Laboratory Investigation - Table of Contents alert Volume 95 Issue 9

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TABLE OF CONTENTS Volume 95, Issue 9 (September 2015) In this issue Inside the USCAP Journals Pathobiology in Focus Mini Review Research Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Inside the USCAP Journals Top Inside the USCAP Journals 2015 95: 974-975; 10.1038/labinvest.2015.102 Full Text Pathobiology in Focus Top Clinical significance of the integrin α6β4 in human malignancies This review provides a comprehensive summary of integrin α6β4 expression patterns and their prognostic significance in human malignancies, and describes key signaling functions of the integrin α6β4 that contribute to its ability to promote invasion, migration, and survival in carcinoma cells. Rachel L Stewart and Kathleen L O'Connor 2015 95: 976-986; advance online publication, June 29, 2015; 10.1038/labinvest.2015.82 Abstract | Full Text Mini Review Top MicroRNAs in the pathobiology of sarcomas Sarcomas are a rare and heterogeneous group of tumors. This minireview outlines critical roles played by microRNAs in regulating and mediating conserved oncogenic and tumor suppressor signaling networks. Understanding and exploiting these critical interactions may result in new therapeutics for sarcomas and the many other cancers with similarly conserved mechanisms. Anne E Sarver and Subbaya Subramanian 2015 95: 987-994; advance online publication, June 29, 2015; 10.1038/labinvest.2015.81 Abstract | Full Text Research Articles Top ORAL AND GASTROINTESTINAL SYSTEMS FBXW7 negatively regulates ENO1 expression and function in colorectal cancer The tumor suppressor FBXW7 and enolase 1 (ENO) play important roles in human cancers. This study demonstrates that ENO1 is a novel substrate of FBXW7, which binds to ENO1 and promotes its ubiquitination and degradation. Accordingly, FBXW7 inhibits the ENO1-mediated cellular activities. These findings provide a novel molecular insight into FBXW7 tumor suppression through regulation of ENO1. Panpan Zhan, Yuli Wang, Shihu Zhao, Chunyan Liu, Yunshan Wang, Mingxin Wen, Jian-Hua Mao, Guangwei Wei and Pengju Zhang 2015 95: 995-1004; advance online publication, June 22, 2015; 10.1038/labinvest.2015.71 Abstract | Full Text Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma OPEN Increased cytosolic sulfotransferase 2B1b (SULT2B1b) expression correlates with aggressive clinical behaviors and poor prognosis of patients with colorectal carcinoma (CRC), and contributes to cancer cell growth and invasion. This paper suggests that SULT2B1b has an important role in CRC progression and could be a novel prognostic marker and potential therapeutic target for CRC patients. Liang Hu, Guang-Zhen Yang, Yu Zhang, Dan Feng, Yan-Xia Zhai, Hui Gong, Chen-Ye Qi, Hao Fu, Ming-Ming Ye, Qing-Ping Cai and Chun-Fang Gao 2015 95: 1005-1018; advance online publication, June 29, 2015; 10.1038/labinvest.2015.84 Abstract | Full Text GENITOURINARY AND REPRODUCTIVE SYSTEMS Sialic acid supplementation ameliorates puromycin aminonucleoside nephrosis in rats Sialylation defects accompanying proteinuric renal disease lead to podocyte effacement and glomerular filtration barrier dysfunction. This study demonstrates that sialic acid supplementation to nephrotic rats improves proteinuria and restores expression of enzymes involved in redox control and sialoglycoprotein metabolism. These data indicate that desialylation and oxidative stress may be closely related. Izabella Z A Pawluczyk, Maryam G Najafabadi, Jeremy R Brown, Alan Bevington and Peter S Topham 2015 95: 1019-1028; advance online publication, June 29, 2015; 10.1038/labinvest.2015.78 Abstract | Full Text Vascular endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal-induced peritoneal injury This paper demonstrates that lymphangiogenesis develops in the peritoneal cavity of a murine model of peritoneal injury and patients on peritoneal dialysis. Adenovirus expressing soluble vascular endothelial growth factor receptor-3 (VEGFR-3) improves net ultrafiltration by suppressing lymphatic absorption in the murine model. These findings suggest that VEGFR-3 may be targeted to improve net ultrafiltration for patients on peritoneal dialysis. Takeshi Terabayashi, Yasuhiko Ito, Masashi Mizuno, Yasuhiro Suzuki, Hiroshi Kinashi, Fumiko Sakata, Takako Tomita, Daiki Iguchi, Mitsuhiro Tawada, Ryosuke Nishio, Shoichi Maruyama, Enyu Imai, Seiichi Matsuo and Yoshifumi Takei 2015 95: 1029-1043; advance online publication, June 29, 2015; 10.1038/labinvest.2015.87 Abstract | Full Text Prostaglandin E2 increases proximal tubule fluid reabsorption, and modulates cultured proximal tubule cell responses via EP1 and EP4 receptors In diabetes, the proximal tubule is subjected to sodium and water transport challenges. Prostaglandin E2, acting on prostaglandin receptors EP1 and EP4, modifies mouse proximal tubule transport properties and injurious responses. Since proximal tubule growth promotes sodium hyper-reabsorption, contributing to hyperfiltration and injury, proximal tubule prostaglandin receptors are promising therapeutic targets. Rania Nasrallah, Ramzi Hassouneh, Joseph Zimpelmann, Andrew J Karam, Jean-Francois Thibodeau, Dylan Burger, Kevin D Burns, Chris RJ Kennedy and Richard L Hébert 2015 95: 1044-1055; advance online publication, June 29, 2015; 10.1038/labinvest.2015.79 Abstract | Full Text CARDIOVASCULAR AND PULMONARY SYSTEMS MicroRNA-19 triggers epithelial–mesenchymal transition of lung cancer cells accompanied by growth inhibition Overexpression of miR-19 is associated with poor prognosis in lung cancer. This study reveals that miR-19 triggers epithelial–mesenchymal transition (EMT) in lung cancer cells, which plays an important role in invasion and migration. Furthermore, lung cancer cells undergoing EMT induced by miR-19 demonstrate enhanced resistance to apoptosis growth inhibition. Jing Li, Sheng Yang, Wen Yan, Jie Yang, Yu-Juan Qin, Xiao-Lin Lin, Rao-Ying Xie, Sheng-Chun Wang, Wen Jin, Fei Gao, Jun-Wen Shi, Wen-Tao Zhao, Jun-Shuang Jia, Hong-Fen Shen, Jie-Rong Ke, Bin Liu, Yi-Qiao Zhao, Wen-Hua Huang, Kai-Tai Yao, Dan-Juan Li and Dong Xiao 2015 95: 1056-1070; advance online publication, June 22, 2015; 10.1038/labinvest.2015.76 Abstract | Full Text SKIN, SOFT TISSUE AND BONE Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing The frequency and distribution of gene fusions involving protein kinase C (PRKC) were studied in the many different morphological and clinical subsets of benign fibrous histiocytoma. Using FISH and RNA sequencing on formalin-fixed, paraffin-embedded samples, such fusions were detected in most subtypes. In epithelioid fibrous histiocytoma, PRKC and ALK rearrangements were mutually exclusive. Charles Walther, Jakob Hofvander, Jenny Nilsson, Linda Magnusson, Henryk A Domanski, David Gisselsson, Johnbosco Tayebwa, Leona A Doyle, Christopher DM Fletcher and Fredrik Mertens 2015 95: 1071-1076; advance online publication, June 29, 2015; 10.1038/labinvest.2015.83 Abstract | Full Text Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors The heterogeneity of bone and soft tissue sarcomas, and their relative rarity, have made them challenging targets for classification, biomarker identification, and development of improved treatment strategies. This paper demonstrates that high-throughput sequencing approaches and bioinformatic analysis of limited representative sarcoma samples can successfully identify novel candidates for biomarkers and therapeutic targets. Anne E Sarver, Aaron L Sarver, Venugopal Thayanithy and Subbaya Subramanian 2015 95: 1077-1088; advance online publication, June 29, 2015; 10.1038/labinvest.2015.80 Abstract | Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. 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