The EMBO Journal Table of Contents for 14 July 2015; Vol. 34, No. 14

14 July 2015 | Volume 34, Number 14 Submit Table of Contents Have you seen? Review Resource Articles Volume 34, Number 14 Have you seen? Clever space saving—how the cerebral cortex folds During mammalian evolution, the size of the cerebral cortex increased leading to the formation of cortical folds. Large‐scale transcriptome analysis provides new insight into the genetic regulation of cortical folding in the developing ferret brain. Mareike Albert and Wieland B Huttner Published online 28.05.2015 Review ER–endosome contact sites: molecular compositions and functions Membrane contact sites, defined as sites of close apposition between two membranes, are crucial for the direct exchange of information between distinct endomembrane compartments. This review highlights the diverse functions of ER‐endosome contact sites. Camilla Raiborg, Eva M Wenzel, and Harald Stenmark Published online 03.06.2015 Resource Discrete domains of gene expression in germinal layers distinguish the development of gyrencephaly Complex patterns of gene expression emerge in germinal layers during early cortical development of gyrencephalic animals. These modular expression patterns map the eventual location of folds and fissures. Camino de Juan Romero, Carl Bruder, Ugo Tomasello, José Miguel Sanz‐Anquela, and Víctor Borrell Published online 26.04.2015 Articles Loss of MT1‐MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid Alterations in the extracellular matrix caused by loss of protease MT1‐MMP lead to cellular senescence, nuclear lamina abnormalities, and features of premature ageing that can be rescued by treatment with retinoic acid. Ana Gutiérrez‐Fernández, Clara Soria‐Valles, Fernando G Osorio, Jesús Gutiérrez‐Abril, Cecilia Garabaya, Alina Aguirre, Antonio Fueyo, María Soledad Fernández‐García, Xose S Puente, and Carlos López‐Otín Published online 19.05.2015 Chromatin signatures at Notch‐regulated enhancers reveal large‐scale changes in H3K56ac upon activation Genome‐wide mapping of chromatin changes downstream of Notch signalling defines preferred conditions for Su(H) binding and links rapid changes in H3K56 acetylation to enhancer activation. Lenka Skalska, Robert Stojnic, Jinghua Li, Bettina Fischer, Gustavo Cerda‐Moya, Hiroshi Sakai, Shahragim Tajbakhsh, Steven Russell, Boris Adryan, and Sarah J Bray Published online 11.06.2015 Not4‐dependent translational repression is important for cellular protein homeostasis in yeast Not4, a component of the CCR4‐NOT complex, triggers translational repression of mRNAs carrying transiently stalled ribosomes and contributes to the maintenance of protein homeostasis during cellular stress. Steffen Preissler, Julia Reuther, Miriam Koch, Annika Scior, Michael Bruderek, Tancred Frickey, and Elke Deuerling Published online 13.05.2015 Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organization By reconstituting the assembly of human U snRNPs in vitro, this study establishes the sequential action of distinct Sm protein complexes and provides a basis for understanding the defects in spinal muscular atrophy. Nils Neuenkirchen, Clemens Englbrecht, Jürgen Ohmer, Thomas Ziegenhals, Ashwin Chari, and Utz Fischer Published online 11.06.2015 RPA prevents G‐rich structure formation at lagging‐strand telomeres to allow maintenance of chromosome ends The single‐stranded DNA binding protein RPA promotes telomere maintenance by inhibiting accumulation of G‐quadruplex structures at lagging‐strand telomeres. Julien Audry, Laetitia Maestroni, Emmanuelle Delagoutte, Tiphaine Gauthier, Toru M Nakamura, Yannick Gachet, Carole Saintomé, Vincent Géli, and Stéphane Coulon Published online 03.06.2015 Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase Crystal structures of the mitochondrial DNA polymerase, Pol γ, in complex with substrate or antiviral inhibitor zalcitabine provide a basis for understanding Pol γ‐mediated drug toxicity. Michal R Szymanski, Vladmir B Kuznetsov, Christie Shumate, Qingchao Meng, Young‐Sam Lee, Gayatri Patel, Smita Patel, and Y Whitney Yin Published online 08.06.2015 Regulation of the Rev1–pol ζ complex during bypass of a DNA interstrand cross‐link Chromosomal DNA replication integrates with translesion DNA synthesis during DNA interstrand cross‐link repair to limit mutagenesis. Magda Budzowska, Thomas GW Graham, Alexandra Sobeck, Shou Waga, and Johannes C Walter Published online 12.06.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.