Nature Biotechnology Contents: Volume 33 pp 885 - 1007

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Advertisement New White Paper: The Critical Role of Rodent Model Health Standards  This white paper explores 6 health standards factors that can enhance or reduce model relevancy for any study providing pragmatic advice to enable the optimal health standard. Discover the 6 pillars of optimal animal model selection Understand animal health as a response to trends in biomedical research Learn how the 6 pillars impact the model the selection process Download this Paper Now TABLE OF CONTENTS September 2015 Volume 33, Issue 9 Editorial News Correction Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Advertisement   Recombinant Antibody Production Guide Choose the right rAb production service for your Ab drug discovery  See details    Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Nature Collections TARGETING IL-17 IN INFLAMMATORY DISEASE  This Collection highlights the opportunities and potential benefits of interleukin-17-targeted therapies for chronic inflammatory diseases. Produced with support from  Eli Lilly and Company     Editorial Top Incentivizing data donation   p885 doi:10.1038/nbt.3341 Even if human research and clinical practice find a way to integrate personal health data, uptake will remain limited unless people are incentivized to participate. News Top Omics-driven startups challenge healthcare model   pp887 - 889 Cormac Sheridan doi:10.1038/nbt0915-887 UK biotech smashes financing record   p889 doi:10.1038/nbt0915-889a BEAM to fight antimicrobial resistance   p889 doi:10.1038/nbt0915-889b RIKEN suspends first clinical trial involving induced pluripotent stem cells   pp890 - 891 Ken Garber doi:10.1038/nbt0915-890 21st Century Cures Act wins in US House   p891 doi:10.1038/nbt0915-891 Celgene samples from science smorgasbord   pp892 - 893 Asher Mullard doi:10.1038/nbt0915-892 Revamp biotech rules, says White House   p894 doi:10.1038/nbt0915-894a Suicidal thoughts end Amgen's blockbuster aspirations for psoriasis drug   pp894 - 895 Charlie Schmidt doi:10.1038/nbt0915-894b 3D Printed clothing house microorganisms   p896 doi:10.1038/nbt0915-896a Advertisement Automated Protein Sample Prep Shimadzu's Perfinity Workstation automates key proteomics workflow steps to significantly reduce sample preparation times and enhance reproducibility, making it the ideal solution for improving time-consuming, user-dependent protein sample prep workflows for LC-MS/MS. Learn more. Advertisement Join us for the Naturejobs Career Expo London on 18 September!  This career fair offers young, talented researchers an excellent opportunity to meet a diverse selection of national and international employers from academic institutions and scientific industries. The event is free and offers you a chance to get your CV checked, meet and network with employers and leading scientific institutions and attend useful workshops.   Register and find out more.    Correction Top Corrections   p896 doi:10.1038/nbt0915-896b News Top Around the world in a month   p896 doi:10.1038/nbt0915-896c Bioentrepreneur Top Datapage Top 20 translational researchers of 2014   p897 Brady Huggett and Kathryn Paisner doi:10.1038/nbt.3335 Podcast First Rounders Podcast: Stanley Crooke   p897 doi:10.1038/nbt.3336 Opinion and Comment Top Correspondence Why microbial diagnostics need more than money   pp898 - 900 Mark Kessel doi:10.1038/nbt.3328 Availability and payer coverage of BRCA1/2 tests and gene panels   pp900 - 902 Elizabeth Clain, Julia R Trosman, Michael P Douglas, Christine B Weldon and Kathryn A Phillips doi:10.1038/nbt.3322 The payers' perspective on gene therapies   pp902 - 904 Nicolas Touchot and Mathias Flume doi:10.1038/nbt.3332 Removing Bt eggplant from the face of Indian regulators   pp904 - 907 Pushpendra Kumar Gupta, Bhagirath Choudhary and Godelieve Gheysen doi:10.1038/nbt.3331 The nonsensical GMO pseudo-category and a precautionary rabbit hole   pp907 - 908 Giovanni Tagliabue doi:10.1038/nbt.3333 Contesting estimates of cryopreserved embryos in the United States   p909 Dave Snow, Alana Cattapan and Francoise Baylis doi:10.1038/nbt.3342 Contesting estimates of cryopreserved embryos in the United States   p909 doi:10.1038/nbt.3348 Commentary Building a business model in digital medicine   pp910 - 920 David Steinberg, Geoffrey Horwitz and Daphne Zohar doi:10.1038/nbt.3339 Digital medicine companies can incorporate and build on existing business models in tech and biomedicine to bring transformational new products to market and eventually reshape medicine. Unpatients—why patients should own their medical data   pp921 - 924 Leonard J Kish and Eric J Topol doi:10.1038/nbt.3340 For the benefits of digital medicine to be fully realized, we need not only to find a shared home for personal health data but also to give individuals the right to own them. Features Top Patents Biotechnology patents under fire   pp925 - 926 Irena Royzman doi:10.1038/nbt.3334 The courts' new approach not only puts the US biotech industry at a competitive disadvantage but also misapprehends the nature of innovation in biotech. Recent patents in brain-machine interfaces   p927 doi:10.1038/nbt.3351 News and Views Top RNA structure from deep sequencing   pp928 - 929 Eric Westhof doi:10.1038/nbt.3338 A method to identify interacting regions in a folded RNA is a step toward solving RNA structures from sequencing data. See also: Research by Ramani et al. Phosphoproteomics takes it easy   pp929 - 930 Paola Picotti doi:10.1038/nbt.3345 The EasyPhos pipeline simplifies analysis of phosphorylation-dependent signaling networks at high temporal resolution. See also: Research by Humphrey et al. From mass cytometry to cancer prognosis   pp931 - 932 Deborah R Winter, Guy Ledergor and Ido Amit doi:10.1038/nbt.3346 Applying social network algorithms to mass cytometry data from single cancer cells leads to more accurate predictions of patient outcomes. Research Highlights   p932 doi:10.1038/nbt.3337 Biotechnology JOBS of the week Two professorships / associate professorships in biotechnology Norwegian University of Science and Technology (NTNU) Senior Lecturer / Associate Professor in Biochemistry Victoria University of Wellington Two postdoc positions Yeast Genetics and Molecular Biology - Industrial Research Projects VIB Head of the Research Group Systems Biology and Bioinformatics Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute Joint PhD position - Functional Interactomics and Advanced Live Cell Imaging VIB More Science jobs from Computational Biology Top Analysis Prediction of human population responses to toxic compounds by a collaborative competition OPEN   pp933 - 940 Federica Eduati, Lara M Mangravite, Tao Wang, Hao Tang, J Christopher Bare et al. doi:10.1038/nbt.3299 Crowdsourcing analysis improves computational prediction of cytotoxic responses in humans. Research Top Perspective Principles of nanoparticle design for overcoming biological barriers to drug delivery   pp933 - 943 Elvin Blanco, Haifa Shen and Mauro Ferrari doi:10.1038/nbt.3330 Mauro Ferrari and colleagues discuss the biological barriers to delivery of nanoparticle therapeutics to diseased tissues. They propose that greater emphasis should be place on rational particle design that systematically takes into account these barriers. Articles Massively parallel high-order combinatorial genetics in human cells   pp952 - 961 Alan S L Wong, Gigi C G Choi, Allen A Cheng, Oliver Purcell and Timothy K Lu doi:10.1038/nbt.3326 Massively parallel genetic screening reveals synergies between miRNAs regulating cancer cell proliferation and drug resistance. Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy   pp962 - 969 Jerome Chal, Masayuki Oginuma, Ziad Al Tanoury, Benedicte Gobert, Olga Sumara et al. doi:10.1038/nbt.3297 A protocol for differentiating mouse and human pluripotent stem cells into muscle. Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells   pp970 - 979 Matthew J Birket, Marcelo C Ribeiro, Arie O Verkerk, Dorien Ward, Ana Rita Leitoguinho et al. doi:10.1038/nbt.3271 The development of human cardiovascular progenitor cells provides a renewable source of cardiac cell types. Letters High-throughput determination of RNA structure by proximity ligation   pp980 - 984 Vijay Ramani, Ruolan Qiu and Jay Shendure doi:10.1038/nbt.3289 RNA structure is revealed by a high-throughput method that relies on proximity ligation and deep sequencing. See also: News and Views by Westhof Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells   pp985 - 989 Ayal Hendel, Rasmus O Bak, Joseph T Clark, Andrew B Kennedy, Daniel E Ryan et al. doi:10.1038/nbt.3290 Improved efficiency of CRISPR/Cas editing with chemically modified synthetic sgRNAs. High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics   pp990 - 995 Sean J Humphrey, S Babak Azimifar and Matthias Mann doi:10.1038/nbt.3327 Phosphoproteomes are rapidly measured in parallel to track the dynamics of insulin signaling in the liver. See also: News and Views by Picotti Overexpression of receptor-like kinase ERECTA improves thermotolerance in rice and tomato   pp996 - 1003 Hui Shen, Xiangbin Zhong, Fangfang Zhao, Yanmei Wang, Bingxiao Yan et al. doi:10.1038/nbt.3321 The heat tolerance of rice and tomato plants is increased by overexpression of the ERECTA gene. Careers and Recruitment Top MASS AWIS: Supporting women in science for over a decade   pp1005 - 1006 Tooba Cheema and Joanne Kamens doi:10.1038/nbt.3347 An advocacy group provides a unique opportunity for professional development that is making a difference for women in scientific and technical careers. People People   p1007 doi:10.1038/nbt.3352 Advertisement Join us for the Naturejobs Career Expo London on 18 September!  This career fair offers young, talented researchers an excellent opportunity to meet a diverse selection of national and international employers from academic institutions and scientific industries. The event is free and offers you a chance to get your CV checked, meet and network with employers and leading scientific institutions and attend useful workshops.   Register and find out more.    Advertisement Nature Microbiology: Call for Papers Launching in January 2016, Nature Microbiology is now open for submissions and inviting high-quality submissions. The journal will cover all aspects of microorganisms be it their evolution, physiology and cell biology, their interactions with each other, with a host, with an environment, or their societal significance.  Submit your next research paper to the journal.     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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