Nature Reviews Molecular Cell Biology contents September 2015 Volume 16 Number 9 pp 515-576

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TABLE OF CONTENTS
September 2015 Volume 16 Number 9
Impact Factor 37.806 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Post-translational modifications Article series: Technologies and techniques  Featured article: Specificity and nonspecificity in RNA–protein interactions Eckhard Jankowsky & Michael E. Harris
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RESEARCH HIGHLIGHTS Top Organelle dynamics: Regulation of mitochondrial function by diet p515 | doi:10.1038/nrm4049 Stearic acid covalently binds to transferrin receptor protein 1 (TFR1) and inhibits TFR1-JNK signalling and E3 ubiquitin ligase HUWE1-mediated ubiquitylation of mitofusin, ensuring proper mitochondrial fusion and function. PDF Cell cycle: Repurposing MYC and E2F in the absence of RB p516 | doi:10.1038/nrm4044 This study shows the mechanism by which, in the absence of RB, MYC and E2F proteins drive unregulated cell proliferation in the intestine. PDF Translation: Competition at the ribosome exit site p516 | doi:10.1038/nrm4046 The nascent polypeptide-associated complex (NAC) at the ribosome exit site contributes to correct targeting of nascent chains by determining whether MetAP or SRP associate with the ribosome. PDF Cell migration: EMT promotes contact inhibition of locomotion p518 | doi:10.1038/nrm4045 Neural crest cells switch from expressing E-cadherin to expressing N-cadherin to undergo contact inhibition of locomotion. PDF IN BRIEF RNA metabolism: ADAR1 suppresses the recognition of self dsRNA | Cell division: Relaxation at the poles | Technique: Mapping DNA G-quadruplex structures | Transcription: PAF1 regulates promoter-proximal pausing | Metabolism: Human bone marrow can make fat | Gene expression: PolyQ repeats regulate transcription PDF Molecular Cell Biology JOBS of the week Two Postdoctoral Fellowships: In Protein NMR and in Molecular and Cell Biology IRIC / Université de Montreal Postdoctoral Scientist Helmholtz Association Post-Doctoral / Senior Research Northwestern University Postdoctoral Position - Developmental Biology Institut Pasteur Postdoc Research Associate - Orthopaedic Surgery Washington University School of Medicine More Science jobs from Molecular Cell Biology EVENT More science events from
REVIEWS		Top
Article series: Post-translational modifications DNA methylation pathways and their crosstalk with histone methylation Jiamu Du, Lianna M. Johnson, Steven E. Jacobsen & Dinshaw J. Patel p519 | doi:10.1038/nrm4043 DNA methylation and H3K9 methylation are typically associated with gene silencing. Genetic, genomic, structural and biochemical data reveal functional connections between these two epigenetic marks. They also highlight how specialized protein domains that recognize the marks are essential for their establishment and maintenance at appropriate genomic loci. Abstract | Full Text | PDF
Specificity and nonspecificity in RNA-protein interactions Eckhard Jankowsky & Michael E. Harris p533 | doi:10.1038/nrm4032 Measurement of protein binding to a large number of RNA variants reveals binding patterns and helps to quantify binding specificities, which enables the development of RNA–protein interaction models. Such models are changing the binary view of RNA binding by proteins as either specific or nonspecific. Abstract | Full Text | PDF
The molecular era of the mitochondrial calcium uniporter Kimberli J. Kamer & Vamsi K. Mootha p545 | doi:10.1038/nrm4039 The recent discovery of the genes encoding components of the mitochondrial calcium uniporter paves the way for further study of its mechanism of action and its relevance to physiological and pathological processes. Abstract | Full Text | PDF
Article series: Technologies and techniques Microfluidics: reframing biological enquiry Todd A. Duncombe, Augusto M. Tentori & Amy E. Herr p554 | doi:10.1038/nrm4041 The unique physical and chemical properties of microfluidic devices have underpinned notable recent advances in molecular cell biology research and will facilitate a new era of biological enquiry of increased precision. Abstract | Full Text | PDF
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PERSPECTIVES		Top
INNOVATION Article series: Technologies and techniques Bricks and blueprints: methods and standards for DNA assembly Arturo Casini, Marko Storch, Geoffrey S. Baldwin & Tom Ellis p568 | doi:10.1038/nrm4014 DNA assembly methods are essential to the field of synthetic biology. Casini et al. discuss the powerful DNA assembly methods and standards developed in the past decade that facilitate the streamlined assembly of genetic networks and even of whole chromosomes and cells. Abstract | Full Text | PDF
Corrigendum: Three-dimensional genome architecture: players and mechanisms Ana Pombo & Niall Dillon p576 | doi:10.1038/nrm4042 Full Text | PDF
Erratum: Short- and long-term effects of chromosome mis-segregation and aneuploidy Stefano Santaguida & Angelika Amon p576 | doi:10.1038/nrm4047 Full Text | PDF
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