The EMBO Journal Table of Contents for September 2015; Vol. 34, No. 18

September 2015 | Volume 34, Number 18 Submit Table of Contents News & Views Review Articles Corrigendum Volume 34, Number 18 News & Views Cancer: leaping the E‐cadherin hurdle E‐cadherin levels determine the barrier for aberrant β‐catenin activation in colon cancer, providing an explanation for the different spectrum of mutations in the Wnt pathway associated with colon cancer as compared to other tumor types. George T Chen and Marian L Waterman Published online 17.08.2015 Better to burn out than it is to rust: coordinating cellular redox states during aging and stress A recent study showing cytosolic and ER redox states to be inversely regulated upon proteotoxic stress sheds further light on the balance between cellular homeostasis and aging. Christopher Rongo Published online 31.07.2015 Review Collaborative protein filaments Bacterial protein filaments can assemble on their own as part of the cytoskeleton, or alternatively may require an scaffolding matrix. The latter, now called collaborative filaments, are conserved and are known to be involved in critical cellular functions, such as cell division. Debnath Ghosal and Jan Löwe Published online 12.08.2015 Articles E‐cadherin can limit the transforming properties of activating β‐catenin mutations In contrast to other Wnt‐driven malignancies colorectal cancer is usually linked to APC loss, and very rarely to β‐catenin activating mutations. Different E‐cadherin levels can explain the variation in transforming potential of β‐catenin mutations in different tumors. David J Huels, Rachel A Ridgway, Sorina Radulescu, Marc Leushacke, Andrew D Campbell, Sujata Biswas, Simon Leedham, Stefano Serra, Runjan Chetty, Guenievre Moreaux, Lee Parry, James Matthews, Fei Song, Ann Hedley, Gabriela Kalna, Fatih Ceteci, Karen R Reed, Valerie S Meniel, Aoife Maguire, Brendan Doyle, Ola Söderberg, Nick Barker, Alastair Watson, Lionel Larue, Alan R Clarke, and Owen J Sansom Published online 03.08.2015 Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments Using genetically encoded sensors this study shows that the opposing redox state in ER lumen and cytosol is altered during ageing and upon disruption of proteostasis. The resulting redox imbalance can spread across tissues. Janine Kirstein, Daisuke Morito, Taichi Kakihana, Munechika Sugihara, Anita Minnen, Mark S Hipp, Carmen Nussbaum‐Krammer, Prasad Kasturi, F Ulrich Hartl, Kazuhiro Nagata, and Richard I Morimoto Published online 29.07.2015 The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis Using a mouse knockout model for tRNA methyltransferase Dnmt2, this study identifies a link between translational fidelity and the differentiation of haematopoietic stem cells. Francesca Tuorto, Friederike Herbst, Nader Alerasool, Sebastian Bender, Oliver Popp, Giuseppina Federico, Sonja Reitter, Reinhard Liebers, Georg Stoecklin, Hermann‐Josef Gröne, Gunnar Dittmar, Hanno Glimm, and Frank Lyko Published online 13.08.2015 RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils The AAA+ ATPase RuvbL is required for aggresome formation and serves as a protein disaggregase that can disassemble amyloids in mammalian and yeast cells. Nava Zaarur, Xiaobin Xu, Patrick Lestienne, Anatoli B Meriin, Mark McComb, Catherine E Costello, Gary P Newnam, Rakhee Ganti, Nina V Romanova, Maruda Shanmugasundaram, Sara TN Silva, Tiago M Bandeiras, Pedro M Matias, Kirill S Lobachev, Igor K Lednev, Yury O Chernoff, and Michael Y Sherman Published online 24.08.2015 Corrigendum Shp2 signaling suppresses senescence in PyMT‐induced mammary gland cancer in mice Linxiang Lan, Jane D Holland, Jingjing Qi, Stefanie Grosskopf, Regina Vogel, Balázs Györffy, Annika Wulf‐Goldenberg, and Walter Birchmeier Published online 14.09.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.