Nature Reviews Microbiology contents September 2015 Volume 13 Number 9 pp 525-598

TABLE OF CONTENTS
September 2015 Volume 13 Number 9
Impact Factor 23.574*	In this issue Research Highlights News and Analysis Reviews Perspectives Also this month Article series: New technologies: methods and applications Vector-borne diseases Also this month  Featured article: Staphylococcal manipulation of host immune responses Vilasack Thammavongsa, Hwan Keun Kim, Dominique Missiakas & Olaf Schneewind
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RESEARCH HIGHLIGHTS Top Antimicrobials: Novel antibodies defeat dengue virus p525 | doi:10.1038/nrmicro3542 Two recent studies report the development of monoclonal antibodies directed against novel epitopes within the viral envelope protein of dengue virus that prevent severe infection in mouse models. PDF Biofilms: Oscillations relieve the siege p526 | doi:10.1038/nrmicro3535 A new study shows that a Bacillus subtilis biofilm community uses metabolic co-dependency to produce growth oscillations that resolve a siege-like metabolic conflict. PDF Microbial ecology: Sorting out viral dark matter p526 | doi:10.1038/nrmicro3541 This study uses a new tool, VirSorter, to search for virus genomes within all publicly available bacterial and archaeal genomic datasets and finds 264 new candidate viral genera. PDF IN BRIEF Bacterial physiology: Hip persisters | Bacterial toxins: Toxins actin(g) up | Vaccines: A protective Ebola vaccine | Structural biology: T6SS cases its own tail | Microbiome: An encrypted growth signature | Bacterial genomics: Evolution of hypervirulence in Klebsiella PDF
NEWS AND ANALYSIS		Top
Genome watch: Looking at Beijing's skyline Dorota Jamrozy & Teemu Kallonen p528 | doi:10.1038/nrmicro3536 This month's Genome Watch explores recent findings on the global population structure and the origin of the successful Mycobacterium tuberculosis Beijing lineage revealed by high-throughput sequencing of global bacterial collections. PDF
REVIEWS		Top
Staphylococcal manipulation of host immune responses Vilasack Thammavongsa, Hwan Keun Kim, Dominique Missiakas & Olaf Schneewind p529 | doi:10.1038/nrmicro3521 During recurrent staphylococcal infections, Staphylococcus aureus uses several strategies to evade detection by the host immune system. In this Review, Schneewind and colleagues describe the staphylococcal factors that manipulate innate and adaptive immune responses through inhibition, modification and phagocyte destruction. Abstract | Full Text | PDF
The yin and yang of hepatitis C: synthesis and decay of hepatitis C virus RNA You Li, Daisuke Yamane, Takahiro Masaki & Stanley M. Lemon p544 | doi:10.1038/nrmicro3506 In this Review, Lemon and colleagues describe the interactions of the RNA genome of hepatitis C virus with various host proteins and microRNAs. They discuss how these interactions affect viral RNA synthesis and decay, and how they influence the long-term persistence of the virus. Abstract | Full Text | PDF
Article series: Article series: New technologies: methods and applications Bacterial protein networks: properties and functions Athanasios Typas & Victor Sourjik p559 | doi:10.1038/nrmicro3508 In this Review, Sourjik and Typas describe the principles of protein-protein interaction networks and the current experimental approaches used to probe these networks in bacteria. They consider how these techniques have led to an increased understanding of the chemotaxis and cell cycle networks in Escherichia coli, highlighting the applicability of such methods to understanding diverse bacterial processes. Abstract | Full Text | PDF | Supplementary information
Article series: Article series: Vector-borne diseases Sexual development in Plasmodium parasites: knowing when it's time to commit Gabrielle A. Josling & Manuel Llinas p573 | doi:10.1038/nrmicro3519 For transmission from mammalian host to mosquito vector, blood-stage malaria parasites must convert from an asexual form to the sexual gametocyte through a process known as gametocytogenesis. In this Review, Josling and Llinas discuss recent studies that have begun to elucidate the molecular basis of this process, in particular the factors involved in commitment to gametocytogenesis. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Unveiling the pathogen behind the vacuole Peter Liehl, Vanessa Zuzarte-Luis & Maria M. Mota p589 | doi:10.1038/nrmicro3504 Following host cell invasion, many bacterial and parasitic pathogens hide from the immune system in an intracellular vacuolar niche. In this Opinion article, Mota and colleagues discuss how these 'professional' vacuolar pathogens can remain susceptible to recognition and clearance by the host. Abstract | Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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