Scientific Reports Biology Table of Contents e-alert: 28 July 2015

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28 July 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Isoform-specific interactions of the von Hippel-Lindau tumor suppressor protein ▶     Giovanni Minervini, Gabriella M. Mazzotta, Alessandro Masiero et al.     Deregulation of the von Hippel-Lindau tumor suppressor protein (pVHL) is considered one of the main causes for malignant renal clear-cell carcinoma (ccRCC) insurgence. In human, …             Structures of intermediates during RES complex assembly ▶     Piotr Wysoczanski, Stefan Becker, Markus Zweckstetter     The action of the spliceosome depends on the stepwise cooperative assembly and disassembly of its components. Very strong cooperativity was observed for the RES (Retention and …             Global-change vulnerability of a key plant resource, the African palms ▶     Anne Blach-Overgaard, Henrik Balslev, John Dransfield et al.     Palms are keystone species in tropical ecosystems and provide essential ecosystem services to rural people worldwide. However, many palm species are threatened by habitat loss …             An in silico platform for predicting, screening and designing of antihypertensive peptides ▶     Ravi Kumar, Kumardeep Chaudhary, Jagat Singh Chauhan et al.     High blood pressure or hypertension is an affliction that threatens millions of lives worldwide. Peptides from natural origin have been shown recently to be highly effective in …             Laser-scanning cytometry can quantify human adipocyte browning and proves effectiveness of irisin ▶     Endre Kristóf, Quang-Minh Doan-Xuan, Péter Bai et al.     Laser-scanning cytometry is presented as a tool allowing population scale analysis of ex vivo human brown adipogenic differentiation. It combines texture analysis and detection …             Anti-CD antibody microarray for human leukocyte morphology examination allows analyzing rare cell populations and suggesting preliminary diagnosis in leukemia ▶     Alina N. Khvastunova, Sofya A. Kuznetsova, Liubov S. Al-Radi et al.     We describe a method for leukocyte sorting by a microarray of anti-cluster-of-differentiation (anti-CD) antibodies and for preparation of the bound cells for morphological or …             A novel laminin β gene BmLanB1-w regulates wing-specific cell adhesion in silkworm, Bombyx mori ▶     Xiaoling Tong, Songzhen He, Jun Chen et al.     Laminins are important basement membrane (BM) components with crucial roles in development. The numbers of laminin isoforms in various organisms are determined by the composition …             Rice stripe virus counters reduced fecundity in its insect vector by modifying insect physiology, primary endosymbionts and feeding behavior ▶     Guijun Wan, Shoulin Jiang, Wenjing Wang et al.     Virus-vector relationships can be complex and diverse as a result of long-term coevolution. Understanding these interactions is crucial for disease and vector management. Rice …             Molecular phylogeny supports S-chaetae as a key character better than jumping organs and body scales in classification of Entomobryoidea (Collembola) ▶     Feng Zhang, Dan-Dan Sun, Dao-Yuan Yu et al.     The jumping organ (furcula) is the most characteristic structure among collembolans, and it is of great taxonomical values at higher levels. The largest superfamily …             In vitro analysis of phosphorothioate modification of DNA reveals substrate recognition by a multiprotein complex ▶     Bo Cao, Xiaoqing Zheng, Qiuxiang Cheng et al.     A wide variety of prokaryotes possess DNA modifications consisting of sequence-specific phosphorothioates (PT) inserted by members of a five-gene cluster. Recent genome mapping …             Doubling Throughput of a Real-Time PCR ▶     Christian D. Ahrberg, Pavel Neužil     The invention of polymerase chain reaction (PCR) in 1983 revolutionized many areas of science, due to its ability to multiply a number of copies of DNA sequences (known as …             BODIPY-doped silica nanoparticles with reduced dye leakage and enhanced singlet oxygen generation ▶     Zhuyuan Wang, Xuehua Hong, Shenfei Zong et al.     Photodynamic therapy (PDT) is a promising modality for cancer treatment. The essential element in PDT is the photosensitizer, which can be excited by light of a specific …             VaccineDA: Prediction, design and genome-wide screening of oligodeoxynucleotide-based vaccine adjuvants ▶     Gandharva Nagpal, Sudheer Gupta, Kumardeep Chaudhary et al.     Immunomodulatory oligodeoxynucleotides (IMODNs) are the short DNA sequences that activate the innate immune system via toll-like receptor 9. These sequences predominantly contain …             Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis ▶     Garik Mkrtchyan, Vasily Aleshin, Yulia Parkhomenko et al.     Thiamin (vitamin B1) is a pharmacological agent boosting central metabolism through the action of the coenzyme thiamin diphosphate (ThDP). However, positive effects, including …             Blockade of dual-specificity phosphatase 28 decreases chemo-resistance and migration in human pancreatic cancer cells ▶     Jungwhoi Lee, Jeong Hun Yun, Jungsul Lee et al.     Pancreatic cancer remains one of the most deadly cancers, with a grave prognosis. Despite numerous endeavors to improve treatment of the neoplasm, limited progress has been made. …             Cortical Activation Patterns of Bodily Attention triggered by Acupuncture Stimulation ▶     Won-Mo Jung, In-Seon Lee, Christian Wallraven et al.     We investigated commonalities and differences in brain responses to enhanced bodily attention around acupuncture points with and without stimulation. Fourteen participants …             Directionality of substrate translocation of the hemolysin A Type I secretion system ▶     Michael H. H. Lenders, Stefanie Weidtkamp-Peters, Diana Kleinschrodt et al.     Type 1 secretion systems (T1SS) of Gram-negative bacteria are responsible for the secretion of various proteases, lipases, S-layer proteins or toxins into the extracellular …             Ganoderma neo-japonicum Imazeki revisited: Domestication study and antioxidant properties of its basidiocarps and mycelia ▶     Wee-Cheat Tan, Umah Rani Kuppusamy, Chia-Wei Phan et al.     Mushroom cultivation benefits humankind as it deliberately encourages wild mushrooms to be commercially propagated while recycling agricultural wastes. Ganoderma neo-japonicum is …             Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods ▶     Karthikeyan Kandasamy, Jacqueline Kai Chin Chuah, Ran Su et al.     The renal proximal tubule is a main target for drug-induced toxicity. The prediction of proximal tubular toxicity during drug development remains difficult. Any in vitro methods …             Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions ▶     Melissa Malvaez, Venuz Y. Greenfield, Alice S. Wang et al.     Environmental stimuli have the ability to generate specific representations of the rewards they predict and in so doing alter the selection and performance of reward-seeking …             Computational Classification Approach to Profile Neuron Subtypes from Brain Activity Mapping Data ▶     Meng Li, Fang Zhao, Jason Lee et al.     The analysis of cell type-specific activity patterns during behaviors is important for better understanding of how neural circuits generate cognition, but has not been well …             Hydrogen sulfide enhances salt tolerance through nitric oxide-mediated maintenance of ion homeostasis in barley seedling roots ▶     Juan Chen, Wen-Hua Wang, Fei-Hua Wu et al.     Hydrogen sulfide (H2S) and nitric oxide (NO) are emerging as messenger molecules involved in the modulation of plant physiological processes. Here, we investigated a signalling …             60,000 years of interactions between Central and Eastern Africa documented by major African mitochondrial haplogroup L2 ▶     Marina Silva, Farida Alshamali, Paula Silva et al.     Mitochondrial DNA (mtDNA) haplogroup L2 originated in Western Africa but is nowadays spread across the entire continent. L2 movements were previously postulated to be related to …             Characterization of RNA silencing components in the plant pathogenic fungus Fusarium graminearum ▶     Yun Chen, Qixun Gao, Mengmeng Huang et al.     The RNA interference (RNAi) plays a critical role in gene regulation in a variety of eukaryotic organisms. However, the role of RNAi remains largely unclear in plant pathogenic …             Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity ▶     Hua Tan, Jiguang Bao, Xiaobo Zhou     Cancer is widely recognized as a genetic disease in which somatic mutations are sequentially accumulated to drive tumor progression. Although genomic landscape studies are …             Calcium ion-induced formation of β-sheet/-turn structure leading to alteration of osteogenic activity of bone morphogenetic protein-2 ▶     Wenjing Zhang, Hongyan He, Yu Tian et al.     Preserving bioactivity of bone morphogenetic protein 2 (BMP-2) still remains a challenge in protein-based therapy. It is not known how Ca2+ released from extracellular matrix or …             Prevalence and patterns of antimicrobial resistance among Escherichia coli isolated from Zambian dairy cattle across different production systems ▶     Geoffrey Mainda, Paul B. Bessell, John B. Muma et al.     This study focused on the use of antibiotics on small, medium and commercial-sized dairy farms in the central region of Zambia and its relationship to antibiotic resistance in …             Tight junction CLDN2 gene is a direct target of the vitamin D receptor ▶     Yong-guo Zhang, Shaoping Wu, Rong Lu et al.     The breakdown of the intestinal barrier is a common manifestation of many diseases. Recent evidence suggests that vitamin D and its receptor VDR may regulate intestinal barrier …             Proteomic analysis reveals that COP9 signalosome complex subunit 7A (CSN7A) is essential for the phase transition of migratory locust ▶     Xi-Wen Tong, Bing Chen, Li-Hua Huang et al.     The migratory locust displays a reversible, density-dependent transition between the two phases of gregaria and solitaria. This phenomenon is a typical kind of behavior …             MitoRCA-seq reveals unbalanced cytocine to thymine transition in Polg mutant mice ▶     Ting Ni, Gang Wei, Ting Shen et al.     Mutations in mitochondrial DNA (mtDNA) can lead to a wide range of human diseases. We have developed a deep sequencing strategy, mitoRCA-seq, to detect low-frequency mtDNA point …             Spontaneous Regeneration of Human Photoreceptor Outer Segments ▶     Jonathan C. Horton, Alicia B. Parker, James V. Botelho et al.     Photoreceptors are damaged in many common eye diseases, such as macular degeneration, retinal detachment, and retinitis pigmentosa. The development of methods to promote the …             Parallel damage in mitochondrial and lysosomal compartments promotes efficient cell death with autophagy: The case of the pentacyclic triterpenoids ▶     Waleska K. Martins, Érico T. Costa, Mário C. Cruz et al.     The role of autophagy in cell death is still controversial and a lot of debate has concerned the transition from its pro-survival to its pro-death roles. The similar structure of …             Field populations of native Indian honey bees from pesticide intensive agricultural landscape show signs of impaired olfaction ▶     Priyadarshini Chakrabarti, Santanu Rana, Sreejata Bandopadhyay et al.     Little information is available regarding the adverse effects of pesticides on natural honey bee populations. This study highlights the detrimental effects of pesticides on honey …             The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells ▶     Huanyu Xu, Sen Guo, Wei Li et al.     Among the identified thousands of circular RNAs (circRNA) in humans and animals, Cdr1as (also known as CiRS-7) was recently demonstrated to act as a powerful miR-7 …             Inner workings of thrombolites: spatial gradients of metabolic activity as revealed by metatranscriptome profiling ▶     J. M. Mobberley, C. L. M. Khodadad, P. T. Visscher et al.     Microbialites are sedimentary deposits formed by the metabolic interactions of microbes and their environment. These lithifying microbial communities represent one of the oldest …             Therapeutic potential of digitoflavone on diabetic nephropathy: nuclear factor erythroid 2-related factor 2-dependent anti-oxidant and anti-inflammatory effect ▶     Yang Yang, Gang Chen, Xiaolan Cheng et al.     Nuclear factor erythroid 2-related factor 2 (Nrf2) has emerged as a therapeutic target in many diseases, because it can induce antioxidant enzymes and other cytoprotective …             CCR2 inhibition sequesters multiple subsets of leukocytes in the bone marrow ▶     Naoki Fujimura, Baohui Xu, Jackson Dalman et al.     Chemokine receptor CCR2 mediates monocyte mobilization from the bone marrow (BM) and subsequent migration into target tissues. The degree to which CCR2 is differentially …             Two complementary approaches for intracellular delivery of exogenous enzymes ▶     Aleksander Rust, Hazirah H. A. Hassan, Svetlana Sedelnikova et al.     Intracellular delivery of biologically active proteins remains a formidable challenge in biomedical research. Here we show that biomedically relevant enzymes can be delivered …             HPVbase – a knowledgebase of viral integrations, methylation patterns and microRNAs aberrant expression: As potential biomarkers for Human papillomaviruses mediated carcinomas ▶     Amit Kumar Gupta, Manoj Kumar     Human papillomaviruses (HPVs) are extremely associated with different carcinomas. Despite consequential accomplishments, there is still need to establish more promising …             2D map projections for visualization and quantitative analysis of 3D fluorescence micrographs ▶     G. Hernán Sendra, Christian H. Hoerth, Christian Wunder et al.     We introduce Map3-2D, a freely available software to accurately project up to five-dimensional (5D) fluorescence microscopy image data onto full-content 2D maps. Similar to the …             Spatiotemporal neural network dynamics for the processing of dynamic facial expressions ▶     Wataru Sato, Takanori Kochiyama, Shota Uono     The dynamic facial expressions of emotion automatically elicit multifaceted psychological activities; however, the temporal profiles and dynamic interaction patterns of brain …             Stomatal closure is induced by hydraulic signals and maintained by ABA in drought-stressed grapevine ▶     Sergio Tombesi, Andrea Nardini, Tommaso Frioni et al.     Water saving under drought stress is assured by stomatal closure driven by active (ABA-mediated) and/or passive (hydraulic-mediated) mechanisms. There is currently no …             AtMYB12 expression in tomato leads to large scale differential modulation in transcriptome and flavonoid content in leaf and fruit tissues ▶     Ashutosh Pandey, Prashant Misra, Dharmendra Choudhary et al.     Plants synthesize secondary metabolites, including flavonoids, which play important role during various stresses for their survival. These metabolites are also considered as …             RE-IIBP Methylates H3K79 and Induces MEIS1-mediated Apoptosis via H2BK120 Ubiquitination by RNF20 ▶     Jin Woo Park, Kee-Beom Kim, Ji-Young Kim et al.     Histone lysine methylation contributes to transcriptional regulation by serving as a platform for the recruitment of various cofactors. Intense studies have been conducted for …             Novel structural co-expression analysis linking the NPM1-associated ribosomal biogenesis network to chronic myelogenous leukemia ▶     Lawrence WC Chan, Xihong Lin, Godwin Yung et al.     Co-expression analysis reveals useful dysregulation patterns of gene cooperativeness for understanding cancer biology and identifying new targets for treatment. We developed a …             A Novel Intravital Imaging Window for Longitudinal Microscopy of the Mouse Ovary ▶     Filip Bochner, Liat Fellus-Alyagor, Vyacheslav Kalchenko et al.     The ovary is a dynamic organ that undergoes dramatic remodeling throughout the ovulatory cycle. Maturation of the ovarian follicle, release of the oocyte in the course of …             A pre-screening FISH-based method to detect CRISPR/Cas9 off-targets in mouse embryonic stem cells ▶     Marianna Paulis, Alessandra Castelli, Michela Lizier et al.     The clustered regularly interspaced short palindromic repeat (CRISPR)/associated 9 (Cas9) technology has been recently added to the tools allowing efficient and easy DNA …             Anti-Human H1N1pdm09 and swine H1N1 Virus Antibodies among Swine Workers in Guangdong Province, China ▶     Jie Wu, Lina Yi, Hanzhong Ni et al.     To assess the potential transmission for zoonotic influenza, sero-antibodies against two kinds of influenza viruses—classical swine H1N1 and human H1N1pdm09 virus were detected …             Hypoxia-inducible miR-182 enhances HIF1α signaling via targeting PHD2 and FIH1 in prostate cancer ▶     Yan Li, Duo Zhang, Xiaoyun Wang et al.     Activation of hypoxia-inducible factor 1α (HIF1α) controls the transcription of genes governing angiogenesis under hypoxic condition during tumorigenesis. Here we show that …             MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells ▶     Marijn Schouten, Silvina A. Fratantoni, Chantal J. Hubens et al.     Adult neurogenesis continuously contributes new neurons to hippocampal circuits and the programmed death of a subset of immature cells provides a primary mechanism controlling …             Genome-wide high-throughput SNP discovery and genotyping for understanding natural (functional) allelic diversity and domestication patterns in wild chickpea ▶     Deepak Bajaj, Shouvik Das, Saurabh Badoni et al.     We identified 82489 high-quality genome-wide SNPs from 93 wild and cultivated Cicer accessions through integrated reference genome- and de novo-based GBS assays. High intra- and …             14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders ▶     Xiangjun Xu, Emily J. Jaehne, Zarina Greenberg et al.     Sequencing and expression analyses implicate 14-3-3ζ as a genetic risk factor for neurodevelopmental disorders such as schizophrenia and autism. In support of this notion, we …             Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation ▶     Hengyi Shao, Yuejia Huang, Liangyu Zhang et al.     Chromosome segregation in mitosis is orchestrated by the dynamic interactions between the kinetochore and spindle microtubules. The microtubule depolymerase mitotic …             A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches ▶     Dongyu Jia, Muhammed Soylemez, Gabriel Calvin et al.     During Drosophila oogenesis, follicle cells sequentially undergo three distinct cell-cycle programs: the mitotic cycle, endocycle, and gene amplification. Notch signaling plays a …             Fluoxetine increases plasticity and modulates the proteomic profile in the adult mouse visual cortex ▶     L. Ruiz-Perera, M. Muniz, G. Vierci et al.     The scarce functional recovery of the adult CNS following injuries or diseases is largely due to its reduced potential for plasticity, the ability to reorganize neural …             Implementation of genome-wide complex trait analysis to quantify the heritability in multiple myeloma ▶     Jonathan S. Mitchell, David C. Johnson, Kevin Litchfield et al.     A sizeable fraction of multiple myeloma (MM) is expected to be explained by heritable factors. Genome-wide association studies (GWAS) have successfully identified a number of …             Quantitative determination of target gene with electrical sensor ▶     Xuzhi Zhang, Qiufen Li, Xianshi Jin et al.     Integrating loop-mediated isothermal amplification (LAMP) with capacitively coupled contactless conductivity detection (C4D), we have developed an electrical sensor for the …             Design and performance of a sericin-alginate interpenetrating network hydrogel for cell and drug delivery ▶     Yeshun Zhang, Jia Liu, Lei Huang et al.     Although alginate hydrogels have been extensively studied for tissue engineering applications, their utilization is limited by poor mechanical strength, rapid drug release, and a …             l-Asparaginase from Streptomyces griseus NIOT-VKMA29: optimization of process variables using factorial designs and molecular characterization of l-asparaginase gene ▶     Balakrishnan Meena, Lawrance Anburajan, Thadikamala Sathish et al.     Marine actinobacteria are known to be a rich source for novel metabolites with diverse biological activities. In this study, a potential extracellular L-asparaginase was …             DNA barcode reference library for Iberian butterflies enables a continental-scale preview of potential cryptic diversity ▶     Vlad Dincă, Sergio Montagud, Gerard Talavera et al.     How common are cryptic species - those overlooked because of their morphological similarity? Despite its wide-ranging implications for biology and conservation, the answer …             Three SAUR proteins SAUR76, SAUR77 and SAUR78 promote plant growth in Arabidopsis ▶     Zhi-Gang Li, Hao-Wei Chen, Qing-Tian Li et al.     Ethylene perceived by a family of five receptors regulates many developmental processes in Arabidopsis. Here we conducted the yeast two-hybrid assay to screen for additional …             Comparison of Therapeutic Effect of Recombinant Tissue Plasminogen Activator by Treatment Time after Onset of Acute Ischemic Stroke ▶     Hai-rong Wang, Miao Chen, Fei-long Wang et al.     We aimed to compare the therapeutic effect of recombinant tissue plasminogen activator (rt-PA) administered at different time windows within the first 6 hours after onset of …             Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways ▶     Jie Liu, Wei Huang, Caiping Ren et al.     Lipid raft proteins have been confirmed to be important in cell signal transduction. Some reports have shown that the aberrant expression of lipid raft proteins is associated …             Position-specific prediction of methylation sites from sequence conservation based on information theory ▶     Yinan Shi, Yanzhi Guo, Yayun Hu et al.     Protein methylation plays vital roles in many biological processes and has been implicated in various human diseases. To fully understand the mechanisms underlying methylation …             Compaction of rolling circle amplification products increases signal integrity and signal-to-noise ratio ▶     Carl-Magnus Clausson, Linda Arngården, Omer Ishaq et al.     Rolling circle amplification (RCA) for generation of distinct fluorescent signals in situ relies upon the self-collapsing properties of single-stranded DNA in commonly used …             The Brain Functional State of Music Creation: an fMRI Study of Composers ▶     Jing Lu, Hua Yang, Xingxing Zhang et al.     In this study, we used functional magnetic resonance imaging (fMRI) to explore the functional networks in professional composers during the creation of music. We compared the …             Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens ▶     Hong-Sen Chen, Shin-Chen Hou, Jhih-Wei Jian et al.     Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody …             A Comprehensive Inter-Tissue Crosstalk Analysis Underlying Progression and Control of Obesity and Diabetes ▶     Pawan Samdani, Meet Singhal, Neeraj Sinha et al.     Obesity is a metabolic state associated with excess of positive energy balance. While adipose tissues are considered the major contributor for complications associated with …             Myo5b knockout mice as a model of microvillus inclusion disease ▶     Fernando Cartón-García, Arend W. Overeem, Rocio Nieto et al.     Inherited MYO5B mutations have recently been associated with microvillus inclusion disease (MVID), an autosomal recessive syndrome characterized by intractable, life-threatening, …             New “haploid biofilm model” unravels IRA2 as a novel regulator of Candida albicans biofilm formation ▶     Chaminda Jayampath Seneviratne, Guisheng Zeng, Thuyen Truong et al.     Clinical isolates of the fungal human pathogen Candida albicans are invariably diploid and heterozygous, impeding genetic study. Recent isolation of C. albicans haploids opens …             Independent Emergence of the Cosmopolitan Asian Chikungunya Virus, Philippines 2012 ▶     Kim-Kee Tan, Ava Kristy D. Sy, Amado O. Tandoc et al.     Outbreaks involving the Asian genotype Chikungunya virus (CHIKV) caused over one million infections in the Americas recently. The outbreak was preceded by a major nationwide …             A Novel Serum 4-microRNA Signature for Lung Cancer Detection ▶     Ernest Nadal, Anna Truini, Asuka Nakata et al.     The aim of this study was to identify differentially-expressed miRNAs in the serum of non-small cell lung cancer (NSCLC) patients that might be a clinically-useful tool for lung …             Possible Signatures of Hominin Hybridization from the Early Holocene of Southwest China ▶     Darren Curnoe, Xueping Ji, Paul S. C. Taçon et al.     We have previously described hominin remains with numerous archaic traits from two localities (Maludong and Longlin Cave) in Southwest China dating to the Pleistocene-Holocene …             Robust gene expression and mutation analyses of RNA-sequencing of formalin-fixed diagnostic tumor samples ▶     Stefan Graw, Richard Meier, Kay Minn et al.     Current genomic studies are limited by the availability of fresh tissue samples. Here, we show that Illumina RNA sequencing of formalin-fixed diagnostic tumor samples produces …             Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells ▶     Hui-Mei Wu, Zi-Feng Jiang, Pei-Shan Ding et al.     Hypoxia which commonly exists in solid tumors, leads to cancer cells chemoresistance via provoking adaptive responses including autophagy. Therefore, we sought to evaluate the …             Pleiotropy across academic subjects at the end of compulsory education ▶     Kaili Rimfeld, Yulia Kovas, Philip S. Dale et al.     Research has shown that genes play an important role in educational achievement. A key question is the extent to which the same genes affect different academic subjects before …             Chemoprevention of Colonic Aberrant Crypt Foci by Novel Schiff Based Dichlorido(4-Methoxy-2-{[2-(Piperazin-4-Ium-1-Yl)Ethyl]Iminomethyl}Phenolate)Cd Complex in Azoxymethane-Induced Colorectal Cancer in Rats ▶     Maryam Hajrezaie, Keivan Shams, Soheil Zorofchian Moghadamtousi et al.     Schiff-based complexes as a source of cancer chemotherapeutic compounds have been subjected to the variety of anticancer studies. The in-vitro analysis confirmed the CdCl2(C14H21N…             The highest-ranking rooster has priority to announce the break of dawn ▶     Tsuyoshi Shimmura, Shosei Ohashi, Takashi Yoshimura     The “cock-a-doodle-doo” crowing of roosters, which symbolizes the break of dawn in many cultures, is controlled by the circadian clock. When one rooster announces the break of …             Unlocking nature’s treasure-chest: screening for oleaginous algae ▶     Stephen P. Slocombe, QianYi Zhang, Michael Ross et al.     Micro-algae synthesize high levels of lipids, carbohydrates and proteins photoautotrophically, thus attracting considerable interest for the biotechnological production of fuels, …             Identification of Drosophila Mutants Affecting Defense to an Entomopathogenic Fungus ▶     Hsiao-Ling Lu, Jonathan B. Wang, Markus A. Brown et al.     Fungi cause the majority of insect disease. However, to date attempts to model host–fungal interactions with Drosophila have focused on opportunistic human pathogens. Here, we …             Characterization of the honeybee AmNaV1 channel and tools to assess the toxicity of insecticides ▶     Pascal Gosselin-Badaroudine, Adrien Moreau, Lucie Delemotte et al.     Pollination is important for both agriculture and biodiversity. For a significant number of plants, this process is highly, and sometimes exclusively, dependent on the …             Two universal physical principles shape the power-law statistics of real-world networks ▶     Tom Lorimer, Florian Gomez, Ruedi Stoop     The study of complex networks has pursued an understanding of macroscopic behaviour by focusing on power-laws in microscopic observables. Here, we uncover two universal …             Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype ▶     Gyu-Beom Jang, Ji-Young Kim, Sung-Dae Cho et al.     The identification of cancer stem cells (CSCs) represents an important milestone in the understanding of chemodrug resistance and cancer recurrence. More specifically, some …             Spider foraging strategy affects trophic cascades under natural and drought conditions ▶     Shengjie Liu, Jin Chen, Wenjin Gan et al.     Spiders can cause trophic cascades affecting litter decomposition rates. However, it remains unclear how spiders with different foraging strategies influence faunal communities, …             Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm ▶     Emmanuel Martinez-Ledesma, Roeland G.W. Verhaak, Victor Treviño     Cancer types are commonly classified by histopathology and more recently through molecular characteristics such as gene expression, mutations, copy number variations, and …             Anion-Responsive Metallopolymer Hydrogels for Healthcare Applications ▶     Jiuyang Zhang, Jing Yan, Parasmani Pageni et al.     Metallopolymers combine a processable, versatile organic polymeric skeleton with functional metals, providing multiple functions and methodologies in materials science. Taking …             A Novel Bio-carrier Fabricated Using 3D Printing Technique for Wastewater Treatment ▶     Yang Dong, Shu-Qian Fan, Yu Shen et al.     The structure of bio-carriers is one of the key operational characteristics of a biofilm reactor. The goal of this study is to develop a series of novel fullerene-type …             Analysing calcium signalling of cells under high shear flows using discontinuous dielectrophoresis ▶     Rebecca Soffe, Sara Baratchi, Shi-Yang Tang et al.     Immobilisation of cells is an important feature of many cellular assays, as it enables the physical/chemical stimulation of cells; whilst, monitoring cellular processes using …             “Do-it-yourself in vitro vasculature that recapitulates in vivo geometries for investigating endothelial-blood cell interactions” ▶     Robert G. Mannino, David R. Myers, Byungwook Ahn et al.     Investigating biophysical cellular interactions in the circulation currently requires choosing between in vivo models, which are difficult to interpret due in part to the …             Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease ▶     Xinzhong Li, Jintao Long, Taigang He et al.     Previous studies have evaluated gene expression in Alzheimer’s disease (AD) brains to identify mechanistic processes, but have been limited by the size of the datasets studied. …             Fish-seastar facilitation leads to algal forest restoration on protected rocky reefs ▶     Nicola M. Galasso, Chiara Bonaviri, Francesco Di Trapani et al.     Although protected areas can lead to recovery of overharvested species, it is much less clear whether the return of certain predator species or a diversity of predator species …             Calcium Spikes in Epithelium: study on Drosophila early embryos ▶     Olga Markova, Sébastien Sénatore, Claire Chardès et al.     Calcium ion acts in nearly every aspect of cellular life. The versatility and specificity required for such a ubiquitous role is ensured by the spatio-temporal dynamics of …             Cultural differences in ant-dipping tool length between neighbouring chimpanzee communities at Kalinzu, Uganda ▶     Kathelijne Koops, Caspar Schöning, Mina Isaji et al.     Cultural variation has been identified in a growing number of animal species ranging from primates to cetaceans. The principal method used to establish the presence of culture in …             Oleanolic acid acrylate elicits antidepressant-like effect mediated by 5-HT1A receptor ▶     James O. Fajemiroye, Prabhakar R. Polepally, Narayan D. Chaurasiya et al.     The development of new drugs for the treatment of depression is strategic to achieving clinical needs of patients. This study evaluates antidepressant-like effect and neural …             Ecdysone promotes growth of imaginal discs through the regulation of Thor in D. melanogaster ▶     Leire Herboso, Marisa M. Oliveira, Ana Talamillo et al.     Animals have a determined species-specific body size that results from the combined action of hormones and signaling pathways regulating growth rate and duration. In Drosophila, …             Global patterns and drivers of phylogenetic structure in island floras ▶     Patrick Weigelt, W. Daniel Kissling, Yael Kisel et al.     Islands are ideal for investigating processes that shape species assemblages because they are isolated and have discrete boundaries. Quantifying phylogenetic assemblage structure …             Clock gene polymorphism and scheduling of migration: a geolocator study of the barn swallow Hirundo rustica ▶     Gaia Bazzi, Roberto Ambrosini, Manuela Caprioli et al.     Circannual rhythms often rely on endogenous seasonal photoperiodic timers involving ‘clock’ genes, and Clock gene polymorphism has been associated to variation in phenology in …             Regulation of T cell function by microRNA-720 ▶     Yu Wang, Zheng Zhang, Dong Ji et al.     Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the …             Genetic analysis and molecular mapping of QTLs for resistance to rice black-streaked dwarf disease in rice ▶     Tong Zhou, Linlin Du, Lijiao Wang et al.     Rice black-streaked dwarf disease, caused by rice black-streaked dwarf virus (RBSDV), is transmitted by small brown planthoppers (Laodelphax striatellus Fallén, SBPH) and causes …             Effect of variation in ovine WFIKKN2 on growth traits appears to be gender-dependent ▶     Jiqing Wang, Huitong Zhou, Qian Fang et al.     WFIKKN2 may play a role in the regulation of muscle growth and development, but to date there have been no reports on the effect of variation in WFIKKN2 on growth and carcass …             A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines ▶     Fang Long, Hua Yang, Yanmin Xu et al.     It has been well claimed that herbal medicines (HMs) elicit effects via a multi-compounds and multi-targets synergistic mode. However, it lacks appropriate strategies to uncover …             PRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem and progenitor cells ▶     Linda Varagnolo, Qiong Lin, Nadine Obier et al.     Cord blood hematopoietic stem cells (CB-HSCs) are an outstanding source for transplantation approaches. However, the amount of cells per donor is limited and culture expansion of …             S-acylation of the Insulin-Responsive Aminopeptidase (IRAP): Quantitative analysis and Identification of Modified Cysteines ▶     Martin W. Werno, Luke H. Chamberlain     The insulin-responsive aminopeptidase (IRAP) was recently identified as an S-acylated protein in adipocytes and other tissues. However, there is currently no information on the …             Novel function of a putative MOC1 ortholog associated with spikelet number per spike in common wheat ▶     Bin Zhang, Xia Liu, Weina Xu et al.     Axillary meristems play an important role in determining final plant architecture and floral structures. Tomato Ls, Arabidopsis LAS and rice MOC1 are orthologous genes regulating …             Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis ▶     Wei-Chieh Lin, Chang-Wen Chen, Yu-Wen Huang et al.     Kallistatin, an endogenous plasma protein, exhibits pleiotropic properties in inhibiting inflammation, oxidative stress and apoptosis, as evidenced in various animal models and …             Specialised emission pattern of leaf trace in a late Permian (253 million-years old) conifer ▶     Hai-Bo Wei, Zhuo Feng, Ji-Yuan Yang et al.     Leaf traces are important structures in higher plants that connect leaves and the stem vascular system. The anatomy and emission pattern of leaf traces are well studied in extant …             Functional Loss of Bmsei Causes Thermosensitive Epilepsy in Contractile Mutant Silkworm, Bombyx mori ▶     Hongyi Nie, Tingcai Cheng, Xiaofeng Huang et al.     The thermoprotective mechanisms of insects remain largely unknown. We reported the Bombyx mori contractile (cot) behavioral mutant with thermo-sensitive seizures phenotype. At …             Body size distributions of the pale grass blue butterfly in Japan: Size rules and the status of the Fukushima population ▶     Wataru Taira, Mayo Iwasaki, Joji M. Otaki     The body size of the pale grass blue butterfly, Zizeeria maha, has been used as an environmental indicator of radioactive pollution caused by the Fukushima nuclear accident. …             Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-ĸB-dependent mechanism ▶     Laura Díaz, Marta Martínez-Bonet, Javier Sánchez et al.     Multiple studies have shown that HIV-1 patients may develop virus reservoirs that impede eradication; these reservoirs include the central nervous system (CNS). Despite an …             Intrinsic hierarchical structural imperfections in a natural ceramic of bivalve shell with distinctly graded properties ▶     Da Jiao, Zengqian Liu, Zhenjun Zhang et al.     Despite the extensive investigation on the structure of natural biological materials, insufficient attention has been paid to the structural imperfections by which the mechanical …             Potential for DNA-based identification of Great Lakes fauna: match and mismatch between taxa inventories and DNA barcode libraries ▶     Anett S. Trebitz, Joel C. Hoffman, George W. Grant et al.     DNA-based identification of mixed-organism samples offers the potential to greatly reduce the need for resource-intensive morphological identification, which would be of value …             Implementation of iodine biokinetic model for interpreting I-131 contamination in breast milk after the Fukushima nuclear disaster ▶     Kotaro Tani, Osamu Kurihara, Eunjoo Kim et al.     After the accident at the Fukushima Daiichi Nuclear Power Plant run by Tokyo Electric Power Company in 2011, breast milk samples obtained from volunteers living in Fukushima and …             Association of matrix metalloproteinase family gene polymorphisms with lung cancer risk: logistic regression and generalized odds of published data ▶     Hongxia Li, Xiaoyan Liang, Xuebing Qin et al.     Many studies have reported the association between the matrix metalloproteinase (MMP) polymorphisms and lung cancer susceptibility, but the results were inconclusive. We …             Oxalate secretion by ectomycorrhizal Paxillus involutus is mineral-specific and controls calcium weathering from minerals ▶     A. Schmalenberger, A. L. Duran, A. W. Bray et al.     Trees and their associated rhizosphere organisms play a major role in mineral weathering driving calcium fluxes from the continents to the oceans that ultimately control …             Erratum: From link-prediction in brain connectomes and protein interactomes to the local-community-paradigm in complex networks ▶     Carlo Vittorio Cannistraci, Gregorio Alanis-Lobato, Timothy Ravasi                 Label Propagation Prediction of Drug-Drug Interactions Based on Clinical Side Effects ▶     Ping Zhang, Fei Wang, Jianying Hu et al.     Drug-drug interaction (DDI) is an important topic for public health, and thus attracts attention from both academia and industry. Here we hypothesize that clinical side effects …             Suppression of Poly(rC)-Binding Protein 4 (PCBP4) reduced cisplatin resistance in human maxillary cancer cells ▶     Yumi Ito, Norihiko Narita, Nozomi Nomi et al.     Cisplatin plays an important role in the therapy for human head and neck cancers. However, cancer cells develop cisplatin resistance, leading to difficulty in treatment and poor …             Insight on how fishing bats discern prey and adjust their mechanic and sensorial features during the attack sequence ▶     Ostaizka Aizpurua, Antton Alberdi, Joxerra Aihartza et al.     Several insectivorous bats have included fish in their diet, yet little is known about the processes underlying this trophic shift. We performed three field experiments with wild …             A microfluidic device to study neuronal and motor responses to acute chemical stimuli in zebrafish ▶     Raphaël Candelier, Meena Sriti Murmu, Sebastián Alejo Romano et al.     Zebrafish larva is a unique model for whole-brain functional imaging and to study sensory-motor integration in the vertebrate brain. To take full advantage of this system, one …             Salvianolic acid A as a multifunctional agent ameliorates doxorubicin-induced nephropathy in rats ▶     Hua-Ying Fan, Ming-Yan Yang, Dong Qi et al.     Nephrotic syndrome (NS) is still a therapeutic challenge. To date there is no ideal treatment. Evidence suggest that multidrug therapy has more effect than monotherapy in …             Escherichia coli of sequence type 3835 carrying blaNDM-1, blaCTX-M-15, blaCMY-42 and blaSHV-12 ▶     Yu Feng, Ping Yang, Yi Xie et al.     New Delhi metallo-β-lactamase (NDM) represents a serious challenge for treatment and public health. A carbapenem-resistant Escherichia coli clinical strain WCHEC13-8 was …             Circadian and ultradian rhythms of clock gene expression in the suprachiasmatic nucleus of freely moving mice ▶     Daisuke Ono, Ken-ichi Honma, Sato Honma     In mammals, the temporal order of physiology and behavior is primarily regulated by the circadian pacemaker located in the hypothalamic suprachiasmatic nucleus (SCN). Rhythms are …             Nonfunctional ingestion of plant miRNAs in silkworm revealed by digital droplet PCR and transcriptome analysis ▶     Ling Jia, Dayan Zhang, Zhonghuai Xiang et al.     Since a plant miRNA (miR168) cross-regulating a mammalian transcript was reported, miRNA-mediated cross-kingdom communication has become one of the most compelling but …             Novel Cathelicidins from Pigeon Highlights Evolutionary Convergence in Avain Cathelicidins and Functions in Modulation of Innate Immunity ▶     Haining Yu, Yiling Lu, Xue Qiao et al.     Cathelicidins are short cationic host defense peptides and play a central role in host innate immune system. Here we identified two novel cathelicidins, Cl-CATH2 and 3, from …             Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury ▶     Weiwei Lin, Na Yuan, Zhen Wang et al.     Autophagy is essentially a metabolic process, but its in vivo role in nuclear radioprotection remains unexplored. We observed that ex vivo autophagy activation reversed the …             Ancestry, admixture and fitness in Colombian genomes ▶     Lavanya Rishishwar, Andrew B. Conley, Charles H. Wigington et al.     The human dimension of the Columbian Exchange entailed substantial genetic admixture between ancestral source populations from Africa, the Americas and Europe, which had evolved …             The pain receptor TRPV1 displays agonist-dependent activation stoichiometry ▶     Adina Hazan, Rakesh Kumar, Henry Matzner et al.     The receptor channel TRPV1 (Transient Receptor Potential Vanilloid 1) is expressed by primary afferent sensory neurons of the pain pathway, where it functions as a sensor of …             An Efficient Genome-Wide Fusion Partner Screening System for Secretion of Recombinant Proteins in Yeast ▶     Jung-Hoon Bae, Bong Hyun Sung, Hyun-Jin Kim et al.     To produce rarely secreted recombinant proteins in the yeast Saccharomyces cerevisiae, we developed a novel genome-wide optimal translational fusion partner (TFP) screening …             Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin ▶     Lan Chang, Wei Cui, Yong Yang et al.     β-amyloid (Aβ) oligomers have been closely implicated in the pathogenesis of Alzheimer’s disease (AD). We found, for the first time, that bis(heptyl)-cognitin, a novel dimeric …             A new functional classification system (FGA/B) with prognostic value for glioma patients ▶     Katharina Friedlein, Yavor Bozhkov, Nirjhar Hore et al.     Despite advances in multimodal treatments, malignant gliomas remain characterized by a short survival time. Surgical treatment is accepted to be the first line of therapy, with …             Hyperosmotic stress activates the expression of members of the miR-15/107 family and induces downregulation of anti-apoptotic genes in rat liver ▶     David Santosa, Mirco Castoldi, Martha Paluschinski et al.     microRNAs are an abundant class of small non-coding RNAs that negatively regulate gene expression. Importantly, microRNA activity has been linked to the control of cellular …             An advanced fragment analysis-based individualized subtype classification of pediatric acute lymphoblastic leukemia ▶     Han Zhang, Hao Cheng, Qingqing Wang et al.     Pediatric acute lymphoblastic leukemia (ALL) is the most common neoplasm and one of the primary causes of death in children. Its treatment is highly dependent on the correct …             Cytosolic pressure provides a propulsive force comparable to actin polymerization during lamellipod protrusion ▶     Daphne Manoussaki, William D. Shin, Clare M. Waterman et al.     Does cytosolic pressure facilitate f-actin polymerization to push the leading edge of a cell forward during self-propelled motion? AFM force-distance (f-d) curves obtained from …             Genome-wide uniparental disomy screen in human discarded morphologically abnormal embryos ▶     Jiawei Xu, Meixiang Zhang, Wenbin Niu et al.     Uniparental disomy (UPD) has been shown to be rare in human normal blastocysts, but its frequency in discarded morphologically abnormal embryos and its relevance to embryonic …             Water regime history drives responses of soil Namib Desert microbial communities to wetting events ▶     Aline Frossard, Jean-Baptiste Ramond, Mary Seely et al.     Despite the dominance of microorganisms in arid soils, the structures and functional dynamics of microbial communities in hot deserts remain largely unresolved. The effects of …             Identification of PblB mediating galactose-specific adhesion in a successful Streptococcus pneumoniae clone ▶     Yu-Chia Hsieh, Tzu-Lung Lin, Che-Ming Lin et al.     The pneumococcal genome is variable and there are minimal data on the influence of the accessory genome on phenotype. Pneumococcal serotype 14 sequence type (ST) 46 had been the …             Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations ▶     W. Joost Lesterhuis, Catherine Rinaldi, Anya Jones et al.     Cancer immunotherapy has shown impressive results, but most patients do not respond. We hypothesized that the effector response in the tumour could be visualized as a complex …             Yindanxinnaotong, a Chinese compound medicine, synergistically attenuates atherosclerosis progress ▶     Long Cheng, Guo-feng Pan, Xiao-dong Zhang et al.     Yindanxinnaotong (YD), a traditional Chinese medicine, has been introduced to clinical medicine for more than a decade, while its pharmacological properties are still not to be …             Fertile fathoms: Deep reproductive refugia for threatened shallow corals ▶     Daniel M. Holstein, Tyler B. Smith, Joanna Gyory et al.     The persistence of natural metapopulations may depend on subpopulations that exist at the edges of species ranges, removed from anthropogenic stress. 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