Scientific Reports Biology Table of Contents e-alert: 25 August 2015

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25 August 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         Join us this September for the Naturejobs Career Expo London 2015!  This career fair offers young, talented researchers an excellent opportunity to meet a diverse selection of national and international employers from academic institutions and scientific industries. The event is free and offers you a chance to get your CV checked, meet and network with employers and leading scientific institutions and attend useful workshops. Register and find out more.           Biological Sciences               STAT1 deficiency redirects IFN signalling toward suppression of TLR response through a feedback activation of STAT3 ▶     Hun Sik Kim, Dong Chan Kim, Hong-Mi Kim et al.     Interferons (IFNs) potentiate macrophage activation typically via a STAT1-dependent pathway. Recent studies suggest a functioning of STAT1-independent pathway in the regulation …             Social, spatial, and temporal organization in a complex insect society ▶     Lauren E. Quevillon, Ephraim M. Hanks, Shweta Bansal et al.     High-density living is often associated with high disease risk due to density-dependent epidemic spread. Despite being paragons of high-density living, the social insects have …             Imaging real-time HIV-1 virion fusion with FRET-based biosensors ▶     Daniel M. Jones, Sergi Padilla-Parra     We have produced a novel, simple and rapid method utilising genetically encodable FRET-based biosensors to permit the detection of HIV-1 virion fusion in living cells. These …             Investigation of Inhibition Mechanism of Chemokine Receptor CCR5 by Micro-second Molecular Dynamics Simulations ▶     Ramin Ekhteiari Salmas, Mine Yurtsever, Serdar Durdagi     Chemokine receptor 5 (CCR5) belongs to G protein coupled receptors (GPCRs) and plays an important role in treatment of human immunodeficiency virus (HIV) infection since HIV uses …             CAMKII-conditional deletion of histone deacetylase 2 potentiates acute methamphetamine-induced expression of immediate early genes in the mouse nucleus accumbens ▶     Oscar V. Torres, Michael T. McCoy, Bruce Ladenheim et al.     Methamphetamine (METH) produces increases in the expression of immediate early genes (IEGs) and of histone deacetylase 2 (HDAC2) in the rat nucleus accumbens (NAc). Here, we …             Organic acids from root exudates of banana help root colonization of PGPR strain Bacillus amyloliquefaciens NJN-6 ▶     Jun Yuan, Nan Zhang, Qiwei Huang et al.     The successful colonization of plant growth promoting rhizobacteria (PGPR) in the rhizosphere is an initial and compulsory step in the protection of plants from soil-borne …             Use of double-stranded DNA mini-circles to characterize the covalent topoisomerase-DNA complex ▶     Armêl Millet, François Strauss, Emmanuelle Delagoutte     The enzymatic DNA relaxation requires the DNA to be transiently nicked and rejoined, the covalent topoisomerase-DNA complex being a key intermediate of the nicking-joining …             Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1 ▶     An Hu, Jing-Juan Huang, Rui-Lin Li et al.     SIRT1 is one of seven mammalian homologs of Sir2 that catalyzes NAD+-dependent protein deacetylation. The aim of the present study is to explore the effect of SIRT1 small …             Systemic Administration of siRNA via cRGD-containing Peptide ▶     Yuanyu Huang, Xiaoxia Wang, Weiyan Huang et al.     Although small interfering RNAs (siRNAs) have been demonstrated to specifically silence their target genes in disease models and clinical trials, in vivo siRNA delivery is still …             Erratum: A Novel Audiovisual Brain-Computer Interface and Its Application in Awareness Detection ▶     Fei Wang, Yanbin He, Jiahui Pan et al.                 Non-immune immunoglobulins shield Schistosoma japonicum from host immunorecognition ▶     Chuang Wu, Nan Hou, Xianyu Piao et al.     Schistosomiasis is a major human parasitic disease with a global impact. Schistosoma japonicum, the most difficult to control, can survive within host veins for decades. …             Polyamine biosynthesis is critical for growth and differentiation of the pancreas ▶     Teresa L. Mastracci, Morgan A. Robertson, Raghavendra G. Mirmira et al.     The pancreas, in most studied vertebrates, is a compound organ with both exocrine and endocrine functions. The exocrine compartment makes and secretes digestive enzymes, while …             A Caged Ret Kinase Inhibitor and its Effect on Motoneuron Development in Zebrafish Embryos ▶     David Bliman, Jesper R. Nilsson, Petronella Kettunen et al.     Proto-oncogene tyrosine-protein kinase receptor RET is implicated in the development and maintenance of neurons of the central and peripheral nervous systems. Attaching …             Smoking Gun or Circumstantial Evidence? Comparison of Statistical Learning Methods using Functional Annotations for Prioritizing Risk Variants ▶     Sarah A. Gagliano, Reena Ravji, Michael R. Barnes et al.     Although technology has triumphed in facilitating routine genome sequencing, new challenges have been created for the data-analyst. Genome-scale surveys of human variation …             Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability ▶     Nina E Ottosson, Xiongyu Wu, Andreas Nolting et al.     Voltage-gated ion channels generate cellular excitability, cause diseases when mutated, and act as drug targets in hyperexcitability diseases, such as epilepsy, cardiac …             Erratum: High-frame rate four dimensional optoacoustic tomography enables visualization of cardiovascular dynamics and mouse heart perfusion ▶     Xosé Luís Deán-Ben, Steven James Ford, Daniel Razansky                 Social distance and anonymity modulate fairness consideration: An ERP study ▶     Rongjun Yu, Pan Hu, Ping Zhang     Previous research indicated that fairness consideration can be influenced by social distance. However, it is not clear whether social distance and anonymity have an interactive …             Natural disturbance reduces disease risk in endangered rainforest frog populations ▶     Elizabeth A. Roznik, Sarah J. Sapsford, David A. Pike et al.     Natural disturbances can drive disease dynamics in animal populations by altering the microclimates experienced by hosts and their pathogens. Many pathogens are highly sensitive …             Population genetic diversity and hybrid detection in captive zebras ▶     Hideyuki Ito, Tanya Langenhorst, Rob Ogden et al.     Zebras are members of the horse family. There are three species of zebras: the plains zebra Equus quagga, the Grevy’s zebra E. grevyi and the mountain zebra E. zebra. The Grevy’s …             Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells ▶     Yuki Yoshino, Chikashi Ishioka     Glycogen synthase kinase-3 beta (GSK-3β) has been investigated as a therapeutic target for numerous human diseases including cancer because of their diverse cellular functions. …             Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy ▶     Wen Yue, Tao Wang, Emmanuel Zachariah et al.     Metformin and aspirin have been studied extensively as cancer preventative and therapeutic agents. However, the underlying molecular mechanisms for the inhibitory effects of …             CoMOGrad and PHOG: From Computer Vision to Fast and Accurate Protein Tertiary Structure Retrieval ▶     Rezaul Karim, Mohd. Momin Al Aziz, Swakkhar Shatabda et al.     The number of entries in a structural database of proteins is increasing day by day. Methods for retrieving protein tertiary structures from such a large database have turn out …             Generalisation within specialization: inter-individual diet variation in the only specialized salamander in the world ▶     Andrea Costa, Sebastiano Salvidio, Mario Posillico et al.     Specialization is typically inferred at population and species level but in the last decade many authors highlighted this trait at the individual level, finding that generalist …             Dynamic subnuclear relocalisation of WRKY40 in response to Abscisic acid in Arabidopsis thaliana ▶     Katja Geilen, Maik Böhmer     WRKY18, WRKY40 and WRKY60 are members of the WRKY transcription factor family and function as transcriptional regulators in ABA signal transduction in Arabidopsis thaliana. Here …             Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs ▶     Xianlong Wang, Jinwei Zhou, Chunwei Cao et al.     Genetic engineering in livestock was greatly enhanced by the emergence of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9), which can …             A novel cell-printing method and its application to hepatogenic differentiation of human adipose stem cell-embedded mesh structures ▶     Seung Hyun Ahn, Hyeong Jin Lee, Ji-Seon Lee et al.     We report a cell-dispensing technique, using a core–shell nozzle and an absorbent dispensing stage to form cell-embedded struts. In the shell of the nozzle, a cross-linking agent …             Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia ▶     Genevra Pillinger, Amina Abdul-Aziz, Lyubov Zaitseva et al.     Approximately 20% of patients with acute myeloid leukaemia (AML) have a mutation in FMS-like-tyrosine-kinase-3 (FLT3). FLT3 is a trans-membrane receptor with a tyrosine kinase …             Isolation of Genetically Tractable Most-Wanted Bacteria by Metaparental Mating ▶     Páraic Ó Cuív, Wendy J. Smith, Sian Pottenger et al.     Metagenomics has rapidly advanced our inventory and appreciation of the genetic potential inherent to the gut microbiome. However it is widely accepted that two key constraints …             Non-quantitative adjustment of offspring sex ratios in pollinating fig wasps ▶     Rui-Wu Wang, Bao-Fa Sun, Jun-Zhou He et al.     Fig wasp is one of the most well known model systems in examining whether or not the parents could adjust their offspring sex ratio to maximize their gene frequency transmission …             Carbon dioxide level and form of soil nitrogen regulate assimilation of atmospheric ammonia in young trees ▶     Lucas C. R. Silva, Alveiro Salamanca-Jimenez, Timothy A. Doane et al.     The influence of carbon dioxide (CO2) and soil fertility on the physiological performance of plants has been extensively studied, but their combined effect is notoriously …             The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway ▶     Emine Guven-Maiorov, Ozlem Keskin, Attila Gursoy et al.     Activated Toll-like receptors (TLRs) cluster in lipid rafts and induce pro- and anti-tumor responses. The organization of the assembly is critical to the understanding of how …             Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn ▶     Nobuko Ohashi, Mika Sasaki, Masayuki Ohashi et al.     Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery. However, a serious adverse effect of TXA is seizure due to inhibition of …             Imaging Fibrosis and Separating Collagens using Second Harmonic Generation and Phasor Approach to Fluorescence Lifetime Imaging ▶     Suman Ranjit, Alexander Dvornikov, Milka Stakic et al.     In this paper we have used second harmonic generation (SHG) and phasor approach to auto fluorescence lifetime imaging (FLIM) to obtain fingerprints of different collagens and …             Heterogeneous lineage marker expression in naive embryonic stem cells is mostly due to spontaneous differentiation ▶     Gautham Nair, Elsa Abranches, Ana M. V. Guedes et al.     Populations of cultured mouse embryonic stem cells (ESCs) exhibit a subfraction of cells expressing uncharacteristically low levels of pluripotency markers such as Nanog. Yet, …             Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model ▶     Yu Seri, Hirofumi Shoda, Akari Suzuki et al.     Peptidyl arginine deiminase 4 (PAD4) is an enzyme that is involved in protein citrullination, and is a target for anti-citrullinated peptide antibodies (ACPAs) in rheumatoid …             Myth busting? Effects of embryo positioning and egg turning on hatching success in the water snake Natrix maura ▶     Fabien Aubret, Gaëlle Blanvillain, Philippe J. R. Kok     It is a common belief that reptile eggs should not be turned after oviposition once the embryo has attached itself to the inner membrane of the shell as it might kill developing …             Sonorensin: A new bacteriocin with potential of an anti-biofilm agent and a food biopreservative ▶     Lipsy Chopra, Gurdeep Singh, Kautilya Kumar Jena et al.     The emergence of antibiotic resistant bacteria has led to exploration of alternative therapeutic agents such as ribosomally synthesized bacterial peptides known as bacteriocins. …             Chimpanzee lip-smacking facilitates cooperative behaviour ▶     Pawel Fedurek, Katie E. Slocombe, Jessica A. Hartel et al.     Signalling plays an important role in facilitating and maintaining affiliative or cooperative interactions in social animals. Social grooming in primates is an example of an …             Large-scale RNA-Seq Transcriptome Analysis of 4043 Cancers and 548 Normal Tissue Controls across 12 TCGA Cancer Types ▶     Li Peng, Xiu Wu Bian, Di Kang Li et al.     The Cancer Genome Atlas (TCGA) has accrued RNA-Seq-based transcriptome data for more than 4000 cancer tissue samples across 12 cancer types, translating these data into …             Real-time analysis of epithelial-mesenchymal transition using fluorescent single-domain antibodies ▶     Julia Maier, Bjoern Traenkle, Ulrich Rothbauer     Vimentin has become an important biomarker for epithelial-mesenchymal transition (EMT), a highly dynamic cellular process involved in the initiation of metastasis and cancer …             Optogenetic control of cell signaling pathway through scattering skull using wavefront shaping ▶     Jonghee Yoon, Minji Lee, KyeoReh Lee et al.     We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront shaping. The wavefront of the incident …             Rheostatic Regulation of the SERCA/Phospholamban Membrane Protein Complex Using Non-Coding RNA and Single-Stranded DNA oligonucleotides ▶     Kailey J. Soller, Raffaello Verardi, Meng Jing et al.     The membrane protein complex between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) and phospholamban (PLN) is a prime therapeutic target for reversing cardiac contractile …             Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions ▶     Natalie E. Farrawell, Isabella A. Lambert-Smith, Sadaf T. Warraich et al.     Amyotrophic lateral sclerosis is a rapidly progressing neurodegenerative disease associated with protein misfolding and aggregation. Most cases are characterized by TDP-43 …             Exometabolom analysis of breast cancer cell lines: Metabolic signature ▶     Lucas Willmann, Thalia Erbes, Sebastian Halbach et al.     Cancer cells show characteristic effects on cellular turnover and DNA/RNA modifications leading to elevated levels of excreted modified nucleosides. We investigated the molecular …             MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1 ▶     Yanan Li, Ling Mao, Yuan Gao et al.     Previous studies have suggested that microRNA-107 (miR-107) regulates cell migration in tumor and promotes Hypoxia Inducible Factor 1α (HIF1α) regulated angiogenesis under …             Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non-alcoholic fatty liver disease ▶     Shamsul Mohd Zain, Zahurin Mohamed, Munir Pirmohamed et al.     A recent genome-wide copy number (CNV) scan identified a 13q12.11 duplication in the exportin-4 (XPO4) gene to be associated with non-alcoholic steatohepatitis (NASH). We sought …             CNV Analysis Associates AKNAD1 with Type-2 Diabetes in Jordan Subpopulations ▶     Rana Dajani, Jin Li, Zhi Wei et al.     Previous studies have identified a number of single nucleotide polymorphisms (SNPs) associated with type-2 diabetes (T2D), but copy number variation (CNV) association has rarely …             Chimeric peptide constructs comprising linear B-cell epitopes: application to the serodiagnosis of infectious diseases ▶     Yudong Lu, Zhong Li, Huan Teng et al.     Linear B-cell epitopes are ideal biomarkers for the serodiagnosis of infectious diseases. However, the long-predicted diagnostic value of epitopes has not been realized. Here, we …             Zero-Determinant Strategies in Iterated Public Goods Game ▶     Liming Pan, Dong Hao, Zhihai Rong et al.     Recently, Press and Dyson have proposed a new class of probabilistic and conditional strategies for the two-player iterated Prisoner’s Dilemma, so-called zero-determinant …             Function does not follow form in gene regulatory circuits ▶     Joshua L. Payne, Andreas Wagner     Gene regulatory circuits are to the cell what arithmetic logic units are to the chip: fundamental components of information processing that map an input onto an output. Gene …             Effect of ethnicity and socioeconomic variation to the gut microbiota composition among pre-adolescent in Malaysia ▶     Chun Wie Chong, Arine Fadzlun Ahmad, Yvonne Ai Lian Lim et al.     Gut microbiota plays an important role in mammalian host metabolism and physiological functions. The functions are particularly important in young children where rapid mental and …             Self protein-protein interactions are involved in TPPP/p25 mediated microtubule bundling ▶     Salvatore DeBonis, Emmanuelle Neumann, Dimitrios A. Skoufias     TPPP/p25 is a microtubule-associated protein, detected in protein inclusions associated with various neurodegenerative diseases. Deletion analysis data show that TPPP/p25 has two …             Generation of clonal zebrafish line by androgenesis without egg irradiation ▶     Jilun Hou, Takafumi Fujimoto, Taiju Saito et al.     Generation of clonal zebrafish will facilitate large-scale genetic screening and help us to overcome other biological and biotechnological challenges due to their isogenecity. …             The structure of an endogenous Drosophila centromere reveals the prevalence of tandemly repeated sequences able to form i-motifs ▶     Miguel Garavís, María Méndez-Lago, Valérie Gabelica et al.     Centromeres are the chromosomal loci at which spindle microtubules attach to mediate chromosome segregation during mitosis and meiosis. In most eukaryotes, centromeres are made …             Dynamic scalp topography reveals neural signs just before performance errors ▶     Hiroki Ora, Tatsuhiko Sekiguchi, Yoshihiro Miyake     Performance errors may cause serious consequences. It has been reported that ongoing activity of the frontal control regions across trials associates with the occurrence of …             Biogeography of Nocardiopsis strains from hypersaline environments of Yunnan and Xinjiang Provinces, western China ▶     Song-Tao He, Xiao-Yang Zhi, Hongchen Jiang et al.     The genus Nocardiopsis is a widespread group within the phylum Actinobacteria and has been isolated from various salty environments worldwide. However, little is known about …             Reconsolidation of a cocaine associated memory requires DNA methyltransferase activity in the basolateral amygdala ▶     Hai-Shui Shi, Yi-Xiao Luo, Xi Yin et al.     Drug addiction is considered an aberrant form of learning, and drug-associated memories evoked by the presence of associated stimuli (drug context or drug-related cues) …             The Multiple DSF-family QS Signals are Synthesized from Carbohydrate and Branched-chain Amino Acids via the FAS Elongation Cycle ▶     Lian Zhou, Yonghong Yu, Xiping Chen et al.     Members of the diffusible signal factor (DSF) family are a novel class of quorum sensing (QS) signals in diverse Gram-negative bacteria. Although previous studies have identified …             The Role of Scleraxis in Fate Determination of Mesenchymal Stem Cells for Tenocyte Differentiation ▶     Yonghui Li, Melissa Ramcharan, Zuping Zhou et al.     Mesenchymal stem cells (MSCs) are pluripotent cells that primarily differentiate into osteocytes, chondrocytes, and adipocytes. Recent studies indicate that MSCs can also be …             Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer ▶     Akira T. Komatsubara, Michiyuki Matsuda, Kazuhiro Aoki     Biosensors based on the principle of Förster (or fluorescence) resonance energy transfer (FRET) have been developed to visualize spatio-temporal dynamics of signalling molecules …             Use of exotic plants to control Spartina alterniflora invasion and promote mangrove restoration ▶     Ting Zhou, Shuchao Liu, Zhili Feng et al.     In coastal China, the exotic invasive Spartina alterniflora is preventing the establishment of native mangroves. The use of exotic species, control of exotic plant invasion, and …             Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype ▶     Yong Fu, Zobeida Cruz-Monserrate, H. Helen Lin et al.     Salivary duct carcinoma (SDC) is an uncommon, but aggressive malignant tumor with a high mortality rate. Herein, we reported the detection of somatic KRAS A146T and Q61H …             Human cell dedifferentiation in mesenchymal condensates through controlled autophagy ▶     Rebecca Pennock, Elen Bray, Paul Pryor et al.     Tissue and whole organ regeneration is a dramatic biological response to injury that occurs across different plant and animal phyla. It frequently requires the dedifferentiation …             ZnuA and zinc homeostasis in Pseudomonas aeruginosa ▶     Victoria G. Pederick, Bart A. Eijkelkamp, Stephanie L. Begg et al.     Pseudomonas aeruginosa is a ubiquitous environmental bacterium and a clinically significant opportunistic human pathogen. Central to the ability of P. aeruginosa to colonise both …             In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response ▶     Masaud Shah, Muhammad Ayaz Anwar, Seolhee Park et al.     The high-risk human papillomavirus E6 (hrHPV E6) protein has been widely studied due to its implication in cervical cancer. In response to viral threat, activated kinases …             Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells ▶     Emi Shoji, Hidetoshi Sakurai, Tokiko Nishino et al.     Duchenne muscular dystrophy (DMD) is a progressive and fatal muscle degenerating disease caused by a dystrophin deficiency. Effective suppression of the primary pathology …             Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1 ▶     Rilei Yu, Victoria A. L. Seymour, Géza Berecki et al.     Cyclic α-conotoxin Vc1.1 (cVc1.1) is an orally active peptide with analgesic activity in rat models of neuropathic pain. It has two disulfide bonds, which can have three …             Vagotomy attenuates bleomycin-induced pulmonary fibrosis in mice ▶     Nana Song, Jun Liu, Saad Shaheen et al.     The progression of pulmonary fibrosis (PF) entails a complex network of interactions between multiple classes of molecules and cells, which are closely related to the vagus …             Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population ▶     Rongxin Chen, Shu Liu, Huijing Ye et al.     Single nucleotide polymorphisms (SNPs) of p53 rs1042522, MDM2 rs2279744 and p21 rs1801270, all in the p53 pathway, which plays a crucial role in DNA damage and genomic …             Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis ▶     Kosuke Saito, Takashi Uebanso, Keiko Maekawa et al.     Nonalcoholic steatohepatitis (NASH) is a major health problem since it often leads to hepatocellular carcinoma. However, the underlying mechanisms of NASH development and …             Patient- and therapy-related factors associated with the incidence of xerostomia in nasopharyngeal carcinoma patients receiving parotid-sparing helical tomotherapy ▶     Tsair-Fwu Lee, Ming-Hsiang Liou, Hui-Min Ting et al.     We investigated the incidence of moderate to severe patient-reported xerostomia among nasopharyngeal carcinoma (NPC) patients treated with helical tomotherapy (HT) and identified …             TGF-βl Suppresses Inflammation in Cell Therapy for Intervertebral Disc Degeneration ▶     Huilin Yang, Cheng Cao, Chunshen Wu et al.     Recent studies suggest that cell therapy may be an effective way to repair intervertebral disc degeneration. As a strong immune suppressor, TGF-β1 has been shown to inhibit …             Discerning the differential molecular pathology of proliferative middle ear lesions using Raman spectroscopy ▶     Rishikesh Pandey, Santosh Kumar Paidi, Jeon Woong Kang et al.     Despite its widespread prevalence, middle ear pathology, especially the development of proliferative lesions, remains largely unexplored and poorly understood. Diagnostic …             Doubling Power Output of Starch Biobattery Treated by the Most Thermostable Isoamylase from an Archaeon Sulfolobus tokodaii ▶     Kun Cheng, Fei Zhang, Fangfang Sun et al.     Biobattery, a kind of enzymatic fuel cells, can convert organic compounds (e.g., glucose, starch) to electricity in a closed system without moving parts. Inspired by natural …             Losing dexterity: patterns of impaired coordination of finger movements in musician’s dystonia ▶     Shinichi Furuya, Kenta Tominaga, Fumio Miyazaki et al.     Extensive training can bring about highly-skilled action, but may also impair motor dexterity by producing involuntary movements and muscular cramping, as seen in focal dystonia …             Mitochondrial Haplotypes Influence Metabolic Traits in Porcine Transmitochondrial Cybrids ▶     Guanghui Yu, Hai Xiang, Jianhui Tian et al.     In farm animals, mitochondrial DNA mutations exist widely across breeds and individuals. In order to identify differences among mtDNA haplotypes, two porcine transmitochondrial …             Female heterogamety in Madagascar chameleons (Squamata: Chamaeleonidae: Furcifer): differentiation of sex and neo-sex chromosomes ▶     Michail Rovatsos, Martina Johnson Pokorná, Marie Altmanová et al.     Amniotes possess variability in sex determining mechanisms, however, this diversity is still only partially known throughout the clade and sex determining systems still remain …             Gene looping facilitates TFIIH kinase-mediated termination of transcription ▶     Scott Medler, Athar Ansari     TFIIH is a general transcription factor with kinase and helicase activities. The kinase activity resides in the Kin28 subunit of TFIIH. The role of Kin28 kinase in the early …             Probing the impact of temperature on molecular events in a developmental system ▶     David Cheung, Jun Ma     A well-appreciated general feature of development is the ability to achieve a normal outcome despite the inevitable variability at molecular, genetic, or environmental levels. …             Alpha-ring Independent Assembly of the 20S Proteasome ▶     Dilrajkaur Panfair, Aishwarya Ramamurthy, Andrew R. Kusmierczyk     Archaeal proteasomes share many features with their eukaryotic counterparts and serve as important models for assembly. Proteasomes are also found in certain bacterial lineages …             A Branching Process to Characterize the Dynamics of Stem Cell Differentiation ▶     David G. Míguez     The understanding of the regulatory processes that orchestrate stem cell maintenance is a cornerstone in developmental biology. Here, we present a mathematical model based on a …             Histone H3K4me3 and H3K27me3 regulatory genes control stable transmission of an epimutation in rice ▶     Xiangsong Chen, Xiaoyun Liu, Yu Zhao et al.     DNA methylation loss can produce inheritable active epialleles in plants. The mechanism involved in the stable transmission of hypomethylated epimuations is presently not clear. …             Cultivating the uncultured: growing the recalcitrant cluster-2 Frankia strains ▶     Maher Gtari, Faten Ghodhbane-Gtari, Imen Nouioui et al.     The repeated failures reported in cultivating some microbial lineages are a major challenge in microbial ecology and probably linked, in the case of Frankia microsymbionts to …             Extreme variation in patterns of tandem repeats in mitochondrial control region of yellow-browed tits (Sylviparus modestus, Paridae) ▶     Xiaoyang Wang, Nian Liu, Hongli Zhang et al.     To investigate the evolutionary pattern and origins of tandem repeats in the mitochondrial control region of the yellow-browed tit (Sylviparus modestus), the control region and …             A new basal sauropod from the pre-Toarcian Jurassic of South Africa: evidence of niche-partitioning at the sauropodomorph–sauropod boundary? ▶     Blair W. McPhee, Matthew F. Bonnan, Adam M. Yates et al.     The early evolution of sauropod dinosaurs remains poorly understood, with a paucity of unequivocal sauropod taxa known from the first twenty million years of the Jurassic. …             Singapore Grouper Iridovirus ORF75R is a Scaffold Protein Essential for Viral Assembly ▶     Fan Wang, Yang Liu, Yi Zhu et al.     Singapore Grouper Iridovirus (SGIV) is a member of nucleo cytoplasmic large DNA viruses (NCLDV). This paper reports the functional analysis of ORF75R, a major structural protein …             Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes ▶     Liina Tserel, Raivo Kolde, Maia Limbach et al.     Human ageing affects the immune system resulting in an overall decline in immunocompetence. Although all immune cells are affected during aging, the functional capacity of T …             Vervets revisited: A quantitative analysis of alarm call structure and context specificity ▶     Tabitha Price, Philip Wadewitz, Dorothy Cheney et al.     The alarm calls of vervet monkeys (Chlorocebus pygerythrus) constitute the classic textbook example of semantic communication in nonhuman animals, as vervet monkeys give …             Investigation of Human Cancers for Retrovirus by Low-Stringency Target Enrichment and High-Throughput Sequencing ▶     Lasse Vinner, Tobias Mourier, Jens Friis-Nielsen et al.     Although nearly one fifth of all human cancers have an infectious aetiology, the causes for the majority of cancers remain unexplained. Despite the enormous data output from …             Comparison of individual component deletions in a glucose-specific phosphotransferase system revealed their different applications ▶     Quanfeng Liang, Fengyu Zhang, Yikui Li et al.     The phosphoenolpyruvate-dependent glucose-specific phosphotransferase system (PTSGlc) is the main glucose uptake pathway in Escherichia coli that affects both substrate …             Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case ▶     Wei Liu, Xuefeng Bai, Yuejuan Liu et al.     Precise cancer classification is a central challenge in clinical cancer research such as diagnosis, prognosis and metastasis prediction. Most existing cancer classification …             Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells ▶     Ana Rosa Soares, Tania Martins-Marques, Teresa Ribeiro-Rodrigues et al.     Intercellular communication is vital to ensure tissue and organism homeostasis and can occur directly, between neighbour cells via gap junctions (GJ), or indirectly, at longer …             Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives ▶     Lan-Xiang Liu, Xue-Quan Wang, Bei Zhou et al.     A series of novel N-substituted carbazole imidazolium salt derivatives has been prepared and investigated for their cytotoxic activity against five human tumor cell lines by MTS …             Elevated expression of mechanosensory polycystins in human carotid atherosclerotic plaques: association with p53 activation and disease severity ▶     Aimilia Varela, Christina Piperi, Fragiska Sigala et al.     Atherosclerotic plaque formation is associated with irregular distribution of wall shear stress (WSS) that modulates endothelial function and integrity. Polycystins (PC)-1/-2 …             Prognostic value of CD44 expression in renal cell carcinoma: a systematic review and meta-analysis ▶     Xintao Li, Xin Ma, Luyao Chen et al.     CD44 is a marker of cancer stem-like cells in renal cell carcinoma (RCC). However, the prognostic value of CD44 in RCC remains controversial. This study evaluated the correlation …             The Phosphorylation Profile of Myosin Binding Protein-C Slow is Dynamically Regulated in Slow-Twitch Muscles in Health and Disease ▶     Maegen A. Ackermann, Jaclyn P. Kerr, Brendan King et al.     Myosin Binding Protein-C slow (sMyBP-C) is expressed in skeletal muscles where it plays structural and regulatory roles. The functions of sMyBP-C are modulated through …             Sensory eye balance in surgically corrected intermittent exotropes with normal stereopsis ▶     Lixia Feng, Jiawei Zhou, Li Chen et al.     Surgery to align a deviated or strabismic eye is often done for both functional as well as cosmetic reasons. Although amblyopia is often an impediment to regaining full …             Assessing the genetic diversity of Cu resistance in mine tailings through high-throughput recovery of full-length copA genes ▶     Xiaofang Li, Yong-Guan Zhu, Babak Shaban et al.     Characterizing the genetic diversity of microbial copper (Cu) resistance at the community level remains challenging, mainly due to the polymorphism of the core functional gene …             Myosin Binding Protein-C Slow Phosphorylation is Altered in Duchenne Dystrophy and Arthrogryposis Myopathy in Fast-Twitch Skeletal Muscles ▶     Maegen A. Ackermann, Christopher W. Ward, Christina Gurnett et al.     Myosin Binding Protein-C slow (sMyBP-C), encoded by MYBPC1, comprises a family of regulatory proteins of skeletal muscles that are phosphorylated by PKA and PKC. MYBPC1 missense …             Aldosterone induces clonal β-cell failure through glucocorticoid receptor ▶     Fang Chen, Jia Liu, Yanyang Wang et al.     Aldosterone excess causes insulin resistance in peripheral tissues and directly impairs the function of clonal β-cell. The aim of this study was to investigate the molecular …             Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy ▶     Xiaojie Zhu, Yun Zhu, Sheng Ye et al.     Enfuvirtide (T20), is the first HIV fusion inhibitor approved for treatment of HIV/AIDS patients who fail to respond to the current antiretroviral drugs. However, its clinical …             Effect of Short-Term Mobile Phone Base Station Exposure on Cognitive Performance, Body Temperature, Heart Rate and Blood Pressure of Malaysians ▶     F. Malek, K. A. Rani, H. A. Rahim et al.     Individuals who report their sensitivity to electromagnetic fields often undergo cognitive impairments that they believe are due to the exposure of mobile phone technology. The …             Long- and Short-Range Electrostatic Fields in GFP Mutants: Implications for Spectral Tuning ▶     M. Drobizhev, P. R. Callis, R. Nifosì et al.     The majority of protein functions are governed by their internal local electrostatics. Quantitative information about these interactions can shed light on how proteins work and …             A Nucleus-Imaging Probe That Selectively Stabilizes a Minor Conformation of c-MYC G-quadruplex and Down-regulates c-MYC Transcription in Human Cancer Cells ▶     Deepanjan Panda, Manish Debnath, Samir Mandal et al.     The c-MYC proto-oncogene is a regulator of fundamental cellular processes such as cell cycle progression and apoptosis. The development of novel c-MYC inhibitors that can act by …             Functional Analysis and Characterization of Differential Coexpression Networks ▶     Chia-Lang Hsu, Hsueh-Fen Juan, Hsuan-Cheng Huang     Differential coexpression analysis is emerging as a complement to conventional differential gene expression analysis. The identified differential coexpression links can be …             Facing the environment: onset and development of UV markings in young fish ▶     Monica Gagliano, Martial Depczynski, Ulrike E. Siebeck     Most colour patterns in animals represent an elegant compromise between conspicuousness to ensure effective communication with preferred receivers and camouflage to avoid …             Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of self-complementary AAV1 vector ▶     Kohei Hironaka, Yoshiyuki Yamazaki, Yukihiko Hirai et al.     Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by a functional deficiency in human arylsulfatase A (hASA). We recently reported that ependymal cells and …             Functional traits drive the contribution of solar radiation to leaf litter decomposition among multiple arid-zone species ▶     Xu Pan, Yao-Bin Song, Guo-Fang Liu et al.     In arid zones, strong solar radiation has important consequences for ecosystem processes. To better understand carbon and nutrient dynamics, it is important to know the …             Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma ▶     Hongjun Wang, Tao Tao, Wei Yan et al.     The goal of this work was to explore the most effective miRNAs affecting glioblastoma multiforme (GBM) phenotype transition and malignant progression. We annotated 491 TCGA …             Imaging Cells in Flow Cytometer Using Spatial-Temporal Transformation ▶     Yuanyuan Han, Yu-Hwa Lo     Flow cytometers measure fluorescence and light scattering and analyze multiple physical characteristics of a large population of single cells as cells flow in a fluid stream …             ABCG2 transporter inhibitor restores the sensitivity of triple negative breast cancer cells to aminolevulinic acid-mediated photodynamic therapy ▶     Pratheeba Palasuberniam, Xue Yang, Daniel Kraus et al.     Photosensitizer protoporphyrin IX (PpIX) fluorescence, intracellular localization and cell response to photodynamic therapy (PDT) were analyzed in MCF10A normal breast epithelial …             Systemic modeling myeloma-osteoclast interactions under normoxic/hypoxic condition using a novel computational approach ▶     Zhiwei Ji, Dan Wu, Weiling Zhao et al.     Interaction of myeloma cells with osteoclasts (OC) can enhance tumor cell expansion through activation of complex signaling transduction networks. Both cells reside in the bone …             OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation ▶     Huarong Chen, Renduo Song, Guohui Wang et al.     Translation is a fundamental cellular process, and its dysregulation can contribute to human diseases such as cancer. During translation initiation the eukaryotic initiation …             CaMKII regulates the strength of the epithelial barrier ▶     Ryo Shiomi, Kenta Shigetomi, Tetsuichiro Inai et al.     Epithelial cells define the boundary between the outside and the inside of our body by constructing the diffusion barrier. Tight junctions (TJs) of epithelial cells function as …             Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27 ▶     Xiaojuan Yu, Senyan Zhang, Liwei Jiang et al.     The recently reported Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans with an approximately 30% mortality rate. The envelope …             Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis ▶     Yinghua Xu, Bin Liu, Kirsi Gröndahl-Yli-Hannuksila et al.     Herd immunity can potentially induce a change of circulating viruses. However, it remains largely unknown that how bacterial pathogens adapt to vaccination. In this study, …             SRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndrome ▶     Mohammad Alinoor Rahman, Yoshiteru Azuma, Farhana Nasrin et al.     The catalytic subunits of acetylcholinesterase (AChE) are anchored in the basal lamina of the neuromuscular junction using a collagen-like tail subunit (ColQ) encoded by COLQ. …             Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain ▶     Lisa Kunsmann, Christian Rüter, Andreas Bauwens et al.     The highly virulent Escherichia coli O104:H4 that caused the large 2011 outbreak of diarrhoea and haemolytic uraemic syndrome secretes blended virulence factors of …                 Nature Publishing Group offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. 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