Nature Communications - 12 August 2015

Advertisement WHITE PAPER: The Role Of rasH2 In An Evolving Pharmaceutical Carcinogenicity Landscape  Changes to the ICH S1 guidelines have been proposed potentially transforming how pharmaceutical carcinogenicity evaluations are conducted. Download To Learn More About: The background and limitations of existing protocols The potential impact of proposed changes to ICH S1 guidelines. How the rasH2 transgenic mouse meets the proposed guidelines Download Now     Weekly Content Alert Nature Communications is now fully open access. Read more. 12 August 2015  Featured image: Dunham et al. show that the ability of the Ebola virus to inhibit interferon response has not increased during the current outbreak. 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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Whole-central nervous system functional imaging in larval Drosophila OPEN William C. Lemon, Stefan R. Pulver, Burkhard Höckendorf, Katie McDole, Kristin Branson, Jeremy Freeman and Philipp J. Keller To understand how neuronal networks function, it is important to measure neuronal network activity at the systems level. Here Lemon et al. develop a framework that combines a high-speed multi-view light-sheet microscope, a whole-CNS imaging assay and computational tools to demonstrate simultaneous functional imaging across the entire isolated Drosophila larval CNS. 11 August 2015 | doi: 10.1038/ncomms8924 Biological Sciences  Biotechnology  Developmental biology  Neuroscience  Single-neuron activity and eye movements during human REM sleep and awake vision OPEN Thomas Andrillon, Yuval Nir, Chiara Cirelli, Giulio Tononi and Itzhak Fried Since the discovery of rapid eye movements (REMs), a critical question endures as to whether they represent time points at which visual-like processing is updated. Here the authors demonstrate that cortical activity during sleep REMs shares many properties with that observed during saccades and vision. 11 August 2015 | doi: 10.1038/ncomms8884 Biological Sciences  Neuroscience  Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study OPEN G. Paul Amminger, Miriam R. Schäfer, Monika Schlögelhofer, Claudia M. Klier and Patrick D. McGorry Long-chain omega-3 polyunsaturated fatty acids are essential for neural development and lack of these fatty acids has been implicated in a number of mental health conditions. Here the authors report the longer-term efficacy of a randomized, double-blind, placebo-controlled clinical trial assessing the effects of fish oil capsules in individuals at ultrahigh risk for psychosis. 11 August 2015 | doi: 10.1038/ncomms8934 Biological Sciences  Medical research  Neuroscience  Water impacting on superhydrophobic macrotextures OPEN Anaïs Gauthier, Sean Symon, Christophe Clanet and David Quéré The behaviour of water impacting on surfaces is crucial to many applications, including anti-icings and self-cleaning. Here, Gauthier et al. show that the contact time of drops on a straight wire decreases with impact speed in a step manner due to the fragmentation of water in evenly divided subunits. 11 August 2015 | doi: 10.1038/ncomms9001 Physical Sciences  Applied physics  Fluids and plasma physics  Mitotic redistribution of the mitochondrial network by Miro and Cenp-F OPEN Gil Kanfer, Thibault Courthéoux, Martin Peterka, Sonja Meier, Martin Soste, Andre Melnik, Katarina Reis, Pontus Aspenström, Matthias Peter, Paola Picotti and Benoît Kornmann During mitosis, mitochondria partition into daughter cells through microtubule-based transport. Here the authors show that the mitochondrial protein Miro and the cytoskeletal-associated protein Cenp-F interact in a cell-cycle dependent manner to promote microtubule-directed movement of mitochondria. 11 August 2015 | doi: 10.1038/ncomms9015 Biological Sciences  Biochemistry  Cell biology  Refining the pathway of carbide insertion into the nitrogenase M-cluster OPEN Jared A. Wiig, Yilin Hu and Markus W. Ribbe Carbide insertion plays a pivotal role in the biosynthesis of M-cluster, the cofactor of nitrogenase. Here the authors further define the pathway for interstitial carbide atom insertion, showing that the SAM-derived methyl group is transferred to a FeS precursor sulfur before hydrogen abstraction via an SN2-type reaction. 11 August 2015 | doi: 10.1038/ncomms9034 Biological Sciences  Biochemistry  Chemical biology  Geographic range did not confer resilience to extinction in terrestrial vertebrates at the end-Triassic crisis Alexander M. Dunhill and Matthew A. Wills Rates of extinction vary through geological time. Here, the authors show that wider geographic range confers greater resilience to extinction in terrestrial vertebrates throughout the Triassic and Jurassic but geographic range is not associated with extinction resilience at the end-Triassic crisis. 11 August 2015 | doi: 10.1038/ncomms8980 Biological Sciences  Ecology  Evolution  Palaeontology  High spectral purity Kerr frequency comb radio frequency photonic oscillator OPEN W. Liang, D. Eliyahu, V. S. Ilchenko, A. A. Savchenkov, A. B. Matsko, D. Seidel and L. Maleki An optical frequency comb demodulated on a photodiode can generate a radio frequency signal with high spectral purity at a frequency corresponding to the comb spacing. Here, Liang et al. demonstrate a frequency-comb-based radio frequency photonic oscillator characterized with low phase noise and high frequency stability. 11 August 2015 | doi: 10.1038/ncomms8957 Physical Sciences  Applied physics  Optical physics  Resolving bundled microtubules using anti-tubulin nanobodies OPEN Marina Mikhaylova, Bas M. C. Cloin, Kieran Finan, Robert van den Berg, Jalmar Teeuw, Marta M. Kijanka, Mikolaj Sokolowski, Eugene A. Katrukha, Manuel Maidorn, Felipe Opazo, Sandrine Moutel, Marylin Vantard, Frank Perez, Paul M. P. van Bergen en Henegouwen, Casper C. Hoogenraad, Helge Ewers and Lukas C Kapitein Super-resolution imaging of microtubules requires labels that increase their apparent diameter, making it difficult to resolve individual microtubules within a bundle. Here, the authors develop single-chain antibody fragments against tubulin that enable closely spaced individual microtubules to be distinguished in cells. 11 August 2015 | doi: 10.1038/ncomms8933 Biological Sciences  Biotechnology  Cell biology  Improved binding site assignment by high-resolution mapping of RNA–protein interactions using iCLIP OPEN Christian Hauer, Tomaz Curk, Simon Anders, Thomas Schwarzl, Anne-Marie Alleaume, Jana Sieber, Ina Hollerer, Madhuri Bhuvanagiri, Wolfgang Huber, Matthias W. Hentze and Andreas E. Kulozik Individual-nucleotide resolution crosslinking and immunoprecipitation (iCLIP) can map RNA binding sites of RNA-binding proteins (RBPs). Here, the authors report an analysis tool that improves the binding site assignment for some RBPs that have length-dependent broader distribution for their iCLIP fragments. 11 August 2015 | doi: 10.1038/ncomms8921 Biological Sciences  Bioinformatics  Molecular biology  IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis OPEN Rei Nakamura, Abdoulaye Sene, Andrea Santeford, Abdelaziz Gdoura, Shunsuke Kubota, Nicole Zapata and Rajendra S. Apte Pathological neovascularization causes blinding eye disease. Here the authors show that IL10 activates STAT3 signalling in the macrophages in the ageing eye, promoting their polarization towards a pro-angiogenic phenotype; interfering with this pathway reverses the pathology in a mouse model. 11 August 2015 | doi: 10.1038/ncomms8847 Biological Sciences  Immunology  Direct oriented growth of armchair graphene nanoribbons on germanium OPEN Robert M. Jacobberger, Brian Kiraly, Matthieu Fortin-Deschenes, Pierre L. Levesque, Kyle M. McElhinny, Gerald J. Brady, Richard Rojas Delgado, Susmit Singha Roy, Andrew Mannix, Max G. Lagally, Paul G. Evans, Patrick Desjardins, Richard Martel, Mark C. Hersam, Nathan P. Guisinger and Michael S. Arnold Semiconducting armchair graphene nanoribbons with sub-10 nm width are of great technological importance but yet to realize. Here, the authors report growth of such nanoribbons on germanium and controlled crystallographic orientation and well-defined armchair edges are obtained. 10 August 2015 | doi: 10.1038/ncomms9006 Physical Sciences  Materials science  Nanotechnology  Sequential substitution of K+ bound to Na+,K+-ATPase visualized by X-ray crystallography OPEN Haruo Ogawa, Flemming Cornelius, Ayami Hirata and Chikashi Toyoshima The Na+,K+-ATPase moves three Na+ ions out of the cell and transfers two K+ ions in the opposite direction. Here the authors use X-ray crystallography to look at the substitution of two bound K+ with those in the medium and show that it occurs sequentially through a narrow gate. 10 August 2015 | doi: 10.1038/ncomms9004 Biological Sciences  Biochemistry  High diversity stabilizes the thermal resilience of pollinator communities in intensively managed grasslands OPEN Sara Kühsel and Nico Blüthgen How variation in species responses to climate may influence the resilience of ecological communities to environmental change is not fully understood. Here, the authors characterize the thermal niches of insect pollinator communities and show that resilience increases along a gradient of land-use intensity. 10 August 2015 | doi: 10.1038/ncomms8989 Biological Sciences  Ecology  Oestrogen sulfotransferase ablation sensitizes mice to sepsis Xiaojuan Chai, Yan Guo, Mengxi Jiang, Bingfang Hu, Zhigang Li, Jie Fan, Meihong Deng, Timothy R. Billiar, Heidi R. Kucera, Nilesh W. Gaikwad, Meishu Xu, Peipei Lu, Jiong Yan, Haiyan Fu, Youhua Liu, Lushan Yu, Min Huang, Su Zeng and Wen Xie Sepsis, a systemic inflammatory response to bacterial infection, can lead to organ failure and death. Here, Chai et al. investigate the mechanisms behind the septic response and identify the role of oestrogen sulfotransferase in this process in mice. 10 August 2015 | doi: 10.1038/ncomms8979 Biological Sciences  Immunology  Genome-wide analysis of the genetic regulation of gene expression in human neutrophils OPEN Anand Kumar Andiappan, Rossella Melchiotti, Tuang Yeow Poh, Michelle Nah, Kia Joo Puan, Elena Vigano, Doreen Haase, Nurhashikin Yusof, Boris San Luis, Josephine Lum, Dilip Kumar, Shihui Foo, Li Zhuang, Anusha Vasudev, Astrid Irwanto, Bernett Lee, Alessandra Nardin, Hong Liu, Furen Zhang, John Connolly et al. Neutrophils are abundant immune cells important for antimicrobial defence and in autoimmunity. Here, by mapping expression quantitative trait loci (eQTL) in neutrophils of Chinese ethnicity from Singapore, Andiappan et al. provide a resource for understanding immune-related trait associated genetic variants. 10 August 2015 | doi: 10.1038/ncomms8971 Biological Sciences  Genetics  Molecular biology  Decoding genome-wide GadEWX-transcriptional regulatory networks reveals multifaceted cellular responses to acid stress in Escherichia coli OPEN Sang Woo Seo, Donghyuk Kim, Edward J. O’Brien, Richard Szubin and Bernhard O. Palsson GadEWX regulons play a critical role in transcription regulation in response to acid stress. By reconstructing genome-wide GadEWX transcriptional network, here the authors show how GadEWX simultaneously coordinates many other cellular processes to produce the overall response of E. coli to acid stress. 10 August 2015 | doi: 10.1038/ncomms8970 Biological Sciences  Microbiology  Molecular biology  DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing OPEN Kazutaka Nishina, Wenying Piao, Kie Yoshida-Tanaka, Yumiko Sujino, Tomoko Nishina, Tsuyoshi Yamamoto, Keiko Nitta, Kotaro Yoshioka, Hiroya Kuwahara, Hidenori Yasuhara, Takeshi Baba, Fumiko Ono, Kanjiro Miyata, Koichi Miyake, Punit P. Seth, Audrey Low, Masayuki Yoshida, C. Frank Bennett, Kazunori Kataoka, Hidehiro Mizusawa et al. Antisense oligonucleotides (ASOs) can repress the expression of specific genes. Here, the authors show that a DNA/RNA heteroduplex oligonucleotide (HDO) with a structure different from ASOs is more potent in suppressing target gene expression, and causes a less adverse effect in mouse liver. 10 August 2015 | doi: 10.1038/ncomms8969 Biological Sciences  Biotechnology  Molecular biology  Adiabatic far-field sub-diffraction imaging OPEN Hu Cang, Alessandro Salandrino, Yuan Wang and Xiang Zhang Conventional optical imaging systems are limited in resolution by the decay of the evanescent wave carrying fine feature information. Here, Cang et al. propose an adiabatic lens that allows far-field optical systems to project an image of near-field features and achieve sub-50 nm imaging resolution in the visible. 10 August 2015 | doi: 10.1038/ncomms8942 Physical Sciences  Applied physics  Nanotechnology  Optical physics  Hydride bridge in [NiFe]-hydrogenase observed by nuclear resonance vibrational spectroscopy OPEN Hideaki Ogata, Tobias Krämer, Hongxin Wang, David Schilter, Vladimir Pelmenschikov, Maurice van Gastel, Frank Neese, Thomas B. Rauchfuss, Leland B. Gee, Aubrey D. Scott, Yoshitaka Yoda, Yoshihito Tanaka, Wolfgang Lubitz and Stephen P. Cramer Understanding the catalytic mechanism of redox-active hydrogenases is a key to efficient hydrogen production and consumption. Here, the authors use nuclear resonance vibrational spectroscopy to study [NiFe]-hydrogenase, and observe a bridging hydride structure in an EPR silent intermediate. 10 August 2015 | doi: 10.1038/ncomms8890 Chemical Sciences  Analytical chemistry  Biochemistry  Biophysics  Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis OPEN Uday Ganapathy, Joeli Marrero, Susannah Calhoun, Hyungjin Eoh, Luiz Pedro Sorio de Carvalho, Kyu Rhee and Sabine Ehrt Mycobacterium tuberculosis feeds on host fatty acids during infection, a process that requires a fructose bisphosphatase (FBPase) enzyme for gluconeogenesis. Here, Ganapathy et al. show that the bacterium has two different FBPases and that this enzymatic activity is required for full virulence. 10 August 2015 | doi: 10.1038/ncomms8912 Biological Sciences  Biochemistry  Microbiology  Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice Joseph R. Burgoyne, Olena Rudyk, Hyun-ju Cho, Oleksandra Prysyazhna, Natasha Hathaway, Amanda Weeks, Rachel Evans, Tony Ng, Katrin Schröder, Ralf P. Brandes, Ajay M. Shah and Philip Eaton The regulatory subunits (RI) of protein kinase A (PKA) form a disulfide bond in response to cellular hydrogen peroxide. Here the authors show that disulfide-activation of PKARIa regulates VEGF-induced angiogenesis in mice and may represent a new therapeutic target in diseases with abnormal angiogenesis. 10 August 2015 | doi: 10.1038/ncomms8920 Biological Sciences  Cell biology  Developmental biology  Medical research  A scalable and operationally simple radical trifluoromethylation OPEN Joel W. Beatty, James J. Douglas, Kevin P. Cole and Corey R. J. Stephenson Trifluoromethylation is a key transformation, particularly for pharmaceuticals, but many reagents are expensive and difficult to scale up. Here, the authors show that trifluoroacetic anhydride can act as a CF3 source, allowing the radical reactions to be easily and inexpensively carried out at scale. 10 August 2015 | doi: 10.1038/ncomms8919 Chemical Sciences  Catalysis  Organic chemistry  The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores OPEN Ho-Soo Lee, Yong-Yea Park, Mi-Young Cho, Sunyoung Chae, Young-Suk Yoo, Myung-Hee Kwon, Chang-Woo Lee and Hyeseong Cho Polo-like kinase 1 (PLK1) is recruited to kinetochores during mitosis, where it is required for proper chromosome alignment. Lee et al. show that the chromatin-remodelling factor RSF1 is required for PLK1 recruitment, and that this function depends on phosphorylation of RSF1 by the mitotic kinase CDK1. 10 August 2015 | doi: 10.1038/ncomms8904 Biological Sciences  Cell biology  Piezotransistive transduction of femtoscale displacement for photoacoustic spectroscopy OPEN Abdul Talukdar, M. Faheem Khan, Dongkyu Lee, Seonghwan Kim, Thomas Thundat and Goutam Koley Microelectromechanical systems—micrometre-sized devices with movable parts—make highly sensitive transducers. Here, the authors fabricate an integrated gallium nitride microcantilever and heterojunction field effect transistor that uses piezoelectric effects to measure displacement at the femtoscale level. 10 August 2015 | doi: 10.1038/ncomms8885 Physical Sciences  Applied physics  Nanotechnology  PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation OPEN Valeria Iansante, Pui Man Choy, Sze Wai Fung, Ying Liu, Jian-Guo Chai, Julian Dyson, Alberto Del Rio, Clive D’Santos, Roger Williams, Shilpa Chokshi, Robert A Anders, Concetta Bubici and Salvatore Papa Tumour cells can survive by evading cell death pathways and altering their metabolism to adapt to their local environment. In this study, Iansante et al. show that the anti-apoptotic protein PARP14 maintains low PKM2 activity, leading to enhanced glycolysis, demonstrating a link between suppression of apoptosis and altered metabolism. 10 August 2015 | doi: 10.1038/ncomms8882 Biological Sciences  Cancer  Cell biology  Nanometre-scale probing of spin waves using single-electron spins OPEN Toeno van der Sar, Francesco Casola, Ronald Walsworth and Amir Yacoby Exploring magnetic excitations and spin textures on the nanoscale may lead to new spintronic technologies and new understanding of condensed matter. Here, the authors demonstrate the potential of single-electron spins in diamond to image such excitations by characterizing spin waves in a ferromagnetic microdisc. 07 August 2015 | doi: 10.1038/ncomms8886 Physical Sciences  Applied physics  Nanotechnology  Molecular metal–Nx centres in porous carbon for electrocatalytic hydrogen evolution OPEN Hai-Wei Liang, Sebastian Brüller, Renhao Dong, Jian Zhang, Xinliang Feng and Klaus Müllen Hydrogen evolution from water promises a future clean energy source, however the cost of noble metal catalysts, which are necessary for high efficiency, are very expensive. Here, the authors fabricate a porous cobalt–nitrogen/carbon catalyst which can deliver high activity and stability but at reduced cost. 07 August 2015 | doi: 10.1038/ncomms8992 Chemical Sciences  Catalysis  Materials science  Physical chemistry  Super-resolution photoacoustic imaging through a scattering wall Donald B. Conkey, Antonio M. Caravaca-Aguirre, Jake D. Dove, Hengyi Ju, Todd W. Murray and Rafael Piestun With wavefront shaping, imaging through scattering walls is possible, but this technique requires generating feedback from behind the wall. Here, Conkey et al. use photoacoustic feedback for wavefront optimization for sub-acoustic resolution imaging behind a scattering wall with an improved signal-to-noise ratio. 07 August 2015 | doi: 10.1038/ncomms8902 Physical Sciences  Optical physics  A steep-slope transistor based on abrupt electronic phase transition OPEN Nikhil Shukla, Arun V. Thathachary, Ashish Agrawal, Hanjong Paik, Ahmedullah Aziz, Darrell G. Schlom, Sumeet Kumar Gupta, Roman Engel-Herbert and Suman Datta The intrinsic properties of conventional semiconductors limits the speed and efficiency of field-effect transistors. Here, the authors take advantage of the insulator-to-metal transition in vanadium dioxide to create a transistor with reversible and steep-slope switching at room temperature. 07 August 2015 | doi: 10.1038/ncomms8812 Physical Sciences  Applied physics  Materials science  Experimental superposition of orders of quantum gates OPEN Lorenzo M. Procopio, Amir Moqanaki, Mateus Araújo, Fabio Costa, Irati Alonso Calafell, Emma G. Dowd, Deny R. Hamel, Lee A. Rozema, Časlav Brukner and Philip Walther It has been conjectured that not only states but also quantum operations can be placed in a superposition of causal order. Here, the authors use a qubit superpose the order in which two photonic gates are applied, which is shown to enable a more efficient detection of their commutation relations. 07 August 2015 | doi: 10.1038/ncomms8913 Physical Sciences  Optical physics  Coupling of individual quantum emitters to channel plasmons OPEN Esteban Bermúdez-Ureña, Carlos Gonzalez-Ballestero, Michael Geiselmann, Renaud Marty, Ilya P. Radko, Tobias Holmgaard, Yury Alaverdyan, Esteban Moreno, Francisco J. García-Vidal, Sergey I. Bozhevolnyi and Romain Quidant The confined surface plasmon-polariton modes in plasmonic waveguides are a promising platform for single-photon manipulation in small, coplanar architectures. Here, Bermúdez Ureña et al. demonstrate efficient coupling of a single quantum emitter to the supported modes of a V-groove plasmonic waveguide. 07 August 2015 | doi: 10.1038/ncomms8883 Physical Sciences  Nanotechnology  Optical physics  Diastereomeric liquid crystal domains at the mesoscale Dong Chen, Michael R. Tuchband, Balazs Horanyi, Eva Korblova, David M. Walba, Matthew A. Glaser, Joseph E. Maclennan and Noel A. Clark Helical nanofilaments—composed of achiral, bent core molecules—have been shown to assemble into left- and right-handed structures. Here, the authors show diastereomeric interactions on the mesocale between chiral liquid crystal guest compounds and helical nanofilament-based pores. 07 August 2015 | doi: 10.1038/ncomms8763 Physical Sciences  Condensed matter  Nanotechnology  Optical physics  Superhydrophobic-like tunable droplet bouncing on slippery liquid interfaces OPEN Chonglei Hao, Jing Li, Yuan Liu, Xiaofeng Zhou, Yahua Liu, Rong Liu, Lufeng Che, Wenzhong Zhou, Dong Sun, Lawrence Li, Lei Xu and Zuankai Wang The impact of drops on surfaces is highly relevant to our daily life and many industrial applications, such as self-cleaning and ink printing. Here, Hao et al. show the transition from superhydrophobic-like drop bouncing, due to a trapped air layer, to substrate-dependent bouncing on a liquid thin film. 07 August 2015 | doi: 10.1038/ncomms8986 Physical Sciences  Applied physics  Fluids and plasma physics  Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif Petr Tesina, Kateřina Čermáková, Magdalena Hořejší, Kateřina Procházková, Milan Fábry, Subhalakshmi Sharma, Frauke Christ, Jonas Demeulemeester, Zeger Debyser, Jan De Rijck, Václav Veverka and Pavlína Řezáčová LEDGF/p75, a protein involved in HIV integration and leukaemia, interacts with various cellular proteins via its integrase binding domain (IBD). Here, the authors show that the interaction is mediated by an intrinsically disordered IBD-binding motif (IBM) on all known cellular partners of LEDGF/p75. 06 August 2015 | doi: 10.1038/ncomms8968 Biological Sciences  Biochemistry  Molecular biology  Structural basis for the blockade of MATE multidrug efflux pumps OPEN Martha Radchenko, Jindrich Symersky, Rongxin Nie and Min Lu MATE transporters confer bacterial multidrug resistance by transporting drugs across cell membranes. Here, the authors present new structures of the DinF and NorM MATE transporters and reveal insights into the mechanisms of substrate transport and MATE inhibition by small-molecule pharmaceuticals. 06 August 2015 | doi: 10.1038/ncomms8995 Biological Sciences  Biochemistry  Biophysics  An on-chip electrical transport spectroscopy approach for in situ monitoring electrochemical interfaces OPEN Mengning Ding, Qiyuan He, Gongming Wang, Hung-Chieh Cheng, Yu Huang and Xiangfeng Duan In situ probing electrochemical interfaces is important for the development of improved electrocatalysts. Here, the authors present an on-chip electrical transport spectroscopy approach, which enables in situ monitoring the dynamic electrochemical interface characteristics. 06 August 2015 | doi: 10.1038/ncomms8867 Chemical Sciences  Applied physics  Materials science  Design of a platform technology for systemic delivery of siRNA to tumours using rolling circle transcription OPEN Mihue Jang, Jong Hwan Kim, Hae Yun Nam, Ick Chan Kwon and Hyung Jun Ahn RNA interference has provided a promising tool to suppress the expression of specific genes associated with human diseases. Here, the authors present a platform technology for the systemic delivery of siRNA to tumour sites using rolling circle transcription. 06 August 2015 | doi: 10.1038/ncomms8930 Biological Sciences  Cancer  Nanotechnology  A C–H bond activation-based catalytic approach to tetrasubstituted chiral allenes OPEN Shangze Wu, Xin Huang, Wangteng Wu, Pengbin Li, Chunling Fu and Shengming Ma The enantioselective synthesis of tetrasubstituted allenes is a challenging task. Here, the authors report a rhodium-catalysed process for the coupling of alkynes with arenes, allowing access to fully substituted allenes—including enantioenriched products. 06 August 2015 | doi: 10.1038/ncomms8946 Chemical Sciences  Catalysis  Organic chemistry  MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation OPEN Julia R. Pon, Jackson Wong, Saeed Saberi, Olivia Alder, Michelle Moksa, S. -W. Grace Cheng, Gregg B. Morin, Pamela A. Hoodless, Martin Hirst and Marco A. Marra Mutations in the transcription factor MEF2B are found in diffuse large B-cell lymphoma. In this study, the authors map the DNA-binding sites of the transcription factor in cells in vitro and find that the mutations decrease the ability of MEF2B to activate transcription. 06 August 2015 | doi: 10.1038/ncomms8953 Biological Sciences  Cancer  Genetics  Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity OPEN Donald A. Winkelmann, Eva Forgacs, Matthew T. Miller and Ann M. Stock Omecamtiv Mecarbil (OM) is a small molecule allosteric effector of cardiac myosin in clinical trials for treatment of systolic heart failure. Here the authors determine the crystal structure of an OM-bound human β-cardiac myosin motor domain to provide molecular level insight into the mechanism of drug action. 06 August 2015 | doi: 10.1038/ncomms8974 Biological Sciences  Biophysics  Medicinal chemistry  Molecular biology  Multiphoton harvesting metal–organic frameworks OPEN Hong Sheng Quah, Weiqiang Chen, Martin K. Schreyer, Hui Yang, Ming Wah Wong, Wei Ji and Jagadese J. Vittal Metal–organic frameworks (MOFs) combining the properties of the metal ions and organic ligands are been proposed for many applications. Here Quah et al. demonstrate multiphoton excitation fluorescence in MOF materials enhanced by high quantum yielding guest molecules and Förster resonance energy transfer. 06 August 2015 | doi: 10.1038/ncomms8954 Physical Sciences  Inorganic chemistry  Materials science  Optical physics  Museum samples reveal rapid evolution by wild honey bees exposed to a novel parasite OPEN Alexander S. Mikheyev, Mandy M. Y. Tin, Jatin Arora and Thomas D. Seeley Introduction of pathogens can cause colony collapse in honey bees. Here, the authors use museum specimens to show widespread colony mortality but unaffected nuclear genetic diversity in a wild population of honey bees in North America following the introduction of ectoparasitic Varroa mites. 06 August 2015 | doi: 10.1038/ncomms8991 Biological Sciences  Ecology  Evolution  Destructive tsunami-like wave generated by surf beat over a coral reef during Typhoon Haiyan OPEN Volker Roeber and Jeremy D. Bricker The failure of a broad fringing coral reef to protect the village of Hemani from a tsunami-like wave during Typhoon Haiyan came as a destructive surprise. Here, the authors present results from a phase-resolving wave model and show that the steep reef face facilitated the release of energetic infragravity waves. 06 August 2015 | doi: 10.1038/ncomms8854 Earth Sciences  Oceanography  Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection OPEN Yvonne C. F. Su, Justin Bahl, Udayan Joseph, Ka Man Butt, Heidi A. Peck, Evelyn S. C. Koay, Lynette L. E. Oon, Ian G. Barr, Dhanasekaran Vijaykrishna and Gavin J. D. Smith Influenza A H1N1/2009 virus emerged from swine and rapidly replaced the seasonal H1N1 virus. Here, the authors show that natural selection acting on H1N1/2009 after introduction into humans was driven by adaptation to the new host but later selection has been driven by immunological escape. 06 August 2015 | doi: 10.1038/ncomms8952 Biological Sciences  Evolution  Genetics  Virology  Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues OPEN Erica L. Scheller, Casey R. Doucette, Brian S. Learman, William P. Cawthorn, Shaima Khandaker, Benjamin Schell, Brent Wu, Shi-Ying Ding, Miriam A. Bredella, Pouneh K. Fazeli, Basma Khoury, Karl J. Jepsen, Paul F. Pilch, Anne Klibanski, Clifford J. Rosen and Ormond A. MacDougald Bone marrow contains adipocytes, which have been thought to form one type of marrow adipose tissue (MAT). Here, the authors identify two MAT subpopulations in mice and humans—‘regulated’ and ‘constitute’ MAT—which show distinct phenotypic and cellular traits, and respond differently to cold exposure. 06 August 2015 | doi: 10.1038/ncomms8808 Biological Sciences  Medical research  Qubit entanglement between ring-resonator photon-pair sources on a silicon chip OPEN J. W. Silverstone, R. Santagati, D. Bonneau, M. J. Strain, M. Sorel, J. L. O’Brien and M. G. Thompson Scalable photonic devices for quantum information processing require on-chip quantum states engineering. Here the authors report the creation of entangled photon pairs on a silicon-on-insulator chip by integrating resonant photon sources, spectral demultiplexers and reconfigurable optics in a single device. 06 August 2015 | doi: 10.1038/ncomms8948 Physical Sciences  Optical physics  The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling OPEN Young-Suk Yoo, Yong-Yea Park, Jae-Hoon Kim, Hyeseon Cho, Song-Hee Kim, Ho-Soo Lee, Tae-Hwan Kim, You Sun Kim, Youngsoo Lee, Chul-Joong Kim, Jae U Jung, Jong-Soo Lee and Hyeseong Cho RNA viral infections trigger an immune response mediated by the formation of aggregates of the MAVS protein. Here the authors show that the mitochondrial protein MARCH5 modulates this response by transferring ubiquitin to MAVS aggregates, thus promoting their proteasomal degradation. 06 August 2015 | doi: 10.1038/ncomms8910 Biological Sciences  Cell biology  Immunology  Virology  Mode-selective vibrational modulation of charge transport in organic electronic devices OPEN Artem A. Bakulin, Robert Lovrincic, Xi Yu, Oleg Selig, Huib J. Bakker, Yves L. A. Rezus, Pabitra K. Nayak, Alexandr Fonari, Veaceslav Coropceanu, Jean-Luc Brédas and David Cahen The electronic properties of organic molecules are sensitive to structural dynamics, but device control through this phenomenon has not been attained. Bakulin et al. show that the photoconductivity can be modulated by selective excitation of molecular vibrations in an organic optoelectronic device. 06 August 2015 | doi: 10.1038/ncomms8880 Physical Sciences  Condensed matter  Materials science  Physical chemistry  Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant OPEN Zhiguang Yuchi, Siobhan M. Wong King Yuen, Kelvin Lau, Ainsley Q. Underhill, Razvan L. Cornea, James D. Fessenden and Filip Van Petegem The ryanodine receptor (RyR) is a large multi-domain ion channel that functions to release calcium from the endoplasmic or sarcoplasmic reticulum. Here the authors present crystal structures of the SPRY1 and tandem repeat domains of RyR, allowing precise positioning of the domains and linking disease mutations to RyR function. 06 August 2015 | doi: 10.1038/ncomms8947 Biological Sciences  Biochemistry  Biophysics  Cell biology  Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications OPEN Fuyao Liu, Xiuxia He, Hongda Chen, Junping Zhang, Huimao Zhang and Zhenxin Wang Coordination polymers are promising drug delivery nanomaterials as their structural properties can be easily controlled. Here, Wang et al. prepare coordination nanodots that integrate cancer imaging and therapeutic functions with beneficial renal clearance. 06 August 2015 | doi: 10.1038/ncomms9003 Biological Sciences  Cancer  Nanotechnology  Low surface recombination velocity in solution-grown CH3NH3PbBr3 perovskite single crystal OPEN Ye Yang, Yong Yan, Mengjin Yang, Sukgeun Choi, Kai Zhu, Joseph M. Luther and Matthew C. Beard Surface recombination velocity can have a major impact on solar cell performance. Here, Yang et al. measure surface recombination dynamics in perovskite single crystals using broadband transient reflectance spectroscopy. Grain size is crucial to avoid the effects of surface recombination on carrier lifetime. 06 August 2015 | doi: 10.1038/ncomms8961 Physical Sciences  Materials science  Optical physics  Physical chemistry  Inhibition of stationary phase respiration impairs persister formation in E. coli OPEN Mehmet A. Orman and Mark P. Brynildsen A few bacterial cells within a genetically homogeneous population can become ‘persisters’, or temporarily tolerant to antibiotics. Here Orman and Brynildsen show that development of persisters among growth-arrested E. coli cells can be prevented by inhibiting bacterial respiration. 06 August 2015 | doi: 10.1038/ncomms8983 Biological Sciences  Biochemistry  Microbiology  Drosophila germ granules are structured and contain homotypic mRNA clusters OPEN Tatjana Trcek, Markus Grosch, Andrew York, Hari Shroff, Timothée Lionnet and Ruth Lehmann What regulates mRNAs transcript localization in the germ granules in Drosophila is unclear. Here Trcek et al. identify that germ plasm proteins are homogeneously distributed in germ granules but once localized, individual mRNAs form homotypic clusters, contributing structure to the germ granules. 05 August 2015 | doi: 10.1038/ncomms8962 Biological Sciences  Cell biology  Developmental biology  Exceptional river gorge formation from unexceptional floods L. Anton, A. E. Mather, M. Stokes, A. Muñoz-Martin and G. De Vicente Previous studies suggest that rates of gorge formation are controlled by bedrock erodibility, erosion mechanism and hillslope processes. Here, the authors show evidence of rapid gorge formation in granite bedrock and report no relationship with flood size or bedload, attributing the rate to pre-existing jointing. 05 August 2015 | doi: 10.1038/ncomms8963 Earth Sciences  Geology and geophysics  An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis OPEN Sylvain Meunier, Maria Shvedunova, Nhuong Van Nguyen, Leonor Avila, Isabelle Vernos and Asifa Akhtar The heptameric KAT8-associated nonspecific lethal complex consists of highly conserved chromatin modifier proteins. Here, the authors show a role for the members of the complex in regulating microtubule assembly during mitosis. 05 August 2015 | doi: 10.1038/ncomms8889 Biological Sciences  Cell biology  Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements OPEN Thomas S. Morley, Jonathan Y. Xia and Philipp E. Scherer Insulin resistance in adipose tissue is a hallmark of obesity. Here, the authors generate inducible adipocyte-specific PTEN knockout mice to demonstrate that enhanced insulin sensitivity in adipose tissue is directly linked to improved systemic metabolic homeostasis, despite an increase in fat mass. 05 August 2015 | doi: 10.1038/ncomms8906 Biological Sciences  Medical research  Turning terminally differentiated skeletal muscle cells into regenerative progenitors OPEN Heng Wang, Sara Lööf, Paula Borg, Gustavo A. Nader, Helen M. Blau and András Simon Newts can regenerate amputated limbs via unknown mechanism involving dedifferentiation of cells in the stump into progenitors that contribute to the new appendages. Here the authors show that skeletal muscle dedifferentiation in regenerating newt limbs relies on a diverted programmed cell death response by myofibers. 05 August 2015 | doi: 10.1038/ncomms8916 Biological Sciences  Cell biology  Developmental biology  CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury OPEN Hirokuni Akahori, Vinit Karmali, Rohini Polavarapu, Alicia N. Lyle, Daiana Weiss, Eric Shin, Ahsan Husain, Nawazish Naqvi, Richard Van Dam, Anwer Habib, Cheol Ung Choi, Adrienne L. King, Kimberly Pachura, W. Robert Taylor, David J. Lefer and Aloke V. Finn CD163 is a glycoprotein receptor expressed on the surface of macrophages. Here, the authors demonstrate that a soluble form of CD163 can act as a decoy receptor for the pro inflammatory cytokine TWEAK, thereby revealing a new mechanism for the regulation of tissue repair after ischaemic injury. 05 August 2015 | doi: 10.1038/ncomms8792 Biological Sciences  Medical research  Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke OPEN Gab Seok Kim, Li Yang, Guoqi Zhang, Honggang Zhao, Magdy Selim, Louise D. McCullough, Michael J. Kluk and Teresa Sanchez The sphingolipid sphingosine-1-phosphate (S1P) plays a vital role in vascular homeostasis through the interaction with its receptors S1PR1-5. Here, by using genetic and pharmacological approaches, the authors show that S1PR2-mediated signaling is crucial for the disruption of cerebrovascular integrity and development of intracerebral haemorrhage in a mouse stroke model. 05 August 2015 | doi: 10.1038/ncomms8893 Biological Sciences  Medical research  Mto2 multisite phosphorylation inactivates non-spindle microtubule nucleation complexes during mitosis OPEN Weronika E. Borek, Lynda M. Groocock, Itaru Samejima, Juan Zou, Flavia de Lima Alves, Juri Rappsilber and Kenneth E. Sawin In S. pombe, cytoplasmic microtubule nucleation, which depends on the Mto1/2 complex, ceases during mitosis. Here, Borek et al., show that multisite phosphorylation of Mto1/2 during mitosis disassembles the Mto1/2 complex and prevents microtubule nucleation activity. 05 August 2015 | doi: 10.1038/ncomms8929 Biological Sciences  Cell biology  Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation OPEN Alexander W. Lohman, Igor L. Leskov, Joshua T. Butcher, Scott R. Johnstone, Tara A. Stokes, Daniela Begandt, Leon J. DeLalio, Angela K. Best, Silvia Penuela, Norbert Leitinger, Kodi S. Ravichandran, Karen Y. Stokes and Brant E. Isakson Endothelial cell activation by inflammation requires extracellular ATP release. Here the authors show that TNF-α induces Src-family kinase-dependent ATP release by Pannexin1 channels in endothelial cells, and that Pannexin1 is required for leukocyte adhesion and emigration into the inflamed tissue. 05 August 2015 | doi: 10.1038/ncomms8965 Biological Sciences  Immunology  Molecular biology  Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses OPEN Eric C. Dunham, Logan Banadyga, Allison Groseth, Abhilash I. Chiramel, Sonja M. Best, Hideki Ebihara, Heinz Feldmann and Thomas Hoenen Concerns have been raised regarding potential increase in the virulence of the Ebola virus during the current West African outbreak. Here the authors show that the ability to inhibit interferon response, one of the aspects of Ebola virus virulence, does not differ between the prototype Mayinga and isolates from the current outbreak. 05 August 2015 | doi: 10.1038/ncomms9000 Biological Sciences  Immunology  Virology  Dielectrophoretic manipulation of the mixture of isotropic and nematic liquid OPEN Soo-Dong Kim, Bomi Lee, Shin-Woong Kang and Jang-Kun Song Nematic and isotropic liquid phases can coexist within a narrow temperature window. Here, Kim et al. show how to control this mixed phase via thermal and dielectrophoretic manipulations, based on which nematic microfilaments in an isotropic medium, or vice versa, are demonstrated. 05 August 2015 | doi: 10.1038/ncomms8936 Physical Sciences  Condensed matter  Materials science  Multicohort analysis of the maternal age effect on recombination OPEN Hilary C. Martin, Ryan Christ, Julie G. Hussin, Jared O’Connell, Scott Gordon, Hamdi Mbarek, Jouke-Jan Hottenga, Kerrie McAloney, Gonnecke Willemsen, Paolo Gasparini, Nicola Pirastu, Grant W. Montgomery, Pau Navarro, Nicole Soranzo, Daniela Toniolo, Veronique Vitart, James F. Wilson, Jonathan Marchini, Dorret I. Boomsma, Nicholas G. Martin et al. The question of whether recombination rate increases with maternal age is controversial, with conflicting prior evidence. Here, Martin et al. analyse nine cohorts in the largest SNP-based analysis of this question and find a small positive increase with maternal age in the number of crossovers. 05 August 2015 | doi: 10.1038/ncomms8846 Biological Sciences  Genetics  High-rate aluminium yolk-shell nanoparticle anode for Li-ion battery with long cycle life and ultrahigh capacity OPEN Sa Li, Junjie Niu, Yu Cheng Zhao, Kang Pyo So, Chao Wang, Chang An Wang and Ju Li Aluminium offers an attractive alternative anode for lithium-ion batteries, but its practical performance falls far short of the theoretical promise. Here, the authors present a yolk-shell structured nanocomposite anode of aluminium core and titanium oxide shell which displays outstanding electrochemical properties. 05 August 2015 | doi: 10.1038/ncomms8872 Chemical Sciences  Nanotechnology  Physical chemistry    Nature Communications JOBS of the week Research Associate University College London (UCL) Post-doctoral Research Scholar University of Miami Investigator Scientist Medical Research Council - Laboratory of Molecular Biology Lecturer / Senior Lecturer in Physical Geography University of Glasgow Doctoral Program Fellowships Graduate School of Life Sciences (GSLS), University of Würzburg Research Associate The University of Warwick Research Associate Parkinson's Institute and Clinical Center Research Associate in Mixed Methods University of Bristol Bioinformatician The Genome Analysis Centre (TGAC) Postdoctoral position(s) INSERM - IMRB U955 - Team 10 More Science jobs from Nature Communications EVENT The Annual Conference of the International Society for Bipolar Disorders 13.07.16 Amsterdam More science events from       Latest Corrigendum     Optoelectronic crystal of artificial atoms in strain-textured molybdenum disulphide Hong Li, Alex W. Contryman, Xiaofeng Qian, Sina Moeini Ardakani, Yongji Gong, Xingli Wang, Jeffrey M. Weisse, Chi Hwan Lee, Jiheng Zhao, Pulickel M. Ajayan, Ju Li, Hari C. Manoharan and Xiaolin Zheng 06 August 2015 | doi: 10.1038/ncomms9080 Physical Sciences  Materials science  Nanotechnology      Advertisement Join us this September for the Naturejobs Career Expo London 2015!  This career fair offers young, talented researchers an excellent opportunity to meet a diverse selection of national and international employers from academic institutions and scientific industries. The event is free and offers you a chance to get your CV checked, meet and network with employers and leading scientific institutions and attend useful workshops. Register and find out more.     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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