Nature Immunology Contents: September 2015 Volume 16 pp 891 - 999

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TABLE OF CONTENTS September 2015 Volume 16, Issue 9 Correspondence News and Views Commentary Research Highlights Review Articles Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Microbiology: Call for Papers Launching in January 2016, Nature Microbiology is now open for submissions and inviting high-quality submissions. The journal will cover all aspects of microorganisms be it their evolution, physiology and cell biology, their interactions with each other, with a host, with an environment, or their societal significance.  Submit your next research paper to the journal.     Correspondence Top CD8+ T cell diversification by asymmetric cell division   pp891 - 893 Michael Flossdorf, Jens Rössler, Veit R Buchholz, Dirk H Busch and Thomas Höfer doi:10.1038/ni.3235 See also: Correspondence by Arsenio et al. Reply to: "CD8+ T cell diversification by asymmetric cell division"   pp893 - 894 Janilyn Arsenio, Boyko Kakaradov, Patrick J Metz, Gene W Yeo and John T Chang doi:10.1038/ni.3234 See also: Correspondence by Flossdorf et al. News and Views Top Co-ordination of intrathymic self-representation   pp895 - 896 Graham Anderson and William E Jenkinson doi:10.1038/ni.3251 Intrathymic expression of self antigens is key for central tolerance. RNA-sequencing analysis of tissue-restricted antigens in individual medullary thymic epithelial cells reveals co-ordination in the gene-expression patterns that ensures effective self-representation for the production of self-tolerant T cells. See also: Article by Brennecke et al. | Article by Meredith et al. IL-26 AMPs up the TH17 arsenal   pp897 - 898 Jacob S Lee and Daniel J Cua doi:10.1038/ni.3256 A previously unknown function for TH17 cell-derived IL-26 as a direct antimicrobial agent and activator of DNA-sensing innate immunity is now reported. See also: Article by Meller et al. LRRK2 and Nod2 promote lysozyme sorting in Paneth cells   pp898 - 900 Juliana D B Rocha, Michael G Schlossmacher and Dana J Philpott doi:10.1038/ni.3255 Paneth cell dysfunction has been linked to Crohn's disease. Nod2 and LRRK2, two genetic susceptibility factors for this disease, are now shown to have a role in regulating the sorting of lysozyme in Paneth cells and its secretion into the crypt space and, ultimately, in maintenance of the intestinal barrier. See also: Article by Zhang et al. TCF-1 and LEF-1 help launch the TFH program   pp900 - 901 Masato Kubo doi:10.1038/ni.3254 Follicular helper T cells (TFH cells) differentiate from naive T cells, but the picture of this differentiation process remains incomplete. Two studies now identify the related transcriptional regulators TCF-1 and LEF-1 as important early participants in this process. See also: Article by Choi et al. | Article by Xu et al. Immunology JOBS of the week Scientist / Sr. Scientist Immunology Valera Postdoc Scientist Immunology Universitätsklinikum Heidelberg Senior Scientist – Center for Immuno-Oncology Dana-Farber Cancer Institute (DFCI) Tenure-Track Assistant Professor Faculty Position Duke University Medical Center Professor in Haematopathology Combined with a Post as Specialist Physician Uppsala University Hospital More Science jobs from Immunology EVENT IMMUNOLOGY 2016™ - AAI Annual Meeting 13th May - 17th May 2016 Seattle, USA More science events from Commentary Top Teaching 'big data' analysis to young immunologists   pp902 - 905 Joachim L Schultze doi:10.1038/ni.3250 Everyone and everything seems to go 'big data' these days. The task ahead will be to train young immunologists to formulate intelligent hypotheses using big data resources. Research Highlights Top Neonatal non-responsiveness | Engineered for success | Oral mucosa Langerhans cells | RORγt+ Treg cells | Nociceptors in asthma | Neutrophil contributions to tumors Review Top Phagocytosis of apoptotic cells in homeostasis   pp907 - 917 Sanja Arandjelovic and Kodi S Ravichandran doi:10.1038/ni.3253 Billions of cells in the body die through apoptosis every day and are cleared by both professional and non-professional phagocytes. Arandjelovic and Ravichandran review how apoptotic cell clearance is critical for immune homeostasis. Advertisement Ultra-Sensitive Biomarker Assay Service from PBL Assay Science  Dedicated assay team to execute & develop fit-for-purpose Single Molecule Array (SIMOA™) immunoassays: IL-6, IL-10, IL-17A, IL-23, IP-10, TNFa, TRAIL, 3-plexes, custom fg/ml sensitivities for analytes in serum, plasma, & other matrices Multiplexing capabilities  Let PBL help with your complex assay needs.    Articles Top Commensal bacteria direct selective cargo sorting to promote symbiosis   pp918 - 926 Qin Zhang, Ying Pan, Ruiqing Yan, Benhua Zeng, Haifang Wang et al. doi:10.1038/ni.3233 Mucosal immunity is influenced by commensal bacteria. Liu and colleagues show that commensals direct selective cargo sorting in Paneth cells through the cytosolic sensor NOD2 and the kinase LRRK2 to promote symbiosis. See also: News and Views by Rocha et al. Antigen-specific NK cell memory in rhesus macaques   pp927 - 932 R Keith Reeves, Haiying Li, Stephanie Jost, Eryn Blass, Hualin Li et al. doi:10.1038/ni.3227 Recent studies have shown features of antigen-specific memory in mouse NK cells, but it is unclear whether this phenomenon also exists in primates. Barouch and colleagues provide evidence for robust, durable, antigen-specific NK cell memory induced in primates after infection or vaccination. Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells   pp933 - 941 Philip Brennecke, Alejandro Reyes, Sheena Pinto, Kristin Rattay, Michelle Nguyen et al. doi:10.1038/ni.3246 How expression of tissue-restricted self-antigens (TRA) is coordinated in medullary thymic epithelial cells (mTECs) remains unclear. Steinmetz and colleagues use single-cell RNA-sequencing to describe clusters of co-expressed TRAs. See also: News and Views by Anderson & Jenkinson Aire controls gene expression in the thymic epithelium with ordered stochasticity   pp942 - 949 Matthew Meredith, David Zemmour, Diane Mathis and Christophe Benoist doi:10.1038/ni.3247 How expression of tissue-restricted self antigens is coordinated in medullary thymic epithelial cells has remained unclear. Benoist and colleagues use single-cell RNA sequencing to identify clusters of co-expressed tissue-restricted antigens. See also: News and Views by Anderson & Jenkinson The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells   pp950 - 960 Almut Dufner, Agnes Kisser, Sandra Niendorf, Anja Basters, Sonja Reissig et al. doi:10.1038/ni.3230 Post-translational modifications regulate various signaling cascades downstream of the TCR. Knobeloch and colleagues show that the deubiquitinase USP8 is required for thymocyte development by interacting with the adaptor Gads upon TCR stimulation. T cell receptor dwell times control the kinase activity of Zap70   pp961 - 969 Christian Klammt, Lucie Novotná, Dongyang T Li, Miriam Wolf, Amy Blount et al. doi:10.1038/ni.3231 Recruitment of the kinase Zap70 to the T cell receptor (TCR) is essential for signal transduction. Lillemeier and colleagues show that the conformation of Zap70 controls TCR dwell time, which in turn controls Zap70 activity. TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26   pp970 - 979 Stephan Meller, Jeremy Di Domizio, Kui S Voo, Heike C Friedrich, Georgios Chamilos et al. doi:10.1038/ni.3211 TH17 cells have important roles at mucosal surfaces in both health and disease. Gilliet and colleagues show that IL-26 is preferentially produced by human TH17 cells and that this cytokine has both alarmin and direct antimicrobial functions. See also: News and Views by Lee & Cua LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6   pp980 - 990 Youn Soo Choi, Jodi A Gullicksrud, Shaojun Xing, Zhouhao Zeng, Qiang Shan et al. doi:10.1038/ni.3226 Follicular helper T cells (TFH cells) are specialized effector CD4+ T cells that help B cells develop germinal centers and memory. Crotty and colleagues show that the transcription factors LEF-1 and TCF-1 are required for early TFH differentiation. See also: News and Views by Kubo The transcription factor TCF-1 initiates the differentiation of TFH cells during acute viral infection   pp991 - 999 Lifan Xu, Yi Cao, Zhunyi Xie, Qizhao Huang, Qiang Bai et al. doi:10.1038/ni.3229 Follicular helper T cells (TFH cells) require the transcription factor Bcl-6 and are antagonized by the transcription factor Blimp1 (encoded by Prdm1). Lilin Ye and colleagues show that acute viral infection induces the transcription factor TCF-1, which promotes TFH differentiation by enhancing Bcl6 expression while suppressing that of Prdm1. See also: News and Views by Kubo Top   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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