The EMBO Journal Table of Contents for 13 August 2015; Vol. 34, No. 16

13 August 2015 | Volume 34, Number 16 Submit Table of Contents News & Views Articles Volume 34, Number 16 News & Views Autophagosomes and lipid droplets: no longer just chewing the fat Recent studies highlight the emerging complex relationship between lipid droplet biology and autophagy. Vojo Deretic Published online 10.07.2015 Optochemistry to control the microtubule cytoskeleton Use of microtubule drugs is limited by their toxicity and the inability to precisely control spatial and temporal parameters of treatment. A recent report in Cell describes drugs—photostatins—that can be activated and deactivated by light to achieve precise spatiotemporal control. Carsten Janke and Michel O Steinmetz Published online 17.07.2015 Articles Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis Under nitrogen starvation, lipid droplet (LD) biogenesis and mobilization enzymes regulate autophagy; the process requires ER‐LD contact site proteins. Tomer Shpilka, Evelyn Welter, Noam Borovsky, Nira Amar, Muriel Mari, Fulvio Reggiori, and Zvulun Elazar Published online 10.07.2015 Crosstalk between Akt/GSK3β signaling and dynamin‐1 regulates clathrin‐mediated endocytosis Activation of dynamin‐1 by Akt and GSK3β in non‐neuronal cells alters the rate and regulation of CME, providing a feed‐forward pathway between signaling and endocytosis. Carlos R Reis, Ping‐Hung Chen, Saipraveen Srinivasan, François Aguet, Marcel Mettlen, and Sandra L Schmid Published online 02.07.2015 Membrane protrusion powers clathrin‐independent endocytosis of interleukin‐2 receptor The initiation of interleukin‐2 receptor (IL‐2R) endocytosis follows a unique mechanism of outward membrane deformation via protrusions and requires IL‐2R interaction with the WAVE complex. Cyril Basquin, Michaël Trichet, Helena Vihinen, Valérie Malardé, Thibault Lagache, Léa Ripoll, Eija Jokitalo, Jean‐Christophe Olivo‐Marin, Alexis Gautreau, and Nathalie Sauvonnet Published online 29.06.2015 JNK‐dependent gene regulatory circuitry governs mesenchymal fate Combining transcriptome analysis and patient data this study illustrates how JNK signaling drives EMT progression via a panel of specific transcription factors, several of which are linked to EMT for the first time. Sanjeeb Kumar Sahu, Angela Garding, Neha Tiwari, Sudhir Thakurela, Joern Toedling, Susanne Gebhard, Felipe Ortega, Nikolai Schmarowski, Benedikt Berninger, Robert Nitsch, Marcus Schmidt, and Vijay K Tiwari Published online 08.07.2015 Assembly of Slx4 signaling complexes behind DNA replication forks The stepwise assembly of Slx4 protein complexes on chromatin during DNA replication stress promotes checkpoint signaling. Attila Balint, TaeHyung Kim, David Gallo, Jose Renato Cussiol, Francisco M Bastos de Oliveira, Askar Yimit, Jiongwen Ou, Ryuichiro Nakato, Alexey Gurevich, Katsuhiko Shirahige, Marcus B Smolka, Zhaolei Zhang, and Grant W Brown Published online 25.06.2015 Chimeric adaptor proteins translocate diverse type VI secretion system effectors in Vibrio cholerae Pandemic V. cholerae share T6SS‐dependent effectors with no conserved translocation motifs. Vibrio cholerae encodes an array of Tap‐1 adaptors with variable ends, presumably generated through recombination, in order to translocate diverse effectors. Daniel Unterweger, Benjamin Kostiuk, Rina Ötjengerdes, Ashley Wilton, Laura Diaz‐Satizabal, and Stefan Pukatzki Published online 19.07.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.