Nature Cell Biology contents: September 2015 Volume 17 Number 9, pp 1089 - 1228

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Advertisement Novel, selective GRK2/3 inhibitor available Cmpd101 is a novel, selective G-protein coupled receptor kinase 2 and 3 inhibitor (IC50 values are 35, 290 nM and 125 µM at GRK2, GRK3 and GRK5 respectively). Selective at a broad range of other kinases. Useful for studying roles of GRK2/3 in GPCR desensitization.   View product data from Hello Bio TABLE OF CONTENTS September 2015 Volume 17, Issue 9 Perspective News and Views Articles Resource Corrigendum Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Noncoding RNAs in Endocrinology  Noncoding RNAs have important roles in the development and regulation of the endocrine system. This web collection on noncoding RNAs in endocrinology highlights current and future applications of noncoding RNAs as diagnostic and prognostic biomarkers and as therapeutic targets for personalized management of patients with a wide range of endocrine diseases. Access the collection online.     Perspective Top Microtubule nucleation at the centrosome and beyond   pp1089 - 1093 Sabine Petry and Ronald D. Vale doi:10.1038/ncb3220 Microtubule polymerization is initiated by γ-tubulin containing complexes. Petry and Vale discuss factors involved in localizing and activating γ-tubulin at different locations in the cell. News and Views Top Actin shapes the autophagosome   pp1094 - 1096 Petter Holland and Anne Simonsen doi:10.1038/ncb3224 Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional autophagosome. See also: Article by Mi et al. Fumarate in DNA repair   pp1096 - 1097 Susan P. Lees-Miller doi:10.1038/ncb3232 A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks. See also: Article by Jiang et al. Articles Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation   pp1099 - 1111 Qiong A. Wang, Caroline Tao, Lei Jiang, Mengle Shao, Risheng Ye et al. doi:10.1038/ncb3217 By analysing inducible knockout mice, Scherer and colleagues report that the adipogenic transcription factor C/EBPα is dispensable for white adipogenesis in mouse embryos, but not in adults. Cell Biology JOBS of the week Assistant Professor in Cell Biology Yale University School of Medicine Junior Group Leader in the cell and development biology programme CRG – Centre for Genomic Regulation Two Postdoctoral Fellowships: In Protein NMR and in Molecular and Cell Biology IRIC / Université de Montreal Post-Doctoral / Senior Research Northwestern University Postdoctoral Position - Developmental Biology Institut Pasteur More Science jobs from Cell Biology EVENT Cell Biology of Yeasts 03.11.15 Cold Spring Harbor, USA More science events from CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane   pp1112 - 1123 Na Mi, Yang Chen, Shuai Wang, Mengran Chen, Mingkun Zhao et al. doi:10.1038/ncb3215 Mi et al. show that CapZ regulates autophagosomal membrane shaping by controlling the assembly of an actin scaffold in the autophagosomal precursor. See also: News and Views by Holland & Simonsen Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore   pp1124 - 1133 Takashi Akera, Yuhei Goto, Masamitsu Sato, Masayuki Yamamoto and Yoshinori Watanabe doi:10.1038/ncb3219 Watanabe and colleagues demonstrate that the spindle assembly checkpoint protein Mad1 promotes gliding of misaligned chromosomes towards the cell equator, through an interaction with Cut7, a kinesin-5 motor. Adaptive changes in the kinetochore architecture facilitate proper spindle assembly   pp1134 - 1144 Valentin Magidson, Raja Paul, Nachen Yang, Jeffrey G. Ault, Christopher B. O'Connell et al. doi:10.1038/ncb3223 Using light- and electron microscopy, Khodjakov, Mogilner and colleagues find that the shape of the kinetochore undergoes dramatic changes during mitosis. Computational analysis suggests that this facilitates correct chromosome attachment. Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity   pp1145 - 1157 Antonis Kourtidis, Siu P. Ngok, Pamela Pulimeno, Ryan W. Feathers, Lomeli R. Carpio et al. doi:10.1038/ncb3227 Anastasiadis and colleagues report the presence of two spatially and functionally distinct E-cadherin-based junctional complexes, which influence cell behaviour either by regulating miRNA processing or by promoting p120 catenin and Src signalling. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation   pp1158 - 1168 Yuhui Jiang, Xu Qian, Jianfeng Shen, Yugang Wang, Xinjian Li et al. doi:10.1038/ncb3209 Lu and colleagues find that in response to ionizing radiation, DNA-PK phosphorylates fumarase breaks for local generation of fumarate, which in turn enhances DNA-PK recruitment by inhibiting histone H3 demethylation. See also: News and Views by Lees-Miller Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis   pp1169 - 1181 Lin Yuan, Yanrong Lv, Hongchang Li, Haidong Gao, Shanshan Song et al. doi:10.1038/ncb3218 By screening 85 deubiquitylation enzymes, Zhang and colleagues identify OTUD3 as an enzyme that upregulates PTEN levels by deubiquitylation and acts as a tumour suppressor in synergy with another PTEN DUB, USP13. Niche appropriation by Drosophila intestinal stem cell tumours   pp1182 - 1192 Parthive H. Patel, Devanjali Dutta and Bruce A. Edgar doi:10.1038/ncb3214 Patel et al. report that Drosophila intestinal stem cell tumours are generated by stress- and EGFR-signalling, followed by extrusion of neighbouring enterocytes, enterocytic cytokine expression and paracrine signalling for tumour growth. Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation   pp1193 - 1204 Maria-Giuseppina Procopio, Csaba Laszlo, Dania Al Labban, Dong Eun Kim, Pino Bordignon et al. doi:10.1038/ncb3228 Procopio et al. report that combined loss of p53 and the CSL transcriptional regulator leads to stromal and cancer cell expansion by bypassing the fibroblast senescence caused by CSL deficiency and promoting cancer-associated fibroblast activation. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype   pp1205 - 1217 Nicolás Herranz, Suchira Gallage, Massimiliano Mellone, Torsten Wuestefeld, Sabrina Klotz et al. doi:10.1038/ncb3225 Gil and colleagues report that mTOR affects the tumour-related effects of the senescence-associated secretory phenotype (SASP), by inhibiting the translation of the MAPKAPK2 kinase and thereby preventing the ZFP36L1-mediated SASP mRNA decay. Resource Top Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth   pp1218 - 1227 Francesca Zanconato, Mattia Forcato, Giusy Battilana, Luca Azzolin, Erika Quaranta et al. doi:10.1038/ncb3216 Piccolo and colleagues report that the YAP/TAZ factors form ternary complexes with TEAD and AP-1 factors to drive a transcriptional program that promotes cell proliferation and tumour growth. Corrigendum Top Corrigendum: The oncogene c-Jun impedes somatic cell reprogramming   p1228 Jing Liu, Qingkai Han, Tianran Peng, Meixiu Peng, Bei Wei et al. doi:10.1038/ncb3235 Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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