Nature Reviews Neuroscience contents September 2015 Volume 16 Number 9 pp 507-574

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TABLE OF CONTENTS
September 2015 Volume 16 Number 9
Impact Factor 31.427 *	In this issue Research Highlights Progress Reviews Perspectives Also this month  Featured article: Auditory dysfunction in schizophrenia: integrating clinical and basic features Daniel C. Javitt & Robert A. Sweet
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RESEARCH HIGHLIGHTS Top Neural coding: Speed awareness p507 | doi:10.1038/nrn4008 A new study identifies a population of 'speed cells' in the rat medial entorhinal cortex that is likely to contribute to path integration. PDF Neuropharmacology: Pain relief without pairing up p508 | doi:10.1038/nrn4007 The formation of a heteromer between cannabinoid 1 receptor and 5-hydroxytryptamine (serotonin) receptor 2A in the brain is required for cannabinoid-induced cognitive impairment, but not analgesia, in mice. PDF Neurotransmission: Sticking the brakes on p508 | doi:10.1038/nrn4013 Presynaptic β-neurexins regulate synaptic strength at excitatory synapses by modulating endocannabinoid signalling. PDF Neurodegeneration: Reelin' from loss p509 | doi:10.1038/nrn4006 In the adult mouse CNS, reelin protects against amyloid-β-induced synaptic and behavioural deficits. PDF Neurodegenerative disease: A neutrophil invasion p510 | doi:10.1038/nrn4014 Neutrophil infiltration of the brain drives cognitive decline in mouse models of Alzheimer disease and is regulated by the integrin LFA-1. PDF IN BRIEF Genes and disease: Organoids assist in ASD research | Sensory processing: Itchy astrocytes | Neuronal circuits: Peckish flies are less picky | Glia: Gasping for breath | Cerebral Cortex: Cortical reconstruction | Learning and memory: Demethylated learning | Circadian rhythms: The rhythm regulator | Neurotransmitter receptors: Recoding the pathways PDF Neuroscience JOBS of the week Postdoctoral positions in Molecular Neuroscience The John Hopkins University School of Medicine Postdoctoral Position: Molecular and Functional Neuroscience Tulane University Postdoctoral Position in Migraine and Pain Research Washington University School of Medicine Associate or Full Professor / Director, Alzheimer's Disease Cooperative Study (ADCS) University of California San Diego Doctoral Program Fellowships Graduate School of Life Sciences (GSLS), University of Würzburg More Science jobs from Neuroscience EVENT Neuroscience R&D Technologies Conference 03.12.15 Barcelona, Spain More science events from
PROGRESS		Top
NaV1.9: a sodium channel linked to human pain Sulayman D. Dib-Hajj, Joel A. Black & Stephen G. Waxman p511 | doi:10.1038/nrn3977 Emerging evidence suggests a role for the voltage-gated sodium channel NaV1.9 in pain. In this Progress article, Dib-Hajj, Black and Waxman analyse the findings from three studies that report mutations in the gene encoding NaV1.9 in pain disorders, and suggest that NaV1.9 may be a potential therapeutic target for pain. Abstract | Full Text | PDF
REVIEWS		Top
Finding the engram Sheena A. Josselyn, Stefan Köhler & Paul W. Frankland p521 | doi:10.1038/nrn4000 Memory storage is thought to be mediated by lasting physical changes, or engrams, in the brain. In this Review, Josselyn and colleagues discuss characteristics of the engram and describe the recent progress that has been made in identifying neurons involved in specific engrams. Abstract | Full Text | PDF
Auditory dysfunction in schizophrenia: integrating clinical and basic features Daniel C. Javitt & Robert A. Sweet p535 | doi:10.1038/nrn4002 Schizophrenia is characterized by various neurocognitive deficits, including impairments in auditory function. In this Review, Javitt and Sweet examine the behavioural, neurophysiological and structural evidence for auditory cortical dysfunction in this disorder and explore some of the possible underlying mechanisms. Abstract | Full Text | PDF
From the genetic architecture to synaptic plasticity in autism spectrum disorder Thomas Bourgeron p551 | doi:10.1038/nrn3992 Recent years have seen considerable interest in the genetics of autism spectrum disorder (ASD). In this Review, Thomas Bourgeron examines the genetic architecture of this disorder and how ASD-linked mutations might affect synaptic plasticity, before exploring the synaptic homeostasis hypothesis of ASD. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome Frances K. Wiseman et al. p564 | doi:10.1038/nrn3983 Individuals with Down syndrome have an enhanced risk of developing early onset Alzheimer disease. Here, the authors describe the features of Alzheimer disease in Down syndrome and show how understanding the genetic and pathogenic mechanisms of this form of Alzheimer disease may shed light on more general mechanisms of neurodegeneration. Abstract | Full Text | PDF | Supplementary information
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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