Scientific Reports Biology Table of Contents e-alert: 8 September 2015

If you are unable to see the message below, click here to view.

08 September 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Impairment of T cell development and acute inflammatory response in HIV-1 Tat transgenic mice ▶     Giuseppe Fiume, Annarita Scialdone, Francesco Albano et al.     Immune activation and chronic inflammation are hallmark features of HIV infection causing T-cell depletion and cellular immune dysfunction in AIDS. Here, we addressed the issue …             LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells ▶     Yuho Maki, Junya Fujimoto, Wenhua Lang et al.     We recently demonstrated that lysosomal protein transmembrane 4 beta (LAPTM4B) is elevated in non-small cell lung cancers (NSCLCs) and in the surrounding premalignant airway …             Identification and analysis of the N6-methyladenosine in the Saccharomyces cerevisiae transcriptome ▶     Wei Chen, Hong Tran, Zhiyong Liang et al.     Knowledge of the distribution of N6-methyladenosine (m6A) is invaluable for understanding RNA biological functions. However, limitation in experimental methods impedes the …             Unveiling the metabolic potential of two soil-derived microbial consortia selected on wheat straw ▶     Diego Javier Jiménez, Diego Chaves-Moreno, Jan Dirk van Elsas     Based on the premise that plant biomass can be efficiently degraded by mixed microbial cultures and/or enzymes, we here applied a targeted metagenomics-based approach to explore …             Young dispersal of xerophil Nitraria lineages in intercontinental disjunctions of the Old World ▶     Ming-Li Zhang, Kamshat Temirbayeva, Stewart C. Sanderson et al.     Many cases of intercontinental disjunct distributions of seed plants have been investigated, however few have concerned the continents of Eurasia (mainly Central Asia), Africa, …             Electrophysiological evidences demonstrating differences in brain functions between nonmusicians and musicians ▶     Li Zhang, Weiwei Peng, Jie Chen et al.     Long-term music training can improve sensorimotor skills, as playing a musical instrument requires the functional integration of information related to multimodal sensory …             Evaluation of drug-targetable genes by defining modes of abnormality in gene expression ▶     Junseong Park, Jungsul Lee, Chulhee Choi     In the post-genomic era, many researchers have taken a systematic approach to identifying abnormal genes associated with various diseases. However, the gold standard has not been …             Personality traits predict brain activation and connectivity when witnessing a violent conflict ▶     Jan Van den Stock, Ruud Hortensius, Charlotte Sinke et al.     As observers we excel in decoding the emotional signals telling us that a social interaction is turning violent. The neural substrate and its modulation by personality traits …             Differential Contributions of Nonmuscle Myosin II Isoforms and Functional Domains to Stress Fiber Mechanics ▶     Ching-Wei Chang, Sanjay Kumar     While is widely acknowledged that nonmuscle myosin II (NMMII) enables stress fibers (SFs) to generate traction forces against the extracellular matrix, little is known about how …             Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria ▶     Daniel Garrido, Santiago Ruiz-Moyano, Danielle G. Lemay et al.     Breast milk enhances the predominance of Bifidobacterium species in the infant gut, probably due to its large concentration of human milk oligosaccharides (HMO). Here we screened …             Light pollution disrupts sleep in free-living animals ▶     Thomas Raap, Rianne Pinxten, Marcel Eens     Artificial lighting can alter individual behaviour, with often drastic and potentially negative effects on biological rhythms, daily activity and reproduction. Whether this is …             Molecular Evolution of the Capsid Gene in Norovirus Genogroup I ▶     Miho Kobayashi, Shima Yoshizumi, Sayaka Kogawa et al.     We studied the molecular evolution of the capsid gene in all genotypes (genotypes 1–9) of human norovirus (NoV) genogroup I. The evolutionary time scale and rate were estimated …             Circadian Modulation of 8-Oxoguanine DNA Damage Repair ▶     Nicola Manzella, Massimo Bracci, Elisabetta Strafella et al.     The DNA base excision repair pathway is the main system involved in the removal of oxidative damage to DNA such as 8-Oxoguanine (8-oxoG) primarily via the 8-Oxoguanine DNA …             Proteomic Changes Associated with Successive Reproductive Periods in Male Polychaetous Neanthes arenaceodentata ▶     Kondethimmanahalli H. Chandramouli, Donald Reish, Huoming Zhang et al.     The polychaetous annelid Neanthes acuminata complex has a widespread distribution, with the California population referred to as N. arenaceodentata. The reproductive pattern in …             Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells ▶     Xiaodong Jin, Feifei Li, Xiaogang Zheng et al.     Heavy ion beams have advantages over conventional radiation in radiotherapy due to their superb biological effectiveness and dose conformity. However, little information is …             The nitric oxide synthase 3 G894T polymorphism associated with Alzheimer’s disease risk: a meta-analysis ▶     Shengyuan Liu, Fangfang Zeng, Changyi Wang et al.     The association between the G894T polymorphism (Glu298Asp) of nitric oxide synthase 3 (NOS3) and risk of Alzheimer’s disease (AD) was explored by performing a meta-analysis of …             A protein with simultaneous capsid scaffolding and dsRNA-binding activities enhances the birnavirus capsid mechanical stability ▶     Johann Mertens, Santiago Casado, Carlos P. Mata et al.     Viral capsids are metastable structures that perform many essential processes; they also act as robust cages during the extracellular phase. Viruses can use multifunctional …             Chick tendon fibroblast transcriptome and shape depend on whether the cell has made its own collagen matrix ▶     Ching-Yan Chloé Yeung, Leo A. H. Zeef, Chloe Lallyett et al.     Collagen- and fibrin-based gels are extensively used to study cell behaviour. However, 2D–3D and collagen-fibrin comparisons of gene expression, cell shape and …             A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells ▶     Huan He, Dong-Wei Li, Li-Yun Yang et al.     Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that …             EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway ▶     Meng-Feng Tsai, Tzu-Hua Chang, Shang-Gin Wu et al.     Malignant pleural effusion (MPE) is a common clinical problem in non-small cell lung carcinoma (NSCLC) patients; however, the underlying mechanisms are still largely unknown. …             Whole-genome Sequencing for Tracing the Transmission Link between Two ARD Outbreaks Caused by a Novel HAdV Serotype 7 Variant, China ▶     Shaofu Qiu, Peng Li, Hongbo Liu et al.     From December 2012 to February 2013, two outbreaks of acute respiratory disease caused by HAdV-7 were reported in China. We investigated possible transmission links between these …             Reduced greenhouse gas mitigation potential of no-tillage soils through earthworm activity ▶     Ingrid M. Lubbers, Kees Jan van Groenigen, Lijbert Brussaard et al.     Concerns about rising greenhouse gas (GHG) concentrations have spurred the promotion of no-tillage practices as a means to stimulate carbon storage and reduce CO2 emissions in …             Stabilizing synchrony by inhomogeneity ▶     Ehsan Bolhasani, Alireza Valizadeh     We show that for two weakly coupled identical neuronal oscillators with strictly positive phase resetting curve, isochronous synchrony can only be seen in the absence of noise …             Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function ▶     Somayeh Jamali, Michael Klier, Samantha Ames et al.     The most aggressive tumour cells, which often reside in hypoxic environments, rely on glycolysis for energy production. Thereby they release vast amounts of lactate and protons …             Effects of acoustic levitation on the development of zebrafish, Danio rerio, embryos ▶     Maria Sundvik, Heikki J. Nieminen, Ari Salmi et al.     Acoustic levitation provides potential to characterize and manipulate material such as solid particles and fluid in a wall-less environment. While attempts to levitate small …             Dimeric interactions and complex formation using direct coevolutionary couplings ▶     Ricardo N. dos Santos, Faruck Morcos, Biman Jana et al.     We develop a procedure to characterize the association of protein structures into homodimers using coevolutionary couplings extracted from Direct Coupling Analysis (DCA) in …             Associations between antioxidant vitamins and the risk of invasive cervical cancer in Chinese women: A case-control study ▶     Liyuan Guo, Hong Zhu, Chengjun Lin et al.     Previous studies on the associations between dietary antioxidant vitamins and the risk of cervical cancer remain inconsistent, and little evidence is available for serum …             The motility-proliferation-metabolism interplay during metastatic invasion ▶     Inbal Hecht, Sari Natan, Assaf Zaritsky et al.     Metastasis is the major cause for cancer patients’ death, and despite all the recent advances in cancer research it is still mostly incurable. Understanding the mechanisms that …             Binding interface between the Salmonella σS/RpoS subunit of RNA polymerase and Crl: hints from bacterial species lacking crl ▶     Paola Cavaliere, Christina Sizun, Fabienne Levi-Acobas et al.     In many Gram-negative bacteria, including Salmonella enterica serovar Typhimurium (S. Typhimurium), the sigma factor RpoS/σS accumulates during stationary phase of growth, and …             A novel recombinant slow-release TNF α-derived peptide effectively inhibits tumor growth and angiogensis ▶     Yi Ma, Shaojun Zhao, Shutao Shen et al.     RMP16, a recombinant TNF α-derived polypeptide comprising a specific human serum albumin (HSA)-binding 7-mer peptide identified by phage display screening (WQRPSSW), a cleavage …             NF-κB signaling is essential for resistance to heat stress-induced early stage apoptosis in human umbilical vein endothelial cells ▶     Yanan Liu, Gengbiao Zhou, Zhenglian Wang et al.     Cell apoptosis induced by heat stress is regulated by a complex signaling network. We previously reported that a p53-dependent pathway is involved. Here, we present evidence that …             The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex ▶     Jamie E. Marshall, Bayan H. A. Faraj, Alexandre R. Gingras et al.     Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pneumoniae. It kills cells by forming pores assembled from oligomeric rings in …             Hidden biodiversity in an ancient lake: phylogenetic congruence between Lake Tanganyika tropheine cichlids and their monogenean flatworm parasites ▶     Maarten P. M. Vanhove, Antoine Pariselle, Maarten Van Steenberge et al.     The stunning diversity of cichlid fishes has greatly enhanced our understanding of speciation and radiation. Little is known about the evolution of cichlid parasites. Parasites …             Competition with wind-pollinated plant species alters floral traits of insect-pollinated plant species ▶     Floriane Flacher, Xavier Raynaud, Amandine Hansart et al.     Plant traits related to attractiveness to pollinators (e.g. flowers and nectar) can be sensitive to abiotic or biotic conditions. Soil nutrient availability, as well as …             Evidence for loss of nepotism in the evolution of permanent sociality ▶     Reut Berger-Tal, Yael Lubin, Virginia Settepani et al.     Kin selected benefits of cooperation result in pronounced kin discrimination and nepotism in many social species and favour the evolution of sociality. However, low variability …             Evidence for equal size cell divisions during gametogenesis in a marine green alga Monostroma angicava ▶     Tatsuya Togashi, Yusuke Horinouchi, Hironobu Sasaki et al.     In cell divisions, relative size of daughter cells should play fundamental roles in gametogenesis and embryogenesis. Differences in gamete size between the two mating types …             Human testicular peritubular cells secrete pigment epithelium-derived factor (PEDF), which may be responsible for the avascularity of the seminiferous tubules ▶     S. Windschüttl, C. Kampfer, C. Mayer et al.     Male fertility depends on spermatogenesis, which takes place in the seminiferous tubules of the testis. This compartment is devoid of blood vessels, which are however found in …             Establishment of immunoassay for detecting HPV16 E6 and E7 RNA ▶     Sen Ding, Steven Y. Qian, Yang Zhang et al.     Cervical carcinoma is the most prevalent malignancy second only to breast cancer among women worldwide. Since more than 99% of cervical cancers are caused by human papilloma …             Architecture of the Synaptophysin/Synaptobrevin Complex: Structural Evidence for an Entropic Clustering Function at the Synapse ▶     Daniel J. Adams, Christopher P. Arthur, Michael H. B. Stowell     We have purified the mammalian synaptophysin/synaptobrevin (SYP/VAMP2) complex to homogeneity in the presence of cholesterol and determined the 3D EM structure by single particle …             Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex ▶     Christoph M. Zehendner, Anne Sebastiani, André Hugonnet et al.     Accumulating evidence suggests a pivotal role of PDGFRß positive cells, a specific marker for central nervous system (CNS) pericytes, in tissue scarring. Identification of cells …             Identification of outliers in a genomic scan for selection along environmental gradients in the bamboo locust, Ceracris kiangsu ▶     Xiao-Jing Feng, Guo-Fang Jiang, Zhou Fan     Identification of loci under divergent selection is a key step in understanding the evolutionary process because those loci are responsible for the genetic variations that affect …             Aphid-induced Defences in Chilli Affect Preferences of the Whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae) ▶     Khalid A. Saad, M. N. Mohamad Roff, Rebecca H. Hallett et al.     The sweetpotato whitefly (WF), Bemisia tabaci, is a major pest that damages a wide range of vegetable crops in Malaysia. WF infestation is influenced by a variety of factors, …             The novel ABC transporter ABCH1 is a potential target for RNAi-based insect pest control and resistance management ▶     Zhaojiang Guo, Shi Kang, Xun Zhu et al.     Insect pests cause serious crop damage and develop high-level resistance to chemical insecticides and Bacillus thuringiensis (Bt) insecticidal Cry toxins. A new promising …             FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization ▶     Yaling Jiang, Yixin Liao, Hui He et al.     Human endometrium decidualization, which involves endometrial stromal proliferation and differentiation, is a prerequisite for embryo implantation, thus successful pregnancy. The …             High-resolution non-contact measurement of the electrical activity of plants in situ using optical recording ▶     Dong-Jie Zhao, Yang Chen, Zi-Yang Wang et al.     The limitations of conventional extracellular recording and intracellular recording make high-resolution multisite recording of plant bioelectrical activity in situ challenging. …             Comparative Proteomics Analyses of Two Races of Fusarium oxysporum f. sp. conglutinans that Differ in Pathogenicity ▶     Erfeng Li, Jian Ling, Gang Wang et al.     Fusarium oxysporum is a soil-inhabiting fungus that induces vascular wilt and root rot in a variety of plants. F. oxysporum f. sp. conglutinans (Foc), which comprises two races, …             Mixed gaits in small avian terrestrial locomotion ▶     Emanuel Andrada, Daniel Haase, Yefta Sutedja et al.     Scientists have historically categorized gaits discretely (e.g. regular gaits such as walking, running). However, previous results suggest that animals such as birds might mix or …             Multigenerational effects of parental prenatal exposure to famine on adult offspring cognitive function ▶     Jie Li, Lixin Na, Hao Ma et al.     The effects of prenatal nutrition on adult cognitive function have been reported for one generation. However, human evidence for multigenerational effects is lacking. We examined …             The Optimized Fabrication of Nanobubbles as Ultrasound Contrast Agents for Tumor Imaging ▶     Wen Bin Cai, Heng Li Yang, Jian Zhang et al.     Nanobubbles, which have the potential for ultrasonic targeted imaging and treatment in tumors, have been a research focus in recent years. With the current methods, however, the …             Novel approach for label free super-resolution imaging in far field ▶     Sergey A. Alexandrov, James McGrath, Hrebesh Subhash et al.     Progress in the emerging areas of science and technology, such as bio- and nano-technologies, depends on development of corresponding techniques for imaging and probing the …             Genetic association of RIT2 rs12456492 polymorphism and Parkinson’s disease susceptibility in Asian populations: a meta-analysis ▶     Yanjun Lu, Wei Liu, Kun Tan et al.     Recent studies investigating the association of the Ras-like without CAAX 2 (RIT2) polymorphism, rs12456492, with Parkinson’s disease (PD) are controversial. We performed a …             K-factor image deshadowing for three-dimensional fluorescence microscopy ▶     Tali Ilovitsh, Aryeh Weiss, Amihai Meiri et al.     The ability to track single fluorescent particles within a three dimensional (3D) cellular environment can provide valuable insights into cellular processes. In this paper, we …             CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X ▶     Madina Karimova, Niklas Beschorner, Werner Dammermann et al.     Current antiviral therapies cannot cure hepatitis B virus (HBV) infection; successful HBV eradication would require inactivation of the viral genome, which primarily persists in …             Expression of decoy receptor 3 in kidneys is associated with allograft survival after kidney transplant rejection ▶     Shuo-Chun Weng, Kuo-Hsiung Shu, Ming-Ju Wu et al.     Decoy receptor 3 (DcR3) expression in kidneys has been shown to predict progression of chronic kidney disease. We prospectively investigated a cohort comprising 96 renal …             Self-organization of waves and pulse trains by molecular motors in cellular protrusions ▶     A. Yochelis, S. Ebrahim, B. Millis et al.     Actin-based cellular protrusions are an ubiquitous feature of cells, performing a variety of critical functions ranging from cell-cell communication to cell motility. The …             Erratum: 18 GHz electromagnetic field induces permeability of Gram-positive cocci ▶     The Hong Phong Nguyen, Yury Shamis, Rodney J. Croft et al.                 Erratum: Retina specific GCAPs in zebrafish acquire functional selectivity in Ca2+-sensing by myristoylation and Mg2+-binding ▶     Stefan Sulmann, Farina Vocke, Alexander Scholten et al.                 Phosphoproteomic profiling of tumor tissues identifies HSP27 Ser82 phosphorylation as a robust marker of early ischemia ▶     Muhammad Saddiq Zahari, Xinyan Wu, Sneha M. Pinto et al.     Delays between tissue collection and tissue fixation result in ischemia and ischemia-associated changes in protein phosphorylation levels, which can misguide the examination of …             Corrigendum: Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy ▶     Guozhen Cui, Luchen Shan, Lin Guo et al.                 Biological Sources of Intrinsic and Extrinsic Noise in cI Expression of Lysogenic Phage Lambda ▶     Xue Lei, Wei Tian, Hongyuan Zhu et al.     Genetically identical cells exposed to homogeneous environment can show remarkable phenotypic difference. To predict how phenotype is shaped, understanding of how each factor …             Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation ▶     Ana Paula Crestani, Flávia Zacouteguy Boos, Josué Haubrich et al.     Memories can be destabilized by the reexposure to the training context, and may reconsolidate into a modified engram. Reconsolidation relies on some particular molecular …             Mimicking a natural pathway for de novo biosynthesis: natural vanillin production from accessible carbon sources ▶     Jun Ni, Fei Tao, Huaiqing Du et al.     Plant secondary metabolites have been attracting people’s attention for centuries, due to their potentials; however, their production is still difficult and costly. The rich …             Tet-mediated imprinting erasure in H19 locus following reprogramming of spermatogonial stem cells to induced pluripotent stem cells ▶     P. Bermejo-Álvarez, P. Ramos-Ibeas, K.E. Park et al.     Selective methylation of CpG islands at imprinting control regions (ICR) determines the monoparental expression of a subset of genes. Currently, it is unclear whether artificial …             18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination ▶     Jieru Zhou, Wei Cai, Min Jin et al.     Microglia are intrinsic immune cells in the central nervous system (CNS). The under controlled microglia activation plays important roles in inflammatory demyelination diseases, …             PEA-CLARITY: 3D molecular imaging of whole plant organs ▶     William M. Palmer, Antony P. Martin, Jamie R. Flynn et al.     Here we report the adaptation of the CLARITY technique to plant tissues with addition of enzymatic degradation to improve optical clearing and facilitate antibody probe …             MircoRNA-33a inhibits epithelial-to-mesenchymal transition and metastasis and could be a prognostic marker in non-small cell lung cancer ▶     Lihua Yang, Jie Yang, Jingqiu Li et al.     Understanding the molecular mechanism by which epithelial mesenchymal transition (EMT)-mediated cancer metastasis and how microRNA (miRNA) regulates lung cancer progression via …             Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease ▶     Jiexia Ding, Meng Li, Xingyong Wan et al.     MicroRNA-34a (miR-34a) is thought to be involved in nonalcoholic fatty liver disease (NAFLD). However, the association between altered expression of miR-34a and the …             High expression of SOX30 is associated with favorable survival in human lung adenocarcinoma ▶     Fei Han, Wenbin Liu, Hualiang Xiao et al.     In our previous study, we had identified SOX30 as a novel tumor suppressor that acts through direct regulation of p53 transcription in human lung cancer. Here, we sought to …             Micro-concentration Lipopolysaccharide as a Novel Stimulator of Megakaryocytopoiesis that Synergizes with IL-6 for Platelet Production ▶     Di Wu, Jun Xie, Xuejun Wang et al.     Lipopolysaccharide (LPS) induces platelet activation and enhances platelet sensitivity to aggregation, which might alter platelet counts. We found that serial doses of …             BA-j as a novel CDK1 inhibitor selectively induces apoptosis in cancer cells by regulating ROS ▶     Shixuan Zhang, Yongming Bao, Xiulan Ju et al.     Cyclin-dependent kinase 1 (CDK1) is the only necessary CDK in cell proliferation and a novel target in the development of anticancer drugs. 8-Hydroxypiperidinemethyl-baicalein …             Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory Mechanisms ▶     Yuan Xu, Xian Liu, Yulan Wang et al.     A combinatorial pharmacophore (CP) model for Multidrug and toxin extrusion 1 (MATE1/SLC47A1) inhibitors was developed based on a data set including 881 compounds. The CP model …             The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop ▶     Rosina Noto, Loredana Randazzo, Samuele Raccosta et al.     Neuroserpin (NS) is an inhibitory protein belonging to the serpin family and involved in several pathologies, including the dementia Familial Encephalopathy with Neuroserpin …             Multiplexed In-cell Immunoassay for Same-sample Protein Expression Profiling ▶     Jing Shang, Pavel Zrazhevskiy, Nadia Postupna et al.     In-cell immunoassays have become a valuable tool for protein expression analysis complementary to established assay formats. However, comprehensive molecular characterization of …             Chondrocytes-Specific Expression of Osteoprotegerin Modulates Osteoclast Formation in Metaphyseal Bone ▶     Baoli Wang, Hongting Jin, Bing Shu et al.     Bone marrow stromal cells/osteoblasts were originally thought to be the major player in regulating osteoclast differentiation through expressing RANKL/OPG cytokines. Recent …             Erratum: A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients ▶     Aniruddha Chatterjee, Anna L. Leichter, Vicky Fan et al.                 Formation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activity ▶     Wen Zhang, Min Chen, Yan Ling Wu et al.     G-quadruplexes formed in telomeric DNA sequences at human chromosome ends can be a novel target for the development of therapeutics for the treatment of cancer patients. Herein, …             Evidence for the expression of abundant microRNAs in the locust genome ▶     Yanli Wang, Feng Jiang, Huimin Wang et al.     Substantial accumulation of neutral sequences accounts for genome size expansion in animal genomes. Numerous novel microRNAs (miRNAs), which evolve in a birth and death manner, …             Role of local and distant functional connectivity density in the development of minimal hepatic encephalopathy ▶     Rongfeng Qi, Long Jiang Zhang, Hui Juan Chen et al.     The progression of functional connectivity (FC) patterns from non-hepatic encephalopathy (non-HE) to minimal HE (MHE) is not well known. This resting-state functional magnetic …             LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia ▶     Yaping Wang, Peng Wu, Rufeng Lin et al.     Long non-coding RNA (lncRNA) was referred to be participating in various malignant tumors. Location based analysis of the mechanism in lncRNA and genes have been highly focused. …             Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy ▶     Lauren Scarfe, Aleksandra Rak-Raszewska, Stefania Geraci et al.     Maximising the use of preclinical murine models of progressive kidney disease as test beds for therapies ideally requires kidney function to be measured repeatedly in a safe, …             SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathway ▶     Kunkun Han, Xin Xu, Zhuan Xu et al.     The mammalian target of rapamycin (mTOR) is extensively involved in multiple myeloma (MM) pathophysiology. In the present study, we reported a novel small molecule SC06 that …             Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma ▶     J. Zhang, J. Y. Huang, Y. N. Chen et al.     Gastric cancer is one of the most aggressive cancers and is the second leading cause of cancer death worldwide. Approximately 40% of global gastric cancer cases occur in China, …             Rapid, high efficiency isolation of pancreatic ß-cells ▶     Susan M. Clardy, James F. Mohan, Claudio Vinegoni et al.     The ability to isolate pure pancreatic ß-cells would greatly aid multiple areas of diabetes research. We developed a fluorescent exendin-4-like neopeptide conjugate for the rapid …             Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway ▶     Shulan Su, Jinao Duan, Ting Chen et al.     Frankincense and myrrh are highly effective in treatment of inflammatary diseases, but lacking of the therapy mechanisms. We undertook this stuty to evaluate the effects on …             Myeloid-related protein 8 induces self-tolerance and cross-tolerance to bacterial infection via TLR4- and TLR2-mediated signal pathways ▶     Andrew P. Coveney, Wei Wang, Justin Kelly et al.     Myeloid-related protein 8 (Mrp8) is the active component of Mrp8/14 protein complex released by phagocytes at the site of infection and stimulates inflammatory responses. …             Silica bioreplication preserves three-dimensional spheroid structures of human pluripotent stem cells and HepG2 cells ▶     Yan-Ru Lou, Liisa Kanninen, Bryan Kaehr et al.     Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, …             IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway ▶     Kentaro Sumida, Yosuke Ohno, Junya Ohtake et al.     Myeloid-derived suppressor cells (MDSCs) are immune negative regulators in the tumour microenvironment. Interleukin (IL)-11, a member of IL-6 family cytokines, functions through …             Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides ▶     Ana Maranha, Patrick J. Moynihan, Vanessa Miranda et al.     Mycobacteria synthesize unique intracellular methylglucose lipopolysaccharides (MGLP) proposed to modulate fatty acid metabolism. In addition to the partial esterification of …             Molecular insights into Zeaxanthin-dependent quenching in higher plants ▶     Pengqi Xu, Lijin Tian, Miroslav Kloz et al.     Photosynthetic organisms protect themselves from high-light stress by dissipating excess absorbed energy as heat in a process called non-photochemical quenching (NPQ). Zeaxanthin …             Glucanocellulosic ethanol: the undiscovered biofuel potential in energy crops and marine biomass ▶     Christian Falter, Claudia Zwikowics, Dennis Eggert et al.     Converting biomass to biofuels is a key strategy in substituting fossil fuels to mitigate climate change. Conventional strategies to convert lignocellulosic biomass to ethanol …             The Synergetic Coupling among the Cellular Antioxidants Glutathione Peroxidase/Peroxiredoxin and Other Antioxidants and its Effect on the Concentration of H2O2 ▶     Hamid Molavian, Ali Madani Tonekaboni, Mohammad Kohandel et al.     Glutathione peroxidase (GPx), peroxiredoxin (Prx), and catalase are the major antioxidants at the cellular level and protect cell compartments against hydrogen peroxide (H2O2). …             Mass spectrometry imaging reveals new biological roles for choline esters and Tyrian purple precursors in muricid molluscs ▶     David Rudd, Maurizio Ronci, Martin R. Johnston et al.     Despite significant advances in chemical ecology, the biodistribution, temporal changes and ecological function of most marine secondary metabolites remain unknown. One such …             Enhancing flavonoid production by systematically tuning the central metabolic pathways based on a CRISPR interference system in Escherichia coli ▶     Junjun Wu, Guocheng Du, Jian Chen et al.     The limited supply of intracellular malonyl-CoA in Escherichia coli impedes the biological synthesis of polyketides, flavonoids and biofuels. Here, a clustered regularly …             PI4K-beta and MKNK1 are regulators of hepatitis C virus IRES-dependent translation ▶     Joachim Lupberger, Claudia Casanova, Benoit Fischer et al.     Cellular translation is down-regulated by host antiviral responses. Picornaviridae and Flaviviridae including hepatitis C virus (HCV) evade this process using internal ribosomal …             Inhibitory effects of magnolol and honokiol on human calcitonin aggregation ▶     Caiao Guo, Liang Ma, Yudan Zhao et al.     Amyloid formation is associated with multiple amyloidosis diseases. Human calcitonin (hCT) is a typical amyloidogenic peptide, its aggregation is associated with medullary …             Whole Genome Phylogeny of Bacillus by Feature Frequency Profiles (FFP) ▶     Aisuo Wang, Gavin J. Ash     Fifty complete Bacillus genome sequences and associated plasmids were compared using the “feature frequency profile” (FFP) method. The resulting whole-genome phylogeny supports …             Physicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells ▶     B. Santos-Carballal, L. J. Aaldering, M. Ritzefeld et al.     Cancer gene therapy requires the design of non-viral vectors that carry genetic material and selectively deliver it with minimal toxicity. Non-viral vectors based on cationic …             Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors ▶     Geoffrey Masuyer, Jonathan R. Davies, Kevin Moore et al.     The botulinum neurotoxin type D is one of seven highly potent toxins produced by Clostridium botulinum which inhibit neurotransmission at cholinergic nerve terminals. A …             Can you see what I am talking about? Human speech triggers referential expectation in four-month-old infants ▶     Hanna Marno, Teresa Farroni, Yamil Vidal Dos Santos et al.     Infants’ sensitivity to selectively attend to human speech and to process it in a unique way has been widely reported in the past. However, in order to successfully acquire …             Long-Term Exposure to High Altitude Affects Response Inhibition in the Conflict-monitoring Stage ▶     Hailin Ma, Yan Wang, Jianhui Wu et al.     To investigate the effects of high-altitude exposure on response inhibition, event-related potential (ERP) components N2 and P3 were measured in Go/NoGo task. The participants …             Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice ▶     Le Yang, Zhen Han, Lei Tian et al.     Sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) system has been implicated in the pathological process of liver injury. This study was designed to evaluate the effects of …             Super-resolution mapping of glutamate receptors in C. elegans by confocal correlated PALM ▶     Jeroen Vangindertael, Isabel Beets, Susana Rocha et al.     Photoactivated localization microscopy (PALM) is a super-resolution imaging technique based on the detection and subsequent localization of single fluorescent molecules. PALM is …             Segmented molecular design of self-healing proteinaceous materials ▶     Veikko Sariola, Abdon Pena-Francesch, Huihun Jung et al.     Hierarchical assembly of self-healing adhesive proteins creates strong and robust structural and interfacial materials, but understanding of the molecular design and …             One-Step Synthesis of Chiral Oxindole-type Analogues with Potent Anti-inflammatory and Analgesic Activities ▶     Yulong Sun, Jia Liu, Xianxing Jiang et al.     Here we report a facile approach to synthesize highly optically active oxindole-type analogues with both high yield and enantioselectivity. This single-step synthesis strategy …             Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization ▶     Meixiang Yang, Yanguo Liu, Guangwen Ren et al.     A low partial oxygen pressure (hypoxia) occurs in many pathological environments, such as solid tumors and inflammatory lesions. Understanding the cellular response to hypoxic …             Infrared video tracking of Anopheles gambiae at insecticide-treated bed nets reveals rapid decisive impact after brief localised net contact ▶     Josephine E.A. Parker, Natalia Angarita-Jaimes, Mayumi Abe et al.     Long-lasting insecticidal bed nets (LLINs) protect humans from malaria transmission and are fundamental to malaria control worldwide, but little is known of how mosquitoes …             Selective in vivo and in vitro activities of 3,3′-4-nitrobenzylidene-bis-4-hydroxycoumarin against methicillin-resistant Staphylococcus aureus by inhibition of DNA polymerase III ▶     Zheng Hou, Ying Zhou, Jing Li et al.     As the persistent resistance of Staphylococcus aureus to available antibiotics is associated with high infection incidence, mortality rate and treatment cost, novel antibacterial …             The diversity and abundance of As(III) oxidizers on root iron plaque is critical for arsenic bioavailability to rice ▶     Min Hu, Fangbai Li, Chuanping Liu et al.     Iron plaque is a strong adsorbent on rice roots, acting as a barrier to prevent metal uptake by rice. However, the role of root iron plaque microbes in governing metal redox …             PrP charge structure encodes interdomain interactions ▶     Javier Martínez, Rosa Sánchez, Milagros Castellanos et al.     Almost all proteins contain charged residues, and their chain distribution is tailored to fulfill essential ionic interactions for folding, binding and catalysis. Among proteins, …             A new formulation of Gamma Delta Tocotrienol has superior bioavailability compared to existing Tocotrienol-Rich Fraction in healthy human subjects ▶     Puvaneswari Meganathan, Rafid Salim Jabir, Ho Gwo Fuang et al.     Gamma and delta tocotrienols are isomers of Vitamin E with established potency in pre-clinical anti-cancer research. This single-dose, randomized, crossover study aimed to …             Thermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model ▶     Qinjie Wu, Ning Wang, Tao He et al.     Tissue adhesion is a common complication after surgery. In this work, a dexamethasone loaded polymeric micelles in thermosensitive hydrogel composite (Dex hydrogel) was prepared, …             Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice ▶     Jiali Liu, Fang Zhou, Qianying Chen et al.     Patients with inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, often suffer drug intolerance. This resistance can be divided into intrinsic …             The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis ▶     Thomas Lanzicher, Valentina Martinelli, Luca Puzzi et al.     Atomic force microscopy (AFM) cell loading/unloading curves were used to provide comprehensive insights into biomechanical behavior of cardiomyocytes carrying the lamin A/C …                     • Careers & Jobs           naturejobs.com Science jobs of the week       Faculty Position     Vanderbilt University            Postdoctoral Scientist positions     John Innes Centre (JIC)            Research Associate (non-tenure track)     Indiana University            Clinical Research Fellow     Plymouth University            Postdoctoral Scientist     Medical Research Council            Research Scientist     The Center For Human Reproduction            3 Granted Postdoc Positions in Cancer Research     Université catholique de Louvain (UCL)            Faculty Position in the Life Sciences     Stowers Institute for Medical Research            Postdoctoral Research Scientist     Cancer Research UK Beatson Institute in Glasgow            PhD Fellowships in Life Sciences     University of Lausanne (UNIL)          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. Keep up-to-date with the latest sector trends, vote in our reader poll and sign-up to receive the monthly Naturejobs newsletter.           • Scientific Reports events Directory featured events           natureevents directory featured events         Cell Biology of Yeasts     3rd November 2015 Cold Spring Harbor, USA         Natureevents Directory is the premier resource for scientists looking for the latest scientific conferences, courses, meetings and symposia. Featured across Nature Publishing Group journals and centrally at natureevents.com it is an essential reference guide to scientific events worldwide.                 Your email address is in the Scientific Reports: Biology mailing list. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For other enquiries, please contact our customer feedback department Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's offices: Principal offices: London - New York - Tokyo Worldwide offices: Basingstoke - Boston - Buenos Aires - Delhi - Hong Kong - Madrid - Melbourne - Munich - Paris - San Francisco - Seoul - Washington DC Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.