receptor stimulation, regulate the trafficking of mitochondria to phagosomes to deliver reactive oxygen species. PDF JOURNAL CLUB A first look at TH cell transcriptomes p668 | doi:10.1038/nri3913 John O'Shea describes a 2000 paper by Rogge et al. that was the first to compare the transcriptomes of human TH1 cells and TH2 cells. PDF Mucosal immunology: Battle scars p668 | doi:10.1038/nri3932 Acute infection can lead to chronic lymphadenopathy and long-term immune impairment. PDF Immunology JOBS of the week Postdoctoral Fellow (210316) The Henry M.Jackson Foundation Research Scientist (#79025) California Institute for Biomedical Research Creation of New Junior Research Groups Institut Pasteur Post Doctoral Research Associate Texas Tech University Health Sciences Center El Paso Fulltime professor: Cristallography and modelling of multi-enzyme complexes in virology (27 2010) KU Leuven More Science jobs from Immunology EVENT International Congress of Immunology 2016 21.08.16 South Wharf, Victoria, Australia More science events from
REVIEWS		Top
Immunological hallmarks of stromal cells in the tumour microenvironment Shannon J. Turley, Viviana Cremasco & Jillian L. Astarita p669 | doi:10.1038/nri3902 Emerging evidence suggests that the stroma of the tumour microenvironment can shape antitumour immunity and responsiveness to immunotherapy. The stromal cells and the signals they produce that influence tumour-infiltrating leukocytes, as well as the implications for cancer treatment, are reviewed here. Abstract | Full Text | PDF
γδ T cells in cancer Bruno Silva-Santos, Karine Serre & Hakan Norell p683 | doi:10.1038/nri3904 γδ T cells have unique specificities, high clonal frequencies and a pre-activated differentiation status that allow rapid and non-redundant responses to tumours. Here, the authors review their often contrasting roles in cancer and the opportunities for γδ T cell-based cancer therapies. Abstract | Full Text | PDF
How leukocytes cross the vascular endothelium Dietmar Vestweber p692 | doi:10.1038/nri3908 Reciprocal interactions between leukocytes and endothelial cells enable leukocytes to recognize the blood vessel endothelium in areas of inflammation and transmigrate across the endothelial barrier to mount an immune response in infected and/or damaged tissues. Abstract | Full Text | PDF
Sizing up the key determinants of the CD8+ T cell response David C. Tscharke, Nathan P. Croft, Peter C. Doherty & Nicole L. La Gruta p705 | doi:10.1038/nri3905 Here, the authors explain how the specificity and magnitude of the primary cytotoxic T lymphocyte (CTL) response is determined during a viral infection. They discuss the different factors that influence the recruitment and expansion of naive CTL precursors, and they explain how technological advances have enabled a more accurate quantitation of these responses. Abstract | Full Text | PDF
PERSPECTIVES		Top
ESSAY Resistance and tolerance to foreign elements by prokaryotic immune systems - curating the genome Gregory W. Goldberg & Luciano A. Marraffini p717 | doi:10.1038/nri3910 This Essay considers how prokaryotic and mammalian immune systems ensure tolerance or resistance to genetic elements. In particular, the authors discuss the restriction-modification and CRISPR-Cas activities of prokaryotes and the analogous immune pathways found in mammals. Abstract | Full Text | PDF
Corrigendum: Eicosanoid storm in infection and inflammation Edward A. Dennis & Paul C. Norris p724 | doi:10.1038/nri3928 Full Text | PDF
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