Nature Communications - 9 September 2015

Advertisement Accelerating Neuroscience Research A major challenge in neuroscience research and drug discovery is the lack of easy access to relevant animal models for use in screening drug candidates. The Advanced Neuroscience Mouse Model Portfolio provides simplified access to models and services for the study of neuronal disease and signaling. Learn about extensive phenotyping data, and aging services to help accelerate research outcomes. Learn More     Weekly Content Alert Nature Communications is now fully open access. Read more. 09 September 2015  Featured image: Yang et al. report the fabrication of laser-scribed dendritic silver for use in ultrathin flexible electronics. Latest content: Articles Errata Journal homepage Recommend to library Web feed   Advertisement An open access journal dedicated to highlighting the most important scientific advances in Parkinson's disease research, spanning the motor and non-motor disorders of Parkinson's disease. 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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Returners and explorers dichotomy in human mobility OPEN Luca Pappalardo, Filippo Simini, Salvatore Rinzivillo, Dino Pedreschi, Fosca Giannotti and Albert-László Barabási Human mobility studies established that a high degree of predictability coexists with the variability of individual mobility. Here, the authors, by looking at mobile phone and GPS data, identify and model the emergence of two classes of mobility patterns in humans, returners and explorers. 08 September 2015 | doi: 10.1038/ncomms9166 Physical Sciences  Theoretical physics  In vivo capture and label-free detection of early metastatic cells Samira M. Azarin, Ji Yi, Robert M. Gower, Brian A. Aguado, Megan E. Sullivan, Ashley G. Goodman, Eric J. Jiang, Shreyas S. Rao, Yinying Ren, Susan L. Tucker, Vadim Backman, Jacqueline S. Jeruss and Lonnie D Shea Tumour metastasis is a significant source of mortality, often because it is detected at an advanced stage. In this study, in an effort to identify metastasis at an early stage, Azarin et. al. capture and image metastasizing cells in mice in vivo using a biomaterial scaffold. 08 September 2015 | doi: 10.1038/ncomms9094 Biological Sciences  Cancer  Medical research  Dynamic kirigami structures for integrated solar tracking OPEN Aaron Lamoureux, Kyusang Lee, Matthew Shlian, Stephen R. Forrest and Max Shtein Tilting planar photovoltaic panels to track the position of the sun over the day can add to yearly energy consumption. Here, Lamoureaux et al. propose a kirigami solar cell structure with solar tracking integrated within the design, reducing cost, structural weight and bulk associated with conventional tracking. 08 September 2015 | doi: 10.1038/ncomms9092 Physical Sciences  Applied physics  Materials science  Optical physics  Multilevel animal societies can emerge from cultural transmission OPEN Maurício Cantor, Lauren G. Shoemaker, Reniel B. Cabral, César O. Flores, Melinda Varga and Hal Whitehead Multilevel societies are comprised of hierarchically nested levels of social organization, but how they arise is not well understood. Here Cantor et al. find that the emergence of sperm whale clans is more likely to be driven by cultural transmission of acoustic repertoires than via stochastic processes. 08 September 2015 | doi: 10.1038/ncomms9091 Biological Sciences  Ecology  Zoology  Involvement of a eukaryotic-like ubiquitin-related modifier in the proteasome pathway of the archaeon Sulfolobus acidocaldarius OPEN Rana S. Anjum, Sian M. Bray, John K. Blackwood, Mairi L. Kilkenny, Matthew A. Coelho, Benjamin M. Foster, Shurong Li, Julie A. Howard, Luca Pellegrini, Sonja-Verena Albers, Michael J. Deery and Nicholas P. Robinson Small archaeal ubiquitin-like modifiers (SAMPs) have been hypothesized to be part of an ancestral version of the ubiquitin-proteasome system. Here, Anjum et al. identify a SAMP homologous to the eukaryotic ubiquitin-related modifier-1 and show that it is processed by the 20S core proteasome in S. acidocaldarius. 08 September 2015 | doi: 10.1038/ncomms9163 Biological Sciences  Biochemistry  Biophysics  Molecular biology  Borromean three-body FRET in frozen Rydberg gases OPEN R. Faoro, B. Pelle, A. Zuliani, P. Cheinet, E. Arimondo and P. Pillet Rydberg atoms are promising platform for quantum simulations, due to their strong and controllable dipole–dipole interactions. Here, the authors predict few-body processes in Rydberg atoms which resemble fluorescence resonance energy transfer in biological setting, and observe them in cold caesium atoms. 08 September 2015 | doi: 10.1038/ncomms9173 Physical Sciences  Atomic and molecular physics  Global priorities for an effective information basis of biodiversity distributions OPEN Carsten Meyer, Holger Kreft, Robert Guralnick and Walter Jetz Comprehensive digital information on species distributions is crucial for research in ecology, evolution and conservation. Here, Meyer et al. find large gaps and biases in global vertebrate point records, especially in emerging economies, and identify key factors currently limiting information. 08 September 2015 | doi: 10.1038/ncomms9221 Biological Sciences  Ecology  Accessing topological superconductivity via a combined STM and renormalization group analysis Lars Elster, Christian Platt, Ronny Thomale, Werner Hanke and Ewelina M. Hankiewicz A topological superconductor is an exotic state of matter that is gapped in the bulk but possesses gapless surface states, but its identification has been so far elusive. Here, the authors develop a theory for scanning tunnelling microscopy which would allow to resolve topological superconductor states. 08 September 2015 | doi: 10.1038/ncomms9232 Physical Sciences  Condensed matter  Theoretical physics  Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR OPEN Fan Yang, Xiao Yu, Chuan Liu, Chang-Xiu Qu, Zheng Gong, Hong-Da Liu, Fa-Hui Li, Hong-Mei Wang, Dong-Fang He, Fan Yi, Chen Song, Chang-Lin Tian, Kun-Hong Xiao, Jiang-Yun Wang and Jin-Peng Sun G-protein-coupled receptors (GPCRs) signal via G proteins or arrestin-mediated pathways; the plasticity of arrestin proteins is thought to underlie their function. Here, the authors use NMR to examine how β-arrestin-1 recognizes different GPCR phospho-barcodes, and how this triggers structural rearrangements to fulfill selective functions. 08 September 2015 | doi: 10.1038/ncomms9202 Biological Sciences  Biochemistry  Integrin-linked kinase regulates the niche of quiescent epidermal stem cells OPEN Jessica Morgner, Sushmita Ghatak, Tobias Jakobi, Christoph Dieterich, Monique Aumailley and Sara A. Wickström Integrin-linked kinase (ILK) is known to modulate the extracellular matrix and hair follicle morphogenesis. Here, Morgner et al. show that lack of ILK causes an aberrant ratio of basement membrane laminins, activating stem cells and predisposing skin to carcinogenesis. 08 September 2015 | doi: 10.1038/ncomms9198 Biological Sciences  Cell biology  Developmental biology  Anomalous quantum criticality in an itinerant ferromagnet C. L. Huang, D. Fuchs, M. Wissinger, R. Schneider, M. C. Ling, M. S. Scheurer, J. Schmalian and H. v. Löhneysen A system’s properties near a quantum phase transition scale differently than near a finite-temperature phase transition. Here, the authors identify an anomalously small dynamic scaling exponent from magnetization and specific heat measurements in the itinerant ferromagnet SrCaRuO which is at odds with current theory. 08 September 2015 | doi: 10.1038/ncomms9188 Physical Sciences  Applied physics  Condensed matter  From coherent shocklets to giant collective incoherent shock waves in nonlocal turbulent flows OPEN G. Xu, D. Vocke, D. Faccio, J. Garnier, T. Roger, S. Trillo and A. Picozzi Understanding turbulent flows arising from random dispersive waves that interact through nonlinearities is a challenging issue in physics. Here, the authors model and observe experimentally in a nonlinear optics set-up the transition between a sea of small-scale shocklets and a giant collective shock wave. 08 September 2015 | doi: 10.1038/ncomms9131 Physical Sciences  Fluids and plasma physics  Optical physics  Ultraviolet luminosity density of the universe during the epoch of reionization OPEN Ketron Mitchell-Wynne, Asantha Cooray, Yan Gong, Matthew Ashby, Timothy Dolch, Henry Ferguson, Steven Finkelstein, Norman Grogin, Dale Kocevski, Anton Koekemoer, Joel Primack and Joseph Smidt The luminosity of ultraviolet light emitted by the first galaxies in the universe traces the formation and evolution of stars and galaxies which led to the epoch of reionization. Here the authors use data from the Hubble Space Telescope and through a model provide a bound for the total luminosity. 08 September 2015 | doi: 10.1038/ncomms8945 Physical Sciences  Astronomy  Theoretical physics  Defining the relationship between infection prevalence and clinical incidence of Plasmodium falciparum malaria OPEN Ewan Cameron, Katherine E. Battle, Samir Bhatt, Daniel J. Weiss, Donal Bisanzio, Bonnie Mappin, Ursula Dalrymple, Simon I. Hay, David L. Smith, Jamie T. Griffin, Edward A. Wenger, Philip A. Eckhoff, Thomas A. Smith, Melissa A. Penny and Peter W. Gething Mathematical models are used to predict malaria burden to inform disease control efforts. Here, Cameron et al. use Bayesian statistics to calibrate previous models against a data set of age-structured prevalence and incidence, generating stratified forecasts of the prevalence–incidence relationship. 08 September 2015 | doi: 10.1038/ncomms9170 Biological Sciences  Bioinformatics  Medical research  Microbiology  Two spatiotemporally distinct value systems shape reward-based learning in the human brain OPEN Elsa Fouragnan, Chris Retzler, Karen Mullinger and Marios G. Philiastides Learning to reinforce rewarding decisions and avoiding repeated mistakes is critical, yet the neural systems mediating feedback processing in value-guided choices remain elusive. Here the authors uncover the spatiotemporal dynamics of two separate but interacting value systems during learning. 08 September 2015 | doi: 10.1038/ncomms9107 Biological Sciences  Neuroscience  IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation OPEN Pengyan Xia, Shuo Wang, Zhen Xiong, Buqing Ye, Li-Yu Huang, Ze-Guang Han and Zusen Fan RIG-I-MAVS signalling pathway is involved in mediating antiviral response to RNA viruses. Here the authors report that insulin receptor tyrosine kinase substrate (IRTKS) mediates MAVS degradation and thus acts as a negative regulator of the innate antiviral response. 08 September 2015 | doi: 10.1038/ncomms9132 Biological Sciences  Immunology  Virology  Transform-limited single photons from a single quantum dot OPEN Andreas V. Kuhlmann, Jonathan H. Prechtel, Julien Houel, Arne Ludwig, Dirk Reuter, Andreas D. Wieck and Richard J. Warburton Photons emitted from a quantum dot typically have slightly different frequencies owing to various sources of noise. Here, the authors suppress the noise, notably the noise arising from the nuclear spins, and demonstrate single-photon emission with a transform-limited optical linewidth. 08 September 2015 | doi: 10.1038/ncomms9204 Physical Sciences  Materials science  Nanotechnology  Optical physics  Critical heat flux maxima during boiling crisis on textured surfaces OPEN Navdeep Singh Dhillon, Jacopo Buongiorno and Kripa K. Varanasi Cooling hot surfaces by boiling water is widely practiced, but the amount of heat transfer is normally constrained by vapour layer formation at sufficiently high temperatures. Here, the authors report the maximum in the critical heat flux on textured hydrophilic surfaces at an intermediate texture density. 08 September 2015 | doi: 10.1038/ncomms9247 Physical Sciences  Applied physics  Fluids and plasma physics  Quadruple-junction lattice coherency and phase separation in a binary-phase system OPEN Sung-Yoon Chung, Si-Young Choi, Jin-Gyu Kim and Young-Min Kim The overall physical properties of binary-phase systems ranging from metallic alloys to soft polymers are affected by phase-separation morphologies. Here, Chung et al. use atomic-resolution electron microscopy to demonstrate the influence of quadruple junctions on the morphology evolution during phase separation. 08 September 2015 | doi: 10.1038/ncomms9252 Physical Sciences  Materials science  Ambipolar solution-processed hybrid perovskite phototransistors OPEN Feng Li, Chun Ma, Hong Wang, Weijin Hu, Weili Yu, Arif D. Sheikh and Tom Wu Organolead halide perovskites exhibit good optoelectronic properties. Here, the authors fabricated and characterized ambipolar phototransistors based on solution-processed organolead triiodide and mixed-halide perovskites exhibiting high electron and hole mobilities and high photoresponsivities. 08 September 2015 | doi: 10.1038/ncomms9238 Physical Sciences  Applied physics  Materials science  Modular pathway rewiring of Saccharomyces cerevisiae enables high-level production of L-ornithine OPEN Jiufu Qin, Yongjin J. Zhou, Anastasia Krivoruchko, Mingtao Huang, Lifang Liu, Sakda Khoomrung, Verena Siewers, Bo Jiang and Jens Nielsen The complexity of yeast amino acid metabolism has limited carbon channelling to produce valuable chemical metabolites. Here, the authors implement a yeast customized pathway optimization strategy and demonstrate its use for overproduction of L-ornithine, an intermediate of L-arginine biosynthesis. 08 September 2015 | doi: 10.1038/ncomms9224 Biological Sciences  Biotechnology  Microbiology  Sparsity-based super-resolved coherent diffraction imaging of one-dimensional objects OPEN Pavel Sidorenko, Ofer Kfir, Yoav Shechtman, Avner Fleischer, Yonina C. Eldar, Mordechai Segev and Oren Cohen In measurements that employ phase retrieval algorithms, such as coherent diffraction imaging, reconstruction of one-dimensional signals is challenging due to ambiguity issues. Here, the authors demonstrate super-resolution coherent imaging of one-dimensional objects by utilizing sparsity prior information. 08 September 2015 | doi: 10.1038/ncomms9209 Physical Sciences  Optical physics  Carrier multiplication detected through transient photocurrent in device-grade films of lead selenide quantum dots OPEN Jianbo Gao, Andrew F. Fidler and Victor I. Klimov In semiconductors, the absorption of a high energy photon can result in the formation of several charge pairs. Here the authors perform ultrafast photocurrent measurements on thin films to explore how quantum dot couplings and the electric field influence multiexciton photovoltaic devices. 08 September 2015 | doi: 10.1038/ncomms9185 Physical Sciences  Materials science  Nanotechnology  Optical physics  Combined operando X-ray diffraction–electrochemical impedance spectroscopy detecting solid solution reactions of LiFePO4 in batteries OPEN Michael Hess, Tsuyoshi Sasaki, Claire Villevieille and Petr Novák A clear understanding of the phase behaviour of lithium-ion electrode materials is essential for the development of the field. Here, the authors report a combined X-ray diffraction–electrochemical impedance spectroscopy method to detect solid solution reactions of LiFePO4. 08 September 2015 | doi: 10.1038/ncomms9169 Chemical Sciences  Materials science  Physical chemistry  A quantitative description of Ndc80 complex linkage to human kinetochores OPEN Aussie Suzuki, Benjamin L. Badger and Edward D. Salmon The Ndc80 complex acts as an interface between kinetochores and spindle microtubules, and is recruited to the kinetochore by several different proteins. Suzuki et al. use protein counting techniques and RNA interference to quantify the interaction stoichiometries within this intricate cellular structure. 08 September 2015 | doi: 10.1038/ncomms9161 Biological Sciences  Cell biology  Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp OPEN Shiqiang Gao, Jatin Nagpal, Martin W. Schneider, Vera Kozjak-Pavlovic, Georg Nagel and Alexander Gottschalk Cyclic guanosine monophosphate (cGMP) is a cellular second messenger involved in many processes including regulation of neuronal excitability and vascular tone. Gao, Nagpal et al., employ a fungal rhodopsin to optogenetically control cGMP levels in multiple systems including C. elegans sensory neurons. 08 September 2015 | doi: 10.1038/ncomms9046 Biological Sciences  Cell biology  Neuroscience  Shot noise generated by graphene p–n junctions in the quantum Hall effect regime OPEN N. Kumada, F. D. Parmentier, H. Hibino, D. C. Glattli and P. Roulleau Dirac fermions at a p–n junction can exhibit a wide variety of unusual properties. Here, the authors investigate the dynamics of such fermions in a graphene junction using shot noise measurements and demonstrate the crucial role of junction length. 04 September 2015 | doi: 10.1038/ncomms9068 Physical Sciences  Applied physics  Condensed matter  Ultrafast visualization of crystallization and grain growth in shock-compressed SiO2 OPEN A. E. Gleason, C. A. Bolme, H. J. Lee, B. Nagler, E. Galtier, D. Milathianaki, J. Hawreliak, R. G. Kraus, J. H. Eggert, D. E. Fratanduono, G. W. Collins, R. Sandberg, W. Yang and W. L. Mao Pressure- and temperature-induced phase transitions have long been studied, but little is known about the processes by which the atoms rearrange. Here, the authors present in situ measurements on shock compressed fused silica, revealing an amorphous to crystalline high pressure stishovite phase transition. 04 September 2015 | doi: 10.1038/ncomms9191 Physical Sciences  Condensed matter  Geology and geophysics  Materials science  Nitrogen-embedded buckybowl and its assembly with C60 OPEN Hiroki Yokoi, Yuya Hiraoka, Satoru Hiroto, Daisuke Sakamaki, Shu Seki and Hiroshi Shinokubo Curved π-conjugated molecules have potentially interesting chemical and electronic properties but the harsh conditions required for their synthesis can make it difficult to incorporate heteroatoms. Here, the authors prepare a π-extended azacorannulene with nitrogen in its centre. 04 September 2015 | doi: 10.1038/ncomms9215 Chemical Sciences  Organic chemistry  Origin and dynamics of vortex rings in drop splashing OPEN Ji San Lee, Su Ji Park, Jun Ho Lee, Byung Mook Weon, Kamel Fezzaa and Jung Ho Je Drop impact on a liquid surface leads to the formation of vortex rings, but this process is still poorly understood due to the lack of effective experimental characterization. Here, Lee et al. visualize the process using ultrafast X-ray phase-contrast imaging and follow the dynamics of vortex rings. 04 September 2015 | doi: 10.1038/ncomms9187 Physical Sciences  Condensed matter  Fluids and plasma physics  Nanoscale imaging of buried topological defects with quantitative X-ray magnetic microscopy OPEN C. Blanco-Roldán, C. Quirós, A. Sorrentino, A. Hierro-Rodríguez, L. M. Álvarez-Prado, R. Valcárcel, M. Duch, N. Torras, J. Esteve, J. I. Martín, M. Vélez, J. M. Alameda, E. Pereiro and S. Ferrer Transmission X-ray microscopy allows for the imaging of magnetic domains in thin film materials. Here, the authors exploit the angular dependence of the magnetic contrast to extract out-of-plane canting angles of stripe domains and topological defects in NdCo5 films buried under a NiFe layer. 04 September 2015 | doi: 10.1038/ncomms9196 Physical Sciences  Applied physics  Condensed matter  Spinal corollary discharge modulates motion sensing during vertebrate locomotion OPEN Boris P. Chagnaud, Roberto Banchi, John Simmers and Hans Straka Corollary discharges inform the central nervous system about impending motor activity. Here, Chagnaud et al. show that, in Xenopus tadpoles, shared efferent neural pathways to the inner ear and lateral line adjust the sensitivity of sensory afferents during locomotor activity. 04 September 2015 | doi: 10.1038/ncomms8982 Biological Sciences  Neuroscience  Zoology  Non-covalent synthesis of supermicelles with complex architectures using spatially confined hydrogen-bonding interactions OPEN Xiaoyu Li, Yang Gao, Charlotte E. Boott, Mitchell A. Winnik and Ian Manners Ubiquitous in nature, hierarchical architectures are less commonly achieved in synthetic functional materials. Here, the authors design and carefully assemble block copolymer micelles into complex supermicelles using hydrogen bonding in orthogonal combination with other non-covalent interactions. 04 September 2015 | doi: 10.1038/ncomms9127 Chemical Sciences  Materials science  Organic chemistry  Edge mixing dynamics in graphene p–n junctions in the quantum Hall regime OPEN Sadashige Matsuo, Shunpei Takeshita, Takahiro Tanaka, Shu Nakaharai, Kazuhito Tsukagoshi, Takahiro Moriyama, Teruo Ono and Kensuke Kobayashi A graphene p–n junction can be created by connecting electrical gates that generate electron-doped and hole-doped areas in a flake. Here, the authors use shot-noise measurements to provide microscopic evidence that edge states are uniquely mixed along the junction in the quantum Hall regime. 04 September 2015 | doi: 10.1038/ncomms9066 Physical Sciences  Applied physics  Condensed matter  Imaging of alignment and structural changes of carbon disulfide molecules using ultrafast electron diffraction Jie Yang, Joshua Beck, Cornelis J. Uiterwaal and Martin Centurion Imaging the structure of molecules in transient excited states remains a challenge due to the extreme requirements for spatial and temporal resolution. Here, the authors probe the dynamics in CS2 using ultrafast electron diffraction and femtosecond laser mass spectrometery. 04 September 2015 | doi: 10.1038/ncomms9172 Physical Sciences  Atomic and molecular physics  Optical physics  Piezoresistivity in single DNA molecules OPEN Christopher Bruot, Julio L. Palma, Limin Xiang, Vladimiro Mujica, Mark A. Ratner and Nongjian Tao Piezoresistivity finds many applications in micro-electromechanical systems, but a piezoresistive material at a molecular level has not yet been demonstrated. Here, Bruot et al. show this effect in double helix DNA molecules due to the electronic coupling between neighbouring bases upon mechanical force. 04 September 2015 | doi: 10.1038/ncomms9032 Physical Sciences  Biophysics  Materials science  Nanotechnology  Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures OPEN Tommy Stödberg, Amy McTague, Arnaud J. Ruiz, Hiromi Hirata, Juan Zhen, Philip Long, Irene Farabella, Esther Meyer, Atsuo Kawahara, Grace Vassallo, Stavros M. Stivaros, Magnus K. Bjursell, Henrik Stranneheim, Stephanie Tigerschiöld, Bengt Persson, Iftikhar Bangash, Krishna Das, Deborah Hughes, Nicole Lesko, Joakim Lundeberg et al. The potassium-chloride co-transporter, KCC2 is an essential component in maintaining a gradient for chloride ions in neurons. Here Stodberg and colleagues identify loss-of-function mutations in the encoding gene SLC12A5, which impair normal synaptic function associated with early-onset epilepsy. 03 September 2015 | doi: 10.1038/ncomms9038 Biological Sciences  Genetics  Molecular biology  Neuroscience  Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis OPEN Elisavet Fotiou, Silvia Martin-Almedina, Michael A. Simpson, Shin Lin, Kristiana Gordon, Glen Brice, Giles Atton, Iona Jeffery, David C. Rees, Cyril Mignot, Julie Vogt, Tessa Homfray, Michael P. Snyder, Stanley G. Rockson, Steve Jeffery, Peter S. Mortimer, Sahar Mansour and Pia Ostergaard Primary lymphoedema can lead to the swelling of the extremities and facial dysmorphism. Here the authors present evidence that compound heterozygous and homozygous mutations in PIEZO1 result in an autosomal recessive form of generalised lymphatic dysplasia. 03 September 2015 | doi: 10.1038/ncomms9085 Biological Sciences  Genetics  Immunology  Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds OPEN Vanessa Delfosse, Béatrice Dendele, Tiphaine Huet, Marina Grimaldi, Abdelhay Boulahtouf, Sabine Gerbal-Chaloin, Bertrand Beucher, Dominique Roecklin, Christina Muller, Roger Rahmani, Vincent Cavaillès, Martine Daujat-Chavanieu, Valérie Vivat, Jean-Marc Pascussi, Patrick Balaguer and William Bourguet Endocrine-disrupting chemicals act on nuclear hormone receptors, such as PXR. Here, Delfosse et al. show how two such chemicals interact with each other in the PXR ligand-binding pocket, forming a so-called supramolecular ligand that is a more potent PXR activator than each of the two chemicals alone. 03 September 2015 | doi: 10.1038/ncomms9089 Biological Sciences  Chemical biology  Medical research  Medicinal chemistry  Abscisic acid transporters cooperate to control seed germination OPEN Joohyun Kang, Sojeong Yim, Hyunju Choi, Areum Kim, Keun Pyo Lee, Luis Lopez-Molina, Enrico Martinoia and Youngsook Lee Seed germination is repressed by release of the plant hormone abscisic acid (ABA) to the embryo from the surrounding endosperm tissue. Here Kang et al. characterize four different ABA transporters and propose that they act in concert to control ABA release and regulate germination. 03 September 2015 | doi: 10.1038/ncomms9113 Biological Sciences  Plant sciences  Atomic basis for therapeutic activation of neuronal potassium channels OPEN Robin Y. Kim, Michael C. Yau, Jason D. Galpin, Guiscard Seebohm, Christopher A. Ahern, Stephan A. Pless and Harley T. Kurata The antiepileptic drug retigabine potentiates neuronal KCNQ potassium channels. Here, the authors use a combination of unnatural amino acid mutagenesis and electrophysiology to show that retigabine acts by hydrogen bonding with a tryptophan indole nitrogen in the channel pore. 03 September 2015 | doi: 10.1038/ncomms9116 Biological Sciences  Biophysics  Chemical biology  A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism OPEN Anders Krarup, Daphné Truan, Polina Furmanova-Hollenstein, Lies Bogaert, Pascale Bouchier, Ilona J. M. Bisschop, Myra N. Widjojoatmodjo, Roland Zahn, Hanneke Schuitemaker, Jason S. McLellan and Johannes P. M. Langedijk Respiratory syncytial virus (RSV) is a highly contagious childhood pathogen of the respiratory tract for which no vaccine is currently available. Here the authors present a strategy to stabilize the RSV F protein in a prefusion conformation that can elicit a strong protective immune response in animal models. 03 September 2015 | doi: 10.1038/ncomms9143 Biological Sciences  Biochemistry  Virology  Fractal dendrite-based electrically conductive composites for laser-scribed flexible circuits OPEN Cheng Yang, Xiaoya Cui, Zhexu Zhang, Sum Wai Chiang, Wei Lin, Huan Duan, Jia Li, Feiyu Kang and Ching-Ping Wong Electrically conductive composites are increasingly being studied for their favourable mechanical and electrical properties. Here, the authors employ a new synthetic strategy to attain fractal silver micro-dendrites which can be laser-scribed for implementation in flexible printed microelectronics. 03 September 2015 | doi: 10.1038/ncomms9150 Physical Sciences  Applied physics  Materials science  Nanotechnology  Kinase-independent role for CRAF-driving tumour radioresistance via CHK2 OPEN Sunil J. Advani, Maria Fernanda Camargo, Laetitia Seguin, Ainhoa Mielgo, Sudarshan Anand, Angel M. Hicks, Joseph Aguilera, Aleksandra Franovic, Sara M. Weis and David A. Cheresh Tumors hijack cellular pathways to evade the effects of cancer therapy. Here, Advani et al. show that DNA damage-induced phosphorylation of CRAF Serine 338 triggers DNA repair by recruiting CHK2, highlighting a role for CRAF independent from its canonical function as a kinase. 03 September 2015 | doi: 10.1038/ncomms9154 Biological Sciences  Biochemistry  Cancer  Projected phase-change memory devices OPEN Wabe W. Koelmans, Abu Sebastian, Vara Prasad Jonnalagadda, Daniel Krebs, Laurent Dellmann and Evangelos Eleftheriou Nanoscale resistive memory devices could become critical building blocks in emerging brain-inspired computing paradigms. Here, the authors demonstrate such a device—a projected memory cell—based on a phase-change material that decouples resistance storage from the information-retrieval process. 03 September 2015 | doi: 10.1038/ncomms9181 Physical Sciences  Applied physics  Nanotechnology  Two-photon-like microscopy with orders-of-magnitude lower illumination intensity via two-step fluorescence OPEN Maria Ingaramo, Andrew G. York, Eric J. Andrade, Kristin Rainey and George H. Patterson Two-photon fluorescence gives a quadratic response, which improves imaging in thick samples but requires extremely intense illumination. Here, the authors describe two-step fluorescent imaging, a much lower intensity approach to quadratic excitation, via reversible photoswitchable fluorophores. 03 September 2015 | doi: 10.1038/ncomms9184 Physical Sciences  Cell biology  Optical physics  Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5 OPEN G. Stefano Brigidi, Brendan Santyr, Jordan Shimell, Blair Jovellar and Shernaz X. Bamji Synaptic plasticity is mediated by the dynamic localization of proteins at synapses, which is partly controlled via palmitoylation of synaptic proteins. Here, the authors show how neuronal activity regulates the palmitoylation reaction through the translocation of the palmitoyl-acyl transferase DHHC5. 03 September 2015 | doi: 10.1038/ncomms9200 Biological Sciences  Biochemistry  Neuroscience  Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning OPEN Cécile Jacovetti, Scot J. Matkovich, Adriana Rodriguez-Trejo, Claudiane Guay and Romano Regazzi Pancreatic β-cells are less responsive to changes in glucose concentration in newborn than in adult rats. Here, the authors show that functional β-cell maturation is associated with changes in miRNA expression induced by nutritional shifts at the suckling-to-weaning transition. 02 September 2015 | doi: 10.1038/ncomms9084 Biological Sciences  Medical research  Flexible transition metal dichalcogenide nanosheets for band-selective photodetection OPEN Dhinesh Babu Velusamy, Richard Hahnkee Kim, Soonyoung Cha, June Huh, Reza Khazaeinezhad, Sahar Hosseinzadeh Kassani, Giyoung Song, Suk Man Cho, Sung Hwan Cho, Ihn Hwang, Jinseong Lee, Kyunghwan Oh, Hyunyoug Choi and Cheolmin Park Transition metal dichalgogenide sheets prepared by liquid phase exfoliation can be limited in terms of scalability. Here, Velusamy et al. use a scalable liquid phase exfoliation process to fabricate micrometre thick composite nanosheets with amine-terminated polymers, which exhibit photo-detective properties. 02 September 2015 | doi: 10.1038/ncomms9063 Physical Sciences  Materials science  Nanotechnology  Signature of magnetic-dependent gapless odd frequency states at superconductor/ferromagnet interfaces OPEN A. Di Bernardo, S. Diesch, Y. Gu, J. Linder, G. Divitini, C. Ducati, E. Scheer, M.G. Blamire and J.W.A. Robinson In the proximity of noncollinear magnetization, the Cooper-paired electrons of a superconductor may exist in a spin-triplet state. Here, the authors use scanning tunnel methods to directly observe this effect in Niobium as an adjacent film of Holmium is driven between helical and ferromagnetic order. 02 September 2015 | doi: 10.1038/ncomms9053 Physical Sciences  Applied physics  Condensed matter  Controlling and probing non-abelian emergent gauge potentials in spinor Bose-Fermi mixtures OPEN Nguyen Thanh Phuc, Gen Tatara, Yuki Kawaguchi and Masahito Ueda Abelian and non-abelian emergent gauge fields govern the physics of many topological phenomena, such as Hall effects. Here the authors show theoretically that in a spinor Bose-Fermi mixture the non-abelianness of the gauge potential can be tuned, offering the chance to study the abelian-non-abelian crossover. 02 September 2015 | doi: 10.1038/ncomms9135 Physical Sciences  Atomic and molecular physics  Theoretical physics  Development of high-yield influenza A virus vaccine viruses OPEN Jihui Ping, Tiago J.S. Lopes, Chairul A. Nidom, Elodie Ghedin, Catherine A. Macken, Adam Fitch, Masaki Imai, Eileen A. Maher, Gabriele Neumann and Yoshihiro Kawaoka The availability of high-yield virus strains remains an important bottleneck in the rapid production of influenza vaccines. Here, the authors report the development of influenza A vaccine backbone that improves the virus yield of various seasonal and pandemic influenza vaccine strains in cell culture. 02 September 2015 | doi: 10.1038/ncomms9148 Biological Sciences  Immunology  Virology  Hyperspectral light sheet microscopy OPEN Wiebke Jahr, Benjamin Schmid, Christopher Schmied, Florian O. Fahrbach and Jan Huisken Multicolour information is required to study the complex interplay of biological tissues. Here, Jahr et al. acquire spectral information at high resolution for each pixel in a hyperspectral light sheet microscope, while maintaining its perpendicular illumination and low phototoxicity. 02 September 2015 | doi: 10.1038/ncomms8990 Biological Sciences  Biotechnology  Developmental biology  Optical physics  Counter inhibition between leukotoxins attenuates Staphylococcus aureus virulence OPEN Pauline Yoong and Victor J. Torres Staphylococcus aureus strains produce a family of highly related toxins that puncture the cytoplasmic membrane of susceptible cells. Here, Yoong and Torres show that the toxins can counteract each other in a cell type-dependent manner by forming inactive hybrid complexes, thus modulating S. aureus virulence. 02 September 2015 | doi: 10.1038/ncomms9125 Biological Sciences  Microbiology  Realizing high figure of merit in heavy-band p-type half-Heusler thermoelectric materials OPEN Chenguang Fu, Shengqiang Bai, Yintu Liu, Yunshan Tang, Lidong Chen, Xinbing Zhao and Tiejun Zhu Thermoelectric materials could be used to convert waste heat into useful electricity, but the ideal substance needs to both optimize the electrical power factor and suppress thermal conductivity. Here, the authors report a high figure of merit of 1.5 at 1,200 K in the p-type half-Heusler alloy FeNbSb. 02 September 2015 | doi: 10.1038/ncomms9144 Physical Sciences  Materials science  Gradual onset and recovery of the Younger Dryas abrupt climate event in the tropics OPEN J.W. Partin, T.M. Quinn, C.-C. Shen, Y. Okumura, M.B. Cardenas, F.P. Siringan, J.L. Banner, K. Lin, H.-M. Hu and F.W. Taylor The Younger Dryas cooling event has been identified in ice records in the Northern Hemisphere, but the effects of this cold snap on the tropics are poorly known. Here, the authors present a speleothem record and model simulations, showing that tropical hydroclimate recovered slower than temperatures in Greenland. 02 September 2015 | doi: 10.1038/ncomms9061 Earth Sciences  Climate science  The links between ecosystem multifunctionality and above- and belowground biodiversity are mediated by climate OPEN Xin Jing, Nathan J. Sanders, Yu Shi, Haiyan Chu, Aimée T. Classen, Ke Zhao, Litong Chen, Yue Shi, Youxu Jiang and Jin-Sheng He Plant biodiversity often has a positive influence on ecosystem functioning. Here Jing et al. show that belowground diversity can also significantly impact ecosystem multifunctionality, but its relative effect varies by regional-scale climate variation. 02 September 2015 | doi: 10.1038/ncomms9159 Biological Sciences  Ecology  Plant sciences  Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation OPEN Sugata Manna, Jong Kyong Kim, Catherine Baugé, Margaret Cam, Yongmei Zhao, Jyoti Shetty, Melanie S. Vacchio, Ehydel Castro, Bao Tran, Lino Tessarollo and Rémy Bosselut Histone post-translational modifications such as the trimethylation of histone H3 at lysine 27 (H3K27Me3), affect DNA accessibility and transcription. Here, the authors show that Jmjd3 and Utx, two H3K27Me3 demethylases, are important for regulating the expression of genes involved in terminal thymocyte differentiation. 02 September 2015 | doi: 10.1038/ncomms9152 Biological Sciences  Immunology    Nature Communications JOBS of the week Faculty Position Vanderbilt University Postdoctoral Scientist positions John Innes Centre (JIC) Research Associate (non-tenure track) Indiana University Clinical Research Fellow Plymouth University Postdoctoral Scientist Medical Research Council Research Scientist The Center For Human Reproduction 3 Granted Postdoc Positions in Cancer Research Université catholique de Louvain (UCL) Faculty Position in the Life Sciences Stowers Institute for Medical Research Postdoctoral Research Scientist Cancer Research UK Beatson Institute in Glasgow PhD Fellowships in Life Sciences University of Lausanne (UNIL) More Science jobs from Nature Communications EVENT LS2 Annual Meeting 2016 26.02.16 Lausanne, Switzerland More science events from       Latest Errata     Erratum: Super-resolution photoacoustic imaging through a scattering wall Donald B. Conkey, Antonio M. Caravaca-Aguirre, Jake D. Dove, Hengyi Ju, Todd W. Murray and Rafael Piestun 08 September 2015 | doi: 10.1038/ncomms9380 Physical Sciences  Optical physics      Erratum: Analysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms Alexej Abyzov, Shantao Li, Daniel Rhee Kim, Marghoob Mohiyuddin, Adrian M. Stütz, Nicholas F. Parrish, Xinmeng Jasmine Mu, Wyatt Clark, Ken Chen, Matthew Hurles, Jan O. Korbel, Hugo Y. K. Lam, Charles Lee and Mark B. Gerstein 08 September 2015 | doi: 10.1038/ncomms9389 Biological Sciences  Genetics      Erratum: A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration OPEN Xuan Cao, Tomonori Kaneko, Jenny S. Li, An-Dong Liu, Courtney Voss and Shawn S.C. Li 08 September 2015 | doi: 10.1038/ncomms9320 Biological Sciences  Cell biology      Erratum: Steady-state cross-correlations for live two-colour super-resolution localization data sets OPEN Matthew B. Stone and Sarah L. Veatch 08 September 2015 | doi: 10.1038/ncomms9319 Biological Sciences  Biotechnology  Cell biology      Erratum: Topological data analysis of contagion maps for examining spreading processes on networks Dane Taylor, Florian Klimm, Heather A. Harrington, Miroslav Kramár, Konstantin Mischaikow, Mason A. Porter and Peter J. Mucha 04 September 2015 | doi: 10.1038/ncomms9374 Physical Sciences  Theoretical physics      Advertisement Nature Microbiology: Call for Papers Launching in January 2016, Nature Microbiology is now open for submissions and inviting high-quality submissions. The journal will cover all aspects of microorganisms be it their evolution, physiology and cell biology, their interactions with each other, with a host, with an environment, or their societal significance.  Submit your next research paper to the journal.     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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