Molecular Systems Biology - New articles published - 1 Sep 2015

August 2015 | Volume 11, Number 8 Submit Table of Contents Articles Volume 11, Number 8 Articles Comprehensive assembly of novel transcripts from unmapped human RNA‐Seq data and their association with cancer Comprehensive analysis of unmapped reads from a large number of cancer and normal RNA‐Seq datasets identifies 2,550 previously unassembled human transcripts. Some of the transcripts are cancer type‐ or tissue‐specific, suggesting context‐dependent functions. Majid Kazemian, Min Ren, Jian‐Xin Lin, Wei Liao, Rosanne Spolski, and Warren J Leonard Published online 07.08.2015 Extensive allele‐specific translational regulation in hybrid mice Deep sequencing‐based transcriptome and polysome profiling reveals extensive allele‐specific translational regulation in an F1 hybrid mouse, which enables global analysis of cis‐regulatory elements and the coordination between transcriptional and translational regulation. Jingyi Hou, Xi Wang, Erik McShane, Henrik Zauber, Wei Sun, Matthias Selbach, and Wei Chen Published online 07.08.2015 Stress‐response balance drives the evolution of a network module and its host genome The evolution of a synthetic gene circuit that trades off costly gene expression for drug resistance is analyzed computationally. The predictions are validated experimentally by adjusting gene expression in the absence or presence of environmental stress. Caleb González, Joe Christian J Ray, Michael Manhart, Rhys M Adams, Dmitry Nevozhay, Alexandre V Morozov, and Gábor Balázsi Published online 31.08.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.