Monday, August 31, 2015

Molecular Therapy - Table of Contents alert Volume 23 Issue 9

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Molecular Therapy

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TABLE OF CONTENTS

Volume 23, Issue 9 (September 2015)

In this issue
Editorial
In This Issue
Research Highlights
Commentaries
Original Articles

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Molecular Therapy - Oncolytics is an online-only, open access journal, focusing on the development and clinical testing of viral, cellular, and other biological therapies targeting cancer.

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Join the Editors of Molecular Therapy for a dinner and "meet and greet" at the ESGCT and FSGT Collaborative Congress

We hope you will join us for a "meet and greet" at the ESGCT and FSGT Collaborative Congress on September 18th, from 6:30-8pm. Enjoy dinner in the main hall and learn more about publishing in and getting involved with the Molecular Therapy family of journals.

Space is limited, so we appreciate your RSVPing to the event by September 15th.
 
 

Editorial

Top

Hemophilia Gene Therapy: Caught Between a Cure and an Immune Response

Roland W. Herzog

Mol Ther 2015 23: 1411-1412; 10.1038/mt.2015.135

Full Text

In This Issue

Top

In This Issue

Mol Ther 2015 23: 1414; 10.1038/mt.2015.136

Full Text

Research Highlights

Top

Research Highlights

Mol Ther 2015 23: 1415; 10.1038/mt.2015.137

Full Text

Commentaries

Top

mRNA: Fulfilling the Promise of Gene Therapy

Drew Weissman and Katalin Karikó

Mol Ther 2015 23: 1416-1417; 10.1038/mt.2015.138

Full Text

Self-Destruct Genetic Switch to Safeguard iPS Cells

Zoltán Ivics

Mol Ther 2015 23: 1417-1420; 10.1038/mt.2015.139

Full Text

Hopx and the Cardiomyocyte Parentage

Michael D Schneider, Andrew H Baker and Paul Riley

Mol Ther 2015 23: 1420-1422; 10.1038/mt.2015.140

Full Text

Original Articles

Top

Gene Augmentation Therapy Restores Retinal Function and Visual Behavior in a Sheep Model of CNGA3 Achromatopsia

Eyal Banin, Elisha Gootwine, Alexey Obolensky, Raaya Ezra-Elia, Ayala Ejzenberg, Lina Zelinger, Hen Honig, Alexander Rosov, Esther Yamin, Dror Sharon, Edward Averbukh, William W Hauswirth and Ron Ofri

Mol Ther 2015 23: 1423-1433; advance online publication, June 19, 2015; 10.1038/mt.2015.114

Abstract | Full Text

ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice

Kai Y Mak, Ruth Chin, Sharon C Cunningham, Miriam R Habib, Joseph Torresi, Alexandra F Sharland, Ian E Alexander, Peter W Angus and Chandana B Herath

Mol Ther 2015 23: 1434-1443; advance online publication, May 25, 2015; 10.1038/mt.2015.92

Abstract | Full Text

Tumor Microenvironment Remodeling by 4-Methylumbelliferone Boosts the Antitumor Effect of Combined Immunotherapy in Murine Colorectal Carcinoma

Mariana Malvicini, Esteban Fiore, Valentina Ghiaccio, Flavia Piccioni, Miguel Rizzo, Lucila Olmedo Bonadeo, Mariana García, Marcelo Rodríguez, Juan Bayo, Estanislao Peixoto, Catalina Atorrasagasti, Laura Alaniz, Jorge Aquino, Pablo Matar and Guillermo Mazzolini

Mol Ther 2015 23: 1444-1455; advance online publication, June 24, 2015; 10.1038/mt.2015.112

Abstract | Full Text

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large AnimalsMTOPEN

Andreas Thess, Stefanie Grund, Barbara L Mui, Michael J Hope, Patrick Baumhof, Mariola Fotin-Mleczek and Thomas Schlake

Mol Ther 2015 23: 1456-1464; advance online publication, June 8, 2015; 10.1038/mt.2015.103

Abstract | Full Text

miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction

Swaroopa Guda, Christian Brendel, Raffaele Renella, Peng Du, Daniel E Bauer, Matthew C Canver, Jennifer K Grenier, Andrew W Grimson, Sophia C Kamran, James Thornton, Helen de Boer, David E Root, Michael D Milsom, Stuart H Orkin, Richard I Gregory and David A Williams

Mol Ther 2015 23: 1465-1474; advance online publication, June 17, 2015; 10.1038/mt.2015.113

Abstract | Full Text

An Inducible Caspase-9 Suicide Gene to Improve the Safety of Therapy Using Human Induced Pluripotent Stem Cells

Shigeki Yagyu, Valentina Hoyos, Francesca Del Bufalo and Malcolm K Brenner

Mol Ther 2015 23: 1475-1485; advance online publication, May 29, 2015; 10.1038/mt.2015.100

Abstract | Full Text

Aptamers Selected to Postoperative Lung Adenocarcinoma Detect Circulating Tumor Cells in Human BloodMTOPEN

Galina S Zamay, Olga S Kolovskaya, Tatiana N Zamay, Yury E Glazyrin, Alexey V Krat, Olga Zubkova, Ekaterina Spivak, Mohammed Wehbe, Ana Gargaun, Darija Muharemagic, Mariia Komarova, Valentina Grigorieva, Andrey Savchenko, Andrey A Modestov, Maxim V Berezovski and Anna S Zamay

Mol Ther 2015 23: 1486-1496; advance online publication, June 10, 2015; 10.1038/mt.2015.108

Abstract | Full Text

Mesenchymal Stromal Cells for Linked Delivery of Oncolytic and Apoptotic Adenoviruses to Non-small-cell Lung Cancers

Valentina Hoyos, Francesca Del Bufalo, Shigeki Yagyu, Miki Ando, Gianpietro Dotti, Masataka Suzuki, Lisa Bouchier-Hayes, Ramon Alemany and Malcolm K Brenner

Mol Ther 2015 23: 1497-1506; advance online publication, June 18, 2015; 10.1038/mt.2015.110

Abstract | Full Text

A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination ImmunotherapyMTOPEN

Julien Valton, Valérie Guyot, Alan Marechal, Jean-Marie Filhol, Alexandre Juillerat, Aymeric Duclert, Philippe Duchateau and Laurent Poirot

Mol Ther 2015 23: 1507-1518; advance online publication, June 10, 2015; 10.1038/mt.2015.104

Abstract | Full Text

Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy

Jonas Doerr, Annika Böckenhoff, Benjamin Ewald, Julia Ladewig, Matthias Eckhardt, Volkmar Gieselmann, Ulrich Matzner, Oliver Brüstle and Philipp Koch

Mol Ther 2015 23: 1519-1531; advance online publication, June 10, 2015; 10.1038/mt.2015.106

Abstract | Full Text

Phase 1b Trial of Biweekly Intravenous Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus in Colorectal Cancer

Se Hoon Park, Caroline J Breitbach, Jeeyun Lee, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Anne Moon, Jae-Hee Mun, Erica M Sommermann, Liliana Maruri Avidal, Rick Patt, Adina Pelusio, James Burke, Tae-Ho Hwang, David Kirn and Young Suk Park

Mol Ther 2015 23: 1532-1540; advance online publication, June 15, 2015; 10.1038/mt.2015.109

Abstract | Full Text

Case Report of a Fatal Serious Adverse Event Upon Administration of T Cells Transduced With a MART-1-specific T-cell Receptor

Joost H van den Berg, Raquel Gomez-Eerland, Bart van de Wiel, Lenie Hulshoff, Daan van den Broek, Adriaan Bins, Hanno L Tan, Jane V Harper, Namir J Hassan, Bent K Jakobsen, Annelies Jorritsma, Christian U Blank, Ton N M Schumacher and John B A G Haanen

Mol Ther 2015 23: 1541-1550; advance online publication, April 21, 2015; 10.1038/mt.2015.60

Abstract | Full Text

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